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Mother-to-child kinetics and exposure assessment model for co-exposure to methylmercury and POPs during perinatal periods

Research Project

Project/Area Number 21249039
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionTohoku University

Principal Investigator

SATOH Hiroshi  東北大学, 大学院・医学系研究科, 名誉教授 (40125571)

Co-Investigator(Kenkyū-buntansha) NAKAI Kunihiko  東北大学, 大学院・医学系研究科, 教授 (00291336)
KUROKAWA Naoyuki  東北大学, 大学院・医学系研究科, 助教 (30431505)
TATSUTA Nozomi  東北大学, 大学院・医学系研究科, 助手 (40547709)
Research Collaborator IWAI Miyuki (SHIMADA Miyuki)  東北大学, 大学院・医学系研究科, 日本学術振興会特別研究員
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥43,680,000 (Direct Cost: ¥33,600,000、Indirect Cost: ¥10,080,000)
Fiscal Year 2011: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2010: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2009: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Keywords環境保健 / トキシコキネティクス / 環境汚染物質 / 残留性有機汚染物質 / PCBs / メチル水銀 / 混合ばく露 / ポリ塩素化ビフェニル / メチル永銀 / 周産期ばく露 / POPs
Research Abstract

Methylmercury (MeHg)and persistent organic pollutantspoly (POPs)such as PCBs and DDTs are environmentally persistent neurodevelopmental toxicants. They can be transferred from the mother to the fetus via palacenta and to the infant via breastfeeding. The main sources of the exposures to MeHg and POPs are food, particularly the consumption of fish and fish products in Japan. We previously carried out an animal experiment to examine the effect of co-exposure to MeHg and POPs on mother-to-child kinetics using mice and guinea pig. We administered MeHg and POPs using whale oil for POPs exposure. p, p'-DDE-d8 added was similarly accumulated and, d8 provided a useful index for predicting the distribution of DDTs. We observed negative effects on eye opening and open field test in group of mice of high contaminated POPs oil.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (20 results)

All 2011 2010 2009

All Journal Article (8 results) (of which Peer Reviewed: 6 results) Presentation (6 results) Book (6 results)

  • [Journal Article] 【母子の健康と環境影響どこまでわかっているの? どう答えればいいの? 】母子への環境影響Q & Aお母さんからの質問にどう答えるか2011

    • Author(s)
      佐藤洋, 上島通浩ら
    • Journal Title

      助産雑誌

      Volume: 65 Pages: 999-1007

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【母子の健康と環境影響どこまでわかっているの?どう答えればいいの?】母子への環境影響Q&Aお母さんからの質問にどう答えるか2011

    • Author(s)
      佐藤洋, 上島通浩, ら
    • Journal Title

      助産雑誌

      Volume: 65 Pages: 999-1007

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 動き出した"エコチル調査"-環境省「子供の健康と環境に関する全国調査」"エコチル調査"前史2011

    • Author(s)
      佐藤洋
    • Journal Title

      医学のあゆみ

      Volume: 235 Pages: 1083-1086

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 動き出した エコチル調査-環境省「子供の健康と環境に関する全国調査」 エコチル調査 前史2010

    • Author(s)
      佐藤洋
    • Journal Title

      医学のあゆみ

      Volume: 235 Pages: 1083-1086

    • Related Report
      2011 Final Research Report
  • [Journal Article] Co-exposure to methylmercury and PCBs increases accumulation of PCBs in the brains of offspring mice2010

    • Author(s)
      Shimada, M., T. Nakamura, N. Sugawara, K. Yaginuma, N. Tatsuta, N. Kurokawa, K. Nakai, H. Satoh
    • Journal Title

      Organohalogen Compounds

      Volume: 72 Pages: 232-235

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 化学物質と環境・健康2010

    • Author(s)
      佐藤洋
    • Journal Title

      食品衛生研究

      Volume: 60 Pages: 15-25

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] Gene expression profiles in the brain of the neonate mouse perinatally exposed to methylmercury and/or polychlorinated biphenyls2010

    • Author(s)
      Shimada, M., S. Kameo, N. Sugawara, K. Yaginuma-Sakurai, N. Kurokawa, S. Mizukami-Murata, K. Nakai, I. Hitoshi, H. Satoh
    • Journal Title

      Archives of Toxicology

      Volume: 84 Pages: 271-286

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression profiles in the brain of the neonate mouse perinatally exposed to methylmercury and/or polychlorinated biphenyls.2010

    • Author(s)
      Shimada M., S.Kameo, et al.
    • Journal Title

      Archives of Toxicology 84

      Pages: 271-286

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 低濃度メチル水銀ばく露の生体影響-胎児におけるばく露の神経行動学的影響と成人におけるばく露の心拍変動におよぼす影響-2011

    • Author(s)
      佐藤洋
    • Organizer
      メチル水銀ミーティング
    • Place of Presentation
      東京
    • Year and Date
      2011-12-21
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 環境化学物質への胎児期ばく露の出生後の影響:子どもの健康と環境に関する全国調査(エコチル調査)への期待2010

    • Author(s)
      佐藤洋
    • Organizer
      第39回日本環境変異原学会
    • Place of Presentation
      筑波
    • Related Report
      2011 Final Research Report
  • [Presentation] Co-exposure to methylmercury and PCBs increases accumulation of PCBs in the brains of offspring mice2010

    • Author(s)
      Shimada, M., T. Nakamura, N. Sugawara, K. Yaginuma, N. Tatsuta, N. Kurokawa, K. Nakai, H. Satoh
    • Organizer
      30th International Symposium on Halogenated Persistent Organic Pollutants
    • Place of Presentation
      San Antonio, Texas, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] 環境化学物質への胎児期ばく露の出生後の影響:子どもの健康と環境に関する全国調査(土コチル調査)への期待2010

    • Author(s)
      佐藤洋
    • Organizer
      第39回日本環境変異原学会
    • Place of Presentation
      筑波
    • Related Report
      2010 Annual Research Report
  • [Presentation] 食品による重金属ばく露と健康被害2009

    • Author(s)
      佐藤洋
    • Organizer
      日本トキシコロジー学会 ; 第7回市民公開セミナー
    • Place of Presentation
      盛岡
    • Year and Date
      2009-07-05
    • Related Report
      2011 Final Research Report
  • [Presentation] 食品による重金属ばく露と健康被害2009

    • Author(s)
      佐藤洋
    • Organizer
      日本トキシコロジー学会;第7回市民公開セミナー
    • Place of Presentation
      盛岡
    • Year and Date
      2009-07-05
    • Related Report
      2009 Annual Research Report
  • [Book] 小児臨床栄養学, 食品に含まれる有害物質と妊産婦2011

    • Author(s)
      佐藤洋
    • Total Pages
      97
    • Publisher
      株式会社診断と治療社
    • Related Report
      2011 Final Research Report
  • [Book] レアメタル便覧, カドミウム2011

    • Author(s)
      柳沼梢, 佐藤洋
    • Publisher
      株式会社丸善
    • Related Report
      2011 Final Research Report
  • [Book] レアメタル便覧, 水銀2011

    • Author(s)
      島田美幸, 佐藤洋
    • Publisher
      株式会社丸善
    • Related Report
      2011 Final Research Report
  • [Book] レアメタル便覧,水銀2011

    • Author(s)
      島田美幸, 佐藤洋
    • Publisher
      株式会社丸善
    • Related Report
      2010 Annual Research Report
  • [Book] 小児臨床栄養学,食品に含まれる有害物質と妊産婦2011

    • Author(s)
      佐藤洋
    • Total Pages
      97
    • Publisher
      株式会社診断と治療社
    • Related Report
      2010 Annual Research Report
  • [Book] レアメタル便覧,水銀2010

    • Author(s)
      島田美幸, 佐藤洋
    • Publisher
      株式会社 丸善(印刷中)
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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