The immunopathological study on leukocyte adhesion molecule DNAM-1 (CD226)

• Project/Area Number: 21249026
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: University of Tsukuba
• Principal Investigator: SHIBUYA Akira 筑波大学, 医学医療系, 教授 (80216027)
• Co-Investigator(Renkei-kenkyūsha): SHIBUYA Kazuko 筑波大学, 医学医療系, 准教授 (00302406) ; HONDA Shinichiro 筑波大学, 医学医療系, 准教授 (60360640) ; TAHARA Satoko 筑波大学, 医学医療系, 助教 (20360589)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥48,230,000 (Direct Cost: ¥37,100,000、Indirect Cost: ¥11,130,000); Fiscal Year 2011: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000); Fiscal Year 2010: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000); Fiscal Year 2009: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
• Keywords: CD226 / 腫瘍免疫 / 感染免疫 / 自己免疫 / DNAM-1

Research Abstract

The molecular mechanisms underlying immune responses to cancer, autoimmune diseases, and infectious diseases have been unclear. Elucidation of the molecular mechanisms is essentially required to overcome these intractable diseases. We previously identified leukocyte activating receptor DNAM-1 that is expressed on NK cells, T cell and macrophages ant its ligands. In this study, we clarify the role of DNAM-1 in the pathogenesis of diseases and develop the basis of molecular targeting therapy to these diseases.

Research Products

• [Journal Article] Identification of phosphatidylserine as a ligand for the CD300a immunoreceptor (2012)
  • Author(s): Nakahashi-Oda C, Tahara-Hanaoka S, Honda S, Shibuya K, Shibuya A
  • Journal Title: BBRC Volume: 417 Pages: 646-650
• [Journal Article] Isolation and characterization of na.ANove follicular dendritic cells (2012)
  • Author(s): Usui K, Honda S, Yoshizawa Y, Nakahashi-Oda C, Tahara-Hanaoka S, Shibuya K, Shibuya A
  • Journal Title: Mol Immunol Volume: 50 Pages: 172-6
• [Journal Article] Isolation and characterization of naive follicular dendritic cells (2012)
  • Author(s): Kenta Usui
  • Journal Title: Molecular Immunology Volume: 50 Issue: 3 Pages: 172-176
  • DOI: 10.1016/j.molimm.2011.11.010
  • Peer Reviewed
• [Journal Article] B1b lymphocyte-derived antibodies control Borrelia hermsii independent of Fcα/μ receptor and in the absence of host cell contact (2011)
  • Author(s): Colombo MJ, Abraham D, Shibuya A, Alugupalli KR
  • Journal Title: Immunol Res Volume: 51 Pages: 249-56
  • NAID: 120007137337
• [Journal Article] The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses (2011)
  • Author(s): Nakano-Yokomizo T, Tahara-Hanaoka S, Nakahashi-Oda C, Nabekura T, Nadia K. Tchao, Kadosaki M, Totsuka N, Kurita N, Nakamagoe K, Tamaoka A, Takai T, Yasui T, Kikutani H, Honda S, Shibuya K, Lewis L. Lanier, Shibuya A
  • Journal Title: J Exp Med Volume: 208(8) Pages: 1661-1671
• [Journal Article] Ingested allergens must be absorbed systemically to induce systemic anaphylaxis. Ingested allergens must be absorbed systemically to induce systemic anaphylaxis (2011)
  • Author(s): Strait RT, Mahler A, Hogan S, Khodoun M, Shibuya A, Finkelman FD
  • Journal Title: J Allergy ClinImmunol Volume: 127 Pages: 982-989
• [Journal Article] DNAX accessory molecule-1 (DNAM-1) plays an important role in alloreactive CD8^+ T cells responsible for the exacerbation of acute graft-versus-host disease (2011)
  • Author(s): Nabekura T, Shibuya K, Shibuya A. Replyto Seth et al
  • Journal Title: Proc Natl Acad Sci USA Volume: 108(10)E34
• [Journal Article] B1b lymphocyte-derived antibodies control Borrelia hermsii independent of Fca/μ receptor and in the absence of host cell contact (2011)
  • Author(s): Colombo MJ, et.al.
  • Journal Title: Immunol Res Volume: 51 Issue: 2-3 Pages: 249-256
  • DOI: 10.1007/s12026-011-8260-8
  • Peer Reviewed
• [Journal Article] The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses (2011)
  • Author(s): Takako Nakano-Yokomizo, et.al.
  • Journal Title: J Exp Med Volume: 8 Issue: 8 Pages: 1661-1671
  • DOI: 10.1084/jem.20101623
  • Peer Reviewed
• [Journal Article] Ingested allergens must be absorbed systemically to induce systemic an aphylaxis (2011)
  • Author(s): Strait RT, et.al.
  • Journal Title: J Allergy Clin Immunol Volume: 127 Issue: 4 Pages: 982-989
  • DOI: 10.1016/j.jaci.2011.01.034
  • Peer Reviewed
• [Journal Article] Reply to Seth et al. : DNAX accessory molecule-1(DNAM-1)plays an important role in alloreactive CD8^+ T cells responsible for the exacerbation of acute graR-versus-host disease. (2011)
  • Author(s): Nabekura T, et.al.
  • Journal Title: Proc Natl Acad Sci USA Volume: (in press)
  • Peer Reviewed
• [Journal Article] Critical role of DNAX accessory molecule-1 (DNAM-1) in the development of acute graft-versus-host disease in mice (2010)
  • Author(s): Nabekura T, Shibuya K, Takenaka E, KaiH, Shibata K, Yamashita Y, Harada K, Tahara-Hanaoka S, Honda S, Shibuya A
  • Journal Title: Proc Natl Acad Sci USA Volume: 107 Pages: 18593-18598
  • NAID: 120007137848
• [Journal Article] An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E.mediated immediate hypersensitivity reactions (2010)
  • Author(s): Hitomi K, Tahara-Hanaoka S, Someya S, Fujiki A, Tada H, Sugiyama T, Shibayama S, Shibuya K, Shibuya A
  • Journal Title: Nature Immunology Volume: 11 Pages: 601-607
• [Journal Article] Requirement of the cytoplasmic portion for dimer formation of Fcα/μ receptor expressed on cell surface (2010)
  • Author(s): Cho Y, Honda S, Yoshizawa Y, TakagakiK, Usui K, Shibuya A
  • Journal Title: Mol. Immunol Volume: 47 Pages: 878-882
• [Journal Article] Critical role of DNAX accessory molecule-1(DNAM-1)in the development of acute graft-versus-host disease in mice. (2010)
  • Author(s): Nabekura T, et.al.
  • Journal Title: Proc Natl Acad Sci USA Volume: 107 Pages: 18593-18598
  • Peer Reviewed
• [Journal Article] An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions. (2010)
  • Author(s): Hitomi K, et.al.
  • Journal Title: Nature Immunology Volume: 11 Pages: 601-607
  • Peer Reviewed
• [Journal Article] Requirement of the cytoplasmic portion for dimer formation of Fcα/μ receptor expressed on cell surface. (2010)
  • Author(s): Yukiko Cho, et.al.
  • Journal Title: Molecular Immunology 47 Pages: 878-882
  • Peer Reviewed
• [Journal Article] Enhanced humoral immune responses against T-independent antigens in Fc α / μR-deficient mice (2009)
  • Author(s): Honda S, Miyamoto A, Cho Y, Usui K, Kurita N, Takeshita K, Takahashi S, Kinoshita T, Fujita T, Tahara-Hanaoka S, Shibuya K, Shibuya A
  • Journal Title: Proc Natl Acad Sci USA Volume: 106 Pages: 11230-11235
  • NAID: 130006949816
• [Journal Article] Regulation of immune responses by the activating and inhibitory myeloid-associate immunoglobuline-like receptors (MAIR)(CD300) (2009)
  • Author(s): Shibuya A, Nakahashi-Oda C, Tahara-Hanaoka S
  • Journal Title: Immune Network Volume: 9 Pages: 41-45
  • NAID: 40017405374
• [Journal Article] Identification of the Fca/mR isoform specifically expressed in the kidney tubule (2009)
  • Author(s): Kurita N, Honda S, Usui K, Shimizu Y, Miyamoto A, Tahara-Hanaoka S, Shibuya K, Shibuya A
  • Journal Title: Mol Immunol Volume: 46 Pages: 749-753
• [Journal Article] Receptor-mediated recognition of melanoma by NK cells and its implications for NK cell-based immunotherapy (2009)
  • Author(s): Lakshmikanth T, Burke S, Ali TH, Kimpfler S, Ursini F, Ruggeri L, Capanni M, Umansky V, Paschen A, SuckerA, Pende D, Groh V, Biassoni R, HoglundP, Kato K, Shibuya K, Schadendorf D, Anichini A, Ferrone S, Velardi A, KarreK, Shibuya A, Carbone E, Colucci F
  • Journal Title: Tissue Antigen Volume: 73 Pages: 519-520
• [Journal Article] NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo (2009)
  • Author(s): Lakshmikanth T, Burke S, Ali TH, Kimpfler S, Ursini F, Ruggeri L, Capanni M, Umansky V, Paschen A, SuckerA, Pende D, Groh V, Biassoni R, HoglundP, Kato K, Shibuya K, Schadendorf D, Anichini A, Ferrone S, Velardi A, Karre K, Shibuya A, Carbone E, Colucci F
  • Journal Title: J Clin Invest Volume: 119 Pages: 1251-1263
• [Journal Article] Enhanced humoral immune responses against T-independent antigens in Fcα/μR-deficient mice. (2009)
  • Author(s): Honda S, et.al.
  • Journal Title: Proc Natl Acad Sci USA 106 Pages: 11230-11235
  • NAID: 130006949816
  • Peer Reviewed
• [Journal Article] Regulation of immune responses by the activating and inhibitory myeloid-associate immunoglobuline-like receptors(MAIR)(CD300). (2009)
  • Author(s): Shibuya A, et.al.
  • Journal Title: Immune Network 9 Pages: 41-45
  • NAID: 40017405374
  • Peer Reviewed
• [Journal Article] Regulation of immune responses by the activating and inhibitory myeloid-associate immunoglobuline-like receptors(MAIR)(CD300). (2009)
  • Author(s): Shibuya A, et.al.
  • Journal Title: Immune Network 46 Pages: 749-753
  • NAID: 40017405374
  • Peer Reviewed
• [Journal Article] NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo. (2009)
  • Author(s): Lakshmikanth T, et.al.
  • Journal Title: J Clin Invest 119 Pages: 1251-1263
  • Peer Reviewed
• [Presentation] Innate immune response receptors (2012)
  • Author(s): 戸塚直也
  • Organizer: World Immune Regulation Meeting-VI
  • Place of Presentation: Zurich, Switzerland
  • Year and Date: 2012-03-20
• [Presentation] Regulation of mast cell activation by inhibitory immunoglobulin-like receptors Allergin-1 and MAIR-1(CD300a) (2012)
  • Author(s): Shibuya A
  • Organizer: University Medical Center Utrecht Department of Immunology
  • Place of Presentation: Amsterdam, Netherlands
  • Year and Date: 2012-03-16
• [Presentation] Regulation of mast cell activation by inhibitory immunoglobulin-like receptors Allergin-1 and MAIR-1(CD300a) (2012)
  • Author(s): 渋谷彰
  • Organizer: University Medical Center Utrecht Department of Immunology
  • Place of Presentation: Amsterdam, Netherlands(招待講演)
  • Year and Date: 2012-03-16
• [Presentation] An immunoglobulin-like receptor, Allergin-1, inhibits allergic diseases (2012)
  • Author(s): 田原聡子
  • Organizer: University of California
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2012-03-14
• [Presentation] クローン病感受性遺伝子Nod2の機能解析-菌体認識センサーNod2の腸管における役割- (2012)
  • Author(s): 金倫基
  • Organizer: 第49回遺伝医学研究会
  • Place of Presentation: 東京女子医科大学
  • Year and Date: 2012-03-08
• [Presentation] An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions (2011)
  • Author(s): 田原聡子
  • Organizer: 第40回日本免疫学会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-11-29
• [Presentation] MAIR-II(CD300d) on Ly-6Chigh inflammatory monocytes plays a crucial role in inflammatory responses in a murine sepsis model (2011)
  • Author(s): 戸塚直也
  • Organizer: 第40回日本免疫学会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-11-29
• [Presentation] ナイーブマウス脾臓からのFDCの単離 (2011)
  • Author(s): 臼井健太
  • Organizer: 第40回日本免疫学会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-11-29
• [Presentation] Iga/IgM受容体、Fcα/μ受容体の二量体形成の解析 (2011)
  • Author(s): 高垣香那
  • Organizer: 第40回日本免疫学会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-11-29
• [Presentation] Crohn's Disease-Associated Nod2 Mutation Limits production of Pro-Inf lammatory Cytokines to Protect the Host from Enterococcus faecalis-Induced Lethality (2011)
  • Author(s): 金倫基
  • Organizer: 第40回日本免疫学会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-11-28
• [Presentation] ヘルパーT細胞 (2011)
  • Author(s): 渋谷和子
  • Organizer: 第40回日本免疫学会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-11-27
• [Presentation] An immunoreceptor adapter protein, DAP12, suppresses adaptive immune responses mediated by B lymphocytes (2011)
  • Author(s): 小田ちぐさ
  • Organizer: 第40回日本免疫学会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-11-27
• [Presentation] The role of CD155, a noval co-stimulatory molecule in CD4+ T cell, incontact dermatitis (2011)
  • Author(s): 山下由美
  • Organizer: 第40回日本免疫学会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-11-27
• [Presentation] Apoptotic cells mast cellinflammatory responses via the CD300a immunoreceptor. Harnessing Immunity to Prevent and Treat Disease meeting (2011)
  • Author(s): Shibuya A
  • Organizer: Cold Spring Harbor
  • Place of Presentation: New York, USA
  • Year and Date: 2011-11-18
• [Presentation] Apoptotic cells mast cell inflammatory responses via the CD300a immunoreceptor (2011)
  • Author(s): Akira Shibuya
  • Organizer: Harnessing Immunity to Prevent and Treat Disease meeting
  • Place of Presentation: New York, USA
  • Year and Date: 2011-11-18
• [Presentation] アラジンIのアレルギー反応における機能 (2011)
  • Author(s): 田原聡子
  • Organizer: 第61回日本アレルギー学会
  • Place of Presentation: プリンスホテル新高輪
  • Year and Date: 2011-11-11
• [Presentation] Crinical role of DNAM-1 in the development of acute GVHD (2011)
  • Author(s): 渋谷彰
  • Organizer: 第73回日本血液学会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2011-10-14
• [Presentation] ウィルス感染は細菌認識センサーNod1/Nod2の応答性を亢進させ、細菌の二次感染による致死量を上昇させる (2011)
  • Author(s): 金倫基
  • Organizer: 第94回日本細菌学会関東支部総会
  • Place of Presentation: 北里大学白金キャンパス
  • Year and Date: 2011-10-07
• [Presentation] 肥満細胞の活性化を抑制する免疫受容体アラジン1 (2011)
  • Author(s): 渋谷彰
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2011-09-21
• [Presentation] 抑制性免疫受容体による肥満細胞の活性化制御 (2011)
  • Author(s): 渋谷彰
  • Organizer: BD学術セミナー2011免疫学の最前線
  • Place of Presentation: マンダリンオリエンタル東京
  • Year and Date: 2011-09-20
• [Presentation] 急性移植片対宿主病の予知診断法と分子標的療法の開発 (2011)
  • Author(s): 金谷穣
  • Organizer: 第3回造血器腫瘍免疫療法研究会
  • Place of Presentation: 別府ホテル白菊
  • Year and Date: 2011-08-20
• [Presentation] 自己免疫疾患-その病態解明と治療の進歩 (2011)
  • Author(s): 渋谷彰
  • Organizer: 第35回阿蘇シンポジウム
  • Place of Presentation: 阿蘇リゾートグランヴィリオホテル
  • Year and Date: 2011-07-29
• [Presentation] アレルギー免疫学の新しい展開-アレルギー抑制分子 (2011)
  • Author(s): 渋谷彰
  • Organizer: 第46回日本呼吸器学会 中国・四国地方会
  • Place of Presentation: 倉敷市芸文館
  • Year and Date: 2011-07-15
• [Presentation] MAIR-1(CD300d) plays a crucial role in inflammatory responses in a murine sepsis model (2011)
  • Author(s): 戸塚直也
  • Organizer: 13^<th> International TNF Conference
  • Place of Presentation: 淡路夢舞台国際会議場
  • Year and Date: 2011-05-17
• [Presentation] CD226 as a novel Target for Autoimmune Diseases. (2011)
  • Author(s): Akira Shibuya
  • Organizer: Beijing Novo Nordisk Pharmaceuticals Science&Technology Co., Ltd, Beijing
  • Place of Presentation: Beijing(China)
  • Year and Date: 2011-02-24
• [Presentation] アレルギー応答を負に制御する抑制性受容体Allergin.1の発見 (2011)
  • Author(s): 人見香織
  • Organizer: 第20回東京免疫フォーラム
  • Place of Presentation: 東京大学医科学研究所
  • Year and Date: 2011-02-12
• [Presentation] Regulation of mast cell-mediated activation by inhibitory immunoreceptors (2011)
  • Author(s): Shibuya A
  • Organizer: The 3^<rd> Workshop between University of Tsukuba and University of Edinburgh
  • Place of Presentation: Edinburgh, Scotland
• [Presentation] CD226 as a novel Target for Autoimmune Diseases (2011)
  • Author(s): Shibuya A
  • Organizer: Beijing Novo Nordisk Pharmaceuticals Science & Technology Co., Ltd
  • Place of Presentation: Beijing, China
• [Presentation] Biological function of IgMFc receptors (2010)
  • Author(s): Shibuya A
  • Organizer: 6^<th> Annual Symposium on Primary Immunodeficiency Diseases
  • Place of Presentation: California, USA
  • Year and Date: 2010-11-21
• [Presentation] Biological function of IgMFc receptors. (2010)
  • Author(s): Akira Shibuya
  • Organizer: 6^<th> Annual Symposium on Primary Immunodeficiency Diseries
  • Place of Presentation: California, USA
  • Year and Date: 2010-11-21
• [Presentation] Clinical Applications (2010)
  • Author(s): Shibuya A
  • Organizer: The12^<th> Meeting of the Society for Natural Immunity & NK2010
  • Place of Presentation: Dubrovnik, Croatia
  • Year and Date: 2010-09-14
• [Presentation] Clinical Applications (2010)
  • Author(s): Akira Shibuya
  • Organizer: The 12^<th> Meeting of the Society for Natural Immunity & NK 2010
  • Place of Presentation: Dubrovnik, Croatia
  • Year and Date: 2010-09-14
• [Presentation] 抗DNAM-1モノクローナル抗体を用いた移植片対宿主病に対する新規予防および治療法の開発 (2010)
  • Author(s): 鍋倉宰
  • Organizer: 第2回造血器腫瘍免疫療法研究会
  • Place of Presentation: 愛媛大和田本
  • Year and Date: 2010-08-28
• [Presentation] Regulation of serum IgA production by the Fca/u, an Fc receptor for IgA and IgM (2010)
  • Author(s): Shin-ichiro Honda
  • Organizer: 第14回国際免疫学会議
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2010-08-26
• [Presentation] Acritical role of DNAM-1 in the development of acute graft-versus-host disease (2010)
  • Author(s): Tsukasa Nabekura
  • Organizer: 第14回国際免疫学会議
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2010-08-26
• [Presentation] Requirement of cytoplasmic portion for dimer formation of FcaJμreceptor expressed on cell surface (2010)
  • Author(s): Yukiko Cho
  • Organizer: 第14回国際免疫学会議
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2010-08-24
• [Presentation] An immunoreceptor ando adaptor complex, MAIR-□/DAP 12, negatively regulates B cell proliferation (2010)
  • Author(s): Takako Nakano
  • Organizer: 第14回国際免疫学会議
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2010-08-23
• [Presentation] Decreased mortality in MAIR-□(CD300a)-deficient mice with experimental sepsisinduced by cecal ligation and puncture (2010)
  • Author(s): Chigusa Nakahashi-Oda
  • Organizer: 第14回国際免疫学会議
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2010-08-23
• [Presentation] A novel immunoglobulin-like receptor, Allergin-1, inhibits lgE-mediated allergic responses (2010)
  • Author(s): Kaori Hitomi
  • Organizer: 第14回国際免疫学会議
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2010-08-23
• [Presentation] MAIR-□(CD300d)plays a crucial role in inflammatory responses in a murine seps is model (2010)
  • Author(s): Naoya Totsuka
  • Organizer: 第14回国際免疫学会議
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2010-07-24
• [Presentation] Enhanced humoral immune responses against T-independent antigens in Fcα/μR-deficient mice. (2010)
  • Author(s): 渋谷彰
  • Organizer: The 9th International Human Leukocyte Differentiation Antigens Workshop.
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-03-12
• [Presentation] A critical role of DNAM-1 in the development of acute graft-versus-host disease. (2010)
  • Author(s): Tsukasa Nabekura
  • Organizer: Keystone Symposia on Molecular and Cellular Biology.
  • Place of Presentation: Breckenridge, Colorado, USA
  • Year and Date: 2010-03-03
• [Presentation] A critical role of paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, in Inflammatory responses (2010)
  • Author(s): Shibuya A
  • Organizer: The 2010 Midwinter Conference of Immunologysts at Asiloma
  • Place of Presentation: San Francisico, California, USA
  • Year and Date: 2010-01-22
• [Presentation] A novel immunoglobulin-like receptor, Allergin-1, inhibits IgE-mediated allergic responses. CSHL (2010)
  • Author(s): Satoko Tahara-Hanaoka, Kaori Hitomi, Satoru Someya, Akira Fujiki, Hideaki Tada, Tetsuya Sugiyama, Shiro Shibayama, Kazuko Shibuya, Akira Shibuya
  • Organizer: Meeting-Gene Expression & Signaling in the Immune System. Cold Spring Harbor Laboratory, Cold Spring Harbor
  • Place of Presentation: New York, USA
• [Presentation] Identification and characterization of the poliovirus receptor(CD 155)as a novel co-stimulatory molecule in CD4+T cells (2010)
  • Author(s): Yumi Yamashita
  • Organizer: 第14回国際免疫学会議
  • Place of Presentation: 神戸ポートピアホテル
• [Presentation] A novel immunoglobulin-like receptor, Allergin-1, inhibits IgE-mediated allergic responses (2010)
  • Author(s): Satoko Tahara-Hanaoka
  • Organizer: CSHL Meeting-Gene Expression & Signaling in the Immune System
  • Place of Presentation: New York, USA
• [Presentation] 免疫および疾患生物学-a免疫 (2009)
  • Author(s): 渋谷彰
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-12-10
• [Presentation] Negative regulation of B cell proliferation by DAP12 and MAIR-II. (2009)
  • Author(s): Takako Nakano
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-12-04
• [Presentation] Novel prophylactic and therapeutic approaches to GVHD with a monoclonal antibody against DNAM-1. (2009)
  • Author(s): Tsukasa Nabekura
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-12-04
• [Presentation] Regulation of serum IgA production by the Fcα/μR, an Fc receptor for IgA and IgM. (2009)
  • Author(s): 本多伸一郎
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-12-02
• [Presentation] A novel therapeutic approach for sepsis using a monoclonal antibody against MAIR-I(CD300a). (2009)
  • Author(s): Chigusa Nakahashi-Oda
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-12-02
• [Presentation] Enhanced humoral immune responses against T-independent antigens in Fcα/μR-de ficient mice. (2009)
  • Author(s): 本多伸一郎
  • Organizer: 第37回日本臨床免疫学会総会
  • Place of Presentation: 東京ステーションコンファレンス
  • Year and Date: 2009-11-14
• [Presentation] Activation of neutrophils by a novel triggering immunoglobulin-like receptor MAIR-IV. (2009)
  • Author(s): 中埜貴子
  • Organizer: 第37回日本臨床免疫学会総会
  • Place of Presentation: 東京ステーションコンファレンス
  • Year and Date: 2009-11-14
• [Presentation] 自然免疫と免疫病 (2009)
  • Author(s): 渋谷彰
  • Organizer: 第37回日本臨床免疫学会総会
  • Place of Presentation: 東京ステーションコンファレンス
  • Year and Date: 2009-11-13
• [Presentation] Caspase-independent cell death by MAIR-V(CD300LF), Ig-like receptor on myeloid cells. (2009)
  • Author(s): 田原聡子
  • Organizer: 第37回日本臨床免疫学会総会
  • Place of Presentation: 東京ステーションコンファレンス
  • Year and Date: 2009-11-13
• [Presentation] MAIR-Iを分子標的とした敗血症に対する治療法の可能性 (2009)
  • Author(s): 小田ちぐさ
  • Organizer: 第37回日本臨床免疫学会総会
  • Place of Presentation: 東京ステーションコンファレンス
  • Year and Date: 2009-11-13
• [Presentation] 腫瘍免疫監視機構における細胞接着分子DNAM-1の機能 (2009)
  • Author(s): 井口研子
  • Organizer: 第37回日本臨床免疫学会総会
  • Place of Presentation: 東京ステーションコンファレンス
  • Year and Date: 2009-11-13
• [Presentation] Accelerated tumor growth in mice deficient in DNAM-1 receptor. (2009)
  • Author(s): 渋谷彰
  • Organizer: The 5^<th> International Workshop of Kyoto T Cell Conference(KTCC)
  • Place of Presentation: 京都大学芝蘭会館
  • Year and Date: 2009-06-02
• [Remarks] リポジトリ論文URL
  • URL: http://www.tulips.tsukuba.ac.jp/dspace/handle/2241/97904/
• [Remarks] リポジトリ論文URL
  • URL: http://www.tulips.tsukuba.ac.jp/dspace/handle/2241/97904/
• [Remarks] リポジトリ論文
  • URL: http://www.tulips.tsukuba.ac.jp/dspace/handle/2241/97904/
• [Patent(Industrial Property Rights)] 特発性炎症性筋疾患の予防又は治療剤 (2012)
  • Inventor(s): 上阪等, 渋谷彰
  • Industrial Property Rights Holder: 上阪等, 渋谷彰
  • Filing Date: 2012-03-21
• [Patent(Industrial Property Rights)] 臓器移植拒絶予防法の開発 (2012)
  • Inventor(s): 渋谷彰, 渋谷和子, 阿部史枝
  • Industrial Property Rights Holder: 渋谷彰, 渋谷和子, 阿部史枝
  • Filing Date: 2012-01-31
• [Patent(Industrial Property Rights)] 特発性炎症性筋疾患の予防又は治療剤 (2012)
  • Inventor(s): 上阪等、渋谷彰
  • Industrial Property Rights Holder: 東京医科歯科大学、筑波大学
  • Industrial Property Number: 2012-063595
  • Filing Date: 2012-03-21
• [Patent(Industrial Property Rights)] 臓器移植拒絶予防法の開発 (2012)
  • Inventor(s): 渋谷彰、渋谷和子、阿部史枝
  • Industrial Property Rights Holder: 筑波大学
  • Industrial Property Number: 2011-000094
  • Filing Date: 2012-01-31
• [Patent(Industrial Property Rights)] ホスホファチジルセリン結合性物質またはCD300a結合性物質を含む免疫賦活性剤、およびホスホファチジルセリンを含む免疫抑制剤 (2011)
  • Inventor(s): 渋谷彰, 小田ちぐさ, 田原聡子
  • Industrial Property Rights Holder: 渋谷彰, 小田ちぐさ, 田原聡子
  • Filing Date: 2011-11-21
• [Patent(Industrial Property Rights)] 移植片対宿主病予知マーカーおよびその利用 (2011)
  • Inventor(s): 渋谷彰, 小島寛
  • Industrial Property Rights Holder: 渋谷彰, 小島寛
  • Acquisition Date: 2011-12-21
  • Overseas
• [Patent(Industrial Property Rights)] ホスホファチジルセリン結合性物質またはCD300a結合性物質を含む免疫賦活性剤、およびホスホファチジルセリンを含む免疫抑制剤 (2011)
  • Inventor(s): 渋谷彰、小田ちぐさ、田原聡子
  • Industrial Property Rights Holder: 筑波大学
  • Industrial Property Number: 2011-254151
  • Filing Date: 2011-11-21
• [Patent(Industrial Property Rights)] 可溶型CD115による癌の診断とこれを標的とした癌治療 (2010)
  • Inventor(s): 渋谷彰, 渋谷和子, 井口研子
  • Industrial Property Rights Holder: 渋谷彰, 渋谷和子, 井口研子
  • Filing Date: 2010-01-28