| Budget Amount *help |
¥34,060,000 (Direct Cost: ¥26,200,000、Indirect Cost: ¥7,860,000)
Fiscal Year 2011: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2010: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
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| Research Abstract |
Ad4BP/SF-1, a member of nuclear receptor superfamily, plays pivotal role in differentiation and function of the adrenal cortex through regulating various target genes. It has been hypothesized that active enhancers should be exchanged or selected through conversion of chromatin structure when Ad4BP/SF-1 functions during the tissue development. In the present study, we performed ChIP-sequence analyses of theDNA recovered with antibodies for Ad4BP/SF-1 and modified histones. As the consequence, it was found that Ad4BP/SF-1 regulates glycolytic gene expression through binding to enhancers localized in and around the genes.
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