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Search for polymorphisms of genes regulating population-specific morphological traits and functional analyses

Research Project

Project/Area Number 21249046
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Legal medicine
Research InstitutionKurume University

Principal Investigator

KODA Yoshiro  久留米大学, 医学部, 教授 (90231307)

Co-Investigator(Kenkyū-buntansha) SOEJIMA Mikiko  久留米大学, 医学部, 講師 (80279140)
Co-Investigator(Renkei-kenkyūsha) HANIHARA Tsunehiko  北里大学, 医学部, 教授 (00180919)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥30,030,000 (Direct Cost: ¥23,100,000、Indirect Cost: ¥6,930,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2009: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Keywords指紋 / 総隆線数 / 遺伝子多型 / 多因子遺伝 / 多因子遺伝形質 / 隆線数 / ゲノムワイド多型解析 / 関連解析 / FOXP2
Research Abstract

The easily-observed morphological traits such as fingerprints and skin colors had been studied in morphologic field. Recent studies suggest that many genes are responsible for regulation of traits with population-specific manner. In this study, we searched for polymorphisms of genes determining the total ridge counts of ten fingers by genome-wide polymorphism array technique. In addition, we developed a method to distinguish human animal origin based on FOXP2(forkhead box P2) that is involved in speech and language development in humans.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (50 results)

All 2012 2011 2010 Other

All Journal Article (26 results) (of which Peer Reviewed: 26 results) Presentation (17 results) Book (3 results) Remarks (4 results)

  • [Journal Article] Genetic variation of FUT2 in a Vietnamese population: Identification of two novel Se enzyme - Inactivating mutations2012

    • Author(s)
      Soejima, M.
    • Journal Title

      Transfusion

      Volume: 52(6) Issue: 6 Pages: 1268-1275

    • DOI

      10.1111/j.1537-2995.2011.03485.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective quantification of human DNA by real-time PCR of FOXP22012

    • Author(s)
      Soejima M, Hiroshige K, Yoshimoto J, Koda Y
    • Journal Title

      Forensic Sci Int Genet

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nonsynonymous Single-Nucleotide Polymorphisms of the Human Apoptosis-Related Endonuclease-DNA Fragmentation Factor Beta Polypeptide, Endonuclease G, and Flap Endonuclease-1-Genes Show a Low Degree of Genetic Heterogeneity2012

    • Author(s)
      Takeshita H, Fujihara J, Ueki M, Iida R, Koda Y, Soejima M, Yuasa I, Kato H, Nakajima T, Kominato Y, Yasuda T
    • Journal Title

      DNA Cell Biol

      Volume: 1 Pages: 36-42

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High prevalence of an anti-hypertriglyceridemic variant of the MLXIPL gene in Central Asia2011

    • Author(s)
      Nakayama K, Yanagiswa Y, Ogawa A, Ishizuka Y, Munkhtulga L, Charupoonphol P, Supannnatas S, Kuartei S, Chimedregzen U, Koda Y, Ishida T, Kagawa Y, Iwamoto S
    • Journal Title

      J Hum Genet

      Volume: 56 Issue: 12 Pages: 828-833

    • DOI

      10.1038/jhg.2011.109

    • NAID

      10030661852

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphic trial in oxidative damage of arsenic exposed Vietnamese2011

    • Author(s)
      Fujihara J, Soejima M, Yasuda T, Koda Y, Kunito T, Iwata H, Tanabe S, Takeshita H
    • Journal Title

      Toxicol Appl Pharmacol

      Volume: 256 Pages: 174-178

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Confirmation that SNPs in the high mobility group-A2 gene (HMGA2) are associated with adult height in the Japanese population ; wide-ranging population survey of height-related SNPs in HMGA22011

    • Author(s)
      Takeshita H, Fujihara J, Soejima M, Koda Y, Kimura-Kataoka K, Ono R, Yuasa I, Iida R, Ueki M, Nagao M, Yasuda T
    • Journal Title

      Electrophoresis

      Volume: 32 Issue: 14 Pages: 1844-1851

    • DOI

      10.1002/elps.201100128

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid detection of haptoglobin gene deletion in alkaline-denatured blood by loop-mediated isothermal amplification reaction2011

    • Author(s)
      Soejima M, Egashira K, Kawano H, Kawaguchi A, Sagawa K, Koda Y
    • Journal Title

      J Mol Diagn

      Volume: 13 Pages: 334-339

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] First survey of the three gene polymorphisms (PON1 Q192R, eNOS E298D and eNOS C-786T) potentially associated with coronary artery spasm in African populations and comparison with worldwide data2011

    • Author(s)
      Fujihara J, Yasuda T, Kawai Y, Morikawa N, Arakawa K, Koda Y, Soejima M, Kimura-Kataoka K, Takeshita H
    • Journal Title

      Cell Biochem Funct

      Volume: 29 Issue: 2 Pages: 156-163

    • DOI

      10.1002/cbf.1721

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional and genetic survey of all known single-nucleotide polymorphisms within the human deoxyribonuclease I gene in wide-ranging ethnic groups2011

    • Author(s)
      Fujihara J, Ueki M, Yasuda T, Iida R, Soejima M, Koda Y, Kimura-Kataoka K, Kato H, Panduro A, Tongu M, Takesshita H
    • Journal Title

      DNA Cell Biol

      Volume: 30 Pages: 205-217

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distribution of 42-bp variable tandem repeat polymorphism of the cold-induced autoinflammatory syndrome 1 (CIAS1) gene in eight human populations2011

    • Author(s)
      Omi T, Koda Y, Soejima M, Munkhtulga L, Iwamoto S
    • Journal Title

      Leg Med (Tokyo)

      Volume: 13 Pages: 44-46

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TaqMan-based real-time polymerase chain reaction for detection of FUT2 copy number variations : identification of novel Alu-mediated deletion2011

    • Author(s)
      Soejima M, Koda Y
    • Journal Title

      Transfusion

      Volume: 51 Issue: 4 Pages: 762-769

    • DOI

      10.1111/j.1537-2995.2010.02895.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid Detection of Haptoglobin Gene Deletion in Alkaline-Denatured Blood by Loop-Mediated Isothermal Amplification Reaction.2011

    • Author(s)
      Soejima M, Egashira K, Kawano H, Kawaguchi A, Sagawa K, Koda Y.
    • Journal Title

      J Mol Diagnos.

      Volume: (in press)

    • Related Report
      2010 Annual Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TaqMan-based real-time polyimerase chain reaction for detection of FUT2 copy number variations : identification of novel Alu-mediated deletion.2011

    • Author(s)
      Soejima M, Koda Y
    • Journal Title

      Transfusion

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional and genetic survey of all known single-nucleotide polymorphisms within the human deoxyribonuclease I gene in wide-ranging ethnic groups.2011

    • Author(s)
      Fujihara J, Ueki M, Yasuda T, Iida R, Soejima M, Koda Y, Kimura-Kataoka K, Kato H, Panduro A, Tongu M, Takeshita H.
    • Journal Title

      DNA Cell Biol.

      Volume: 30(in press)

    • Related Report
      2010 Annual Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] First survey of the three gene polymorphisms (PONI Q192R, eNOS E298D and eNOS C-786T) potentially associated with coronary artery spasm in African populations and comparison with worldwide data2011

    • Author(s)
      Fujihara J, Yasuda T, Kawai Y, Morikawa N, Arakawa K. Koda Y, Soejima M, Kimura-Kataoka K, Takeshita H
    • Journal Title

      Cell Biochem Funct

      Volume: 29 Pages: 56-63

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 輸血副作用原因遺伝子ハプトグロビン欠失アリルの輸血前診断法の検討2011

    • Author(s)
      神田芳郎、副島美貴子、川野洋之、江頭弘一、佐川公矯
    • Journal Title

      日本輸血細胞治療学会誌

      Volume: 57 Pages: 34-38

    • NAID

      10029418194

    • Related Report
      2010 Annual Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FDistribution of 42-bp variable tandem repeat polymorphism of the cold-induced autoinflammatory syndrome I (CIASI) gene in eight human populations.2011

    • Author(s)
      Omi T, Koda Y, Soejima M, Munkhtulga L, Iwamoto S.
    • Journal Title

      Leg Med (Tokyo)

      Volume: 13 Pages: 44-46

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FGlobal analysis of single nucleotide polymorphisms in the exons of human deoxyribonuclease I-like I and 2 genes.2011

    • Author(s)
      Fujihara J, Yasuda T, lida R, Kimura-Kataoka K, Soejima M, Koda Y, Kato H, Panduro A, Yuasa I, Takeshita H.
    • Journal Title

      Electrophoresis

      Volume: 31 Pages: 3552-3557

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TaqMan-based real-time polymerase chain reaction for detection of FUT2 copy number variations : identification of novel Alu-mediated deletion.2011

    • Author(s)
      Soejima M, Koda Y
    • Journal Title

      Transfusion

      Volume: (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] First survey of the three gene polymorphisms (PON1 Q192R, eNOS E298D and eNOS C-786T) potentially associated with coronary artery spasm in African populations and comparison with worldwide data.2011

    • Author(s)
      Fujihara J, Yasuda T, Kawai Y, Morikawa N, Arakawa K, Koda Y, Soejima M, Kimura-Kataoka K, Takeshita H
    • Journal Title

      Cell Biochem Funct

      Volume: 29 Pages: 56-63

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FDistribution of 42-bp variable tandem repeat polymorphism of the cold-induced autoinflammatory syndrome 1 (CIAS1) gene in eight human populations.2011

    • Author(s)
      Omi T, Koda Y, Soejima M, Munkhtulga L, Iwamoto S.
    • Journal Title

      Leg Med (Tokyo)

      Volume: 13 Pages: 44-46

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FGlobal analysis of single nucleotide polymorphisms in the exons of human deoxyribonuclease I-like 1 and 2 genes.2011

    • Author(s)
      Fujihara J, Yasuda T, Iida R, Kimura-Kataoka K, Soejima M, Koda Y, Kato H, Panduro A, Yuasa I, Takeshita H.
    • Journal Title

      Electrophoresis

      Volume: 31 Pages: 3552-3557

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A biochemical and genetic study on all non-synomntous single nucleotide polymorphisms of the gene encoding human dcoxyribonuclease I potentially relevant to autoimmunity.2010

    • Author(s)
      Yasuda T, Ueki M, Takeshita H, Fujihara J, Kimura-Kataoka K, Iida R, Tsubota E, Soejima M, Koda Y, Kato H, Panduro A.
    • Journal Title

      Int J Biochem CellBiol.

      Volume: 42 Pages: 1216-1225

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development and validation of a SYBR Green I-based real-time polymerase chain reaction method for detection of haptoglobin gene deletion in clinical materials.2010

    • Author(s)
      Soejima M, Tsuchiya Y, Egashira K, Kawano H, Sagawa K, Koda Y
    • Journal Title

      Transfusion

      Volume: 50 Pages: 1322-1327

    • Related Report
      2010 Annual Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A biochemical and genetic study on all non-synonymous single nucleotide polymorphisms of the gene encoding human deoxyribonuclease I potentially relevant to autoimmunity.2010

    • Author(s)
      Yasuda T, Ueki M, Takeshita H, Fujihara J, Kimura-Kataoka K, Iida R, Tsubota E, Soejima M, Koda Y, Kato H, Panduro A.
    • Journal Title

      Int J Biochem CellBiol.

      Volume: 42 Pages: 1216-1225

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective quantification of human DNA by real-time PCR of FOXP2

    • Author(s)
      Soejima M, Hiroshige K, Yoshimoto J, Koda Y
    • Journal Title

      Forensic Sci Int Genet

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] FOXP2を用いた人獣鑑別法2011

    • Author(s)
      副島美貴子, 廣重憲一, 吉本譲爾, 神田芳郎
    • Organizer
      日本DNA多型学会第20回学術集会
    • Place of Presentation
      はまぎんホールヴィアマーレ(神奈川県)
    • Year and Date
      2011-12-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 心筋に広範な収縮帯壊死を認めた小児虐待の一剖検例2011

    • Author(s)
      神田芳郎, 副島美貴子
    • Organizer
      第61回日本法医学会学術九州地方集会
    • Place of Presentation
      長崎大学医学部良順会館ボードウィンホール(長崎県)
    • Year and Date
      2011-10-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] FOXP2を用いたヒトDNAの選択的定量法2011

    • Author(s)
      副島美貴子, 神田芳郎
    • Organizer
      第61回日本法医学会学術九州地方集会
    • Place of Presentation
      長崎大学医学部良順会館ボードウィンホール(長崎県)
    • Year and Date
      2011-10-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] Simple method for identification of human DNA by real-time PCR of FOXP22011

    • Author(s)
      Koda Y, Soejima M, Hiroshige K
    • Organizer
      8th International Symposium ADVANCES IN LEGAL MEDICINE
    • Place of Presentation
      Johann Wolfgang Goethe-University (Frankfurt, Germany)
    • Year and Date
      2011-09-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] LAMP法を用いた輸血副作用原因遺伝子ハプトグロビン欠失アリルの検出2011

    • Author(s)
      副島美貴子, 神田芳郎
    • Organizer
      第95次日本法医学会総会
    • Place of Presentation
      コラッセ福島(福島県)
    • Year and Date
      2011-06-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Delta-aminolevulinic acid dehydratase (ALAD) G177C (Asn59Lys)多型の頻度分布における民族差異2011

    • Author(s)
      藤原純子, 竹下治男, 安田年博, 加藤秀章, 神田芳郎, 副島美貴子
    • Organizer
      第95次日本法医学会総会
    • Place of Presentation
      コラッセ福島(福島県)
    • Year and Date
      2011-06-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒ素代謝に関与するAS3MT遺伝子多型の民族差異2011

    • Author(s)
      藤原純子, 竹下治男, 安田年博, 加藤秀章, 神田芳郎, 副島美貴子
    • Organizer
      第95次日本法医学会総会
    • Place of Presentation
      コラッセ福島(福島県)
    • Year and Date
      2011-06-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] LAMP法を用いた輸血副作用原因遺伝子Hp^<del>の検出法2011

    • Author(s)
      神田芳郎, 川野洋之, 江頭弘一, 佐川公矯
    • Organizer
      第59回日本輸血・細胞治療学会総会
    • Place of Presentation
      (震災により中止)(紙上発表)
    • Year and Date
      2011-04-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] FOXP2を用いた人獣鑑別法2011

    • Author(s)
      副島美貴子, 廣重憲一, 吉本譲爾, 神田芳郎
    • Organizer
      日本DNA多型学会第20回学術集会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] FOXP2を用いたヒトDNAの選択的定量法2011

    • Author(s)
      副島美貴子, 神田芳郎
    • Organizer
      第61回日本法医学会学術九州地方集会
    • Place of Presentation
      長崎
    • Related Report
      2011 Final Research Report
  • [Presentation] Y染色体のハプログループを利用した民族推定法の開発2010

    • Author(s)
      室友紀, 今村真二, 渡部有希菜, 中村博明, 藤原純子, 飯田礼子, 安田年博, 木村かおり, 湯浅勲, 副島美貴子, 神田芳郎, 竹下治男
    • Organizer
      日本DNA多型学会第19回学術集会
    • Place of Presentation
      三島市(静岡県)
    • Year and Date
      2010-11-18
    • Related Report
      2010 Annual Research Report 2009 Annual Research Report
  • [Presentation] TaqMan法を用いたFUT2CNV検査法を用いた新規Alu mediated deletionの同定2010

    • Author(s)
      副島美貴子, 神田芳郎
    • Organizer
      日本DNA多型学会第19回学術集会
    • Place of Presentation
      三島市(静岡県)
    • Year and Date
      2010-11-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] TaqMan法を用いたFUT2 CNV検査法を用いた新規Alu mediated deletionの同定2010

    • Author(s)
      副島美貴子, 神田芳郎
    • Organizer
      日本DNA多型学会第19回学術集会
    • Place of Presentation
      三島市(静岡県)
    • Year and Date
      2010-11-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 急性出血性膵炎により死亡したと思われる水中死体の-症例2010

    • Author(s)
      神田芳郎, 副島美貴子, 上村繁雄
    • Organizer
      第60回日本法医学会学術九州地方集会
    • Place of Presentation
      北九州(福岡県)
    • Year and Date
      2010-10-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 急性出血性膵炎により死亡したと思われる水中死体の一症例2010

    • Author(s)
      神田芳郎, 副島美貴子, 上村繁雄
    • Organizer
      第60回日本法医学会学術九州地方集会
    • Place of Presentation
      北九州(福岡県)
    • Year and Date
      2010-10-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] 輸血副作用原因遺伝子ハプトグロビン欠失アリルの輸血前診断2010

    • Author(s)
      副島美貴子, 神田芳郎
    • Organizer
      第94次日本法医学会総会
    • Place of Presentation
      江戸川区(東京都)
    • Year and Date
      2010-06-25
    • Related Report
      2010 Annual Research Report 2009 Annual Research Report
  • [Presentation] DNASE IおよびDNase II遺伝子exon内SNP検索:集団調査及び酵素活性に及ぼす変異の影響2010

    • Author(s)
      木村かおり, 藤原純子, 竹下治男, 飯田礼子, 安田年博, 副島美貴子, 神田芳郎, 加藤秀章
    • Organizer
      第94次日本法医学会総会
    • Place of Presentation
      江戸川区(東京都)
    • Year and Date
      2010-06-24
    • Related Report
      2010 Annual Research Report 2009 Annual Research Report
  • [Book] DNA多型Vol.192011

    • Author(s)
      副島美貴子, 神田芳郎
    • Total Pages
      305
    • Publisher
      東洋書店
    • Related Report
      2011 Annual Research Report
  • [Book] DNA多型 Vol.182010

    • Author(s)
      副島美貴子, 神田芳郎
    • Total Pages
      305
    • Publisher
      東洋書店
    • Related Report
      2010 Annual Research Report
  • [Book] DNA多型Vol.182010

    • Author(s)
      副島美貴子, 神田芳郎
    • Total Pages
      305
    • Publisher
      東洋書店
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.kurume-u.ac.jp/med/foren/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.med.kurume-u.ac.jp/med/foren/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.kurume-u.ac.jp/med/foren/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.kurume-u.ac.jp/med/foren/

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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