Reconsideration on the molecular identity of MPF
| Project/Area Number |
21247030
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Ochanomizu University (2012-2013)
Tokyo Institute of Technology (2009-2011) |
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Principal Investigator |
KISHIMOTO Takeo お茶の水女子大学, サイエンス&エデュケーションセンター, 客員教授 (00124222)
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| Co-Investigator(Kenkyū-buntansha) |
OKUMURA Eiichi 東京工業大学, 大学院生命理工学研究科, 助教 (00323808)
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| Co-Investigator(Renkei-kenkyūsha) |
TACHIBANA Kazunori 東京工業大学, バイオ研究基盤支援総合センター, 准教授 (60212031)
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| Project Period (FY) |
2009-05-11 – 2013-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥37,050,000 (Direct Cost: ¥28,500,000、Indirect Cost: ¥8,550,000)
Fiscal Year 2012: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2011: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | 細胞周期 / 卵細胞 / ＭＰＦ / サイクリンＢ-Cdk1/Cdc2 / Greatwallキナーゼ / Ensa/Arpp19 / PP2A-B55 / MPF / サイクリンB-Cdc2 / サイクリンB-Ccdc2 |
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| Research Abstract |
MPF (maturation/M phase-promoting factor) is the universal inducer of M-phase in eukaryotic cells. It is currently accepted that MPF is identical to the kinase cyclin B-Cdk1. Here we show that MPF and cyclin B-Cdk1 are not synonymous, and istead, that MPF is a system consisting of cyclin B-Cdk1 and another kinase, Greatwall kinase.
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Report
(5 results)
Research Products
(53 results)
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[Journal Article] Cyclin B-Cdk1 inhibits protein phosphatase PP2A-B55 via a Greatwall kinase-independent mechanism2014
Author(s)
Okumura, E., Morita, A., Wakai, M., Mochida, S., Hara, M., and Kishimoto, T
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Journal Title
J. Cell Biol
Volume: 204
Pages: 881-889
Related Report
Peer Reviewed
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[Journal Article] Cyclin B-Cdk1 inhibits protein phosphatase PP2A-B55 via a Greatwall kinase-independent mechanism.2014
Author(s)
Okumura, E., Morita, A., Wakai, M., Mochida, S., Hara, M., and Kishimoto, T.
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Journal Title
J. Cell Biol.
Volume: 204
Issue: 6
Pages: 881-889
DOI
Related Report
Peer Reviewed
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[Journal Article] Initiation of DNA replication after fertilization is regulated by p90Rsk at pre-RC/pre-IC transition in starfish eggs2010
Author(s)
Tachibana, K., Mori, M., Matsuhira, T., Karino, T., Inagaki, T., Nagayama, A., Nishiyama, A., Hara, M., and Kishimoto, T
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 107
Pages: 5006-5011
Related Report
Peer Reviewed
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[Book] Antibody inhibition of protein activity in starfish oocytes. In "Developmental Biology of the Sea Urchin and other Marine Invertebrates"(Carroll, D. and Stricker, S.A., eds.). Methods in Mol. Biol., vol. 1128, Chap. 212014
Author(s)
Okumura, E., Hara, M., and Kishimoto, T
Publisher
Springer Science+Business Media, New York
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[Book] Cytostatic arrest : Post-ovulation arrest until fertilization in metazoan oocytes. In "Oogenesis : The Universal Process" (Verlhac, M.H. and Villeneuve, A., eds.), Chap. 142010
Author(s)
Nishiyama, T., Tachibana, K., and Kishimoto, T
Publisher
Wiley-Blackwell, UK
Related Report
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[Book] Oogenesis : The Universal Process, Chap. 14 : Cytostatic arrest : Post-ovulation arrest until fertilization in metazoan oocytes(Verlhac, M.H. and Villeneuve, A., eds.)2010
Author(s)
Nishiyama, T., Tachibana, K., Kishimoto, T.
Total Pages
501
Publisher
Wiley-Blackwell, UK
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