| Budget Amount *help |
¥44,200,000 (Direct Cost: ¥34,000,000、Indirect Cost: ¥10,200,000)
Fiscal Year 2012: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
Fiscal Year 2011: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
Fiscal Year 2010: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2009: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
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| Research Abstract |
Flavone, which is known as a cancer preventive agent, induced growth inhibiton, G1 arrest and the decrease of the E2F1 and E2F3, which act for G1/S progression, in prostate cancer cells. Flavone also induced miR-34a, which regulates the expression of E2F1 and E2F3. Furthermore, the inhibition of miR-34a suppressed the G1 arrest and decrease of the E2F1 and E2F3 by the treatment of flavone. These results raise a possibility that cancer preventive agents inhibit the cell proliferation through the in duction of microRNAs.
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