Structure, function and physiological significance of vesicular nucleotide transporter(VNUT)
Project/Area Number |
21249005
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Biological pharmacy
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Research Institution | Okayama University |
Principal Investigator |
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥37,050,000 (Direct Cost: ¥28,500,000、Indirect Cost: ¥8,550,000)
Fiscal Year 2011: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2010: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Fiscal Year 2009: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
|
Keywords | 生化学 / 化学伝達 / トランスポーター / プリン作動性 / ATP / ノックアウトマウス / 神経 / アストロサイト / VNUT / 塩素イオン / ショウジョウバエ / ショウジョウバェ |
Research Abstract |
ATP is a major chemical transmitter in purinergic signal transmission, which distributes throughout the body and plays an essential role in varuous physiological and pathological processes such as the reception of chemical senses and pains, neuroregeneration, platelet aggregation, inflammation. Before secretion, ATP is stored in the secretory vesicles. Vesicular nucleotide transporter(VNUT) is responsible for vesicular storage of nucleotide and thus plays an essential role in the purinergic chemial transmission. This study revealed sturucturral and functional relationship, and physiological significance of VNUT. In particular we established(1) potent and reversible modifiers of VNUT and(2) knockout mice. Using these two tools, we can control purinergic chemical transmisson in vitro and in vivo.
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Report
(4 results)
Research Products
(66 results)
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[Journal Article] Vacuolar transport of nicotine is mediated by a multidrug and toxic compound extrusion(MATE)transporter in Nicoteana tabacum.2009
Author(s)
Morita, M, Shitan, N., Sawada.K., Montagu, V.M., Inze, D., Rischer, H., Goossens, A., Oksman-Caldentey. K.M., Moriyama, Y., Yazaki, K.
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Journal Title
Proc. Natl. Acad. Sci. USA 106(7)
Pages: 2447-2452
Related Report
Peer Reviewed
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[Journal Article] Identification of the vesicular nucleotide transporter(VNUT)in taste cells.2009
Author(s)
Iwatsuki, K., Ichikawa, R., Hiasa, H., Moriyama, Y., Torii, K., Uneyama, H.
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Journal Title
Biochem. Biophys. Res. Commun. 388
Pages: 1-5
Related Report
Peer Reviewed
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