| Budget Amount *help |
¥47,970,000 (Direct Cost: ¥36,900,000、Indirect Cost: ¥11,070,000)
Fiscal Year 2011: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2010: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2009: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
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| Research Abstract |
This study aims at elucidating physiological and pathophysiological significances of D-serine regulation in the central nervous system. In association with its physiological roles, we found D-serine-degrading enzyme, D-amino acid oxidase, distributed to a motoneuronal input and maintain D-serine at a low level in the region. As a pathophysiological approach, we found D-amino acid oxidase controls motoneuron degeneration and loss of its activity increases spinal D-serine level in amyotrophic lateral sclerosis. Independently, we found that streptozotocin-induced type1 diabetes increases hippocampal D-serine through loss of insulin.
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