Analysis of pathomechanisms of bullous pemphigoid and development of novel therapy by using humanized active mouse model

• Project/Area Number: 21249063
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Hokkaido University
• Principal Investigator: SHIMIZU Hiroshi 北海道大学, 大学院・医学研究科, 教授 (00146672)
• Co-Investigator(Kenkyū-buntansha): SHIBAKI Akihiko 北海道大学, 北海道大学病院, 講師 (40291231) ; AKIYAMA Masashi 名古屋大学, 大学院・医学研究科, 教授 (60222551) ; ABE Riichiro 北海道大学, 大学院・医学研究科, 准教授 (60344511) ; NISHIMURA Emi 東京医科歯科大学, 難治疾患研究所, 教授 (70396331) ; NISHIE Wataru 北海道大学, 北海道大学病院, 講師 (20443955)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥47,060,000 (Direct Cost: ¥36,200,000、Indirect Cost: ¥10,860,000); Fiscal Year 2011: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000); Fiscal Year 2010: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000); Fiscal Year 2009: ¥27,560,000 (Direct Cost: ¥21,200,000、Indirect Cost: ¥6,360,000)
• Keywords: 自己免疫疾患 / 水疱性類天疱瘡 / 17型コラーゲン / ヒト化マウス / 疾患モデル動物 / CHO細胞 / NOD-Scid / 自己免疫性疾患

Research Abstract

Bullous pemphigoid (BP) is the most common autoimmune blistering disorder that preferentially occurs in elderly people. To analyze the precise pathomechanisms of BP and to develop a novel therapeutic strategy for BP, we tried to develop a novel active disease model for BP of which lymphocytes, autoantibodies and autoantigens have been humanized. First, we generated COL17-humanized/Nod-Scid mice by crossing COL17-humanized mice with immunodeficient NOD-Scid mice. Next, we developed CHO cells which persistently produce anti-human COL17 IgG4 antibodies using circulating lymphocytes from a BP patient, and injected them into COL17-humanized/Nod-Scid mice. Injected CHO cells could survive in the recipient mice for a long period and continuously produce anti-human COL17 IgG4 in vivo.

Research Products

• [Journal Article] Antibodies to pathogenic epitopes on type XVII collagen cause skin fragility in a complement-dependent and independent manner (2012)
  • Author(s): Natsuga K, Nishie W, Shinkuma S, UjiieH, Nishimura M, Sawamura D, Shimizu H
  • Journal Title: J Immunol Volume: 188 Pages: 5792-5799
  • NAID: 10031131103
  • Peer Reviewed
• [Journal Article] Noncollagenous 16A domain of type XVII collagen-reactive CD4+ T cells play a pivotal role in the development of active disease in experimental bullous pemphigoid model (2012)
  • Author(s): Ujiie H, Shibaki A, Nishie W, ShinkumaS, Moriuchi R, Qiao H, Shimizu H
  • Journal Title: Clin Immunol Volume: 142 Pages: 167-175
  • Peer Reviewed
• [Journal Article] Possible modifier effects of keratin 17 gene mutation onkeratitis-ichthyosis-deafness syndrome (2012)
  • Author(s): Natsuga K, Shinkuma S, Kanda M, SuzukiY, Chosa N, Narita Y, Setoyama M, Nishie W, Akiyama M, Shimizu H
  • Journal Title: Br J Dermatol Volume: 166 Pages: 903-905
  • Peer Reviewed
• [Journal Article] Noncollagenous 16A domain of type XVII collagen-reactive CD4(+) T cells play a pivotal role in the development of active disease in experimental bullous pemphigoid model (2012)
  • Author(s): Ujiie H, Shibaki A, Nishie W, Shinkuma S, Moriuchi R, Qiao H, Shimizu H
  • Journal Title: Clin Immunol Volume: 142 Issue: 2 Pages: 167-175
  • DOI: 10.1016/j.clim.2011.10.002
  • Peer Reviewed
• [Journal Article] Antibodies to pathogenic epitopes on type XVII collagen cause skin fragility in a complement-dependent and-independent manner (2012)
  • Author(s): Natsuga K, Nishie W, Shinkuma S, Ujiie H, Nishimura M, Sawamura D, Shimizu H
  • Journal Title: Journal of Immunology Volume: (印刷中)
  • NAID: 10031131103
  • Peer Reviewed
• [Journal Article] The β9 Loop Domain of PA-PLA(1)α Has a Crucial Role in Autosomal Recessive Woolly Hair/Hypotrichosis (2012)
  • Author(s): Shinkuma S, Inoue A, Aoki J, Nishie W, Natsuga K, Ujiie H, Nomura T, Abe R, Akiyama M, Shimizu H
  • Journal Title: The Journal of Investigative Dermatology Volume: (印刷中) Issue: 8 Pages: 2093-2095
  • DOI: 10.1038/jid.2012.96
  • Peer Reviewed
• [Journal Article] New insight into genotype/phenotype correlations in ABCA12 mutations in harlequin ichthyosis (2011)
  • Author(s): Umemoto H, Akiyama M, Yanagi T, SakaiK, Aoyama Y, Oizumi A, Suga Y, KitagawaY, Shimizu H
  • Journal Title: J Dermatol Sci Volume: 61 Pages: 136-138
  • Peer Reviewed
• [Journal Article] Hair follicle stem cells provide a functional niche for melanocyte stem cells (2011)
  • Author(s): Tanimura S, Tadokoro Y, Inomata K, Binh NT, Nishie W, Yamazaki S, NakauchiH, Tanaka Y, McMillan JR, Sawamura D, Yancey K, Shimizu H, Nishimura EK
  • Journal Title: Cell Stem Cell Volume: 8 Pages: 177-187
  • Peer Reviewed
• [Journal Article] Extremely severe palmoplantar hyperkeratosis in a generalized epidermolytic hyperkeratosis patient with a keratin 1 gene mutation (2011)
  • Author(s): Osawa R, Akiyama M, Izumi K, Ujiie H, Sakai K, Nemoto-Hasebe I, Yanagi T, Koizumi H, Shimizu H
  • Journal Title: J Am Acad Dermatol Volume: 64 Pages: 991-993
  • Peer Reviewed
• [Journal Article] Expression of exon-8-skipped kindlin-1does not compensate for defects of Kindler syndrome (2011)
  • Author(s): Natsuga K, Nishie W, Shinkuma S, Nakamura H, Matsushima Y, Tatsuta A, Komine M, Shimizu H
  • Journal Title: J Dermatol Sci Volume: 61 Pages: 38-44
  • NAID: 10030889702
  • Peer Reviewed
• [Journal Article] A founder effect of c.1938delC in ITGB4 underlies junctional epidermolysis bullosa and its application for prenatal testing (2011)
  • Author(s): Natsuga K, Nishie W, Shinkuma S, Nakamura H, Arita K, Yoneda K, Kusaka T, Yanagihara T, Kosaki R, Sago H, Akiyama M, Shimizu H
  • Journal Title: Exp Dermatol Volume: 20 Pages: 74-76
  • Peer Reviewed
• [Journal Article] Malignant skin tumours in patients with inherited ichthyosis (2011)
  • Author(s): Natsuga K, Akiyama M, Shimizu H
  • Journal Title: Br J Dermatol Volume: 165 Pages: 263-268
  • Peer Reviewed
• [Journal Article] Definitions and outcome measures for bullous pemphigoid : Recommendations by an international panel of experts (2011)
  • Author(s): Murrell DF, Daniel BS, Joly P, Borradori L, Amagai M, Hashimoto T, Caux, Marinovic B, Sinha AA, Hertl M, Bernard P, Sirois D, Cianchini G, Fairley JA, Jonkman MF, Pandya AG, Rubenstein D, Zillikens D, Payne AS, Woodley D, Zambruno G, Aoki V, Pincelli C, Diaz L, Hall RP, Meurer M, Mascaro JM, Jr., Schmidt E, Shimizu H, Zone J, Swerlick R, Mimouni D, Culton D, Lipozencic J, Bince B, Bystryn JC, Werth VP
  • Journal Title: J AmAcad Dermatol
  • Peer Reviewed
• [Journal Article] Childhood subepidermal blistering disease with autoantibodies to type VII collagen and laminin-332 (2011)
  • Author(s): Lin HY, Yanagi T, Akiyama M, IitaniMM, Moriuchi R, Natsuga K, Shinkuma S, Yamane N, Inokuma D, Arita K, Shimizu H
  • Journal Title: Br J Dermatol Volume: 164 Pages: 452-454
  • Peer Reviewed
• [Journal Article] Type XVII collagen ELISA indices significantly decreased after Bullous pemphigoid remission (2011)
  • Author(s): Kusajima E, Akiyama M, Sato M, Natsuga K, Shimizu H
  • Journal Title: Int J Dermatol Volume: 50 Pages: 238-240
  • Peer Reviewed
• [Journal Article] Subepidermal blistering disease with 3 distinct autoantibodies : Anti-BP230, anti-laminin gamma-1, and anti-laminin-332 (2011)
  • Author(s): Kikuchi K, Natsuga K, Shinkuma S, Nishie W, Kajita S, Sato H, Shimizu H
  • Journal Title: J Am Acad Dermatol Volume: 65 Pages: 878-880
  • Peer Reviewed
• [Journal Article] Rapid immunochromatographic test for serum granulysin is useful for the prediction of Stevens-Johnson syndrome and toxic epidermal necrolysis (2011)
  • Author(s): Fujita Y, Yoshioka N, Abe R, MurataJ, Hoshina D, Mae H, Shimizu H
  • Journal Title: J AmAcad Dermatol Volume: 65 Pages: 65-68
  • Peer Reviewed
• [Journal Article] Human IgG1 monoclonal antibody against human collagen 17 noncollagenous 16A domain induces blisters via complement activation in experimental bullous pemphigoid model (2011)
  • Author(s): Li Q, Ujiie H, Shibaki A, Wang G, Moriuchi R, Qiao HJ, Morioka H, ShinkumaS, Natsuga K, Long HA, Nishie W, ShimizuH
  • Journal Title: J Immunol Volume: 185 Pages: 7746-7755
  • Peer Reviewed
• [Journal Article] Bone marrow transplantation restores epidermal basement membrane protein expression and rescues epidermolysis bullosa model mice. (2011)
  • Author(s): Fujita Y, Abe R, Inokuma D, et al.
  • Journal Title: Proc Natl.Acad Sci U S A Volume: 107 Pages: 14345-14350
  • Peer Reviewed
• [Journal Article] A novel active mouse model for Bullous pemphigoid targeting humanized pathogenic antigen (2010)
  • Author(s): Ujiie H, Shibaki A, Nishie W, Sawamura D, Wang G, Tateishi Y, Li Q, Moriuchi R, Qiao H, Nakamura H, AkiyamaM, Shimizu H
  • Journal Title: J Immunol Volume: 184 Pages: 2166-6174
  • Peer Reviewed
• [Journal Article] Human IgG1 mAb against hCOL17 NC16A induces blisters via complement activation in experimental bullous pemphigoid model. (2010)
  • Author(s): Li Q, Shibaki A, Ujiie H, et al.
  • Journal Title: Journal of Immunology Volume: 185 Pages: 7746-7755
  • Peer Reviewed
• [Journal Article] A novel active mouse model for bullous pemphigoid targeting humanized pathogenic antigen. (2010)
  • Author(s): Ujiie H, Shibaki A, Nishie W, et al.
  • Journal Title: Journal of Immunology Volume: 184 Pages: 2166-2174
  • Peer Reviewed
• [Journal Article] Blockade of autoantibody-initiated tissue damage by using recombinant fab antibody fragments against pathogenic autoantigen (2010)
  • Author(s): Wang G, Ujiie H, Shibaki A, Nishie W, Tateishi Y, Kikuchi K, Li Q, McMillan JR, Morioka H, Sawamura D, Nakamura H, Shimizu H
  • Journal Title: Am J Pathol 176 Pages: 914-925
  • Peer Reviewed
• [Journal Article] A novel active mouse model for bullous pemphigoid targeting humanized pathogenic antigen (2010)
  • Author(s): Ujiie H, Shibaki A, Nishie W, Sawamura D, Wang G, Tateishi Y, Li Q, Moriuchi R, Qiao H, Nakamura H, Akiyama M, Shimizu H
  • Journal Title: J Immunol 184 Pages: 2166-2174
  • Peer Reviewed
• [Journal Article] Successful treatment of nail lichen planus with topical tacrolimus (2010)
  • Author(s): Ujiie H, Shibaki A, Akiyama M, Shimizu H
  • Journal Title: Acta Derm Venereol 90 Pages: 218-219
  • Peer Reviewed
• [Journal Article] Hereditary benign telangiectasia : two families with punctate telangiectasias surrounded by anemic halos (2010)
  • Author(s): Ujiie H, Kodama K, Akiyama M, Shimizu H
  • Journal Title: Arch Dermatol 146 Pages: 98-99
  • Peer Reviewed
• [Journal Article] Epidermal triglyceride levels are correlated with severity of ichthyosis in Dorfman-Chanarin syndrome (2010)
  • Author(s): Ujihara M, Nakajima K, Yamamoto M, Teraishi M, Uchida Y, Akiyama M, Shimizu H, Sano S
  • Journal Title: J Dermatol Sci 57 Pages: 102-107
  • NAID: 10027399559
  • Peer Reviewed
• [Journal Article] Response of intractable skin ulcers in recessive dystrophic epidermolysis bullosa patients to an allogeneic cultured dermal substitute (2010)
  • Author(s): Natsuga K, Sawamura D, Goto M, Homma E, Goto-Ohguchi Y, Aoyagi S, Akiyama M, Kuroyanagi Y, Shimizu H
  • Journal Title: Acta Derm Venereol 90 Pages: 165-169
  • Peer Reviewed
• [Journal Article] Circulating IgA and IgE autoantibodies in antilaminin-332 mucous membrane pemphigoid (2010)
  • Author(s): Natsuga K, Nishie W, Shinkuma S, Moriuchi R, Shibata M, Nishimura M, Hashimoto T, Shimizu H
  • Journal Title: Br J Dermatol 162 Pages: 513-517
  • Peer Reviewed
• [Journal Article] Plectin expression patterns determine two distinct subtypes of epidermolysis bullosa simplex (2010)
  • Author(s): Natsuga K, Nishie W, Akiyama M, Nakamura H, Shinkuma S, McMillan JR, Nagasaki A, Has C, Ouchi T, Ishiko A, Hirako Y, Owaribe K, Sawamura D, Bruckner-Tuderman L, Shimizu H
  • Journal Title: Hum Mutat 31 Pages: 308-316
  • Peer Reviewed
• [Journal Article] Controlling the histological margin for non-melanoma skin cancer conveniently using a double-bladed scalpel (2010)
  • Author(s): Aoyagi S, Hata H, Homma E, Shimizu H
  • Journal Title: J Surg Oncol 101 Pages: 175-179
  • Peer Reviewed
• [Journal Article] CD30-positive primary cutaneous anaplastic large-cell lymphoma and definite squamous cell carcinoma (2009)
  • Author(s): Yanagi T, Shimizu T, Kodama K, Nemoto-Hasebe I, Kasai M, Shimizu H
  • Journal Title: Clin Exp Dermatol 34
  • Peer Reviewed
• [Journal Article] Primary cutaneous CD30+ anaplastic large-cell lymphoma with generalized skin involvement and involvement of one peripheral lymph node, successfully treated with low-dose oral etoposide (2009)
  • Author(s): Yamane N, Kato N, Nishimura M, Ito M, Yanagi T, Osawa R
  • Journal Title: Clin Exp Dermatol 34
  • Peer Reviewed
• [Journal Article] Bloody nipple discharge in an infant (2009)
  • Author(s): Ujiie H, Akiyama M, Osawa R, Shida S, Aoyagi S, Shimizu H
  • Journal Title: Arch Dermatol 145 Pages: 1068-1069
  • Peer Reviewed
• [Journal Article] Glycosylation specific for adhesion molecules in epidermis and its receptor revealed by glycoform-focused reverse genomics (2009)
  • Author(s): Uematsu R, Shinohara Y, Nakagawa H, Kurogochi M, Furukawa J, Miura Y, Akiyama M, Shimizu H, Nishimura S
  • Journal Title: Mol Cell Proteomics 8 Pages: 232-244
  • Peer Reviewed
• [Journal Article] Embryonic hair follicle fate change by augmented{beta}-catenin through Shh and Bmp signaling (2009)
  • Author(s): Suzuki K, Yamaguchi Y, Villacorte M, Mihara K, Akiyama M, Shimizu H, Taketo MM, Nakagata N, Tsukiyama T, Yamaguchi TP, Birchmeier W, Kato S, Yamada G
  • Journal Title: Development 136 Pages: 367-372
  • Peer Reviewed
• [Journal Article] Pemphigus foliaceus associated with oesophageal cancer (2009)
  • Author(s): Shinkuma S, Akiyama M, Torii-Saito N, Natsuga K, Tateishi Y, Ito K, Hirota J, Shimizu Y, Shichinohe T, Shimizu H
  • Journal Title: J Eur Acad Dermatol Venereol 23 Pages: 473-474
  • Peer Reviewed
• [Journal Article] Secondary syphilis mimicking warts in an HIV-positive patient (2009)
  • Author(s): Shinkuma S, Abe R, Nishimura M, Natsuga K, Fujita Y, Nomura T, Nishie W, Shimizu H
  • Journal Title: Sex Transm Infect 85 Pages: 484-484
  • Peer Reviewed
• [Journal Article] ABCA12 is a major causative gene for non-bullous congenital ichthyosiform erythroderma (2009)
  • Author(s): Sakai K, Akiyama M, Yanagi T, McMillan JR, Suzuki T, Tsukamoto K, Sugiyama H, Hatano Y, Hayashitani M, Takamori K, Nakashima K, Shimizu H
  • Journal Title: J Invest Dermatol 129 Pages: 2306-2309
  • Peer Reviewed
• [Journal Article] Collagen XVII participates in keratinocyte adhesion to collagen IV, and in p38MAPK-dependent migration and cell signaling (2009)
  • Author(s): Qiao H, Shibaki A, Long HA, Wang G, Li Q, Nishie W, Abe R, Akiyama M, Shimizu H, McMillan JR
  • Journal Title: J Invest Dermatol 129 Pages: 2288-2295
  • Peer Reviewed
• [Journal Article] A novel PTPN11 missense mutation in a patient with LEOPARD syndrome (2009)
  • Author(s): Osawa R, Akiyama M, Yamanaka Y, Ujiie H, Nemoto-Hasebe I, Takeda A, Yanagi T, Shimizu H
  • Journal Title: Br J Dermatol 161 Pages: 1202-1204
  • Peer Reviewed
• [Journal Article] Disseminated cutaneous Mycobacterium kansasii infection in an patient infected with the human immunodeficiency virus (2009)
  • Author(s): Nomura Y, Nishie W, Shibaki A, Ibata M, Shimizu H
  • Journal Title: Clin Exp Dermatol 34 Pages: 625-626
  • Peer Reviewed
• [Journal Article] Progressive Refractory Ulcer of the Nipple : A Quiz (2009)
  • Author(s): Nomura Y, Akiyama M, Nishie W, SHimizu H
  • Journal Title: Acta Derm Venereol 89 Pages: 445-447
  • Peer Reviewed
• [Journal Article] Widespread keratosis follicularis squamosa (2009)
  • Author(s): Nomura Y, Abe M, Natsuga K, Moriuchi R, Kawasaki H, Mayuzumi M, Yasuoka A, Shimizu H
  • Journal Title: Clin Exp Dermatol 34 Pages: 519-520
  • Peer Reviewed
• [Journal Article] Prevalent and rare mutations in the gene encoding filaggrin in Japanese patients with ichthyosis vulgaris and atopic dermatitis (2009)
  • Author(s): Nomura T, Akiyama M, Sandilands A, Nemoto-Hasebe I, Sakai K, Nagasaki A, Palmer CN, Smith FJ, McLean WH, Shimizu H
  • Journal Title: J Invest Dermatol 129 Pages: 1302-1305
  • Peer Reviewed
• [Journal Article] A novel humanized neonatal autoimmune blistering skin disease model induced by maternally transferred antibodies (2009)
  • Author(s): Nishie W, Sawamura D, Natsuga K, Shinkuma S, Goto M, Shibaki A, Ujiie H, Olasz E, Yancey KB, Shimizu H
  • Journal Title: J Immunol 183 Pages: 4088-4093
  • Peer Reviewed
• [Journal Article] FLG mutation p.Lys4021X in the C-terminal imperfect filaggrin repeat in Japanese patients with atopic eczema (2009)
  • Author(s): Nemoto-Hasebe I, Akiyama M, Nomura T, Sandilands A, McLean WH, Shimizu H
  • Journal Title: Br J Dermatol 161 Pages: 1387-1390
  • Peer Reviewed
• [Journal Article] Clinical severity correlates with impaired barrier in filaggrin-related eczema (2009)
  • Author(s): Nemoto-Hasebe I, Akiyama M, Nomura T, Sandilands A, McLean WH, Shimizu H
  • Journal Title: J Invest Dermatol 129 Pages: 682-689
  • Peer Reviewed
• [Journal Article] Novel mutation p.Gly59Arg in GJB6 encoding connexin 30 underlies plamoplantar keratoderma with pseudoainhum, knuckle pads and hearing loss (2009)
  • Author(s): Nemoto-Hasebe I, Akiyama M, Kudo S, Ishiko A, Tanaka A, Arita K, Shimizu H
  • Journal Title: Br J Dermatol 161 Pages: 452-455
  • Peer Reviewed
• [Journal Article] Animal models of epidermolysis bullosa (2009)
  • Author(s): Natsuga K, Shinkuma S, Nishie W, Shimizu H
  • Journal Title: Dermatol Clin 28 Pages: 137-142
  • Peer Reviewed
• [Journal Article] Epidermolysis bullosa(EB)-diagnosis and therapy (2009)
  • Author(s): McMillan JR, Long HA, Akiyama M, Shimizu H, Kimble RM
  • Journal Title: Wound Practice and Research 17 Pages: 62-70
  • Peer Reviewed
• [Journal Article] Current advances in gene therapy for the treatment of genodermatoses (2009)
  • Author(s): Long HA, McMillan JR, Qiao H, Akiyama M, Shimizu H
  • Journal Title: Curr Gene Ther 9 Pages: 487-494
  • Peer Reviewed
• [Journal Article] Spontaneous giant aneurysm of the superficial temporal artery : case report (2009)
  • Author(s): Kawabori M, Kuroda S, Nakayama N, Kenmotsu Y, Shimizu H, Tanino M, Iwasaki Y
  • Journal Title: Neurol Med Chir 49 Pages: 198-201
  • NAID: 10025947689
  • Peer Reviewed
• [Journal Article] Morphological and genetic analysis of steatocystoma multiplex in an Asian family with pachyonychia congenita type 2 harbouring a KRT17 missense mutation (2009)
  • Author(s): Kanda M, Natsuga K, Nishie W, Akiyama M, Nagasaki A, Shimizu T, Shimizu H
  • Journal Title: Br J Dermatol 160 Pages: 465-468
  • Peer Reviewed
• [Journal Article] Keratinocyte-/fibroblast-targeted rescue of Co17a1-disrupted mice and generation of an exact dystrophic epidermolysis bullosa model using a-human COL7A1 mutation (2009)
  • Author(s): Ito K, Sawamura D, Goto M, Nakamura H, Nishie W, Sakai K, Natsuga K, Shinkuma S, Shibaki A, Uitto J, Denton CP, Nakajima O, Akiyama M, Shimizu H
  • Journal Title: Am J Pathol 175 Pages: 2508-2517
  • Peer Reviewed
• [Journal Article] Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation (2009)
  • Author(s): Inomata K, Aoto T, Binh NT, Okamoto N, Tanimura S, Wakayama T, Iseki S, Hara E, Masunaga T, Shimizu H, Nishimura EK
  • Journal Title: Cell 137 Pages: 1088-1099
  • Peer Reviewed
• [Journal Article] Scleroedema adultorum associated with sarcoidosis (2009)
  • Author(s): Inokuma D, Sawamura D, Shibaki A, Abe R, Shimizu H
  • Journal Title: Clin Exp Dermatol 34
  • Peer Reviewed
• [Journal Article] Autoantibodies against type XVII collagen C-terminal domain in patient with bullous pemphigoid associated with psoriasis vulgaris (2009)
  • Author(s): Inokuma D, Kodama K, Natsuga K, Kasai M, Abe M, Nishie W, Abe R, Hashimoto T, Shimizu H
  • Journal Title: Br J Dermatol 160 Pages: 451-454
  • Peer Reviewed
• [Journal Article] Bowen's disease of the nail matrix presenting as melanonychia : detection of human papillomavirus type 56 (2009)
  • Author(s): Inokuma D, Aoyagi S, Saito N, Iitani MM, Homma E, Hamasaka K, Shimizu H
  • Journal Title: Acta Derm Venereol 89 Pages: 638-639
  • Peer Reviewed
• [Journal Article] Birt-Hogg-Dube syndrome with clear-cell and oncocytic renal tumour and trichoblastoma associated with a novel FLCN mutation (2009)
  • Author(s): Imada K, Dainichi T, Yokomizo A, Tsunoda T, Song YH, Nagasaki A, Sawamura D, Nishie W, Shimizu H, Fukagawa S, Urabe K, Furue M, Hashimoto T, Naito S
  • Journal Title: Br J Dermatol 160 Pages: 1350-1353
  • Peer Reviewed
• [Journal Article] Analysis of Taiwanese ichthyosis vulgaris families further demonstrates differences in FLG mutations between European and Asian populations (2009)
  • Author(s): Hsu CK, Akiyama M, Nemoto-Hasebe I, Nomura T, Sandilands A, Chao SC, Lee JY, Sheu HM, McLean WH, Shimizu H
  • Journal Title: Br J Dermatol 161 Pages: 448-451
  • Peer Reviewed
• [Journal Article] Deficient deletion of apoptotic cells by macrophage migration inhibitory factor(MIF)overexpression accelerates photocarcinogenesis (2009)
  • Author(s): Honda A, Abe R, Yoshihisa Y, Makino T, Matsunaga K, Nishihira J, Shimizu H, Shimizu T
  • Journal Title: Carcinogenesis 30 Pages: 1597-1605
  • Peer Reviewed
• [Journal Article] Melanonychia caused by Stenotrophomonas maltophilia (2009)
  • Author(s): Hamasaka E, Akiyama M, Hala H, Aoyagi S, Shimizu H
  • Journal Title: Clin Exp Dermatol 34 Pages: 242-243
  • Peer Reviewed
• [Journal Article] DNA vaccination against macrophage migration inhibitory factor improves atopic dermatitis in murine models (2009)
  • Author(s): Hamasaka A, Abe R, Koyama Y, Yoshioka N, Fujita Y, Hoshina D, Sasaki M, Hirasawa T, Onodera S, Ohshima S, Leng L, Bucala R, Nishihira J, Shimizu T, Shimizu H
  • Journal Title: J Allergy Clin Immunol 124 Pages: 90-99
  • Peer Reviewed
• [Journal Article] A severe and refractory case of anti-p200 pemphigoid resulting in multiple skin ulcers and scar formation (2009)
  • Author(s): Goto-Ohguchi Y, Nishie W, Akiyama M, Tateishi Y, Aoyagi S, Tsuji-Abe Y, Sawamura D, Ishii N, Hashimoto T, Shimizu H
  • Journal Title: Dermatology 218 Pages: 265-270
  • Peer Reviewed
• [Journal Article] Immunological reconstitution after autologous hematopoietic stem cell transplantation in patients with systemic sclerosis : relationship between clinical benefits and intensity of immunosuppression (2009)
  • Author(s): Bohgaki T, Atsumi T, Bohgaki M, Furusaki A, Kondo M, Sato-Matsumura KC, Abe R, Kataoka H, Horita T, Yasuda S, Amasaki Y, Nishio M, Sawada K, Shimizu H, Koike T
  • Journal Title: J Rheumatol 36 Pages: 1240-1248
  • Peer Reviewed
• [Journal Article] Higher density of label-retaining cells in gingival epithelium (2009)
  • Author(s): Asaka T, Akiyama M, Kitagawa Y, Shimizu H
  • Journal Title: J Dermatol Sci 55 Pages: 132-134
  • NAID: 10025560846
  • Peer Reviewed
• [Journal Article] Type XVII collagen is a key player in tooth enamel formation (2009)
  • Author(s): Asaka T, Akiyama M, Domon T, Nishie W, Natsuga K, Fujita Y, Abe R, Kitagawa Y, Shimizu H
  • Journal Title: Am J Pathol 174 Pages: 91-100
  • Peer Reviewed
• [Journal Article] A novel OSMR mutation in familial primary localized cutaneous amyloidosis in a Japanese family (2009)
  • Author(s): Arita K, Abe R, Baba K, McGrath JA, Akiyama M, Shimizu H
  • Journal Title: J Dermatol Sci 55 Pages: 64-65
  • NAID: 10025334319
  • Peer Reviewed
• [Journal Article] Usefulness of real-time tissue elastography for detecting lymph-node metastases in squamous cell carcinoma (2009)
  • Author(s): Aoyagi S, Izumi K, Hata H, Kawasaki H, Shimizu H
  • Journal Title: Clin Exp Dermatol 34
  • Peer Reviewed
• [Journal Article] Squamous cell carcinoma of the auricle with rhabdoid features (2009)
  • Author(s): Aoyagi S, Hata H, Iitani MM, Homma E, Inokuma D, Shimizu H
  • Journal Title: J Cutan Pathol 36 Pages: 919-921
  • Peer Reviewed
• [Journal Article] Desmogleinl and BP 180 ELISA indexes correlating with disease activity in a patient with coexisting pemphigus foliaceus and bullous pemphigoid (2009)
  • Author(s): Ando S, Sato-Matsumura KC, Kasai M, Nemoto-Hasebe I, Hoshina D, Ohyama B, Hashimoto T, Shimuzu H
  • Journal Title: Clin Exp Dermatol 34
  • Peer Reviewed
• [Journal Article] Bone marrow-derived cells are not the origin of the cancer stem cells in ultraviolet-induced skin cancer (2009)
  • Author(s): Ando S, Abe R, Sasaki M, Murata J, Inokuma D, Shimizu H
  • Journal Title: Am J Pathol 174 Pages: 595-601
  • Peer Reviewed
• [Journal Article] A randomized double-blind trial of intravenous immunoglobulin for pemphigus (2009)
  • Author(s): Amagai M, Ikeda S, Shimizu H, Iizuka H, Hanada K, Aiba S, Kaneko F, Izaki S, Tamaki K, Ikezawa Z, Takigawa M, Seishima M, Tanaka T, Miyachi Y, Katayama I, Horiguchi Y, Miyagawa S, Furukawa F, Iwatsuki K, Hide M, Tokura Y, Furue M, Hashimoto T, Ihn H, Fujiwara S, Nishikawa T, Ogawa H, Kitajima Y, Hashimoto K
  • Journal Title: J Am Acad Dermatol 60 Pages: 595-603
  • Peer Reviewed
• [Journal Article] Conradi-Hunermann-Happle syndrome with abnormal lamellar granule contents (2009)
  • Author(s): Akiyama M, Sakai K, Hayasaka K, Tabata N, Yamada M, Ujiie H, Shibaki A, Shimizu H
  • Journal Title: Br J Dermatol 160 Pages: 1335-1337
  • Peer Reviewed
• [Journal Article] Granulysin as a marker for early diagnosis of the Stevens-Johnson syndrome (2009)
  • Author(s): Abe R, Yoshioka N, Murata J, Fujita Y, Shimizu H
  • Journal Title: Ann Intern Med 151 Pages: 514-515
  • Peer Reviewed
• [Journal Article] Revised nomenclature and classification of inherited ichthyoses : Results of the First Ichthyosis
  • Author(s): Vinzenz O, Gianluca T, Akiyama M, Claudine B-B, Christine B, Emmanuelle B, Philippe C, John JD, Peter E, Judith F, Philip F, Michal G, John H, Hashimoto T, Ingrid H, Hans CH, Daniel H, Alain H, Ishida-Yamamoto A, Withold KJ, Sancy L, Irene L, Juliette M-H, Leonhard M, Fanny M-P, Amy SP, Gabriele R, Matthias S, Shimizu H, Eli S, Maurice vS, Alain T, Jorge RT, Pierre V, Anders V, Mary W, Heiko T
  • Journal Title: J Am Acad Dermatol (in press)
  • Peer Reviewed
• [Journal Article] Three-base deletion mutation c. 120_122delGTT in ATP2A2 leads to the unique phenotype of comedonal Darier disease
  • Author(s): Tsuruta D, Akiyama M, Ishida-Yamamoto A, Imanishi H, Mizuno N, Sowa J, Kobayashi H, Ishii M, Kurokawa I, Shimizu H
  • Journal Title: Br J Dermatol (in press)
  • Peer Reviewed
• [Journal Article] An Indian family with Sjogren-Larsson syndrome caused by a novel ALDH3A2 mutation
  • Author(s): Sakai K, Akiyama M, Yanagi T, Nampoothiri S, Mampilly T, V S, Shimizu H
  • Journal Title: Int J Dermatol (in press)
  • Peer Reviewed
• [Journal Article] Extremely severe palmoplantar hyperkeratosis in a generalized epidermolytic hyperkeratosis patient with a keratin 1 gene mutation
  • Author(s): Osawa R, Akiyama M, Izumi K, Ujiie H, Sakai K, Nemoto-Hasebe I, Yanagi T, Koizumi H, Shimizu H
  • Journal Title: J Am Acad Dermatol (in press)
  • Peer Reviewed
• [Journal Article] Type XVII collagen ELISA indices significantly decreased after bullous pemphigoid remission
  • Author(s): Kusajima E, Akiyama M, Sato M, Natsuga K, Shimizu H
  • Journal Title: Int J Dermatol (in press)
  • Peer Reviewed
• [Journal Article] Two cases of cutaneous sporotrichosis in continental/microthermal climatezone : global warming alert?
  • Author(s): Inokuma D, Shibaki A, Shimizu H
  • Journal Title: Clin Exp Dermatol (in press)
  • Peer Reviewed
• [Journal Article] Aleukemic leukemia cutis with extensive bone involvement
  • Author(s): Iitani MM, Abe R, Yanagi T, Hamasaka A, Tateishi Y, Abe Y, Ito M, Kondo T, Kubota K, Shimizu H
  • Journal Title: J Am Acad Dermatol (in press)
  • Peer Reviewed
• [Journal Article] Transglutaminasel Preferred substrate peptide K5 is an efficient tool in diagnosis of lamellar ichthyosis
  • Author(s): Akiyama M, Sakai K, Yanagi T, Fukushima S, Ihn H, Hitomi K, Shimizu H
  • Journal Title: Am J Pathol (in press)
  • Peer Reviewed
• [Journal Article] Topical application of anti-angiogenic peptides based on pigment epithelium-derived factor can improve psoriasis
  • Author(s): Abe R, Yamagishi SI, Fujita Y, Hoshina D, Sasaki M, Nakamura K, Matsui T, Shimizu T, Bucala R, Shimizu H
  • Journal Title: J Dermatol Sci (in press)
  • NAID: 10027399968
  • Peer Reviewed
• [Presentation] Novel mouse models of human skin diseases (2011)
  • Author(s): Ujiie H, Nishie W, et al.
  • Organizer: The 22nd World Congress of Dermatology
  • Place of Presentation: COEX Convention and Exhibition Center (Korea)(招待講演)
  • Year and Date: 2011-05-29
• [Presentation] Therapeutic Strategies For TargetingAutoreactive T Cells In Autoimmune Bullous Diseases (2011)
  • Author(s): Ujiie H, Shibaki A, Moriuchi R, Shimizu H
  • Organizer: 22nd World Congress of Dermatology
  • Place of Presentation: Soul, Korea
• [Presentation] Novel Mouse Models of Human Skin Diseases (2011)
  • Author(s): Ujiie H, Nishie W, Fujita Y, ShibakiA, Shimizu H
  • Organizer: 22nd World Congress of Dermatology
  • Place of Presentation: Soul, Korea
• [Presentation] アトピー性皮膚炎におけるフィラグリン遺伝子変異 (2010)
  • Author(s): 清水宏
  • Organizer: 第34回小児皮膚科学セミナー
  • Place of Presentation: 新宿野村ビル48階野村コンファレンスプラザ東京
  • Year and Date: 2010-03-20
• [Presentation] Humanization of autoantigen to develop novel models of autoimmunity (2010)
  • Author(s): Shimizu H
  • Organizer: 37th Annual Meeting"Arbeitsgemeinschaft Dermato logische Forschung"
  • Place of Presentation: Univestity of Lubeck, Lubeck, Germany
  • Year and Date: 2010-02-18
• [Presentation] アトピー性皮膚炎におけるフィラグリン遺伝子変異 (2010)
  • Author(s): 清水宏
  • Organizer: 日本皮膚科学会東北六県合同地方会学術大会第349回例会
  • Place of Presentation: 民陵会館2階「記念ホール」仙台
  • Year and Date: 2010-02-07
• [Presentation] 眼部に生じた壊疽性膿皮症の2例 (2010)
  • Author(s): 齋藤奈央, 柳輝希, 林欣宇, 笠井聡美, 山根尚子, 猪熊大輔, 加瀬諭, 大野健太郎, 皆川英彦, 清水宏
  • Organizer: 第381回日本皮膚科学会北海道地方会
  • Place of Presentation: 北海道大学学術交流会館札幌
  • Year and Date: 2010-02-06
• [Presentation] ステロイド外用にて早期に寛解した小児後天性表皮水疱症の1例 (2010)
  • Author(s): 林欣宇, 柳輝希, 飯谷麻里夏, 守内玲寧, 崎山幸雄, 清水宏
  • Organizer: 第381回日本皮膚科学会北海道地方会
  • Place of Presentation: 北海道大学学術交流会館札幌
  • Year and Date: 2010-02-06
• [Presentation] Yellow nail syndromeの1例 (2010)
  • Author(s): 林韻欣, 阿部理一郎, 柳輝希, 阿部由紀子, 眞木賀奈子, 清水宏
  • Organizer: 第381回日本皮膚科学会北海道地方会
  • Place of Presentation: 北海道大学学術交流会館札幌
  • Year and Date: 2010-02-06
• [Presentation] 重篤な眼症状を伴った木村氏病の1例 (2010)
  • Author(s): 渡邉美佳, 氏家英之, 齊藤奈央, 柳輝希, 阿部理一郎, 清水宏
  • Organizer: 第381回日本皮膚科学会北海道地方会
  • Place of Presentation: 北海道大学学術交流会館札幌
  • Year and Date: 2010-02-06
• [Presentation] ペグインターフェロンfΩ-2bの局所注射にて皮膚潰瘍を生じた1例 (2010)
  • Author(s): 泉健太郎, 猪熊大輔, 松村若菜, 秦洋郎, 秋山真志, 清水宏, 西谷道子
  • Organizer: 第381回日本皮膚科学会北海道地方会
  • Place of Presentation: 北海道大学学術交流会館札幌
  • Year and Date: 2010-02-06
• [Presentation] 角層下膿疱症(Subcorneal pustular dermatosis : SPD)の1例. (2010)
  • Author(s): 水野修, 阿部理一郎, 新熊悟, 阿部由紀子, 清水宏
  • Organizer: 第381回日本皮膚科学会北海道地方会
  • Place of Presentation: 北海道大学学術交流会館札幌
  • Year and Date: 2010-02-06
• [Presentation] 骨髄異形成症候群を合併した壊疽性膿皮症の1例 (2010)
  • Author(s): 松村若菜, 氏家英之, 泉健太郎, 秋山真志, 清水宏, 今野哲, 重松明男, 小野澤真弘
  • Organizer: 第381回日本皮膚科学会北海道地方会
  • Place of Presentation: 北海道大学学術交流会館札幌
  • Year and Date: 2010-02-06
• [Presentation] アトピー性皮膚炎の予防・治療法の開発及び確立に関する研究 (2010)
  • Author(s): 清水宏, 戸倉新樹, 秋山真志, 有田賢
  • Organizer: 免疫アレルギ疾患等予防・治療研究事業研究報告会
  • Place of Presentation: KKRホテル東京10階瑞宝の間東京
  • Year and Date: 2010-01-26
• [Presentation] Active Mouse Model for BullousPemphigoid (2010)
  • Author(s): Shimizu H
  • Organizer: The 7^<th> Annual Scientific Meeting Australasian Society for Dermatology Research
  • Place of Presentation: Australia
• [Presentation] Active Mouse Model for Bullous Pemphigoid. (2010)
  • Author(s): Shimizu H
  • Organizer: The 7th Annual Scientific Meeting Austral asian Society for Dermatology Research.
  • Place of Presentation: Hilton Hotel Cairns, Cairns, Australia 招待講演
• [Presentation] 幽門閉鎖合併単純型表皮水疱症におけるプレクチン発現パターンの解析 (2009)
  • Author(s): 清水宏, 夏賀健, 西江渉
  • Organizer: 稀少難治性皮膚疾患に関する調査研究班 平成21年度第2回総会
  • Place of Presentation: KKRホテル東京11階丹頂の間東京
  • Year and Date: 2009-12-18
• [Presentation] 塊状のIgA沈着を呈したDuhring疱疹状皮膚炎の1例 (2009)
  • Author(s): 林欣宇, 氏家英之, 渡邉美佳, 馬場慶子, 新熊悟, 阿部理一郎, 清水宏
  • Organizer: 第380回日本皮膚科学会北海道地方会
  • Place of Presentation: 北海道大学学術交流会館札幌
  • Year and Date: 2009-12-12
• [Presentation] 第2期梅毒の1例 (2009)
  • Author(s): 林韻欣, 藤田靖幸, 有田賢, 清水宏
  • Organizer: 第380回日本皮膚科学会北海道地方会
  • Place of Presentation: 北海道大学学術交流会館札幌
  • Year and Date: 2009-12-12
• [Presentation] 腹部に生じた血管肉腫の1例 (2009)
  • Author(s): 本間英里奈, 青柳哲, 笠井聡美, 松村若菜, 渡邉美佳, 馬場慶子, 飯谷麻里, 秦洋郎, 藤田靖幸, 清水宏
  • Organizer: 第380回日本皮膚科学会北海道地方会
  • Place of Presentation: 北海道大学学術交流会館札幌
  • Year and Date: 2009-12-12
• [Presentation] 皮下型平滑筋肉腫の1例 (2009)
  • Author(s): 馬場慶子, 青柳哲, 西村真智子, 秦洋郎, 清水宏, 松村和子
  • Organizer: 第380回日本皮膚科学会北海道地方会
  • Place of Presentation: 北海道大学学術交流会館札幌
  • Year and Date: 2009-12-12
• [Presentation] 筋肉内浸潤および脾梗塞を呈した進行期菌状息肉症の1例 (2009)
  • Author(s): 渡邉美佳, 氏家英之, 馬場慶子, 阿部理一郎, 芝木晃彦, 山田洋介, 山口圭介, 神山俊哉, 清水宏
  • Organizer: 第380回日本皮膚科学会北海道地方会
  • Place of Presentation: 北海道大学学術交流会館札幌
  • Year and Date: 2009-12-12
• [Presentation] Wells症候群との鑑別を要したアレルギー性肉芽種性血管炎(AGA)の1例 (2009)
  • Author(s): 松村若菜, 藤田靖幸, 馬場慶子, 山根尚子, 芝木晃彦, 清水宏, 片岡浩
  • Organizer: 第380回日本皮膚科学会北海道地方会
  • Place of Presentation: 北海道大学学術交流会館札幌
  • Year and Date: 2009-12-12
• [Presentation] Humanization of autoantigen:水疱性類天疱瘡の病態解明と新規治療法開発 (2009)
  • Author(s): 清水宏
  • Organizer: 第37回日本臨床免疫学会総会
  • Place of Presentation: 東京ステーションコンファレンス東京
  • Year and Date: 2009-11-14
• [Presentation] アトピー性皮膚炎患者におけるフィラグリン遺伝子変異 (2009)
  • Author(s): 清水宏
  • Organizer: 第39回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
  • Place of Presentation: 国立京都国際会館京都
  • Year and Date: 2009-11-07
• [Presentation] 亜鉛による歯科金属アレルギーの1例 (2009)
  • Author(s): 齋藤奈央, 山根尚子, 松村若菜, 藤田靖幸, 猪熊大輔, 黒嶋伸一郎, 浜坂幸吉, 清水宏
  • Organizer: 第39回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
  • Place of Presentation: 国立京都国際会館京都
  • Year and Date: 2009-11-07
• [Presentation] 血漿交換療法が著効した中毒性表皮壊死症の一例 (2009)
  • Author(s): 馬場慶子, 阿部理一郎, 飯谷麻里, 猪熊大輔, 三浦正義, 安藤佐土美, 松村和子, 清水宏
  • Organizer: 第39回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
  • Place of Presentation: 国立京都国際会館京都
  • Year and Date: 2009-11-07
• [Presentation] フィラグリン遺伝子変異による皮膚バリア機能障害は、アトピー性皮膚炎の重要な発症因子である (2009)
  • Author(s): 清水宏
  • Organizer: 第61回日本皮膚科学会西部支部学術大会
  • Place of Presentation: 別府国際コンベンションセンター大分
  • Year and Date: 2009-10-25
• [Presentation] 北海道で発症したスポロトリコーシス (2009)
  • Author(s): 猪熊大輔, 芝木晃彦, 清水宏, 芝木秀臣
  • Organizer: 第61回日本皮膚科学会西部支部学術大会
  • Place of Presentation: 別府国際コンベンションセンター大分
  • Year and Date: 2009-10-25
• [Presentation] (Plenary Lecture)"Mouse models of human diseases" (2009)
  • Author(s): Shimizu H
  • Organizer: The 18th Annual Meeting of the European Academy of Dermatology and Venereology
  • Place of Presentation: The Internationales Congress Centrum Berlin, Berlin, Germany
  • Year and Date: 2009-10-08
• [Presentation] (JSID Symposium)Atopic dermatitis : Its skin barrier function and filaggrin mutations (2009)
  • Author(s): Shimizu H
  • Organizer: The 18th Congress of the European Academy of Dermatology and Venereology
  • Place of Presentation: The Internationales Congress Centrum Berlin, Berlin, Germany
  • Year and Date: 2009-10-07
• [Presentation] 11歳男児にみられた乳腺嚢胞の1例 (2009)
  • Author(s): 林韻欣, 青柳哲, 齋藤奈央, 秦洋郎, 芝木晃彦, 清水宏
  • Organizer: 第379回日本皮膚科学会北海道地方会
  • Place of Presentation: 大正富山医薬品(株)5階会議室札幌
  • Year and Date: 2009-10-03
• [Presentation] 胸肋関節から生じた皮膚腺病の一例 (2009)
  • Author(s): 松村若菜, 阿部理一郎, 泉健太郎, 保科大地, 阿部由紀子, 清水宏
  • Organizer: 第379回日本皮膚科学会北海道地方会
  • Place of Presentation: 大正富山医薬品(株)5階会議室札幌
  • Year and Date: 2009-10-03
• [Presentation] プレクチンの発現様式の違いによって2種類の表皮水疱症の臨床型が決定される (2009)
  • Author(s): 夏賀健, 西江渉, 秋山真志, 新熊悟, 中村秀樹, 長崎暁理, Has C, 大内健嗣, 石河晃, 平子義章, 尾張部克志, 澤村大輔, Leena B-T, 清水宏
  • Organizer: 第379回日本皮膚科学会北海道地方会
  • Place of Presentation: 大正富山医薬品(株)5階会議室札幌
  • Year and Date: 2009-10-03
• [Presentation] 表皮水疱症の新しい治療法"骨髄移植" (2009)
  • Author(s): 清水宏
  • Organizer: 第73回日本皮膚科学会東部支部学術大会
  • Place of Presentation: 甲府富士屋ホテル山梨
  • Year and Date: 2009-09-27
• [Presentation] 汎発性膿疱性乾癬に進展したPsoriatic onycho-pachydermo periostitis(POPP)の1例 (2009)
  • Author(s): 渡遷美佳, 氏家英之, 飯谷麻里, 阿部理一郎, 清水宏
  • Organizer: 第73回日本皮膚科学会東部支部学術大会
  • Place of Presentation: 甲府富土屋ホテル山梨
  • Year and Date: 2009-09-27
• [Presentation] タクロリム軟膏外用が奏効した爪扁平苔癬5例のまとめ (2009)
  • Author(s): 氏家英之, 芝木晃彦, 秋山真志, 清水宏
  • Organizer: 第73回日本皮膚科学会東部支部学術大会
  • Place of Presentation: 甲府富土屋ホテル山梨
  • Year and Date: 2009-09-27
• [Presentation] 周囲への浸潤傾向を示した顆粒細胞腫の1例 (2009)
  • Author(s): 洪綺憶, 青柳哲, 本間英里奈, 西村真智子, 笠井麻希, 秦洋郎, 松村和子, 清水宏
  • Organizer: 第73回日本皮膚科学会東部支部学術大会
  • Place of Presentation: 甲府富土屋ホテル山梨
  • Year and Date: 2009-09-27
• [Presentation] Gemcitabineにより強皮症様皮疹を呈した一例 (2009)
  • Author(s): 笠井聡美, 阿部理一郎, 泉健太郎, 藤田靖幸, 阿部由紀子, 清水宏, 桑名将城, 河上洋
  • Organizer: 第73回日本皮膚科学会東部支部学術大会
  • Place of Presentation: 甲府富土屋ホテル山梨
  • Year and Date: 2009-09-27
• [Presentation] Plectin expression in epidermolysis bullosa simplex(EBS)with muscular dystrophy vs.in EBS with pyloric atresia (2009)
  • Author(s): Natsuga K, Nishie W, Akiyama M, Ouchi T, Ishiko A, Hirako Y, Owaribe K, Buckner-Tuderman L, Shimizu H
  • Organizer: The 39th European Society for Dermatological Research(ESDR)Annual Meeting
  • Place of Presentation: Semmelweis University, Budapest, Hungary
  • Year and Date: 2009-09-10
• [Presentation] ABCA subfamily member expression in the epidermis is altered by knockdown of ABCA12 (2009)
  • Author(s): Long H, Akiyama M, Yanagi T, Shimizu H
  • Organizer: The 39th European Society for Dermatological Research(ESDR)Annual Meeting
  • Place of Presentation: Semmelweis University, Budapest, Hungary
  • Year and Date: 2009-09-10
• [Presentation] Both hematopoietic and mesenchymal stem cells contribute to the production of basement membrane protein in bone marrow transplantation treatment model mouse (2009)
  • Author(s): Fujita Y, Abe R, Inokuma D, Nishie W, Nakamura H, Akiyama M, Sawamura D, Shimizu H
  • Organizer: The 39th European Society for Dermatological Research(ESDR)Annual Meeting
  • Place of Presentation: Semmelweis University, Budapest, Hungary
  • Year and Date: 2009-09-10
• [Presentation] Collagen XVII in hemidesmosomes is involved in keratinocyte-collagen IV adhesion and p38-MAPK-dependent cell migration and signaling (2009)
  • Author(s): McMillan J, Qiao H, Shibaki A, Long H, Wang G, Nishie W, Akiyama M, Shimizu H
  • Organizer: The 39th European Society for Dermatological Research(ESDR)Annual Meeting
  • Place of Presentation: Semmelweis University, Budapest, Hungary
  • Year and Date: 2009-09-10
• [Presentation] Transdifferentiation of bone marrow stem cells into keratinocytes (2009)
  • Author(s): Shimizu H
  • Organizer: EB 2009
  • Place of Presentation: Mariott Hotel, Vienna, Austria
  • Year and Date: 2009-09-07
• [Presentation] Novel animal models for skin diseases : Message from Sapporo (2009)
  • Author(s): Shimizu H
  • Organizer: ADA 129th Annual Meeting
  • Place of Presentation: Park City, Htah, U.S.A
  • Year and Date: 2009-08-22
• [Presentation] 発熱を伴った紅斑、丘疹 (2009)
  • Author(s): 飯谷麻里, 小玉和郎, 馬場慶子, 野村友希子, 川崎浩之, 山中快子, 阿部由紀子, 阿部理一郎, 清水宏
  • Organizer: 第25回皮膚病理組織学会
  • Place of Presentation: 石垣記念ホール東京
  • Year and Date: 2009-07-29
• [Presentation] 筋ジストロフィー合併単純型表皮水疱症におけるプレクチン発現パターンの解析 (2009)
  • Author(s): 清水宏, 夏賀健, 西江渉
  • Organizer: 稀少難治性皮膚疾患に関する調査研究班 平成21年度第1回総会
  • Place of Presentation: KKRホテル東京11階丹頂の間東京
  • Year and Date: 2009-07-24
• [Presentation] 頭皮円形欠損部に対する簡便な局所皮弁による再建例 (2009)
  • Author(s): 青柳哲, 本間英里奈, 秦洋郎, 清水宏
  • Organizer: 第24回日本皮膚外科学会・学術大会
  • Place of Presentation: 名鉄犬山ホテル愛知
  • Year and Date: 2009-06-21
• [Presentation] 播種性血管内凝固症候群を合併したStevens-Johnson syndromeの1例 (2009)
  • Author(s): 野村友希子, 阿部理一郎, 太田光, 馬場慶子, 秦洋郎, 山根尚子, 清水宏
  • Organizer: 第378回日本皮膚科学会北海道地方会
  • Place of Presentation: 旭川市大雪クリスタルホール旭川
  • Year and Date: 2009-06-14
• [Presentation] 北海道で発症したスポロトリコーシス (2009)
  • Author(s): 猪熊大輔, 芝木晃彦, 清水宏, 芝木秀臣
  • Organizer: 第378回日本皮膚科学会北海道地方会
  • Place of Presentation: 旭川市大雪クリスタルホール旭川
  • Year and Date: 2009-06-14
• [Presentation] 水疱性類天疱瘡:up-date (2009)
  • Author(s): 清水宏
  • Organizer: 第1回関西皮膚自己免疫疾患談話会
  • Place of Presentation: 大阪リーガロイヤルホテルタワーウイング2階「桐の間」大阪
  • Year and Date: 2009-06-12
• [Presentation] 水疱性類天疱瘡の病態解明と新規治療法の開発 (2009)
  • Author(s): 清水宏
  • Organizer: 第46回日本臨床分子医学会学術集会
  • Place of Presentation: 東京国際フォーラム東京
  • Year and Date: 2009-04-13
• [Presentation] Genetic variation of DSG3 is associated with pemphigus vulgaris among Japanese (2009)
  • Author(s): Niizeki H, Asada H, Amagai M, Oka A, Inoko H, Hashimoto T, Ikeda S, Shimizu H, Kitajima Y, Miyagawa S, Yamamoto S, Aoyama Y, Ichiki Y, Shimizu T, Takahashi H, Kuwana M, Shirakata Y, Hashimoto K, Yamamoto T, Iwatsuki K, Inaoki M, Fujimoto W, Nakamura K, Kishimoto K, Kaneko F, Kunii T, Aiba S, Terui T
  • Organizer: The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: JAL resort, Fukuoka, Japan
• [Presentation] Genotoxic Stress Induces Hair Graying Through Melanocyte Stem Cell Differentiation in the niche (2009)
  • Author(s): Inomata K, Aoto T, Binh NT, Okamoto N, Tanimura S, Wakayama T, Iseki S, Hara E, Masunaga T, Shimizu H, Nishimura EK
  • Organizer: The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: JAL resort, Fukuoka, Japan
• [Presentation] Novel mutation of FLG, p.Lys4021X in the C-terminal imperfect filaggrin repeat in Japanese atopic dermatitis patients (2009)
  • Author(s): Nemoto-Hasebe I, Akiyama M, Nomura T, Sandilands A, McLean W, Shimizu H
  • Organizer: The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: JAL resort, Fukuoka, Japan
• [Presentation] Presence of plectin rodless isoform is a key predictor of phenotypic severity in plectin deficient epidermolysis bullosa simpex (2009)
  • Author(s): Natsuga K, Nishie W, Akiyama M, Shinkuma S, Nakamura H, McMillan JR, Nagasaki A, Has C, Ouchi T, Ishiko A, Hirako Y, Owaribe K, Sawamura D, Leena B-T, Shimizu H
  • Organizer: The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: JAL resort, Fukuoka, Japan
• [Presentation] Expression of ABCA subfamily member in the epidermis is affected by knockout of ABCA12 (2009)
  • Author(s): Long HA, Akiyama M, Yanagi T, Shimizu H
  • Organizer: The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: JAL resort, Fukuoka, Japan
• [Presentation] Establishment of a novel experimental model of human angiosarcoma (2009)
  • Author(s): Hoshina D, Abe R, Hata H, Fujita Y, Yoshioka N, Aoyagi T, Shimizu H
  • Organizer: The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: JAL resort, Fukuoka, Japan
• [Presentation] Stem cell transplantation treatment restores deficient type XVII collagen in junctional epidermolysis bullosa model mice (2009)
  • Author(s): Fujita Y, Abe R, Inokuma D, Sasaki M, Natsuga K, Nishie W, Nakamura H, Akiyama M, Sawamura D, Shimizu H
  • Organizer: The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: JAL resort, Fukuoka, Japan
• [Presentation] Development of a rapid immunochromatographic test for the detection of high-level serum ranulysin in an early stage of SJS and TEN (2009)
  • Author(s): Abe R, Yoshioka N, Murata J, Fujita Y, Hoshina D, Mae H, Shimizu H
  • Organizer: The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: JAL resort, Fukuoka, Japan
• [Presentation] (Symposium)Lessons from a Novel Mouse Model for Epidermolysis Bullosa (2009)
  • Author(s): Shimizu H
  • Organizer: 11th World Congress of Pediatric Dermatology
  • Place of Presentation: Queen Sirikit National Convention Center, Bangkok, Thailand
• [Presentation] (Symposium)Harlequin Ichthyosis and Lamellar Ichthyosis : Molecular Diagnosis and Prenatal Diagnosis (2009)
  • Author(s): Shimizu H
  • Organizer: 11th World Congress of Pediatric Dermatology
  • Place of Presentation: Queen Sirikit National Convention Center, Bangkok, Thailand
• [Presentation] Abca12. -|- harlequin ichthyosis model mouse shows alveolar collapse as well as severe fetal skin barrier defects (2009)
  • Author(s): Yanagi T, Akiyama M, Nishihara H, Sakai K, Nishie W, Tanaka S, Shimizu H
  • Organizer: The 4th Joint Meeting of Japanese Dermatological Association and Australasian College of Dermatologists
  • Place of Presentation: Hokkaido University, Sapporo, Japan
• [Presentation] Development of an active bullous pemphigoid mouse model (2009)
  • Author(s): Ujiie H, Shibaki A, Nishie W, Sawamura D, Wang G, Tateishi Y, Li Q, Nakamura H, Akiyama M, Shimizu H
  • Organizer: The 4th Joint Meeting of Japanese Dermatological Association and Australasian College of Dermatologists
  • Place of Presentation: Hokkaido University, Sapporo, Japan
• [Presentation] A case of disseminated intravascular coagulation associated with Stevens-Johnson syndrome (2009)
  • Author(s): Nomura Y, Abe R, Ota H, Baba K, Hata H, Yamane N, Shimizu H
  • Organizer: The 4th Joint Meeting of Japanese Dermatological Association and Australasian College of Dermatologists
  • Place of Presentation: Hokkaido University, Sapporo, Japan
• [Presentation] Bone marrow transplantation restores deficient epidermal basement membrane protein and improves the clinical phenotype in epidermolysis bullosa model mice (2009)
  • Author(s): Fujita Y, Abe R, Inokuma D, Sasaki M, Hoshina D, Nishie W, Natsuga K, McMilan J, Nakamura H, Shimizu H
  • Organizer: The 4th Joint Meeting of Japanese Dermatological Association and Australasian College of Dermatologists
  • Place of Presentation: Hokkaido University, Sapporo, Japan
• [Presentation] Hemidesmosomal collagen XVII enhances keratinocyte adhesion to collagen IV, and in p38-MAPK-dependent migration and cell signaling (2009)
  • Author(s): McMillan J, Qiao H, Shibaki A, Long H, Wang G, Li Q, Nishie W, Abe R, Akiyama M, Shimizu H
  • Organizer: 6th Annual Scientific Meeting Australasian Society for Dermatology Research
  • Place of Presentation: Courtyard by Marriott Surfers Paradise, QLD, Australia
• [Presentation] Collagen XVII participates in keratinocyte adhesion to collagen IV, and in p38-MAPK-dependent migration and cell signaling (2009)
  • Author(s): Qiao H, Shibaki A, Long H, Wang G, Li Q, Nishie W, Abe R, Akiyama M, Shimizu H, McMillan J
  • Organizer: the 69th Society for Investigative Dermatology Annual Meeting
  • Place of Presentation: Palais des congres Montreal, Canada
• [Presentation] フィラグリン遺伝子変異を有するアミロイド苔癬 (2009)
  • Author(s): 野村友希子, 秋山真志, 長谷部育恵, 剱持靖子, 乃村俊史, 清水宏
  • Organizer: 第36回皮膚かたち研究学会学術大会
  • Place of Presentation: 宮崎県医師会館宮崎
• [Presentation] ヒト血管肉腫実験モデルを用いた抗ヒトVEGF抗体(bevacizumab)の抗腫瘍効果の検討 (2009)
  • Author(s): 保科大地, 阿部理一郎, 秦洋郎, 藤田靖幸, 青柳哲, 清水宏
  • Organizer: 第16回分子皮膚科学フォーラム
  • Place of Presentation: 札幌グランドホテル札幌
• [Presentation] Kindler症候群の日本人症例 (2009)
  • Author(s): 夏賀健, 西江渉, 新熊悟, 中村秀樹, 長崎暁理, 清水宏, 立田彩, 小宮根真弓, 松島陽一郎
  • Organizer: 第31回水疱症研究会
  • Place of Presentation: 大和屋本店・愛媛県医師会館松山
• [Presentation] 重篤な後遺症を残した成人麻疹脳炎の1例 (2009)
  • Author(s): 飯谷麻里, 伊藤圭, 和田剛志, 澤村淳, 清水宏
  • Organizer: 第60回日本皮膚科学会中部支部学術大会
  • Place of Presentation: 国立京都国際会館京都
• [Presentation] 血清granulysin値は重症薬疹の発症早期に上昇する (2009)
  • Author(s): 吉岡直也, 阿部理一郎, 村田純子, 藤田靖幸, 清水宏
  • Organizer: 第21回日本アレルギー学会春季臨床大会
  • Place of Presentation: 長良川国際会議場岐阜
• [Presentation] 基底細胞癌に対するdouble bladed scalpelを用いたmicrographic surgeryの経験 (2009)
  • Author(s): 青柳哲, 秦洋郎, 泉建太郎, 清水宏
  • Organizer: 第25回日本皮膚悪性種瘍学会学術大会
  • Place of Presentation: 岡山コンベンションセンター岡山
• [Presentation] 表在播種型汗孔角化症に有棘細胞癌およびBowen病を生じた1例 (2009)
  • Author(s): 山根尚子, 青柳哲, 馬慶場子, 秦洋郎, 清水宏, 菊池敏郎
  • Organizer: 第25回日本皮膚悪性腫瘍学会学術大会
  • Place of Presentation: 岡山コンベンションセンター岡山
• [Presentation] OSMR遣伝子変異を確認しえた日本人家族性皮膚限局性アミロイドーシスの1例 (2009)
  • Author(s): 有田賢, 阿部理一郎, 馬場慶子, 秋山真志, 清水宏
  • Organizer: 第108回日本皮膚科学会総会
  • Place of Presentation: 福岡国際会議場、マリンメッセ福岡福岡
• [Presentation] 道化師様魚鱗癬モデルマウスは、肺胞拡張不全と重篤な皮膚バリア障害を来す (2009)
  • Author(s): 柳輝希, 秋山真志, 西原広史, 坂井香織, 西江渉, 田中仲哉, 清水宏
  • Organizer: 第108回日本皮膚科学会総会
  • Place of Presentation: 福岡国際会議場、マリンメッセ福岡福岡
• [Presentation] フィラグリン遺伝子変異関連アトピー性皮膚炎では、臨床重症度とバリア障害重証度は相関する (2009)
  • Author(s): 長谷部育恵, 秋山真志, 乃村後史, Sandilands A, Mclean I, 清水宏
  • Organizer: 第108回日本皮膚科学会総会
  • Place of Presentation: 福岡国際会議場、マリンメッセ福岡福岡
• [Presentation] 皮膚結節性アミロイドーシスの2例 (2009)
  • Author(s): 泉健太郎, 猪熊大輔, 笠井麻希, 藤田靖幸, 氏家英之, 山中快子, 伊藤圭, 清水宏
  • Organizer: 第108回日本皮膚科学会総会
  • Place of Presentation: 福岡国際会議場、マリンメッセ福岡福岡
• [Presentation] 道化師様魚鱗癬の1例 (2009)
  • Author(s): 高野優佳子, 後藤瑞生, 甲斐宜貴, 片桐一元, 藤原作平, 関口和人, 泉達郎, 山田喜三郎, 中塚和夫, 秋山真志, 清水宏
  • Organizer: 第108回日本皮膚科学会総会
  • Place of Presentation: 福岡国際会議場、マリンメッセ福岡福岡
• [Book] Treatment of Skin Disease 3rd Edition-Comprehensive Therapeutic Strategies (2010)
  • Author(s): Tsuji-Abe, Y., Shimizu, H.
  • Total Pages: 2
  • Publisher: Mosby-Elsevier
• [Book] 皮膚科診療カラーアトラス大系 (2009)
  • Author(s): 乃村俊史, 清水宏
  • Total Pages: 4
  • Publisher: 講談社
• [Book] 臨床検査データブック2009-2010 (2009)
  • Author(s): 清水宏
  • Total Pages: 2
  • Publisher: 医学書院
• [Book] 皮膚疾患最新の治療2009-2010 (2009)
  • Author(s): 清水宏
  • Total Pages: 1
  • Publisher: 南江堂
• [Book] からだの科学 (2009)
  • Author(s): 新熊悟, 夏賀健, 清水宏
  • Total Pages: 5
  • Publisher: 日本評論社
• [Book] 第2版 皮膚疾患診療 実践ガイド 皮膚科遺伝相談 (2009)
  • Author(s): 守内玲寧, 芝木晃彦, 清水宏
  • Total Pages: 2
  • Publisher: 文光堂
• [Book] 第2版 皮膚疾患診療 実践ガイド 膿疱を生じる疾患 (2009)
  • Author(s): 守内玲寧, 芝木晃彦, 清水宏
  • Total Pages: 1
  • Publisher: 文光堂
• [Book] 第2版 皮膚疾患診療 実践ガイド 水疱を生じる疾患 (2009)
  • Author(s): 守内玲寧, 芝木晃彦, 清水宏
  • Total Pages: 1
  • Publisher: 文光堂