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A study on determinants of subclinical atherosclerosis

Research Project

Project/Area Number 21249043
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionShiga University of Medical Science

Principal Investigator

UESHIMA Hirotsugu  滋賀医科大学, 生活習慣病予防センター, 特任教授 (70144483)

Co-Investigator(Kenkyū-buntansha) MIURA Katsuyuki  滋賀医科大学, 医学部, 教授 (90257452)
KITA Yoshikuni  滋賀医科大学, 医学部, 助教 (30147524)
TAKASHIMA Naoyuki  滋賀医科大学, 生活習慣病予防センター, 特任助教 (80435883)
KADOTA Aya  滋賀医科大学, 医学部, 特任講師 (60546068)
KADOWAKI Takashi  滋賀医科大学, 医学部, 客員助教 (30324578)
OKUDA Nagako  滋賀医科大学, 生活習慣病予防センター, 客員助教 (80452233)
MURAKAMI Yoshitaka  滋賀医科大学, 医学部, 准教授 (90305855)
OHKUBO Tkayoshi  滋賀医科大学, 医学部, 准教授 (60344652)
FUJIYOSHI Akira  滋賀医科大学, 医学部, 特任助教 (10567077)
NAGASAWA Shinya  滋賀医科大学, 医学部, 客員助教 (30510341)
Co-Investigator(Renkei-kenkyūsha) KADOWAKI Sayaka  滋賀医科大学, 医学部, 客員助教 (60510344)
MITSUNAMI Kenichi  滋賀医科大学, 医学部, 教授 (10127037)
HORIE Minoru  滋賀医科大学, 医学部, 教授 (90183938)
KASHIWAGI Atsunori  滋賀医科大学, 医学部, 副学長 (20127210)
MURATA Kiyoshi  滋賀医科大学, 医学部, 教授 (20127038)
MAEGAWA Hiroshi  滋賀医科大学, 医学部, 教授 (00209363)
NAKAMURA Yasuyuki  京都女子大学, 家政学部, 教授 (20144371)
SEKIKAWA Akira  滋賀医科大学, 医学部, 客員准教授 (10216525)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000)
Fiscal Year 2011: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Fiscal Year 2010: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2009: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Keywords動脈硬化 / 公衆衛生学 / 疫学 / 国際共同研究 / 一般住民 / 一般地域住民
Research Abstract

We proposed to complete the follow-up examination over six years(2009 through 2015) on the participants(n. 1, 300, age 40-79 years) we randomly sampled previously. In this proposal covering year 2005 to 2011, we planned to run follow-up examination approximately 500 participants. By the end of March 2012, we have done the follow-up examination on more than 700 participants, well beyond the planned number. Another subsidiary plan, a comparison of our cohort with the Multi-Ethnic Study of Atherosclerosis in US, is in good progress. Furthermore, we have reported prevalence of subclinical atherosclerosis, namely coronary artery calcification(CAC) and intima-media thickness of the carotid artery(IMTC), as well as association between serum levels of lipoprotein-associated phospholipase A2 and those measures of subclinical atherosclerosis(i. e. CAC, IMTC) using a random sample from a general Japanese population

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (24 results)

All 2012 2011 2010 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (14 results)

  • [Journal Article] The prevalence of aortic calcification in Japanese compared to white and Japanese-American middle-aged men is confounded by the amount of cigarette smoking2012

    • Author(s)
      El-Saed A, Kadowaki T, Fujiyoshi A, Nakamura Y, Miura K, Ueshima H, Sekikawa A., 他11名、17番目
    • Journal Title

      Int J Cardiol

      Volume: (in Press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Coronary artery calcification by computed tomography in epidemiologic research and cardiovascular disease prevention2012

    • Author(s)
      Sekikawa A, Fujiyoshi A, Miura K, Ueshima H., 他7名11番目
    • Journal Title

      J Epidemiol

      Volume: 22(3) Pages: 188-98

    • NAID

      10030617938

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparability in coronary artery calcium scores on CT scan between two community-based cohort studies2011

    • Author(s)
      Fujiyoshi A, Kadowaki T, Kadowaki S, Sekikawa A, Ohkubo T, Miura K, Edmundowicz D, Budoff MJ, Murata K, Liu K, Ueshima H.
    • Journal Title

      Int J Cardiol

      Volume: 149(2) Pages: 244-5

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparability in coronary artery calcium scores on CT scan between two community-based cohort studies.2011

    • Author(s)
      藤吉朗(共著上島弘嗣, ほか)
    • Journal Title

      Int J Cardiol

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ERA JUMP Study group.: Circulating levels of 8 cytokines and marine n-3 fatty acids and indices of obesity in Japanese, white, and Japanese American middle-aged men2010

    • Author(s)
      Sekikawa A, Kadowaki T, Maegawa H, Kadota A, Ueshima H, 他10名14番目
    • Journal Title

      J Interferon Cytokine Res.

      Volume: 30(7) Pages: 541-8

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ERA-JUMP Study Group.: Serum n-6 fatty acids and lipoprotein subclasses in middle-aged men : the population-based cross-sectional ERA-JUMP study2010

    • Author(s)
      Choo J, Ueshima H, Kadowaki T, Miura K, Sekikawa A, 他11名2番目
    • Journal Title

      Am J Clin Nutr.

      Volume: 91(5) Pages: 1195-203

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Circulating levels of 8 cytokines and marine n-3 fatty acids and indices of obesity in Japanese, white, and Japanese American middle-aged men.2010

    • Author(s)
      関川暁(共著上島弘嗣, ほか)
    • Journal Title

      J Interferon Cytokine Res

      Volume: 30(7) Pages: 541-548

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum n-6 fatty acids and lipoprotein subclasses in middle-aged men : the population-based cross-sectional ERA-JUMP Study.2010

    • Author(s)
      Choo J(共著上島弘嗣, ほか)
    • Journal Title

      Am J Clin Nutr

      Volume: 91(5) Pages: 1195-1203

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coronary Artery Calcification by Computed Tomography in Epidemiologic Research and Cardiovascular Disease Prevention

    • Author(s)
      Sekikawa A, Curb JD, Okamura T, Choo J, Fujiyoshi A, Miura K, Kuller LH, Shin C, Ueshima H, et al
    • Journal Title

      J Epidemiol

      Volume: (In Press)

    • NAID

      10030617938

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The prevalence of aortic calcification in Japanese compared to white and Japanese-American middle-aged men is confounded by the amount of cigarette smoking

    • Author(s)
      El-Saed A, Curb JD, Kadowaki T, Fujiyoshi A, Nakamura Y, Miura K, Ueshima H, et al
    • Journal Title

      Int J Cardiol

      Volume: (In Press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Lipoprotein-associated Phospholipase A2 Related to the Risk of Subclinical Carotid Atherosclerosis in a General Male Japanese Population.2012

    • Author(s)
      Hirotsugu Ueshima, Takashi Kadowaki, Katsuyuki Miura, et. al.
    • Organizer
      XVI International Symposium on Atherosclerosis
    • Place of Presentation
      シドニー/オーストラリア
    • Year and Date
      2012-03-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Coronary artery calcification is not uncommon among apparently healthy Japanese men and women : results from the Shiga Epidemiological Study of Subclinical Atherosclerosis(SESSA)2012

    • Author(s)
      Akira Fujiyoshi, Katsuyuki Miura, Takashi Kadowaki, Sayaka Kadowaki, Hirotsugu Ueshima, et al
    • Organizer
      XVI International Symposium on Atherosclerosis
    • Place of Presentation
      シドニー/オーストラリア
    • Year and Date
      2012-03-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Subclinical Atherosclerosis ofCarotid Arteries among Apparently Healthy Japanese Men and Women : The Shiga Epidemiological Study of Subclinical Atherosclerosis2012

    • Author(s)
      Aya Kadota, Katsuyuki Miura, Hirotsugu Ueshima, et. Al.
    • Organizer
      XVI International Symposium on Atherosclerosis
    • Place of Presentation
      シドニー/オーストラリア
    • Year and Date
      2012-03-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Coronary artery calcification is not uncommon among apparently healthy Japanese men and women : results from the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)2012

    • Author(s)
      Akira Fujiyoshi A; Katsuyuki Miura; Takashi Kadowaki; Sayaka Kadowaki; Hirotsugu Ueshima, et al, for the SESSA Research Group
    • Organizer
      XVI International Symposium on Atherosclerosis
    • Place of Presentation
      シドニー/オーストラリア
    • Year and Date
      2012-03-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Lipoprotein-associated Phospholipase A2 Related to the Risk of Subclinical Carotid Atherosclerosis in a General Male Japanese Population2012

    • Author(s)
      Hirotsugu Ueshima, Takashi Kadowaki, Katsuyuki Miura, et.al. for the SESSA Research Group
    • Organizer
      XVI International Symposium on Atherosclerosis
    • Place of Presentation
      シドニー/オーストラリア
    • Year and Date
      2012-03-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Lipoprotein-associated Phospholipase A2 Related to the Risk of Subclinical Carotid Atherosclerosis in a General Male Japanese Population2012

    • Author(s)
      上島弘嗣, 他
    • Organizer
      第76日本循環器学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2012-03-18
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Subclinical Atherosclerosis of Carotid Arteries among Apparently Healthy Japanese2012

    • Author(s)
      門田文、上島弘嗣, 他
    • Organizer
      第76日本循環器学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2012-03-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 冠動脈石灰化は日本人一般集団の男女でもまれではない: SESSA研究2012

    • Author(s)
      門田文、上島弘嗣, 他
    • Organizer
      第76日本循環器学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2012-03-17
    • Related Report
      2011 Final Research Report
  • [Presentation] 冠動脈石灰化は日本人一般集団の男女でもまれではない:SESSA研究2012

    • Author(s)
      藤吉朗、三浦克之、門脇崇、門脇紗也佳、北徹、上島弘嗣, 他, SESSAリサーチグループ
    • Organizer
      第76日本循環器学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2012-03-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肥満と冠動脈石灰化の関連は日韓米4集団で異なるか:国際横断研究2012

    • Author(s)
      藤吉朗、関川暁、大久保孝義、三浦克之、門脇崇、上島弘嗣, 他, ERAJUMPリサーチグループ
    • Organizer
      第22回日本疫学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2012-01-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Subclinical Atherosclerosis of Carotid Arteries among Apparently Healthy Japanese Men and Women : The Shiga Epidemiological Study of Subclinical Atherosclerosis2012

    • Author(s)
      Aya Kadota, Katsuyuki Miura, Hirotsugu Ueshima, et. Al. for the SESSA Research Group
    • Organizer
      XVI International Symposium on Atherosclerosis
    • Place of Presentation
      シドニー/オーストラリア
    • Related Report
      2011 Annual Research Report
  • [Presentation] 日米地域住民対象コホートにおけるCTによる冠動脈石灰化スコアの比較可能性検討2011

    • Author(s)
      藤吉朗、関川暁、大久保孝義、三浦克之、門脇崇、上島弘嗣、他ERAJUMPリサーチグループ
    • Organizer
      第47回日本循環器病予防学会・日本循環器管理研究協議会総会
    • Place of Presentation
      福岡
    • Year and Date
      2011-06-03
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] A Cross-Sectional Association of Visceral Adipose Tissue with Coronary Artery Calcification among White2011

    • Author(s)
      藤吉朗、上島弘嗣、他ERAJUMPリサーチグループ.
    • Organizer
      米国心臓病協会(AHA)循環器疫学学会2011
    • Place of Presentation
      アトランタ/アメリカ
    • Year and Date
      2011-03-25
    • Related Report
      2011 Final Research Report
  • [Presentation] A Cross-Sectional Association of Visceral Adipose Tissue with Coronary Artery Calcification among White, Japanese-American, Japanese, and Korean Men2011

    • Author(s)
      藤吉朗(共同演者:上島弘嗣, ほか)
    • Organizer
      米国心臓病協会(AHA)循環器疫学学会2011
    • Place of Presentation
      アトランタ・米国
    • Year and Date
      2011-03-25
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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