Type-I IFN-dependent control of HSCs and its therapeutic applications for congenital and hematopoietic disorders
| Project/Area Number |
21249033
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
OHTEKI Toshiaki 東京医科歯科大学, 難治疾患研究所, 教授 (50233200)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Fiscal Year 2011: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2010: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
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| Keywords | IFN / HSC / 骨髄移植 / 先天性代謝異常症 / LSC / CML / ウィルス感染 / I型IFNs / IRF2 |
|---|
| Research Abstract |
We found that transient type I IFN signaling induced HSC activation and chronic type I IFN signaling further reduced the number of quiescent HSCs. Based on our findings, we established type I IFN-based preconditioning regimen without irradiation for HSC transplantation, which is applicable to the treatment of a congenital metabolic disorder, mucopolysaccharidosis type VII. In addition, the treatment of chronic myeroid leukemia(CML) with imatinib and poly(I : C), a type I IFN inducer, significantly reduced the recurrence rate of the disease.
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Report
(4 results)
Research Products
(120 results)
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[Journal Article] syntheticdouble-stranded RNA, poly I : C, induces arapid apoptosis of human CD34+cells2011
Author(s)
Liu J, Guo Y-M, Hirokawa M, Iwamoto K, Ubukawa K, Michishita Y, Fujishima N, Tagawa H, Takahashi N, Xiao W, Yamashita J, Ohteki T, Sawada K. A
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Journal Title
ExpHematol
Volume: 40
Pages: 330-341
Related Report
Peer Reviewed
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[Journal Article] Role of SIRPαin regulation of mucosal immunity in the intestine2010
Author(s)
Kanazawa Y, Saito Y, Supriatna Y, Tezuka H, Kotani T, Murata Y, Okazawa H, Ohnishi H, Kinouchi Y, Nojima Y, Ohteki T, Shimosegawa T, Matozaki T
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Journal Title
Genes Cells
Volume: 15
Pages: 1189-1200
Related Report
Peer Reviewed
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[Journal Article] CpG-ODN 2006 andhuman parvovirus B19 genome consensussequences selectively inhibit growth anddevelopment of erythroid progenitor cells2010
Author(s)
Guo Y-M, Ishii K, Hirokawa M, Tagawa H, Ohyagi H, Michishita Y, Ubukawa K, Yamashita J, Ohteki T, Onai N, Kawakami K, Xiao W, Sawada K
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Journal Title
Blood
Volume: 115
Pages: 4569-4579
Related Report
Peer Reviewed
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[Remarks] Sato T et al., Nat Med 15, 696-700(2009)に関する記事が,朝日新聞,毎日新聞,日本経済新聞,中日新聞,秋田さきがけ,岩手日報,河北新報,京都新聞,高知新聞,下野新聞,北日本新聞,福島民報,神戸新聞,西日本新聞,静岡新聞,大阪日日新聞,参院中央新聞,東京新聞,〓島新聞,長崎新聞,福井新聞,岐阜新聞,茨城新聞,佐賀新聞,山梨日日新聞,山陽新聞,四国新聞,沖縄タイムスなどの6月1日朝刊およびウェブ上に掲載された。2009年6月1日報道関連情報
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