| Budget Amount *help |
¥46,150,000 (Direct Cost: ¥35,500,000、Indirect Cost: ¥10,650,000)
Fiscal Year 2011: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2010: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2009: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
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| Research Abstract |
We identified that resident intestinal macrophages include a subpopulation of MCP-1 dependent CCR2+IL-10 producing M. which contributes to gut homeostasis. In IL-10 KO mice, we showed intracellular signaling after phagocytosis is important for production of proinflammatory cytokines by intestinal macrophages. In human Crohn's disease, we demonstrated that intestinal macrophages interact with mucosal NK cells and contribute to enhance of Th1 immune response. Furthermore, our studies demonstrated that bile acids can induce differentiation into IL-12 hypo-producing DCs. Thus, conditioning and regulation of innate immune cells such as macrophages and dendritic cells(DCs) have a potential to be a therapeutic target of Crohn's disease.
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