| Project/Area Number |
21249052
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
NUKIWA Toshihiro 東北大学, 大学院・医学系研究科, 名誉教授 (40129036)
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| Co-Investigator(Kenkyū-buntansha) |
EBINA Masahito 東北大学, 大学院・医学系研究科, 准教授 (10280885)
KIKUCHI Toshiaki 東北大学, 病院, 講師 (10280926)
INOUE Akira 東北大学, 病院, 助教 (70361087)
SAKAKIBARA Tomohiro 東北大学, 病院, 助教 (80422111)
FUKUHARA Tatsurou 東北大学, 病院, 助教 (80400365)
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| Co-Investigator(Renkei-kenkyūsha) |
HAGIWARA Kouichi 埼玉医科大学, 教授 (00240705)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2011: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2010: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Keywords | 肺腺癌 / EGF受容体 / 非喫煙者 / ゲノム / 東アジア / EGFR遺伝子変 / ゲノム解析研究 / EGFR受容体 |
|---|
| Research Abstract |
Therapy for lung cancer has been revolutionized in 21st century. The discovery of somatic EGF receptor mutation with high incidence among Asian ethnics led to the targeted therapy by oral TKI administration. To further understand the biological background of lung cancer we succeeded in slow growing xenograft formation with clinical relevant EGFR mutation using NOD-SCID mice. We have identified candidate genes that could relate to somatic EGFR mutation selection in lung cancer through whole genome SNP microarray analysis of patients harboring EGFR mutations, and exome analysis among patients of familial lung cancer members with EGFR mutations. These findings could provide better treatment and preventive applications in the future.
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