| Budget Amount *help |
¥46,280,000 (Direct Cost: ¥35,600,000、Indirect Cost: ¥10,680,000)
Fiscal Year 2012: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2011: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2010: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2009: ¥21,970,000 (Direct Cost: ¥16,900,000、Indirect Cost: ¥5,070,000)
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| Research Abstract |
In this study, we examined localization of biliary transporters and physiological liver failure in chronic hepatitis by using human liver slices. We could determine the new binding partners (AnexinA2 etc) of biliary transporters by using two-dimensional fluorescence differential analysis with Ethan DIGE. And we could characterize AnexinA2 regulate the canalicular membrane localization of Mrp2. Moreover, inhibitors (CyclopsorinA and Glibenclamide) of Bsep, one of biliary transporter, shows toxicity in the presence of the concentrated bile acids mixtureby using human sandwich cultured hepatocytes.
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