The investigation of the plasticity of cardiac sympathetic neurons in heart failure
| Project/Area Number |
21249051
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥46,150,000 (Direct Cost: ¥35,500,000、Indirect Cost: ¥10,650,000)
Fiscal Year 2011: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2010: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2009: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
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| Keywords | 神経科学 / 循環器・高血圧 / 生体分子 / 脳・神経 / 発生・分化 / 心臓 / 心不全 / 白血病抑制因子 / LIF(白血病抑制因子) / 循環器 / 高血圧 / 発生分化 / 交感神経 |
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| Research Abstract |
During congestive heart failure(CHF), sympathetic neural tone is upregulated, but there is a paradoxical reduction in norepinephrine synthesis and reuptake in the cardiac sympathetic nervous system(SNS). Here we examined whether cholinergic transdifferentiation can occur in the cardiac SNS in rodent models of CHF and investigated the underlying molecular mechanism(s) using genetically modified mice. The cholinergic differentiation factors leukemia inhibitory factor(LIF) and cardiotrophin-1(CT-1) were strongly upregulated in CHF. Thus, CHF causes target-dependent cholinergic transdifferentiation of the cardiac SNS via gp130-signaling cytokines secreted from the failing myocardium.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp130-mediated cytokines2010
Author(s)
Hideaki Kanazawa, Masaki Ieda, Kensuke Kimura, Takahide Arai, Haruko Kawaguchi-Manabe, Jin Endo, Takashi Kawakami, Tokuhiro Kimura, Toshiaki Monkawa, Matsuhiko Hayashi, Akio Iwanami, Hideyuki Okano, Yasunori Okada, Hatsue Ishibashi-Ueda, Satoshi Ogawa, Keiichi Fukuda
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Journal Title
J Clin Invest
Volume: 120(2)
Pages: 408-21
Related Report
Peer Reviewed
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