Elucidating gene X environment interaction in the pathophysiology of schizophrenia using twin research

• Project/Area Number: 21249064
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: The University of Tokyo
• Principal Investigator: KASAI Kiyoto 東京大学, 医学部附属病院, 教授 (80322056)
• Co-Investigator(Renkei-kenkyūsha): KATO Tadafumi 独立行政法人理化学研究所, チームリーダー (30214381) ; ABE Osamu 東京大学, 医学部附属病院, 講師 (50302716) ; KAKIUCHI Chihiro 独立行政法人理化学研究所, 客員研究員 (90342766)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000); Fiscal Year 2011: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000); Fiscal Year 2010: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
• Keywords: 精神生理学 / 双生児 / 統合失調症 / 遺伝 / 環境 / 神経画像

Research Abstract

We collected neuroimaging and blood samples from monozygotic and dizygotic twin pairs and from patients with schizophrenia. We recruited 62 healthy twin adults and 44 twin children. MEG recording of mismatch negativity(MMN) indicated that MMN is heritable. MMN was associated with genetic variation in the GRM3. These results suggest that MMN may be a useful intermediate phenotype for schizophrenia. We also showed that prefrontal cortex activation as measured by NIRS may be also heritable and that these indices were significantly reduced in early phases of schizophrenia, which indicates the usefulness of NIRS as an efficient intermediate phenotype for schizophrenia.

Research Products

• [Journal Article] Effects of metabotropic glutamate receptor 3 genotype on phonetic mismatch negativity (2011)
  • Author(s): Kawakubo Y, Suga M, Tochigi M, Yumoto M, Itoh K, Sasaki T, Kano Y, Kasai K
  • Journal Title: PLoS ONE Volume: 6
  • Peer Reviewed
• [Journal Article] Reply to "Neurogenetic effects of OXTR rs2254298 in the extended limbic system of healthy Caucasian adults" (2011)
  • Author(s): Yamasue H, Suga M, Yahata N, Inoue H, Tochigi M, Abe O, Xiaoxi Liu, Kawamura Y, Mark A Rogers, Takei K, Yamada H, Aoki S, Sasaki T, Kasai K
  • Journal Title: Biol Psychiatry Volume: 70
  • Peer Reviewed
• [Journal Article] Different hemodynamic response patterns in the prefrontal cortical sub-regions according to the clinical stages of psychosis (2011)
  • Author(s): Koike S, Takizawa R, Nishimura Y, Takano Y, Takayanagi Y, Kinou M, Araki T, Harima H, Fukuda M, Okazaki Y, Kasai K
  • Journal Title: Schizophr Res Volume: 132 Pages: 54-61
  • Peer Reviewed
• [Journal Article] Gray and white matter asymmetries in healthy individuals aged 21-29 years : A voxel-based morphometry and diffusion tensor imaging study (2011)
  • Author(s): Takao H, Abe O, Yamasue H, Aoki S, Sasaki H, Kasai K, Yoshioka N, Ohtomo K
  • Journal Title: Hum Brain Mapp Volume: 32 Pages: 1762-1773
  • Peer Reviewed
• [Journal Article] ldiopathic carbonyl stress in a drug-naive case of at risk mental state (2011)
  • Author(s): Arai, et al.
  • Journal Title: Psychiatry Clin Neurosci Volume: 65
  • Peer Reviewed
• [Journal Article] Phonological fluency is uniquely impaired in Japanese-speaking schizophrenia : a confirmation study (2011)
  • Author(s): Suga, et al.
  • Journal Title: Psychiatry Clrn.Neurosci Volume: 65
  • Peer Reviewed
• [Journal Article] No association between CLOCK gene 3111C/T polymorphism and personality traits in Japanese healthy subjects (2011)
  • Author(s): Otowa, et al.
  • Journal Title: Psychiatry Clin Neurosci Volume: 65
  • Peer Reviewed
• [Journal Article] Developmental changes of prefrontal activation in humans : a near-infrared spectroscopy study of preschool children and adults (2011)
  • Author(s): Kawakubo, et al.
  • Journal Title: PLoS ONE Volume: 6
  • Peer Reviewed
• [Journal Article] Effects of metabotropic glutamate receptor 3 genotype on phonetic mismatch negativity (2011)
  • Author(s): Kawakubo, et al.
  • Journal Title: PLoS ONE Volume: 6
  • Peer Reviewed
• [Journal Article] The STGMARI gene is associated with a risk of schizophrenia and activation of the prefrontal cortex (2011)
  • Author(s): Ohi, et al.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 35
  • Peer Reviewed
• [Journal Article] Cortical thickness, gray matter volume, and white matter anisotropy and diffusivity in schizophrenia (2011)
  • Author(s): Murakami, et al.
  • Journal Title: Neuroradiology Volume: 53
  • Peer Reviewed
• [Journal Article] Reply to Neurogenetic effects of OXTR rs2254298 in the extended limbic system of healthy Caucasian adults (2011)
  • Author(s): Yamasue, et al.
  • Journal Title: Biol Psychiatry Volume: 70
  • Peer Reviewed
• [Journal Article] Classification of first-episode schizophrenia patients and healthy subjects by automated MRI measures of regional brain volume and cortical thickness (2011)
  • Author(s): Takayanagi, et al.
  • Journal Title: PLoS ONE Volume: 6
  • Peer Reviewed
• [Journal Article] Different hemodynamic response patterns in the prefrontal cortical sub-regions according to the clinical stages of psychosis (2011)
  • Author(s): Koike, et al.
  • Journal Title: Schizophr Res Volume: 132
  • Peer Reviewed
• [Journal Article] Prefrontal cortex activity during response inhibition associated with excitement symptoms in schizophrenia (2011)
  • Author(s): Nishimura, et al.
  • Journal Title: Brain Res Volume: 1,370
  • Peer Reviewed
• [Journal Article] Impaired ability to organize information in individuals with autism spectrum disorders and their siblings (2011)
  • Author(s): Sumiyoshi, et al.
  • Journal Title: Neurosci Res Volume: 69
  • Peer Reviewed
• [Journal Article] Gray and white matter asymmetries in healthy individuals aged 21-29 years : A voxel-based morphometry and diffusion tensor imaging study (2011)
  • Author(s): Takao, et al.
  • Journal Title: Hum Brain Mapp Volume: 32
  • Peer Reviewed
• [Journal Article] Association between severer dorsolateral prefrontal dysfunction during random number generation and earlier onset in schizophrenia (2011)
  • Author(s): Koike, et al.
  • Journal Title: Clin Neurophysiol Volume: 122
  • Peer Reviewed
• [Journal Article] カルボニルストレス (2011)
  • Author(s): 新井誠, 他
  • Journal Title: 精神科治療学 Volume: 26
  • Peer Reviewed
• [Journal Article] 臨床医学の展望2012 (2011)
  • Author(s): 笠井清登, 他
  • Journal Title: 精神医学 Psychiatry Volume: 4587
  • Peer Reviewed
• [Journal Article] 統合失調症のエピジェネティクス (2011)
  • Author(s): 西岡将基, 他
  • Journal Title: 精神科治療学 Volume: 26
  • Peer Reviewed
• [Journal Article] 気分障害の診断・治療と近赤外線スペクトロスコビー(NIRS)-東大病院「こころの検査プログラム」の紹介- (2011)
  • Author(s): 里村嘉弘, 他
  • Journal Title: Medical Practice Volume: 28
  • Peer Reviewed
• [Journal Article] 精神疾患の脳機能を測る (2011)
  • Author(s): 榊原英輔, 他
  • Journal Title: Brain Medical Volume: 23
  • Peer Reviewed
• [Journal Article] 統合失調症の早期病態解明・診断補助法開発:ユースメンタルヘルスの実現に向けて (2011)
  • Author(s): 笠井清登
  • Journal Title: 精神神経学雑誌 Volume: 113
  • NAID: 10029576461
  • Peer Reviewed
• [Journal Article] Auditory gating deficit to human voices in schizophrenia : a MEG study (2010)
  • Author(s): Hirano S, Hirano Y, Maekawa T, Obayashi C, Oribe N, Monji A, Kasai K, Kanba S, Onitsuka T
  • Journal Title: Schizophr Res Volume: 117 Pages: 61-67
  • Peer Reviewed
• [Journal Article] Association between the oxytocin receptor gene(OXTR) and amygdalar volume in healthy adults (2010)
  • Author(s): Inoue H, Yamasue H, Tochigi M, Abe O, Liu X, Kawamura Y, Takei K, Suga M, Yamada H, Rogers MA, Aoki S, Sasaki T, Kasai K
  • Journal Title: Biol Psychiatry Volume: 68 Pages: 1066-1072
  • Peer Reviewed
• [Journal Article] Effect of tryptophan hydroxylase-2 gene variants on amygdalar and hippocampal volumes (2010)
  • Author(s): Inoue H, Yamasue H, Tochigi M, Takei K, Suga M, Abe O, Yamada H, Rogers MA, Aoki S, Sasaki T, Kasai K
  • Journal Title: Brain Re Volume: 331 Pages: 51-57
  • Peer Reviewed
• [Journal Article] Functional(GT) n polymorphisms in promoter region of N-methyl-D-aspartate receptor 2A subunit(GRIN2A) gene affect hippocampal and amygdala volumes (2010)
  • Author(s): Inoue H, Yamasue H, Tochigi M, Suga M, Iwayama Y, Abe O, Yamada H, Rogers M, Aoki S, Kato T, Sasaki T, Yoshikawa T, Kasai K
  • Journal Title: Genes Brain Behav Volume: 9 Pages: 269-275
  • Peer Reviewed
• [Journal Article] Reduced gray matter volume of Brodmann's Area 45 is associated with severe psychotic symptoms in patients with schizophrenia (2010)
  • Author(s): Suga M, Yamasue H, Abe O, Yamasaki S, Yamada H, Inoue H, Takei K, Aoki S, Kasai K
  • Journal Title: Eur Arch Psychiatry Clin Neurosci Volume: 260 Pages: 465-473
  • Peer Reviewed
• [Journal Article] Volume reduction and altered sulco-gyral pattern of the orbitofrontal cortex in first-episode schizophrenia (2010)
  • Author(s): Takayanagi Y, Takahashi T, Orikabe L, Masuda N, Mozue Y, Nakamura K, Kawasaki Y, Itokawa M, Sato Y, Yamasue H, Kasai K, Okazaki Y, Suzuki M
  • Journal Title: Schizophr Res Volume: 121 Pages: 55-65
  • Peer Reviewed
• [Journal Article] Effect of tryptophan hydroxylase-2 gene variants on amygdalar and hippocampal volumes (2010)
  • Author(s): Inoue H, et al.
  • Journal Title: Brain Res Volume: 17 Pages: 51-57
  • Peer Reviewed
• [Journal Article] Functional (GT)n polymorphisms in promoter region of N-methyl-D-aspartate receptor 2A subunit (GRIN2A) gene affect hippocampal and amygdala volumes (2010)
  • Author(s): Inoue H, et al.
  • Journal Title: Genes Brain Behav Volume: 9 Pages: 269-275
  • Peer Reviewed
• [Journal Article] Psychotic-like experiences (PLEs) and mental health status intwin and singleton Japanese high school students (2010)
  • Author(s): Oshima N, et al.
  • Journal Title: Early Interv Psychiatry Volume: 4 Pages: 206-213
  • Peer Reviewed
• [Journal Article] Functional(GT)n polymorphisms in promoter region of N-methyl-D-aspartate receptor 2A subunit(GRIN2A)gene affect hippocampal and amygdala volumes (2010)
  • Author(s): Inoue H, et al.
  • Journal Title: Genes, Brain and Behavior (in press)
  • Peer Reviewed
• [Journal Article] Cerebral asymmetry in patients with schizophrenia : a voxel-based morphometry(VBM)and diffusion tensor imaging(DTI)study (2010)
  • Author(s): Takao H, et al.
  • Journal Title: Journal of Magnetic Resonance Imaging 31 Pages: 221-6
  • Peer Reviewed
• [Journal Article] 統合失調症のNIRS研究と臨床応用 (2010)
  • Author(s): 滝沢龍、西村幸香、小池進介、笠井清登、福田正人
  • Journal Title: 精神科 (in press)
  • Peer Reviewed
• [Journal Article] 自分自身を変えるこころと脳 (2010)
  • Author(s): 滝沢龍、笠井清登、福田正人
  • Journal Title: こころの科学 150号(in press)
  • Peer Reviewed
• [Journal Article] 統合失調症の神経生理学的研究-NIRSを用いた検討- (2010)
  • Author(s): 滝沢龍、西村幸香、小池進介、笠井清登、福田正人
  • Journal Title: 脳と精神の医学 (in press)
  • NAID: 10028262765
  • Peer Reviewed
• [Journal Article] Structural disruption of the dorsal cingulum bundle is associated with impaired Stroop performance in patients with schizophrenia (2009)
  • Author(s): Takei K, Yamasue H, Abe O, Yamada H, Inoue H, Suga M, Muroi M, Sasaki H, Aoki S, Kasai K
  • Journal Title: Schizophr Res Volume: 114 Pages: 119-127
  • Peer Reviewed
• [Journal Article] Association between sigma-1 receptor gene polymorphism and prefrontal hemodynamic response induced by cognitive activation in schizophrenia (2009)
  • Author(s): Takizawa R, Hashimoto K, Tochigi M, Kawakubo Y, Marumo K, Sasaki T, Fukuda M, Kasai K
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 33 Pages: 491-498
  • Peer Reviewed
• [Journal Article] Association between catechol-o-methyltrasferase val108/158met genotype and prefrontal hemodynamic response in schizophrenia (2009)
  • Author(s): Takizawa R, Tochigi M, Kawakubo Y, Marumo K, Sasaki T, Fukuda M, Kasai K
  • Journal Title: PLoS ONE Volume: 4
  • Peer Reviewed
• [Journal Article] Association between Catechol-O-Methyltrasferase Val108/158Met Genotype and Prefrontal Hemodynamic Response in Schizophrenia (2009)
  • Author(s): 滝沢龍, et al.
  • Journal Title: PLoS ONE 4(5)
  • Peer Reviewed
• [Journal Article] Association between sigma-1 receptor gene polymorphism and prefrontal hemodynamic response induced by cognitive activation in schizophrenia (2009)
  • Author(s): 滝沢龍, et al.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry 33(3) Pages: 491-498
  • Peer Reviewed
• [Journal Article] Gender difference in right lateral prefrontal hemodynamic response while viewing fearful faces : A multi-channel near-infrared spectroscopy study (2009)
  • Author(s): 丸茂浩平, et al.
  • Journal Title: Neurosci Res 63(2) Pages: 89-94
  • Peer Reviewed
• [Journal Article] Structural disruption of the dorsal cingulum bundle is associated with impaired Stroop performance in patients with schizophrenia (2009)
  • Author(s): Takei K, et al.
  • Journal Title: Schizophrenia Research 114 Pages: 119-27
  • Peer Reviewed
• [Journal Article] Differentiation of first-episode schizophrenia patients from healthy controls using ROI-based multiple structural brain variables (2009)
  • Author(s): Takayanagi Y, et al.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry 2009 Sep 13(Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Reduced gray matter volume of Brodmann's Area 45 is associated with severe psychotic symptoms in patients with schizophrenia (2009)
  • Author(s): Suga M, et al.
  • Journal Title: European Archives of Psychiatry and Clinical Neuroscience as an original article 2009 Sep 19(Epub ahead of print)
  • Peer Reviewed
• [Journal Article] 精神病発症期前後の脳構造・機能変化と臨床病期の補助診断法の可能性 (2009)
  • Author(s): 小池進介、笠井清登
  • Journal Title: 精神科治療学 24 Pages: 905-913
  • Peer Reviewed
• [Journal Article] 統合失調症の進行性脳病態仮説 (2009)
  • Author(s): 高野洋輔、小池進介、笠井清登
  • Journal Title: 医学のあゆみ 231 Pages: 1034-1039
  • Peer Reviewed
• [Journal Article] 気分障害のNIRS研究と臨床への応用 (2009)
  • Author(s): 木納賢、滝沢龍、丸茂浩平、笠井清登、福田正人
  • Journal Title: 臨床精神医学 38(4) Pages: 429-436
  • Peer Reviewed
• [Journal Article] NIRSでみる精神疾患の前頭葉機能 (2009)
  • Author(s): 滝沢龍、小池進介、高橋礼花、木納賢、笠井清登
  • Journal Title: 神経内科 71(3) Pages: 286-294
  • Peer Reviewed
• [Journal Article] 統合失調症の神経画像研究 (2009)
  • Author(s): 笠井清登、滝沢龍
  • Journal Title: 精神医学 51(2) Pages: 177-184
  • Peer Reviewed
• [Journal Article] 脳機能計測法を基礎から学ぶ人のために 事象関連電位 P300応用 精神科の立場から (2009)
  • Author(s): 切原賢治、荒木剛、笠井清登
  • Journal Title: 臨床神経生理学 37(3) Pages: 115-120
  • Peer Reviewed
• [Journal Article] 統合失調症における顔認知障害:事象関連電位研究 (2009)
  • Author(s): 切原賢治、荒木剛、笠井清登
  • Journal Title: 脳と精神の医学 20(3) Pages: 207-211
  • NAID: 10028262335
  • Peer Reviewed
• [Journal Article] 統合失調症のグルタミン酸・GABA神経伝達異常 (2009)
  • Author(s): 切原賢治、荒木剛、神出誠一郎、笠井清登
  • Journal Title: 医学のあゆみ 231(10) Pages: 1040-1044
  • Peer Reviewed
• [Presentation] 双先児研究による近赤外線スペクトロスコヒーの前頭側頭部血流変化における遺伝的要因の検討 (2012)
  • Author(s): 榊原英輔, 他
  • Organizer: 日本統合失調症学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-03-17
• [Presentation] 双生児研究法による新版STAI状態-特性不安検査と近赤外線スペクトロスコピーにおける遺伝的要因の検討 (2012)
  • Author(s): 榊原英輔、滝沢龍、西村幸香、木納賢、丸茂浩平、山崎修道、江口聡、武井邦夫、井上秀之、管心、山末英典、川久保友紀、笠井清登
  • Organizer: 第4回日本不安障害学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2012-02-04
• [Presentation] 双王児研究法による新版STAI状態-特性不安検査と近赤外線スベクトロスコピーにおける遺伝的要因の検討 (2012)
  • Author(s): 榊原英輔, 他
  • Organizer: 日本不安障害学会
  • Place of Presentation: 東京
  • Year and Date: 2012-02-04
• [Presentation] 統合失調症の早期段階におけるバイオマーカー研究～ミスマッチ陰性電位～ (2011)
  • Author(s): 永井達哉, 他
  • Organizer: 日本精神保健・予防学会
  • Place of Presentation: 東京
  • Year and Date: 2011-12-03
• [Presentation] 早期精神病における近赤外線スペクトロスコピィ(NIRS)の臨床応用可能性 (2011)
  • Author(s): 小池進介, 他
  • Organizer: 日本精神保健・予防学会
  • Place of Presentation: 東京
  • Year and Date: 2011-12-03
• [Presentation] Integrative neuroimaging studies for schizophrenia targeting early intervention and prevention(IN-STEP). MPS-UT Joint Symposium "Neuroscience" (2011)
  • Author(s): 笠井清登
  • Organizer: マックスプランク協会-東京大学医学部・大学院医学系研究科合同シンポジウム「神経科学」
  • Place of Presentation: 東京
  • Year and Date: 2011-10-28
• [Presentation] Integrative neuroimaging studies for schizophrenia targeting early intervention and prevention (IN-STEP). MPS-UT Joint Symposium "Neuroscience" (2011)
  • Author(s): 笠井清登
  • Organizer: マックスプランク協会-東京大学医学部・大学院医学系研究科合同シンポジウム
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-10-28
• [Presentation] 精神疾患における診断と治療法評価のためのニューロイメージングの役割 (2011)
  • Author(s): 笠井清登
  • Organizer: 順天堂大学大学院医学系研究科老人性疾患病態・治療研究センター「細胞・脳機能研究の融合による神経疾患診断・治療法開発拠点の形成」キックオフシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2011-10-13
• [Presentation] 精神疾患における診断と治療法評価のためのニューロイメージングの役割 (2011)
  • Author(s): 笠井清登
  • Organizer: 「細胞・脳機能研究の融合による神経疾患診断・治療法開発拠点の形成」キックオフシンポジウム
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-10-13
• [Presentation] ユース期の社会神経科学としての統合失調症研究 (2011)
  • Author(s): 笠井清登
  • Organizer: 平成23年度生理研研究会 社会神経科学研究会「今、社会神経科学研究に求められていること」
  • Place of Presentation: 岡崎(招待講演)
  • Year and Date: 2011-10-07
• [Presentation] 精神疾患研究における脳MRI解析の果たす役割 (2011)
  • Author(s): 笠井清登
  • Organizer: 第39回日本磁気共鳴医学会大会
  • Place of Presentation: 小倉
  • Year and Date: 2011-09-30
• [Presentation] 精神疾患研究における脳MRI解析の果たす役割 (2011)
  • Author(s): 笠井清登
  • Organizer: 日本磁気共鳴医学会
  • Place of Presentation: 小倉(招待講演)
  • Year and Date: 2011-09-30
• [Presentation] 統合失調症患者におけるEGR3遣伝子多型と認知課題施行中の脳血液量変化との関連 (2011)
  • Author(s): 西村幸香, 他
  • Organizer: 日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-17
• [Presentation] 脳画像計測の精神疾患への応用 (2011)
  • Author(s): 笠井清登
  • Organizer: 第49回全国大学保健管理協会関東甲信越地方部会研究集会
  • Place of Presentation: 東京
  • Year and Date: 2011-08-04
• [Presentation] 脳画像計測の精神疾患への応用 (2011)
  • Author(s): 笠井清登
  • Organizer: 全国大学保健管理協会関東甲信越地方部会研究集会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-08-04
• [Presentation] 意味カテコリー流暢課題施行時の脳血流変化及びGRM3遺伝子多型との関連:多チャンネルNIRS研究 (2011)
  • Author(s): 木下晃秀, 他
  • Organizer: 日本生物学的精神医学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-22
• [Presentation] CD200遺伝子と統合失調症との関連研究 (2011)
  • Author(s): 西村文親, 他
  • Organizer: 日本生物学的精神医学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-22
• [Presentation] Casein Kinase 2と統合失調症の遺伝学的関連 (2011)
  • Author(s): 吉川茜, 他
  • Organizer: 日本生物学的精神医学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-22
• [Presentation] 当事者に届く生物学的精神医学研究:バイオマーカーを用いた精神疾患の客観的補助診断法の開発 (2011)
  • Author(s): 山口成良, 他
  • Organizer: 日本生物学的精神医学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-21
• [Presentation] Emotional face processing abnormalipatients with schizophrenia : an event-related potential study (2010)
  • Author(s): Tada M, Kiribara K, Araki T, Kawakubo Y, Onitsuka T, Kasai K
  • Organizer: 29^<th> International Congress of Clinical Neurophysiology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2010-10-30
• [Presentation] Prefrontal hemodynamic change in differential clinical staging of schizophrenia. A multi-channel near-infrared spectroscopy(NIRS) study (2010)
  • Author(s): Koike S, Takizawa R, Nishimura Y, Takayanagi Y, Takano Y, Kinou M, ArakKasai K
  • Organizer: 29^<th> International Congress of Clinical Neurophysiology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2010-10-29
• [Presentation] 統合失調症の早期介入に対する神経画像の貢献Integrative neuroimaging studies for schizophrenia targeting early intervention and prevention (2010)
  • Author(s): 笠井清登
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: 小倉
  • Year and Date: 2010-10-07
• [Presentation] 統合失調症の臨床病期に即した脳病態解明と早期介入 (2010)
  • Author(s): 笠井清登
  • Organizer: 第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-03
• [Presentation] 精神科医療における神経画像検査の実用化 (2010)
  • Author(s): 笠井清登
  • Organizer: 第14回精神科医療懇話会
  • Place of Presentation: 東京
  • Year and Date: 2010-06-17
• [Presentation] 精神医学の重要性と統合失調症の早期介入 (2010)
  • Author(s): 笠井清登
  • Organizer: 第27回愛媛県精神神経学会
  • Place of Presentation: 松山
  • Year and Date: 2010-06-12
• [Presentation] 統合失調症の早期病態解明と早期診断法開発 (2010)
  • Author(s): 笠井清登
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-22
• [Presentation] 統合失調症の早期病態解明と早期診断法開発 (2010)
  • Author(s): 笠井清登
  • Organizer: 第106回日本精神神経学会学術総会
  • Place of Presentation: 広島
  • Year and Date: 2010-05-20
• [Presentation] Integrative neuroimaging assessment through clinical stages in schizophrenia (2010)
  • Author(s): Kasai K
  • Organizer: 2＾<nd> Schizophrenia International Research Society Conference
  • Place of Presentation: Florence, Italy
  • Year and Date: 2010-05-13
• [Presentation] Intergrative neuroimaging assessment through clinical stages in schizophrenia (2010)
  • Author(s): Kasai K
  • Organizer: 2^<nd> Schizophrenia International Research Society Conference
  • Place of Presentation: Florence, Italy
  • Year and Date: 2010-04-13
• [Presentation] Inappropriate hemodynamic response in the individuals with at-risk mental state(ARMS), a multi-channel near-infrared spectroscopy(NIRS) stud (2010)
  • Author(s): Koike S, Takizawa R, Nishimura Y, Takayanagi Y, Takano Y, Kinou M, ArakKasai K
  • Organizer: 7^<th> International Conference on Early Psychosis
  • Place of Presentation: Amsterdam
• [Presentation] 統合失調症の早期介入マーカーとしてのMMN (2009)
  • Author(s): 荒木剛,笠井清登
  • Organizer: 第39回日本臨床神経生理学会学術大会
  • Place of Presentation: 北九州
  • Year and Date: 2009-11-20
• [Presentation] 統合失調症の早期マーカーとしてのMMN (2009)
  • Author(s): 荒木剛、笠井清登
  • Organizer: 第39回日本臨床神経生理学会学術大会シンポジウム
  • Place of Presentation: 北九州
  • Year and Date: 2009-11-20
• [Presentation] アットリスク精神状態および初回エピソード統合失調症におけるミスマッチ陰性電位:予備的検討(ポスター) (2009)
  • Author(s): 多田真理子, 他
  • Organizer: 第39回日本臨床神経生理学会学術大会
  • Place of Presentation: 北九州
  • Year and Date: 2009-11-18
• [Presentation] 精神疾患の脳画像診断「光トポグラフィーの精神科臨床への応用」 (2009)
  • Author(s): 笠井清登,鬼塚俊明,荒木剛
  • Organizer: 第37回日本精神科病院協会精神医学会
  • Place of Presentation: 高松
  • Year and Date: 2009-11-13
• [Presentation] At risk mental stateの内側前頭前野におけるグルタミン酸神経系異常:3テスラMRSによる統合失調症患者との比較 (2009)
  • Author(s): 井上秀之, 他
  • Organizer: 第9回精神疾患と認知機能研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-11-07
• [Presentation] Gamma band activity during gaze processing in schizophrenia(poster) (2009)
  • Author(s): Kirihara K, et al.
  • Organizer: 8th International Congress on Brain Electromagnetic Topography
  • Place of Presentation: Kyoto, JAPAN
  • Year and Date: 2009-10-01
• [Presentation] 統合失調症の脳病態と早期介入 (2009)
  • Author(s): 笠井清登
  • Organizer: 第17回脳の世紀シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2009-09-30
• [Presentation] 統合失調症の脳病態と早期介入 (2009)
  • Author(s): 笠井清登
  • Organizer: 第17回 脳の世紀シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2009-09-30
• [Presentation] MEG mismatch abnormalities to speech sounds in schizophrenia : Heritability and relationship to genetics (2009)
  • Author(s): 荒木剛, 笠井清登
  • Organizer: 9th World Congress of Biological Psychiatry
  • Place of Presentation: Paris, France
  • Year and Date: 2009-06-30
• [Presentation] Clinical NIRS application to psychiatric diagnosis and evaluation. Symposium : Near-infrared spectroscopy(NIRS)in psychiatry : Current status and future prospect. (2009)
  • Author(s): 滝沢龍, 笠井清登
  • Organizer: 9th World Congress of Biological Psychiatry
  • Place of Presentation: Paris, France
  • Year and Date: 2009-06-28
• [Presentation] 事象関連電位を統合失調症の早期介入のマーカーとして応用する試みについて (2009)
  • Author(s): 荒木剛, 他
  • Organizer: 第31回日本生物学的精神医学会 シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2009-04-25
• [Presentation] 統合失調症患者における他者の感情理解の脳基盤 (2009)
  • Author(s): 高野洋輔, 他
  • Organizer: 第31回日本生物学的精神医学会
  • Place of Presentation: 京都
  • Year and Date: 2009-04-25
• [Presentation] 関心領域法を用いた脳構造による初回エピソード統合失調症患者と健常者の判断 (2009)
  • Author(s): 高柳洋一郎, 他
  • Organizer: 第31回日本生物学的精神医学会
  • Place of Presentation: 京都
  • Year and Date: 2009-04-25
• [Presentation] Neural correlates of empathy patients with schizophrenia (2009)
  • Author(s): Yamasue H, et al.
  • Organizer: 31th Japanese Society of Biological Psychiatry
  • Place of Presentation: Kyoto, JAPAN
  • Year and Date: 2009-04-24
• [Presentation] 統合失調症のNIRS研究 (2009)
  • Author(s): 滝沢龍、笠井清登、福田正人
  • Organizer: 第31回日本生物学的精神医学会、シンポジウム「統合失調症の神経画像研究・アップデート」
  • Place of Presentation: 京都
  • Year and Date: 2009-04-23
• [Presentation] Effect of Sigma-1 receptor gene polymorphism on prefrontal hemodynamic response in schizophrenia : a multi-channel NIRS study (2009)
  • Author(s): 滝沢龍, et al.
  • Organizer: JSBP Travel Awards for International Meetings Presentation, 31th Annual Meeting of JSBP
  • Place of Presentation: Kyoto, JAPAN
• [Presentation] 統合失調症における作業記憶課題遂行時の前頭葉機能の検討-多チャンネルNIRS研究- (2009)
  • Author(s): 小池進介, 他
  • Organizer: 第31回日本生物学的精神医学会
  • Place of Presentation: 京都
• [Book] 統合失調症の各病期における精神生理学的データ-MMNとMRS-山内俊雄(編集統括):精神疾患と認知機能-最近の進歩- (2011)
  • Author(s): 永井達哉、井上秀之、笠井清登
  • Publisher: 新興医学出版社
• [Book] 精神疾患の臨床検査としての光トポグラフィー検査(NIRS)-先進医療『うつ症状の鑑別診断補助』 (2011)
  • Author(s): 滝沢龍、笠井清登
  • Publisher: 南山堂(印刷中)
• [Book] 精神疾患と認知機能-最近の進歩- (2011)
  • Author(s): 笠井清登, 他
  • Total Pages: 342
  • Publisher: 新興医学出版社
• [Book] 脳バンク 精神疾患の謎を解くために (2011)
  • Author(s): 笠井清登, 他
  • Total Pages: 286
  • Publisher: 光文社
• [Book] 精神疾患診断のたの脳形態・機能検査法 (2011)
  • Author(s): 笠井清登, 他
  • Total Pages: 230
  • Publisher: 新興医学出版社
• [Book] 統合失調症と言語:神経画像的知見 (2010)
  • Author(s): 橋本龍一郎、笠井清登
  • Publisher: 朝倉書店
• [Book] シリーズ朝倉<言語の可能性>中込和幸(編) 5言語と医学 (2010)
  • Author(s): 橋本龍一郎、 笠井清登
  • Total Pages: 23
  • Publisher: 朝倉書店
• [Book] 精神生理学的方法(電気生理学的方法) (2009)
  • Author(s): 切原賢治、荒木剛、笠井清登
  • Publisher: 新興医学出版社
• [Book] 統合ピソード統合失調症の画像・神経生理 (2009)
  • Author(s): 高野洋輔、小池進介、笠井清登
  • Publisher: 中山書店
• [Book] 統合失調症の進行性脳病態仮説 (2009)
  • Author(s): 高野洋輔、小池進介、笠井清登
  • Publisher: 医歯薬出版株式会社
• [Book] NIRSデータの再現性 (2009)
  • Author(s): 西村幸香、滝沢龍、笠井清登
  • Publisher: 中山書店、東京
• [Book] 初回エピソード統合失調症の画像・神経生理.専門医のための精神科臨床リュミエール第5巻 (2009)
  • Author(s): 高野洋輔、切原賢治、笠井清登
  • Total Pages: 240
  • Publisher: 中山書店
• [Book] 構造MRIと精神疾患.専門医のための精神科臨床リュミエール第16巻 (2009)
  • Author(s): 井上秀之、武井邦夫、笠井清登
  • Publisher: 中山書店(印刷中)
• [Book] 初回エピソード統合失調症の画像・神経生理.:専門医のための精神科臨床リュミエール7 (2009)
  • Author(s): 高野洋輔、切原賢治、笠井清登
  • Total Pages: 272
  • Publisher: 中山書店
• [Book] I.人間の前頭葉の構造と機能-臨床を理解するための基礎知識.7.前頭極FPの構造と機能.専門医のための精神科臨床リュミエール21 (2009)
  • Author(s): 滝沢龍、笠井清登、福田正人
  • Publisher: 中山書店(印刷中)
• [Book] III.精神疾患への応用.1.統合失調症・自閉症の前頭葉機能障害とNIRSの臨床応用.(福田正人(編):精神疾患とNIRS) (2009)
  • Author(s): 滝沢龍、川久保友紀、桑原斉、笠井清登
  • Total Pages: 264
  • Publisher: 中山書店
• [Book] II.精神医学におけるNIRS.4.NIRSデータの再現性.(福田正人(編):精神疾患とNIRS) (2009)
  • Author(s): 西村幸香、滝沢龍、笠井清登
  • Total Pages: 264
  • Publisher: 中山書店
• [Book] 第3章 認知機能をどう捉え、評価するのかA.検査法 I.精神生理学的方法(電気生理学的方法)「精神 (2009)
  • Author(s): 切原賢治、荒木剛、笠井清登
  • Total Pages: 341
  • Publisher: 新興医学出版社
• [Remarks]
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