Analyzing neuronal development through deciphering splicing code

• Project/Area Number: 21249013
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Kyoto University (2010-2011); Tokyo Medical and Dental University (2009)
• Principal Investigator: HAGIWARA Masatoshi 京都大学, 大学院・医学研究科, 教授 (10208423)
• Co-Investigator(Kenkyū-buntansha): OONO Kinji 名古屋大学, 医学(系)研究科(研究院), 教授 (80397455) ; TAKEUCHI Akihide 京都大学, 医学(系)研究科(研究院), 准教授 (90436618)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥48,230,000 (Direct Cost: ¥37,100,000、Indirect Cost: ¥11,130,000); Fiscal Year 2011: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000); Fiscal Year 2010: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000); Fiscal Year 2009: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
• Keywords: スプライシング / 大脳皮質形成 / エクソンアレイ / スプライシング調節因子 / プロファイリング解析 / 神経発生 / mRNA / 大脳皮質 / 発現パターン

Research Abstract

We could identified genome wide level of alternative splicing regulation regarding spliced genes and RNA-binding proteins during neuronal development.

Research Products

• [Journal Article] Loss of Sfpq causes long-gene transcriptopathy in the brain. (2018)
  • Author(s): Takeuchi A, Iida K, Tsubota T, Hosokawa M, Denawa M, Brown JB, Ninomiya K, Ito M, Kimura H, Abe T, Kiyonari H, Ohno K, and Hagiwara M
  • Journal Title: Cell Reports. Volume: 23 Issue: 5 Pages: 1326-1341
  • NAID: 120006463742
  • Peer Reviewed / Open Access
• [Journal Article] Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice (2017)
  • Author(s): Akiko Nakano-Kobayashi, Tomonari Awaya, Isao Kii, Yuto Sumida, Yukiko Okuno, Suguru Yoshida, Tomoe Sumida, Haruhisa Inoue, Takamitsu Hosoya and Masatoshi Hagiwara
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of america Volume: 114 Issue: 38 Pages: 10268-10273
  • DOI: 10.1073/pnas.1704143114
  • NAID: 130007900113
  • Peer Reviewed / Open Access
• [Journal Article] RBM24 promotes U1 snRNP recognition of the mutated 5′ splice site in the IKBKAP gene of familial dysautonomia (2017)
  • Author(s): Ohe Kenji、Yoshida Mayumi、Nakano-Kobayashi Akiko、Hosokawa Motoyasu、Sako Yukiya、Sakuma Maki、Okuno Yukiko、Usui Tomomi、Ninomiya Kensuke、Nojima Takayuki、Kataoka Naoyuki、Hagiwara Masatoshi
  • Journal Title: RNA Volume: 23 Issue: 9 Pages: 1393-1403
  • DOI: 10.1261/rna.059428.116
  • Peer Reviewed / Open Access
• [Journal Article] In vitro expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate. (2017)
  • Author(s): Ohta H, Kurimoto K, Okamoto I, Nakamura T, Yabuta Y, Miyauchi H, Yamamoto T, Okuno Y, Hagiwara M, Shirane K, Sasaki H, Saitou M
  • Journal Title: EMBO J Volume: 36 Issue: 13 Pages: 1888-1907
  • DOI: 10.15252/embj.201695862
  • Peer Reviewed / Open Access
• [Journal Article] Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy (2017)
  • Author(s): Sako Yukiya、Ninomiya Kensuke、Okuno Yukiko、Toyomoto Masayasu、Nishida Atsushi、Koike Yuka、Ohe Kenji、Kii Isao、Yoshida Suguru、Hashimoto Naohiro、Hosoya Takamitsu、Matsuo Masafumi、Hagiwara Masatoshi
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 46126-46126
  • DOI: 10.1038/srep46126
  • NAID: 120006355767
  • Peer Reviewed / Open Access
• [Journal Article] Selective inhibition of the kinase DYRK1A by targeting its folding process (2016)
  • Author(s): Kii I., Sumida Y., Goto T., Sonamoto R., Okuno Y., Yoshida S., Kato-Sumida T., Koike Y., Abe M., Nonaka Y., Ikura T., Ito N., Shibuya H., Hosoya T., Hagiwara M.
  • Journal Title: Nat. Commun. Volume: 該当なし Issue: 1 Pages: 11391-11391
  • DOI: 10.1038/ncomms11391
  • NAID: 120005770755
  • Peer Reviewed / Open Access
• [Journal Article] 家族性自律神経失調症の治療薬候補 (2016)
  • Author(s): 大江賢治、萩原正敏
  • Journal Title: 医学のあゆみ Volume: 257 Issue: 4 Pages: 318-319
• [Journal Article] ケミカルバイオロジーから創薬へ (2016)
  • Author(s): 萩原正敏
  • Journal Title: 現代化学 Volume: 541 Pages: 28-30
• [Journal Article] Deciphering targeting rules of splicing modulator compounds: case of TG003. (2015)
  • Author(s): Sakuma M, Iida K, Hagiwara M
  • Journal Title: BMC Mol Biol. Volume: 16 Issue: 1 Pages: 16-16
  • DOI: 10.1186/s12867-015-0044-6
  • NAID: 120005758276
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ (2015)
  • Author(s): Sonamoto R, Kii I, Koike Y, Sumida Y, Kato-Sumida T, Okuno Y, Hosoya T, and Hagiwara M
  • Journal Title: Scientific Reports Volume: 5 Issue: 1 Pages: 1-86
  • DOI: 10.1038/srep12728
  • NAID: 120005820881
  • Peer Reviewed / Open Access
• [Journal Article] Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis. (2015)
  • Author(s): Masaki S, Kii I, Sumida Y, Kato-Sumida, Ogawa Y, Ito N, Nakamura M, Sonamoto R, Kataoka N , Hosoya T, and Hagiwara M
  • Journal Title: Bioorganic & Medicinal Chemistry Volume: 23 Issue: 15 Pages: 4434-4441
  • DOI: 10.1016/j.bmc.2015.06.018
  • Peer Reviewed / Open Access
• [Journal Article] Identification of a Dual Inhibitor of SRPK1 and CK2 that Attenuates Pathological Angiogenesis of Macular Degeneration in Mice. (2015)
  • Author(s): Satoshi Morooka, Mitsuteru Hoshina, Isao Kii, et al.
  • Journal Title: Molecular Pharmacology Volume: 88 Issue: 2 Pages: 316-325
  • DOI: 10.1124/mol.114.097345
  • Peer Reviewed / Open Access
• [Journal Article] Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia. (2015)
  • Author(s): Yoshida M, Kataoka N, Miyauchi K, Ohe K, Iida K, Yoshida S, Nojima T, Okuno Y, Onogi H, Usui T, Takeuchi A, Hosoya T, Suzuki T, Hagiwara M.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 112（9） Issue: 9 Pages: 2764-2769
  • DOI: 10.1073/pnas.1415525112
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 次世代抗ウイルス薬の開発 (2015)
  • Author(s): 山本誠、萩原正敏
  • Journal Title: 感染・炎症・免疫 Volume: 45 Issue: 1
• [Journal Article] 選択的スプライシング・ネットワークを化合物で操作する。Controlling the alternative splicing network with compounds (2015)
  • Author(s): 大江賢治、萩原正敏
  • Journal Title: 生体の科学 Volume: 66 Issue: 2 Pages: 114-118
• [Journal Article] RBFOX and SUP-12 sandwich a guanine base to form a stable complex and regulate tissue-specific splicing. (2014)
  • Author(s): Kuwasako K, Takahashi M, Unzai S, Tsuda K, Yoshikawa S, He F, Kobayashi N, Guntert P, Shirouzu M, Ito T, Tanaka A, Yokoyama S, Hagiwara M, Kuroyanagi H, and Muto Y.
  • Journal Title: Nat. Struct. Mol. Biol. Volume: 21(9) Issue: 9 Pages: 778-86
  • DOI: 10.1038/nsmb.2870
  • Peer Reviewed / Open Access
• [Journal Article] RNA病 (2014)
  • Author(s): 木村亮、萩原正敏
  • Journal Title: 分子精神医学 Volume: 114 Issue: 2 Pages: 62-63
• [Journal Article] 選択的スプライシングを標的とした低分子化合物の医薬品開発 (2014)
  • Author(s): 大江賢治、萩原正敏
  • Journal Title: BIO Clinica BIOLOGYTOPICS Volume: 3 Pages: 95-99
• [Journal Article] キナーゼの多彩な立体構造を標的とした創薬 (2014)
  • Author(s): 喜井勲、萩原正敏
  • Journal Title: 実験医学 Volume: 32 Issue: 2 Pages: 133-139
• [Journal Article] CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans. (2013)
  • Author(s): Kuroyanagi H, Watanabe Y, and Hagiwara M.
  • Journal Title: PLoS Genet Volume: 9(2)
  • Peer Reviewed
• [Journal Article] Position-dependent and neuron-specific splicing regulation by the CELF family RNA-binding protein UNC-75 in Caenorhabditis elegans (2013)
  • Author(s): Kuroyanagi H, Watanabe Y, Suzuki Y, Hagiwara M
  • Journal Title: Nucleic Acids Research Volume: 41 Issue: 7 Pages: 4015-4025
  • DOI: 10.1093/nar/gkt097
  • Peer Reviewed
• [Journal Article] CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans (2013)
  • Author(s): Kuroyanagi H, Watanabe Y, Hagiwara M
  • Journal Title: PLoS Genetics Volume: 9 Issue: 2 Pages: e1003337-e1003337
  • DOI: 10.1371/journal.pgen.1003337
  • Peer Reviewed
• [Journal Article] Topical antiangiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative AMD. (2013)
  • Author(s): Gammons MV, Fedorov O, Ivison D, Du C, Clark T, Hopkins C, Hagiwara M, Dick AD, Cox R, Harper SJ, Hancox JC, Knapp S, Bates DO.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 54(9) Issue: 9 Pages: 6052-6062
  • DOI: 10.1167/iovs.13-12422
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth (2013)
  • Author(s): Pozo N, Zahonero C, Fernández P, Liñares JM, Ayuso A, Hagiwara M, Pérez A, Ricoy JR, Hernández-Laín A, Sepúlveda JM, Sánchez-Gómez P.
  • Journal Title: J Clin Invest. Volume: 123(6) Issue: 6 Pages: 2475-2487
  • DOI: 10.1172/jci63623
  • Peer Reviewed / Open Access
• [Journal Article] Specific inhibition of serine/arginine-rich protein kinase attenuates choroidal neovascularization. (2013)
  • Author(s): Dong Z, Noda K, Kanda A, Fukuhara J, Ando R, Murata M, Saito W, Hagiwara M, Ishida S
  • Journal Title: Mol Vis. Volume: 19 Pages: 536-543
  • Peer Reviewed / Open Access
• [Journal Article] hDbr1 is a nucleocytoplasmic shuttling protein with a protein phosphatase-like motif essential for debranching activity (2013)
  • Author(s): Kataoka, N. Hagiwara, M. and Ohno, M
  • Journal Title: Sci. Rep Volume: 3-1090 Issue: 1 Pages: 1090-1090
  • DOI: 10.1038/srep01090
  • NAID: 120005241441
  • Peer Reviewed / Open Access
• [Journal Article] 可視化スプライシング・レポーターシステムで開く哺乳類の mRNA 制御の世界 (2012)
  • Author(s): 武内章英、萩原正敏
  • Journal Title: 細胞工学 Volume: VOl.31 No.6
  • NAID: 40019333323
• [Journal Article] RNA を標的とした新しい創薬戦略 (2012)
  • Author(s): 萩原正敏、片岡直行
  • Journal Title: 実験医学2012 増刊疾患克服をめざしたケミカルバイオロジー Pages: 46-52
• [Journal Article] Muscle - specific splicing factors ASD - 2 and SUP - 12 cooperatively switch alternative pre - mRNA processing patterns of the ADF/cofilin gene in C. elegans . (2012)
  • Author(s): Ohno G , Ono K , Togo M , Watanabe Y , Ono S ,Hagiwara M , Kuroyanagi H
  • Journal Title: PLoS Genet Volume: 8(10)
  • Peer Reviewed
• [Journal Article] Challenges to congenital genetic disorders with "RNA-targeting" chemical compounds. (2012)
  • Author(s): Ogawa Y, Hagiwara M.
  • Journal Title: Pharmacol Ther. Volume: 134(3) Issue: 3 Pages: 298-305
  • DOI: 10.1016/j.pharmthera.2012.02.001
  • Peer Reviewed
• [Journal Article] Muscle-Specific Splicing Factors ASD-2 and SUP-12 Cooperatively Switch Alternative Pre-mRNA Processing Patterns of the ADF/Cofilin Gene in Caenorhabditis elegans (2012)
  • Author(s): Ohno G, Ono K, Togo M, Watanabe Y, Ono S, Hagiwara M, Kuroyanagi H
  • Journal Title: PLoS Genetics Volume: 8 Issue: 10 Pages: e1002991-e1002991
  • DOI: 10.1371/journal.pgen.1002991
  • Peer Reviewed
• [Journal Article] The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2 (2012)
  • Author(s): Saitoh, N
  • Journal Title: Mol.Biol.Cell Volume: 23 Issue: 6 Pages: 1115-1128
  • DOI: 10.1091/mbc.e11-09-0783
  • Peer Reviewed / Open Access
• [Journal Article] Identification of novel N-(morpholine-4-carbonyloxy) amidine compounds as potent inhibitors against hepatitis C virus replication (2012)
  • Author(s): Kusano-Kitazume A, Sakamoto N, Okuno Y, Sekine-Osajima Y, Nakagawa M, Kakinuma S, Kiyonashi K, Nitta S, Murakawa M, Azuma S, Nishimura-Sakurai Y, Hagiwara M, Watanabe M
  • Journal Title: Antimicrob Agent Chemother Volume: 56(3) Issue: 3 Pages: 1315-23
  • DOI: 10.1128/aac.05764-11
  • Peer Reviewed / Open Access
• [Journal Article] 新しい構造生命科学の未来を拓くために何をなすべきか (2012)
  • Author(s): 萩原正敏
  • Journal Title: 学術の動向 Volume: 12 Pages: 46-61
• [Journal Article] cAMPシグナル (2012)
  • Author(s): 萩原正敏
  • Journal Title: シグナル伝達キーワード事典 Pages: 53-54
• [Journal Article] 可視化スプライシング・レポーターシステムで開く哺乳類のmRNA制御の世界 (2012)
  • Author(s): 武内章英、萩原正敏
  • Journal Title: 細胞工学 Volume: 31
  • NAID: 40019333323
• [Journal Article] RNAを標的とした新しい創薬戦略 (2012)
  • Author(s): 萩原正敏、片岡直行
  • Journal Title: 実験医学 Pages: 46-52
• [Journal Article] Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor. (2011)
  • Author(s): Ninomiya K, Kataoka N, andHagiwara M.
  • Journal Title: J Cell Biol. Volume: 195(1) Pages: 27-40
• [Journal Article] Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing. (2011)
  • Author(s): Debdab M, Carreaux F, Renault S, Soundararajan M, Fedorov O, Filippakopoulos P, Lozach O, Babault L, Tahtouh T, Baratte B, Ogawa Y, Hagiwara M, Eisenreich A, Rauch U, Knapp S, Meijer L, Bazureau JP
  • Journal Title: J Med Chem. Volume: 54(12) Pages: 4172-4186
• [Journal Article] Chemical treatment enhances skipping of a mutated exon in the dystrophin gene. (2011)
  • Author(s): Nishida A, Kataoka N, Takeshima Y, Yagi M, Awano, H, Ota, M, Itoh K, Hagiwara M, and Matsuo M
  • Journal Title: Nature Commun Volume: 2 Pages: 308-308
  • NAID: 120003001398
• [Journal Article] WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing (2011)
  • Author(s): Amin EM, Hua J, Cheung MK, Ni L, Kase S, Ren-nel ES, Gammons M, Nowak DG, Saleem MA, Hagiwara M, Schumacher VA, Harper SJ, Hinton D, Bates DO, Ladomery MR
  • Journal Title: Cancer Cell Volume: 20 Pages: 768-780
  • Peer Reviewed
• [Journal Article] Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor (2011)
  • Author(s): Ninomiya K, Kataoka N, Hagiwara M
  • Journal Title: J Cell Biol Volume: 195(1) Pages: 27-40
  • Peer Reviewed
• [Journal Article] Specific Y14 domains mediate its nucleo-cytoplasmic shuttling and association with spliced mRNA (2011)
  • Author(s): Kataoka N, Diem MD, Yoshida M, Hatai C, Dobashi I, Dreyfuss G, Hagiwara M, Ohno M
  • Journal Title: Sci Rep Volume: 1:92
  • Peer Reviewed
• [Journal Article] Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B : modulation of alternative pre-RNA splicing (2011)
  • Author(s): Debdab M, Carreaux F, Renault S, Soundararajan M, Fedorov O, Filippakopoulos P, Lozach O, Babault L, Tahtouh T, Baratte B, Ogawa Y, Hagiwara M, Eisenreich A, Rauch U, Knapp S, Meijer L, Bazureau JP
  • Journal Title: J Med Chem Volume: 54(12) Pages: 4172-4186
  • Peer Reviewed
• [Journal Article] Chemical treatment enhances skipping of a mutated exon in the dystrophin gene (2011)
  • Author(s): Nishida A, Kataoka N, Takeshima Y, Yagi M, Awano, H, Ota, M, Itoh K, Hagiwara M, Matsuo M
  • Journal Title: Nature communications Volume: 2:308
  • NAID: 120003001398
  • Peer Reviewed
• [Journal Article] RNA pathologies in neurological disorders. Neurochemical Mechanisms in Disease, Advances in Neurobiology (2011)
  • Author(s): Ohno K, Masuda A
  • Journal Title: (Ed by Abel Lajtha)(Springer, New York) Pages: 399-415
• [Journal Article] Myasthenic syndrome caused by plectinopathy (2011)
  • Author(s): Selcen D, Juel VC, Hobson-Webb LD, Smith EC, Stickler DE, Bite AV, Ohno K, Engel AG
  • Journal Title: Neurology Volume: 76 Pages: 327-336
  • Peer Reviewed
• [Journal Article] Urinary 8-hydroxydeoxyguanosine correlate with hallucinations rather than motor symptoms in Parkinson's disease (2011)
  • Author(s): Hirayama M, Nakamura T, Watanabe H, Uchida K, Hama T, Hara T, Niimi Y, Ito M, Ohno K, Sobue G
  • Journal Title: Parkinsonism Relat Disord Volume: 17 Pages: 46-49
  • Peer Reviewed
• [Journal Article] スプライシング制御機構の解明とその臨床応用 (2010)
  • Author(s): 萩原正敏
  • Journal Title: メディカル・サイエンス・ダイジェスト Volume: Vol.36, No.13 Pages: 2-3
• [Journal Article] RNA スプライシングの可視化による創薬スクリーニング (2010)
  • Author(s): 野島孝之、萩原正敏
  • Journal Title: 細胞工学 Volume: Vol.29, No.02 Pages: 175-180
• [Journal Article] RNA プロセシング異常RNA 病を斬る 基礎の基礎 (2010)
  • Author(s): 萩原正敏
  • Journal Title: 細胞工学 Volume: Vol.29, No.02 Pages: 126-130
• [Journal Article] Splicing reportermice revealed the evolutionally conserved switching mechanism of tissue-specific alternative splicing. (2010)
  • Author(s): Takeuchi A, Hosokawa M, Nojima T, Hagiwara M
  • Journal Title: PLOS One Volume: 5
• [Journal Article] Visualization and genetic analysis ofalternative splicing regulation in vivo using fluorescence reporters in transgenic Caenorhabditis elegans. (2010)
  • Author(s): Kuroyanagi H, Ohno G, Sakane, H, Maruoka, H, and Hagiwara M
  • Journal Title: Nature Protoc. Volume: 5 Pages: 1495-1517
• [Journal Article] Splicing reporter mice revealed the evolutionally conserved switching mechanism of tissue-specific alternative exon selection (2010)
  • Author(s): Takeuchi A, Hosokawa M, Nojima T, Hagiwara M
  • Journal Title: PLoS One Volume: 3;5(6)
  • Peer Reviewed
• [Journal Article] RNAプロセシング異常:RNA病を斬る (2010)
  • Author(s): 萩原正敏
  • Journal Title: 細胞工学 Volume: 29(2) Pages: 126-130
• [Journal Article] mRNA スプライシング制御から難治疾患の治療へ (2009)
  • Author(s): 萩原正敏
  • Journal Title: 実験医学 Volume: Vol.27, No.17 Pages: 2870-2875
• [Journal Article] Herpesvirus protein ICP27 switches PML isoform by altering mRNA splicing. (2009)
  • Author(s): Nojima T, Oshiro-Ideue T, Nakanoya H, Kawamura H, Morimoto M, Kawaguchi Y, Kataoka N and Hagiwara M
  • Journal Title: Nucleic. Acids Res. Volume: 37 Pages: 6515-6527
  • Peer Reviewed
• [Journal Article] Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms-a novel therapeutic strategy for angiogenesis (2009)
  • Author(s): Nowak DG, Amin EM, Rennel ES, Hoareau-Aveilla C, Gammons M, Damodoran G, Hagiwara M, Harper SJ, Woolard J, Ladomery MR, Bates DO.
  • Journal Title: J.Biol.Chem Volume: 285 Pages: 5532-5540
  • Peer Reviewed
• [Journal Article] Herpesvirus protein ICP27 switches PML isoform by altering mRNA splicing Nucleic. (2009)
  • Author(s): Nojima T, Oshiro-Ideue T, Nakanoya H, Kawamura H, Morimoto M, Kawaguchi Y, Kataoka N, Hagiwara M
  • Journal Title: Acids Res Volume: 37(19) Pages: 6515-27
  • Peer Reviewed
• [Journal Article] Akt2 regulation of Cdc2-like kinases (Clk/Sty), serine/arginine-rich (SR) protein phosphorylation, and insulin-induced alternative splicing of PKCssII mRNA (2009)
  • Author(s): Jiang K, Patel NA, Watson JE, Apostolatos H, Kleiman E, Hanson O, Hagiwara M, Cooper DR.
  • Journal Title: Endocrinology Volume: 150(5) Pages: 2087-97
  • Peer Reviewed
• [Journal Article] ウイルスによるスプライシング暗号の利用と撹乱 (2009)
  • Author(s): 萩原正敏、野島孝之
  • Journal Title: 実験医学 Volume: 27(10) Pages: 42-47
• [Journal Article] mRNAスプライシング制御から難治疾患の治療へ (2009)
  • Author(s): 萩原正敏
  • Journal Title: 実験医学 Volume: 27(17) Pages: 190-195
• [Journal Article] リン酸化依存的スプライシング制御機構 (2009)
  • Author(s): 萩原正敏
  • Journal Title: 蛋白質 核酸 酵素 Volume: 54(16) Pages: 2055-2059
• [Presentation] Academia drug discovery with novel strategies of chemical biology. (2018)
  • Author(s): Masatoshi Hagiwara
  • Organizer: International Chemical Biology Society.
  • Place of Presentation: China-Shanghai
  • Year and Date: 2018-10-17
• [Presentation] 小分子化合物の新しい可能性 : 遺伝病治療や再生医療の実現に向けて (2018)
  • Author(s): 萩原正敏
  • Organizer: 日本農芸化学会2018年度大会 学術活動強化委員会企画シンポジウム～ケミカルバイオロジー研究の最前線～
  • Place of Presentation: 名古屋
  • Year and Date: 2018-03-16
• [Presentation] Forward Drug Discovery : 表現型スクリーニングから創薬標的の同定へ (2018)
  • Author(s): 萩原正敏
  • Organizer: 京都府京大オフィス産学連携セミナー～創薬・医療技術の現場から～
  • Place of Presentation: 京都
  • Year and Date: 2018-03-14
• [Presentation] エピゲノム創薬で治療可能な難病について」 (2018)
  • Author(s): 萩原正敏
  • Organizer: AMRF-CREST【エピゲノム】領域会議
  • Place of Presentation: 宮城
  • Year and Date: 2018-02-09
• [Presentation] RNAを標的としたアカデミア創薬 (2018)
  • Author(s): 萩原正敏
  • Organizer: 第9回新たな創薬パラダイムの創出
  • Place of Presentation: 東京
  • Year and Date: 2018-01-12
• [Presentation] スプライシング操作薬による遺伝病治療 (2017)
  • Author(s): 萩原正敏
  • Organizer: 2017年度生命科学系学会合同年次大会Con Bio2017
  • Place of Presentation: 兵庫
  • Year and Date: 2017-12-09
• [Presentation] Entrepreneurship Award Lecture (2017)
  • Author(s): Masatoshi Hagiwara
  • Organizer: FAOBMB2017
  • Place of Presentation: KOBE
  • Year and Date: 2017-12-07
• [Presentation] Chemical therapeutics of congenital diseases by manipulating transcriptome. (2017)
  • Author(s): Masatoshi Hagiwara
  • Organizer: Cutting Edge Developments in RNA Biology for the Control of Gene Expression.
  • Place of Presentation: Okinawa-Japan
  • Year and Date: 2017-11-13
• [Presentation] アカデミア創薬のワンストップ拠点構想 (2017)
  • Author(s): 萩原正敏
  • Organizer: 京都大学医薬系総合研究棟「イノベーションハブ京都」開所式典
  • Place of Presentation: 京都
  • Year and Date: 2017-09-13
• [Presentation] 先天性神経疾患を標的とした創薬 (2017)
  • Author(s): 萩原正敏
  • Organizer: 第47回(2017)新潟神経学夏期セミナー
  • Place of Presentation: 新潟
  • Year and Date: 2017-07-29
• [Presentation] エピゲノム創薬で治療できる可能性のある神経疾患などの難病について (2017)
  • Author(s): 萩原正敏
  • Organizer: 第44回日本毒性学会学術年会
  • Place of Presentation: 横浜
  • Year and Date: 2017-07-11
• [Presentation] 遺伝病を治す薬を創ろう!-学生時代からの夢の実現に向けて (2017)
  • Author(s): 萩原正敏
  • Organizer: 平成29年度三医会定期総会
  • Place of Presentation: 三重
  • Year and Date: 2017-06-18
• [Presentation] 基礎研究から医師主導治験に至るワンストップ創薬 (2017)
  • Author(s): 萩原正敏
  • Organizer: 第90回日本薬理学会年会
  • Place of Presentation: 長崎
  • Year and Date: 2017-03-15
• [Presentation] 京都大学におけるアカデミア創薬の取り組みの紹介 (2017)
  • Author(s): 萩原正敏
  • Organizer: The 1^<st> KYOTO-SPARK Symposium Construction of a Drug Discovery Ecosystem between Academia-Pharma
  • Place of Presentation: 京都
  • Year and Date: 2017-02-15
• [Presentation] 脳・生体イメージングの創薬への展開 (2017)
  • Author(s): 萩原正敏
  • Organizer: シンポジウム「健康社会にむけた多次元脳・生体イメージングの総合的推進」
  • Place of Presentation: 東京
  • Year and Date: 2017-01-22
• [Presentation] 京都大学におけるアカデミア創薬の試み (2017)
  • Author(s): 萩原正敏
  • Organizer: 公益社団法人 先端医療振興財団での講演会
  • Place of Presentation: 神戸
  • Year and Date: 2017-01-10
• [Presentation] RNAスプライシングを操作すれば遺伝情報の異常を是正できるか? (2016)
  • Author(s): 萩原正敏
  • Organizer: 生理化学ユニットシンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2016-12-22
• [Presentation] 低分子化合物による再生医療の現実 (2016)
  • Author(s): 萩原正敏
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-12-01
• [Presentation] New chemical therapeutics of genetic diseases by manipulating transcriptome (2016)
  • Author(s): 萩原正敏
  • Organizer: Tokyo Medical & Dental University 15^<th> Surugadai International Symposium & Joint Usage/Research Program of medical research Institute International Symposium
  • Place of Presentation: 東京
  • Year and Date: 2016-11-29
• [Presentation] エクソンスキップ誘導薬とエクソン含有誘導薬による遺伝性難病の治療 (2016)
  • Author(s): 萩原正敏
  • Organizer: 第89回日本生化学会大会
  • Place of Presentation: 宮城
  • Year and Date: 2016-09-25
• [Presentation] トランスクリプトーム創薬の実現に向けて (2016)
  • Author(s): 萩原正敏
  • Organizer: 第43回日本毒性学会学術年会
  • Place of Presentation: 愛知
  • Year and Date: 2016-07-01
• [Presentation] Drug Discovery in Academia -from the drug screening to the clinical trial- (2016)
  • Author(s): 萩原正敏
  • Organizer: 日本ケミカルバイオロジー学会第11回年会(日豪合同ケミカルバイオロジーシンポジウム)
  • Place of Presentation: 京都
  • Year and Date: 2016-06-16
• [Presentation] 京都大学発アカデミア創薬-卓越した基礎研究から医師主導治験まで- (2016)
  • Author(s): 萩原正敏
  • Organizer: 第8回関西ライフサイエンス・リーディングサイエンティストセミナー
  • Place of Presentation: 大阪
  • Year and Date: 2016-06-10
• [Presentation] Diseasome情報を活用したPhenomics創薬へ (2016)
  • Author(s): 萩原正敏
  • Organizer: 第105回病理学会総会
  • Place of Presentation: 宮城
  • Year and Date: 2016-05-13
• [Presentation] 先天性難治疾患のスプライシング治療 (2015)
  • Author(s): 萩原正敏
  • Organizer: 第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] 京都大学におけるワンストップ創薬の試み-卓越した基礎研究から迅速な臨床試験まで- (2015)
  • Author(s): 萩原正敏
  • Organizer: エーザイ株式会社社内研究者向け講演会
  • Place of Presentation: 茨城
  • Year and Date: 2015-10-27
• [Presentation] New chemical therapeutics of genetic diseases by manipulating transcriptome. (2015)
  • Author(s): Masatoshi Hagiwara
  • Organizer: Top Global University Japan, 1^<st> Joint Symposium of International Partners.
  • Place of Presentation: Kyoto JAPAN.
  • Year and Date: 2015-10-02
• [Presentation] 卓越した基礎研究から迅速な臨床試験まで : 京都大学におけるワンストップ創薬の試み (2015)
  • Author(s): 萩原正敏
  • Organizer: 藤田保健衛生大学研究最前線セミナー
  • Place of Presentation: 愛知
  • Year and Date: 2015-10-01
• [Presentation] 今日は治せぬ病を、明日に治す医師を育てる (2015)
  • Author(s): 萩原正敏
  • Organizer: 京都大学医学部校友会第8回総会・講演会
  • Place of Presentation: 京都
  • Year and Date: 2015-09-26
• [Presentation] アカデミアにおけるトランスクリプトーム創薬の試み (2015)
  • Author(s): 萩原正敏
  • Organizer: 科研製薬株式会社における講演会
  • Place of Presentation: 京都
  • Year and Date: 2015-07-29
• [Presentation] 不治の難病に挑むトランスクリプトーム創薬 (2015)
  • Author(s): 萩原正敏
  • Organizer: 第42回日本毒性学会学術年会
  • Place of Presentation: 石川
  • Year and Date: 2015-07-01
• [Presentation] 幸運の女神に後髪なし～難病に対する治療薬開発について～ (2015)
  • Author(s): 萩原正敏
  • Organizer: 学校法人暁中学・高等学校 「第3回キャリア教育講演会」
  • Place of Presentation: 三重
  • Year and Date: 2015-06-17
• [Presentation] セレンディピティーを最大化するアカデミア創薬の試み (2015)
  • Author(s): 萩原正敏
  • Organizer: 京都大学臨床研究総合センター研究セミナー
  • Place of Presentation: 京都
  • Year and Date: 2015-06-17
• [Presentation] トランスクリプトーム創薬による難病治療の試み (2015)
  • Author(s): 萩原正敏
  • Organizer: 文部科学省科学研究費補助金「新学術領域研究(研究領域提案型)」第8回公開シンポジウム
  • Place of Presentation: 宮城
  • Year and Date: 2015-06-08
• [Presentation] トランスクリプトーム創薬による難病の革新的治療薬開発 (2015)
  • Author(s): 萩原正敏
  • Organizer: 第29回日本医学会総会2015
  • Place of Presentation: 京都
  • Year and Date: 2015-04-11
• [Presentation] Challenges to cure congenital diseases with RNA-targeting chemical compounds (2015)
  • Author(s): 萩原正敏
  • Organizer: Molecular Clock 2015 Epigenetic Landscape in Biological Rhythms
  • Place of Presentation: 京都
  • Year and Date: 2015-03-27
• [Presentation] 大学発-セレディピティーの最大化に向けて (2015)
  • Author(s): 萩原正敏
  • Organizer: 薬学会第135年会シンポジウム「動き出した創薬オープンイノベーションネットワーク」
  • Place of Presentation: 兵庫
  • Year and Date: 2015-03-26
• [Presentation] 卓越した基礎研究から迅速な臨床試験まで : 京都大学におけるワンストップ創薬の試み (2015)
  • Author(s): 萩原正敏
  • Organizer: 第88回日本薬理学会 シンポジウム19「ケミカルバイオロジーによる難病治療薬開発の最前線」
  • Place of Presentation: 愛知
  • Year and Date: 2015-03-19
• [Presentation] 情熱大陸 (2015)
  • Author(s): 萩原正敏
  • Organizer: 三重県立桑名高等学校パネルディスカッション
  • Place of Presentation: 三重
  • Year and Date: 2015-03-18
• [Presentation] 卓越した基礎研究から迅速な臨床試験まで : 京都大学におけるワンストップ創薬の試み (2015)
  • Author(s): 萩原正敏
  • Organizer: 京大医学部・萩原先生の講演会(第一三共株式会社)
  • Place of Presentation: 東京
  • Year and Date: 2015-02-19
• [Presentation] 化合物スクリーニングから臨床試験まで : ワンストップ創薬拠点 (2015)
  • Author(s): 萩原正敏
  • Organizer: PDIS最先端セミナー 創薬につなぐ日本の創薬基盤技術 構造生物学とゲノム科学の最前線はここまで来た
  • Place of Presentation: 東京
  • Year and Date: 2015-02-04
• [Presentation] 遺伝病に挑むトランスクリプトーム創薬 (2015)
  • Author(s): 萩原正敏
  • Organizer: 第三回Academy of Aging and Cardiovascular-Diabetes Research
  • Place of Presentation: 東京
  • Year and Date: 2015-01-10
• [Presentation] 難治性疾患に対する創薬 (2014)
  • Author(s): 萩原正敏
  • Organizer: 杏林製薬株式会社創薬研究所における講演会
  • Place of Presentation: 栃木
  • Year and Date: 2014-12-24
• [Presentation] RNA制御の全容解明への挑戦 (2014)
  • Author(s): 武内章英
  • Organizer: 第1回バイオ・フロンティア・プラットフォームシンポジウム「京滋地域アカデミア連関における研究支援体制の整備」
  • Place of Presentation: 京都
  • Year and Date: 2014-12-01
• [Presentation] 医学研究支援の取り組み : 持続的な研究環境・資源の維持に向けて (2014)
  • Author(s): 萩原正敏
  • Organizer: 第1回バイオ・フロンティア・プラットフォームシンポジウム「京滋地域アカデミア連関における研究支援体制の整備」
  • Place of Presentation: 京都
  • Year and Date: 2014-12-01
• [Presentation] ゲノム創薬からセレンティビティ創薬への回帰 (2014)
  • Author(s): 萩原正敏
  • Organizer: 第2回遊人会関西支部会
  • Place of Presentation: 京都
  • Year and Date: 2014-11-28
• [Presentation] Challenges to cure genetic diseases with RNA-targeting chemical compounds. (2014)
  • Author(s): Masatoshi Hagiwara
  • Organizer: Seminar at Emory University school of Medicine Department of Pharmacology
  • Place of Presentation: Atlanta, USA
  • Year and Date: 2014-11-21
• [Presentation] 先天性難治疾患の治療を可能にするトランスクリプトーム創薬戦略 Challenge to hereditary diseases with transcriptom the rapy (2014)
  • Author(s): 萩原正敏
  • Organizer: RCGMフロンティア国際シンポジウム
  • Place of Presentation: 埼玉
  • Year and Date: 2014-11-01
• [Presentation] Drug Discovery and Development in Academia-How to Maximize the Serentivity (2014)
  • Author(s): 萩原正敏
  • Organizer: NIHS SPECIAL LECTURE
  • Place of Presentation: 東京
  • Year and Date: 2014-10-29
• [Presentation] Drug Discovery and Development in Academia-How to Maximize the Serentivity?- (2014)
  • Author(s): 萩原正敏
  • Organizer: Cutting edge information exchange meeting
  • Place of Presentation: 京都
  • Year and Date: 2014-10-09
• [Presentation] Prospective novel therapeutics for tauopathies (2014)
  • Author(s): Masatoshi Hagiwara
  • Organizer: Asia Aging Core for Longevity(AACL)
  • Place of Presentation: Jeju
  • Year and Date: 2014-09-24
• [Presentation] RNAを標的とする創薬によって難治疾患へ挑む (2014)
  • Author(s): 萩原正敏
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 神奈川
  • Year and Date: 2014-09-11
• [Presentation] Challenges to cure genetic diseases with RNA-targeting chemical compounds (2014)
  • Author(s): Masatoshi Hagiwara
  • Organizer: 京都大学・台湾大学共催シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2014-09-02
• [Presentation] 先天性疾患の治療に挑むトランスクリプトーム創薬 (2014)
  • Author(s): 萩原正敏
  • Organizer: 日本プロテオーム学会2014年会
  • Place of Presentation: 茨城
  • Year and Date: 2014-07-18
• [Presentation] 遺伝病治療を可能にするトランスクリプトーム創薬 (2014)
  • Author(s): 萩原正敏
  • Organizer: 第41回日本毒性学会学術年会
  • Place of Presentation: 兵庫
  • Year and Date: 2014-07-02
• [Presentation] トランスクリプトーム創薬による遺伝病の克服 (2014)
  • Author(s): 萩原正敏
  • Organizer: 第4回前立腺生物学シンポジウム 伊勢志摩2014
  • Place of Presentation: 三重
  • Year and Date: 2014-06-27
• [Presentation] 今日は治せぬ病を、明日は治せる医師を、京大は育てる (2014)
  • Author(s): 萩原正敏
  • Organizer: 立伊勢高等学校「第3回科学の甲子園全国優勝/サイエンス・オリンピアド参加報告会」
  • Place of Presentation: 三重
  • Year and Date: 2014-06-22
• [Presentation] Challenges to cure hereditary diseases with “RNA targeting” chemical compounds. (2014)
  • Author(s): Masatoshi Hagiwara
  • Organizer: Bordeaux-Kyoto Symposium, Université de Bordeaux
  • Place of Presentation: Bordeaux, France
  • Year and Date: 2014-05-05
• [Presentation] Challenges to cure genetic disorders with RNA-targeting chemical compounds. (2014)
  • Author(s): Masatoshi Hagiwara
  • Organizer: Seminar at ICREA and Center for Genomic Regulation (CRG)
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-05-02
• [Presentation] Challenges to congenital genetic disorders with “RNA-targeting” chemical compounds. (2014)
  • Author(s): Masatoshi Hagiwara
  • Organizer: Seminar at washington University School of Medicine
  • Place of Presentation: St. Louis USA
  • Year and Date: 2014-04-29
• [Presentation] Challenges to cure genetic diseases with RNA-targeting chemical compounds. (2014)
  • Author(s): Masatoshi Hagiwara
  • Organizer: Seminar at Sanford-Burnham Medical Research Institute
  • Place of Presentation: San Diego USA
  • Year and Date: 2014-04-27
• [Presentation] 遺伝病治療を目指すトランスクリプトーム創薬 (2014)
  • Author(s): 萩原正敏
  • Organizer: 第16回「JBICバイオ関連基盤技術研究会」
  • Place of Presentation: 東京
  • Year and Date: 2014-04-15
• [Presentation] 家族性自立神経失調症を標的とするトランスクリプトーム創薬 (2014)
  • Author(s): 萩原正敏
  • Organizer: 千里ライフサイエンス新適塾『脳はおもしろい』第4回会合
  • Place of Presentation: 大阪
  • Year and Date: 2014-04-11
• [Presentation] RNAを標的とする創薬によって、今は治らぬ病を明日には治す! (2014)
  • Author(s): 萩原正敏
  • Organizer: 第47回京都ききょう会生涯研修会
  • Place of Presentation: 京都
  • Year and Date: 2014-03-21
• [Presentation] Challenge to Cure Hereditary Diseases with “RNA-targeting” Chemical Compounds (2014)
  • Author(s): Masatoshi Hagiwara
  • Organizer: International Conference on Chemical Biology 2014
  • Place of Presentation: インド
  • Year and Date: 2014-02-07
• [Presentation] 京大医学研究科におけるティッシュリソースセンター構想 (2014)
  • Author(s): 萩原正敏
  • Organizer: 京大病院キャンサーバイオバンクシンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2014-02-03
• [Presentation] 網羅的スプライシング暗号解析に基づくRNA病の解明と治療技術の探索 (2014)
  • Author(s): 萩原正敏
  • Organizer: 平成25年度セルイノベーション公開シンポジウム 次世代シーケンス解析技術の超微量化と創薬・医療分野への応用に向けて
  • Place of Presentation: 東京
  • Year and Date: 2014-01-28
• [Presentation] RNA結合タンパクと難治の神経・筋疾患 (2014)
  • Author(s): 萩原正敏
  • Organizer: 転写終結タンパク質のセミナー
  • Place of Presentation: 東京
  • Year and Date: 2014-01-27
• [Presentation] 難治疾患の治療を可能にするトランスクリプトーム創薬戦略 (2014)
  • Author(s): 萩原正敏
  • Organizer: The Graduate Course “Lifestyle-related diseases, Aging and Metabolism” Course Retreat 2013
  • Place of Presentation: 京都
  • Year and Date: 2014-01-19
• [Presentation] 先天性難治疾患の治療を可能にするトランスクリプトーム創薬戦略 (2013)
  • Author(s): 萩原正敏
  • Organizer: 第2回創薬・医療技術基盤プログラムワークショップ「理研発創薬の現状と将来」
  • Place of Presentation: 埼玉
  • Year and Date: 2013-11-29
• [Presentation] Development of DYRK1A inhibitors for novel therapeutics of Alzheimer's disease. (2013)
  • Author(s): Masatoshi Hagiwara
  • Organizer: 6^<th> Asian Aging Core for Longevity (AACL) conference in Kyoto (Aging Research Forum between Japan and Korea)
  • Place of Presentation: 京都
  • Year and Date: 2013-11-02
• [Presentation] 広汎性発達障害に対するエピゲノム創薬 (2013)
  • Author(s): 萩原正敏
  • Organizer: 第23回日本臨床精神神経薬理学会・第43回日本神経精神薬理学会合同年会シンポジウム「エピジェネティクスと精神薬理との接点」
  • Place of Presentation: 沖縄
  • Year and Date: 2013-10-25
• [Presentation] 明日の医療を育む (2013)
  • Author(s): 萩原正敏
  • Organizer: 白菊会総会
  • Place of Presentation: 京都
  • Year and Date: 2013-10-18
• [Presentation] RNAプロセシング異常と神経疾患 (2013)
  • Author(s): 萩原正敏
  • Organizer: 京都府立医科大学医学研究科講義
  • Place of Presentation: 京都
  • Year and Date: 2013-10-01
• [Presentation] 先天性難治疾患に対する創薬の試み : TRNDK (2013)
  • Author(s): 萩原正敏
  • Organizer: 第1回創薬等支援技術基盤プラットフォーム公開シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2013-09-24
• [Presentation] 核内タンパク・RNA複合体の構造と機能 (2013)
  • Author(s): 萩原正敏
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2013-09-11
• [Presentation] 難治疾患の治療を可能にするトランスクリプトーム創薬戦略 (2013)
  • Author(s): 萩原正敏
  • Organizer: 第6回リサーチ・イノベーションミーティング
  • Place of Presentation: 神戸
  • Year and Date: 2013-08-31
• [Presentation] 京都大学医学部の歴史と医学教育 (2013)
  • Author(s): 萩原正敏
  • Organizer: 第14回近畿献体懇話会
  • Place of Presentation: 京都
  • Year and Date: 2013-07-24
• [Presentation] RNAを標的とする創薬によって難治疾患へ挑む (2013)
  • Author(s): 萩原正敏
  • Organizer: 大阪大学セミナー
  • Place of Presentation: 大阪
  • Year and Date: 2013-07-04
• [Presentation] トランスクリプトーム創薬による遺伝病への挑戦 (2013)
  • Author(s): 萩原正敏
  • Organizer: 奈良県立医科大学第二回基礎教育協議会講演会
  • Place of Presentation: 奈良
  • Year and Date: 2013-06-28
• [Presentation] Visualization and manipulation of pre-mRNA processing (2013)
  • Author(s): Masatoshi Hagiwara
  • Organizer: 「時空間情報イメージング研究教育推進拠点」キックオフシンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2013-05-23
• [Presentation] 京都大学におけるセレンディピティ創薬の試み (2013)
  • Author(s): 萩原正敏
  • Organizer: 公開シンポジウム「オールジャパンでの創薬支援体制の構築に向けて」
  • Place of Presentation: 大阪
  • Year and Date: 2013-05-17
• [Presentation] RNAを標的とする創薬によって難治疾患へ挑む ; ダウン症からアルツハイマー病治療薬へ (2013)
  • Author(s): 萩原正敏
  • Organizer: いなべ市医師会学術講演会
  • Place of Presentation: 三重(いなべ)
  • Year and Date: 2013-03-30
• [Presentation] 医薬連携によるワンストップ創薬 (2013)
  • Author(s): 萩原正敏
  • Organizer: 日本薬理学会アカデミア創薬シーズ探索シンポジウム
  • Place of Presentation: 博多
  • Year and Date: 2013-03-22
• [Presentation] mRNAを標的とした新しい創薬研究の展開 (2013)
  • Author(s): 萩原正敏
  • Organizer: 長野哲雄教授定年退職記念シンポジウム「ケミカルバイオロジーの大展開」
  • Place of Presentation: 東京
  • Year and Date: 2013-03-16
• [Presentation] RNAを標的とする創薬で難病に挑む (2013)
  • Author(s): 萩原正敏
  • Organizer: 未来の研究プロジェクトWinter Seminar 2013
  • Place of Presentation: 京都
  • Year and Date: 2013-02-16
• [Presentation] RNAを標的とする創薬によって難治疾患へ挑む (2013)
  • Author(s): 萩原正敏
  • Organizer: 臨床中核拠点シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2013-02-09
• [Presentation] RNAを標的とする創薬で難病に挑む (2013)
  • Author(s): 萩原正敏
  • Organizer: 三重大学医学研究科特別講義
  • Place of Presentation: 三重
  • Year and Date: 2013-02-01
• [Presentation] プロテオームの多様性創出のメカニズムについて (2013)
  • Author(s): 萩原正敏
  • Organizer: JHUPO サテライトシンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2013-01-18
• [Presentation] スプライシング異常による疾患とその治療の可能性 (2012)
  • Author(s): 萩原正敏
  • Organizer: オミックス医療研究会 創薬PG×分科会&データベース分科会シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2012-12-26
• [Presentation] スペックルズ・パラスペックルズに局在するRNA結合蛋白の機能 (2012)
  • Author(s): 萩原正敏
  • Organizer: 第35回日本分子生物学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-11
• [Presentation] Novel DYRK1A inhibitor applicable for Alzheimer disease (2012)
  • Author(s): Masatoshi Hagiwara
  • Organizer: AACL-2012 Seoul Symposium
  • Place of Presentation: Seoul
  • Year and Date: 2012-11-23
• [Presentation] RNAを標的とする創薬で難病に挑む (2012)
  • Author(s): 萩原正敏
  • Organizer: 京大医療薬剤学研究会
  • Place of Presentation: 京都
  • Year and Date: 2012-11-17
• [Presentation] 今日は治せぬ病を、明日は治せる医師を、京大が育てる (2012)
  • Author(s): 萩原正敏
  • Organizer: 京都大学医学部ホームカミングディ
  • Place of Presentation: 京都
  • Year and Date: 2012-11-10
• [Presentation] RNAを操作して先天性の神経筋疾患を薬で治す (2012)
  • Author(s): 萩原正敏
  • Organizer: 長崎大学医学研究科セミナー
  • Place of Presentation: 長崎
  • Year and Date: 2012-10-16
• [Presentation] Chemical targeting of RNA processing for new therapeutics of congenital diseases (2012)
  • Author(s): Masatoshi Hagiwara
  • Organizer: THE 1^<st> official of the INTERNATIONAL CHEMICALBIOLOGY SOCIETY
  • Place of Presentation: Cambridge, USA.
  • Year and Date: 2012-10-04
• [Presentation] New chemical screens for drugs of congenital genetic disorders targeting pre-mRNAs. (2012)
  • Author(s): 萩原正敏
  • Organizer: 名古屋大学農学研究科大学院セミナー
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-24
• [Presentation] Neural development and splicing code (2012)
  • Author(s): 萩原正敏
  • Organizer: 第35回日本神経科学大会「RNA 結合タンパクと病態シンポジウム」
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-21
• [Presentation] RNA を標的とする創薬によって難治疾患に挑む (2012)
  • Author(s): 萩原正敏
  • Organizer: 第36回阿蘇シンポジウム
  • Place of Presentation: 熊本
  • Year and Date: 2012-08-03
• [Presentation] New chemical screens for drugs of congenital genetic disorders targeting pre-mRNAs (2012)
  • Author(s): Masatoshi Hagiwara
  • Organizer: Gordon Research Conference
  • Place of Presentation: Newport, USA.
  • Year and Date: 2012-07-19
• [Presentation] RNA制御異常 (2012)
  • Author(s): 萩原正敏
  • Organizer: 京都大学大学院医学研究科教育コース、神経科学ミニコース「脳科学研究に資する分子ネットワーク解析の最前線」
  • Place of Presentation: 京都
  • Year and Date: 2012-07-13
• [Presentation] Challenges to Congenital Genetic Disorders with "RNA-targeting" Chemical Compounds (2012)
  • Author(s): Masatoshi Hagiwara
  • Organizer: The 22^<nd> CDB Meeting
  • Place of Presentation: Kobe
  • Year and Date: 2012-06-11
• [Presentation] New chemical therapeutics of congenital genetic disorders targeting pre-mRNA (2012)
  • Author(s): Masatoshi Hagiwara
  • Organizer: 日本ケミカルバイオロジー学会第7回年会、国際シンポジウム「新規疾患治療にむけたケミカルバイオロジー研究からの挑戦」
  • Place of Presentation: 京都
  • Year and Date: 2012-06-09
• [Presentation] 哺乳類の脳の発生過程でのmRNA制御の網羅的解析 (2012)
  • Author(s): 武内章英
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨山梨大学甲府キャンパス
  • Year and Date: 2012-03-26
• [Presentation] Challenges to congenital genetic disorder with"RNA-targeting" chemical compounds (2012)
  • Author(s): Masatoshi Hagiwara
  • Organizer: SLAS2013 2^<nd> Annual Conference &Exhibition
  • Place of Presentation: ORLAND,FL,USA.
  • Year and Date: 2012-01-14
• [Presentation] Chemical targeting of RNA processing for new therapeutics of congenital diseases (2012)
  • Author(s): Masatoshi Hagiwara
  • Organizer: THE 1st official of the INTERNATIONAL CHEMICALBIOLOGY SOCIETY
  • Place of Presentation: Cambridge,USA.
  • Invited
• [Presentation] Modulation of mRNA Splicing with Synthetic Kinase Inhibitors and Their Clinical Applications (2011)
  • Author(s): 萩原正敏
  • Organizer: Protein Kinass Regulating RNA Splicing, 2011
  • Place of Presentation: ROSCOFF、フランス(招待講演)
  • Year and Date: 2011-11-16
• [Presentation] New therapeutics by alteration of mRNA expression and processing with small chemicals (2011)
  • Author(s): 萩原正敏
  • Organizer: International Chemical Biology Conference
  • Place of Presentation: Kauffman Foundation Conference, USA
  • Year and Date: 2011-10-12
• [Presentation] RNAを操作して先天性疾患を薬で治す (2011)
  • Author(s): 萩原正敏
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都、京都国際会議場
  • Year and Date: 2011-09-21
• [Presentation] Modulation of pre-mRNA splicing patterns with synthetic chemicals and their clinical applications (2011)
  • Author(s): 萩原正敏
  • Organizer: JST-CRDS主催俯瞰ワークショップ「構造生命科学動的構造情報から創薬へ
  • Place of Presentation: 東京、JST研究開発戦略センター2階大会議室(招待講演)
  • Year and Date: 2011-09-10
• [Presentation] Chembiomolecular Medicinal Chemistry (2011)
  • Author(s): 萩原正敏
  • Organizer: 第10回上原記念生命科学財団国際シンポジウ「生体制御分子科学」
  • Place of Presentation: 東京、ハイアットリージェンシー東京(招待講演)
  • Year and Date: 2011-06-07
• [Presentation] Chemical Treatment enhances skipping of amutated exon in the dystrophin gene (2011)
  • Author(s): 片岡直行、西田篤史、竹島泰弘、八木真理子、粟野宏之、大田光徳、伊東恭子、松尾雅文、萩原正敏
  • Organizer: 日本ケミカルバイオロジー学会 第6回年会
  • Place of Presentation: 東京、東京工業大学
  • Year and Date: 2011-05-25
• [Presentation] 核内構造体(核スペックル)の形成と選択的スプライシングの低分子化合物による制御 (2011)
  • Author(s): 松尾陽太、三原由揮、椛本大和、八木浩亮、上原裕也、岩本はる香、萩原正敏, 他
  • Organizer: 日本ケミカルバイオロジー学会第6回年会
  • Place of Presentation: 東京、東京工業大学
  • Year and Date: 2011-05-25
• [Presentation] ダウン症など先天性難治疾患への挑戦RNAを標的とした創薬の試み (2011)
  • Author(s): 萩原正敏
  • Organizer: 第24回近畿小児科学会
  • Place of Presentation: 神戸、国際会議場(招待講演)
  • Year and Date: 2011-03-13
• [Presentation] Modulation of pre-mRNA splicing patterns with synthetic chemicals and their clinical applications (2011)
  • Author(s): Masatoshi Hagiwara
  • Organizer: 第10回上原記念生命科学財団 国際シンポジウム[生体制御分子科学]
  • Place of Presentation: 東京
• [Presentation] Visuali zation of alternative splicing and the therapeutic manipulation with chemical compounds (2011)
  • Author(s): Masatoshi Hagiwara
  • Organizer: US - Japan Sumer Conference
  • Place of Presentation: USA
• [Presentation] New therapeutics by alteration of mRNA expression and processing with small chemicals" (2011)
  • Author(s): Masatoshi Hagiwara
  • Organizer: International Chemical Biology Conference
  • Place of Presentation: USA
• [Presentation] Visualization of Alternative Splithin with Multi-color Splicing Reporters and Their Application for Screen of Trans-acting Factors and Small Chemicals (2011)
  • Author(s): 萩原正敏
  • Organizer: The16th Annual Meeting of the RNA Society/The RNA Society of Japan 13^<th> Annual Meeting
  • Place of Presentation: Kyoto, Japan
• [Presentation] Splicing resume from stress response (2010)
  • Author(s): 萩原正敏
  • Organizer: Asian Cold Spring Harbor Laboratory 'RNA Biology
  • Place of Presentation: Suzhou、中国(招待講演)
  • Year and Date: 2010-11-05
• [Presentation] Visualization and manipulation of alternative pre-mRNA splicing (2010)
  • Author(s): 萩原正敏
  • Organizer: 中国医科大学大学院特別セミナー
  • Place of Presentation: 中国医科大学(瀋陽)
  • Year and Date: 2010-10-14
• [Presentation] Pre-mRNAスプライシングの組織特異的制御とその異常に起因する疾患 (2010)
  • Author(s): 萩原正敏
  • Organizer: 大学院セミナー
  • Place of Presentation: 京都大学医学部
  • Year and Date: 2010-09-15
• [Presentation] Pre-mRNAスプライシングの組織特異的制御とその異常に起因する疾患 (2010)
  • Author(s): 萩原正敏
  • Organizer: 北海道大学医学部眼科学講座セミナー
  • Place of Presentation: 北海道大学医学部
  • Year and Date: 2010-09-15
• [Presentation] Visualization and manipulation of mRNA splicing (2010)
  • Author(s): 萩原正敏
  • Organizer: 国際生化学分子生物学会
  • Place of Presentation: 上海インターナショナルコンベンションセンター
  • Year and Date: 2010-08-06
• [Presentation] Visualizatio and manipulation of RNA splicing to cure RNA diseases (2010)
  • Author(s): 萩原正敏
  • Organizer: Gorodon Research Conference
  • Place of Presentation: New port, RI, USA(招待講演)
  • Year and Date: 2010-07-23
• [Presentation] 蛋白リン酸化酵素を標的とした創薬:ケミカルバイオロジーによるアプローチ (2010)
  • Author(s): 萩原正敏
  • Organizer: 平成21年度生命融合科学教育部シンポジウム
  • Place of Presentation: 富山県 高志会館カルチャーホール
  • Year and Date: 2010-03-08
• [Presentation] 新しい分子イメージング技術による創薬 (2010)
  • Author(s): 萩原正敏
  • Organizer: 第5回ケミカルバイオロジー・第2回センシングバイオロジーシンポジウム
  • Place of Presentation: 東京医科歯科大学 臨床講堂
  • Year and Date: 2010-02-23
• [Presentation] RNA病を斬る/RNAプロセッシング異常に対する創薬の試み (2010)
  • Author(s): 萩原正敏
  • Organizer: オミックス創薬科学セミナー
  • Place of Presentation: 三重大学大学院
  • Year and Date: 2010-01-27
• [Presentation] Visualizatio and manipulation of RNA splicing to cure RNA diseases (2010)
  • Author(s): Masatoshi Hagiwara
  • Organizer: Gorodon Research Conference
  • Place of Presentation: New port, RI
• [Presentation] Splicing resume from stress response (2010)
  • Author(s): Masatoshi Hagiwara
  • Organizer: Asian Cold Spring Harbor Laboratory 'RNA Biology'
  • Place of Presentation: Suzhou Dushu Lake Conference Center , China
• [Presentation] Decipherment of splicing code and its manipulation for new therapeutics. (2010)
  • Author(s): 萩原正敏
  • Organizer: 2010 RNA国際シンポジウム
  • Place of Presentation: National Cheng Kung University Medical College(台南)
• [Presentation] Host viral interaction on RNA processing (2009)
  • Author(s): 萩原正敏
  • Organizer: TMDU-CMU国際シンポジウム
  • Place of Presentation: 東京医科歯科大学 歯学部講堂
  • Year and Date: 2009-10-13
• [Presentation] ケミカルバイオロジーによる難治疾患への挑戦 (2009)
  • Author(s): 萩原正敏
  • Organizer: 日本薬理学会第81回関東部会
  • Place of Presentation: 東京医科歯科大学 5号館講堂
  • Year and Date: 2009-07-11
• [Presentation] ストレス下でのpre-mRNAの選択的スプライシング (2009)
  • Author(s): 萩原正敏
  • Organizer: 第82回日本生化学大会シンポジウム
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] Session 3「神経疾患におけるスプライシング異常とその制御」 (2009)
  • Author(s): 萩原正敏
  • Organizer: 第2回グローバルCOE国際シンポジウム
  • Place of Presentation: ヒルトン名古屋
• [Presentation] New chemicaltherapeutics ofcongenital genetic disorders targeting pre-mRNA.
  • Author(s): Masatoshi Hagiwara
  • Organizer: 日本ケミカルバイオロジー学会第７回年会、国際シンポジウム「新規疾患治療にむけたケミカルバイオロジー研究からの挑戦」
  • Place of Presentation: 京都
• [Presentation] Challenges to Congenital Genetic Disorders with "RNA-targeting" Chemical Compounds
  • Author(s): Masatoshi Hagiwara
  • Organizer: The 22nd CDB Meeting
  • Place of Presentation: 神戸
  • Invited
• [Presentation] New chemical screens for drugs of congenital genetic disorders targeting pre-mRNAs
  • Author(s): Masatoshi Hagiwara
  • Organizer: Gordon Research Conference
  • Place of Presentation: Newport, USA
  • Invited
• [Presentation] Challenges to congenital genetic disorder with “RNA-targeting” chemical compounds
  • Author(s): Masatoshi Hagiwara
  • Organizer: SLAS2013 2nd Annual Conference & Exhibition
  • Place of Presentation: ORLAND,FL,USA.
  • Invited
• [Presentation] 「 RNAを標的とする創薬によって難治疾患に挑む」
  • Author(s): 萩原正敏
  • Organizer: 第３６回阿蘇シンポジウム
  • Place of Presentation: 熊本
  • Invited
• [Presentation] 「Neural development and splicing code」
  • Author(s): 萩原正敏
  • Organizer: 第３５回日本神経科学大会「RNA結合タンパクと病態シンポジウム」
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] 「スペックルズ・パラスペックルズに局在するＲＮＡ結合蛋白の機能」
  • Author(s): 萩原正敏
  • Organizer: 第３５回日本分子生物学会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] 「プロテオームの多様性創出のメカニズムについて」
  • Author(s): 萩原正敏
  • Organizer: HUPOサテライトシンポジウム
  • Place of Presentation: 京都
  • Invited
• [Remarks]
  • URL: http://www.med.kyoto-u.ac.jp/organization-staff/research/doctoral_course/r-002/
• [Remarks]
  • URL: http://www.anat1dadb.med.kyoto-u.ac.jp/Anat1DADB/HOME/HOME.html
• [Patent(Industrial Property Rights)] Transgenic reporter system that reveals expression profiles and regulation mechanisms of alternative splicing in mammalian organisms (2011)
  • Inventor(s): 萩原正敏、武内章英
  • Industrial Property Rights Holder: 萩原正敏、武内章英
  • Filing Date: 2011-05-31
  • Overseas
• [Patent(Industrial Property Rights)] 遺伝性疾患の予防・改善剤 (2011)
  • Inventor(s): 萩原正敏、片岡直行、松尾雅文、西田篤史
  • Industrial Property Rights Holder: 萩原正敏、片岡直行、松尾雅文、西田篤史
  • Industrial Property Number: 2010-146699
  • Filing Date: 2011-06-27
• [Patent(Industrial Property Rights)] Transgenic reporter system that reveals expression profile and regulation mechanisms of alternative splicing in mammalian organisms (2011)
  • Inventor(s): 萩原正敏、武内章英
  • Industrial Property Rights Holder: 萩原正敏、武内章英
  • Filing Date: 2011-05-31
  • Description: US.61/350,420 2010年6月1日(米国)
  • Overseas
• [Patent(Industrial Property Rights)] 遺伝性疾患の予防・改善剤 (2011)
  • Inventor(s): 片岡直行、松尾雅文、西田篤史
  • Industrial Property Rights Holder: 片岡直行、松尾雅文、西田篤史
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-522455
  • Filing Date: 2011-06-27
  • Description: 13/805,151(US) 11800411.8(EP) 201611191464.0(CN) 2011800303273.8(CN分割) 2012.12.18(US) 2012.12.21(EP) 2011.6.27(CN) 2016.12.21(CN分割)
• [Patent(Industrial Property Rights)] Transgenic reporter system that reveals expression profile and regulation mechanisms of alternative splicing in mammalian organisms (2011)
  • Inventor(s): 萩原正敏、武内章英
  • Industrial Property Rights Holder: 萩原正敏、武内章英
  • Filing Date: 2011-05-31
  • Acquisition Date: 2016-01-29
  • Description: 9,273,364(US) 2576778(EP) 2012.11.29(US) 2013.1.1(EP) 2016.3.1(US) 2017.8.9(EP)
• [Patent(Industrial Property Rights)] 遺伝性疾患の予防・改善剤 (2011)
  • Inventor(s): 片岡直行、松尾雅文、西田篤史
  • Industrial Property Rights Holder: 片岡直行、松尾雅文、西田篤史
  • Filing Date: 2011-06-27
  • Acquisition Date: 2016-06-17
  • Description: 9,241,929(US) 2012.12.18(US) 2016.1.26(US)
• [Patent(Industrial Property Rights)] Transgenic reporter system that reveals expression profiles and regulation mechanisms of alternative splicing in mammalian organisms (2010)
  • Inventor(s): 萩原正敏, 武内章英
  • Industrial Property Rights Holder: 萩原正敏, 武内章英
  • Filing Date: 2010
  • Overseas
• [Patent(Industrial Property Rights)] 遺伝性疾患の予防・改善剤 (2010)
  • Inventor(s): 片岡直行、松尾雅文、西田篤史
  • Industrial Property Rights Holder: 片岡直行、松尾雅文、西田篤史
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2010-146699
  • Filing Date: 2010-06-28
  • Description: PCT/JP2011/003655 2011年6月27日(PCT)