The immunopathological study on leukocyte adhesion molecule DNAM-1 (CD226)
Project/Area Number |
21249026
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Experimental pathology
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Research Institution | University of Tsukuba |
Principal Investigator |
SHIBUYA Akira 筑波大学, 医学医療系, 教授 (80216027)
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Co-Investigator(Renkei-kenkyūsha) |
SHIBUYA Kazuko 筑波大学, 医学医療系, 准教授 (00302406)
HONDA Shinichiro 筑波大学, 医学医療系, 准教授 (60360640)
TAHARA Satoko 筑波大学, 医学医療系, 助教 (20360589)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥48,230,000 (Direct Cost: ¥37,100,000、Indirect Cost: ¥11,130,000)
Fiscal Year 2011: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2010: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2009: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
|
Keywords | CD226 / 腫瘍免疫 / 感染免疫 / 自己免疫 / DNAM-1 |
Research Abstract |
The molecular mechanisms underlying immune responses to cancer, autoimmune diseases, and infectious diseases have been unclear. Elucidation of the molecular mechanisms is essentially required to overcome these intractable diseases. We previously identified leukocyte activating receptor DNAM-1 that is expressed on NK cells, T cell and macrophages ant its ligands. In this study, we clarify the role of DNAM-1 in the pathogenesis of diseases and develop the basis of molecular targeting therapy to these diseases.
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Report
(4 results)
Research Products
(95 results)
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[Journal Article] The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses2011
Author(s)
Nakano-Yokomizo T, Tahara-Hanaoka S, Nakahashi-Oda C, Nabekura T, Nadia K. Tchao, Kadosaki M, Totsuka N, Kurita N, Nakamagoe K, Tamaoka A, Takai T, Yasui T, Kikutani H, Honda S, Shibuya K, Lewis L. Lanier, Shibuya A
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Journal Title
J Exp Med
Volume: 208(8)
Pages: 1661-1671
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[Journal Article] An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E.mediated immediate hypersensitivity reactions2010
Author(s)
Hitomi K, Tahara-Hanaoka S, Someya S, Fujiki A, Tada H, Sugiyama T, Shibayama S, Shibuya K, Shibuya A
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Journal Title
Nature Immunology
Volume: 11
Pages: 601-607
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[Journal Article] Enhanced humoral immune responses against T-independent antigens in Fc α / μR-deficient mice2009
Author(s)
Honda S, Miyamoto A, Cho Y, Usui K, Kurita N, Takeshita K, Takahashi S, Kinoshita T, Fujita T, Tahara-Hanaoka S, Shibuya K, Shibuya A
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Journal Title
Proc Natl Acad Sci USA
Volume: 106
Pages: 11230-11235
NAID
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[Journal Article] Receptor-mediated recognition of melanoma by NK cells and its implications for NK cell-based immunotherapy2009
Author(s)
Lakshmikanth T, Burke S, Ali TH, Kimpfler S, Ursini F, Ruggeri L, Capanni M, Umansky V, Paschen A, SuckerA, Pende D, Groh V, Biassoni R, HoglundP, Kato K, Shibuya K, Schadendorf D, Anichini A, Ferrone S, Velardi A, KarreK, Shibuya A, Carbone E, Colucci F
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Journal Title
Tissue Antigen
Volume: 73
Pages: 519-520
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[Journal Article] NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo2009
Author(s)
Lakshmikanth T, Burke S, Ali TH, Kimpfler S, Ursini F, Ruggeri L, Capanni M, Umansky V, Paschen A, SuckerA, Pende D, Groh V, Biassoni R, HoglundP, Kato K, Shibuya K, Schadendorf D, Anichini A, Ferrone S, Velardi A, Karre K, Shibuya A, Carbone E, Colucci F
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Journal Title
J Clin Invest
Volume: 119
Pages: 1251-1263
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[Presentation] A novel immunoglobulin-like receptor, Allergin-1, inhibits IgE-mediated allergic responses. CSHL2010
Author(s)
Satoko Tahara-Hanaoka, Kaori Hitomi, Satoru Someya, Akira Fujiki, Hideaki Tada, Tetsuya Sugiyama, Shiro Shibayama, Kazuko Shibuya, Akira Shibuya
Organizer
Meeting-Gene Expression & Signaling in the Immune System. Cold Spring Harbor Laboratory, Cold Spring Harbor
Place of Presentation
New York, USA
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[Presentation] 自然免疫と免疫病2009
Author(s)
渋谷彰
Organizer
第37回日本臨床免疫学会総会
Place of Presentation
東京ステーションコンファレンス
Year and Date
2009-11-13
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