| Budget Amount *help |
¥37,050,000 (Direct Cost: ¥28,500,000、Indirect Cost: ¥8,550,000)
Fiscal Year 2011: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2010: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Fiscal Year 2009: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
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| Research Abstract |
ATP is a major chemical transmitter in purinergic signal transmission, which distributes throughout the body and plays an essential role in varuous physiological and pathological processes such as the reception of chemical senses and pains, neuroregeneration, platelet aggregation, inflammation. Before secretion, ATP is stored in the secretory vesicles. Vesicular nucleotide transporter(VNUT) is responsible for vesicular storage of nucleotide and thus plays an essential role in the purinergic chemial transmission. This study revealed sturucturral and functional relationship, and physiological significance of VNUT. In particular we established(1) potent and reversible modifiers of VNUT and(2) knockout mice. Using these two tools, we can control purinergic chemical transmisson in vitro and in vivo.
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