| Budget Amount *help |
¥48,230,000 (Direct Cost: ¥37,100,000、Indirect Cost: ¥11,130,000)
Fiscal Year 2011: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2010: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2009: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
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| Research Abstract |
In order to identify novel molecules localized in the apical organelles of Plasmodium merozoite, we have expressed 193 putative merozoite specific molecules and produced antibodies against each recombinant protein. Among them, 29 were localized at the apical end of the merozoite suggesting novel apical organellar proteins. We then characterized the RBC binding activity and the RBC receptor phenotype against one of the novel micronemal molecules, GAMA. Furthermore, we have constructed erythrocyte protein array including 500 of molecules, and identified an erythrocyte membrane protein which serves as a receptor against erythrocyte-binding rhoptry protein.
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