Morphogenetic regulation through D-serine/serine racemase
Project/Area Number |
21249009
|
Research Category |
Grant-in-Aid for Scientific Research (A)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General anatomy (including Histology/Embryology)
|
Research Institution | Keio University |
Principal Investigator |
AISO Sadakazu 慶應義塾大学, 医学部, 教授 (60138013)
|
Co-Investigator(Renkei-kenkyūsha) |
SASABE Jumpei 慶應義塾大学, 医学部, 助教 (10398612)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥47,970,000 (Direct Cost: ¥36,900,000、Indirect Cost: ¥11,070,000)
Fiscal Year 2011: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2010: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2009: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
|
Keywords | 発生学 / 形態形成学 / D-セリン / 神経変性疾患 / 肝不全 / 腎不全 / 形態形成 / セリンラセメース |
Research Abstract |
This study aims at elucidating physiological and pathophysiological significances of D-serine regulation in the central nervous system. In association with its physiological roles, we found D-serine-degrading enzyme, D-amino acid oxidase, distributed to a motoneuronal input and maintain D-serine at a low level in the region. As a pathophysiological approach, we found D-amino acid oxidase controls motoneuron degeneration and loss of its activity increases spinal D-serine level in amyotrophic lateral sclerosis. Independently, we found that streptozotocin-induced type1 diabetes increases hippocampal D-serine through loss of insulin.
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Report
(4 results)
Research Products
(31 results)