| Co-Investigator(Kenkyū-buntansha) |
宝学 英隆 (寶學 英隆) 奈良先端科学技術大学院大学, 保健管理センター, 教授 (50314323)
中村 祐 香川大学, 医学部, 教授 (70291440)
新崎 信一郎 大阪大学, 医学系研究科, 助教 (60546860)
鎌田 佳宏 大阪大学, 医学系研究科, 助教 (30622609)
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| Budget Amount *help |
¥45,760,000 (Direct Cost: ¥35,200,000、Indirect Cost: ¥10,560,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2010: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2009: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
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| Research Abstract |
Oligosaccharide is one of the most important post-translational modifications of proteins. The oligosaccharide structure is changed in carcinogenesis, differentiation and proliferation. In the present study, we have developed novel glycol-markers for predicting life-style related diseases, using glycol-proteomic analyses. We collected serum samples and clinical information of people who got medical check. We developed a glycol marker, which can distinguish high/low risk people for life-style related diseases in future. We also developed a lectin-antibody ELISA kit for determining agalactosyl IgG, which represents the status of chronic inflammation diseases. Oligosaccharide remodeling mice showed us a pathophysiological signification of aberrant glycosylation involved in life-style related diseases.
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