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Development of the new cell-free device for sever heart failure by restructuring of artificial stem cell niche using extracellular matrixes and stem cell recruitment/differentiation factors

Research Project

Project/Area Number 21249075
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionOsaka University

Principal Investigator

SAWA Yoshiki  大阪大学, 医学系研究科, 教授 (00243220)

Co-Investigator(Kenkyū-buntansha) MATSUMIYA Goro  千葉大学, 医学研究院, 教授 (20314312)
KURATANI Toru  大阪大学, 医学系研究科, 准教授 (90448035)
UENO Takayoshi  大阪大学, 医学系研究科, 講師 (60437316)
SAKAGUCHI Taichi  大阪大学, 医学系研究科, 寄附講座准教授 (10467574)
SHIRAKAWA Yukitoshi  大阪大学, 医学系研究科, 助教 (20457013)
SHIMAMURA Kazuo  大阪大学, 医学系研究科, 寄附講座助教 (10507205)
SAITO Atsuhiro  大阪大学, 医学部附属病院, 助教 (20448038)
MATSUYAMA Akifumi  大阪大学, 医学部附属病院, 特任准教授 (10423170)
MIYAGAWA Shigeru  大阪大学, 医学系研究科, 助教 (70544237)
YAMAUCHI Takashi  大阪大学, 医学系研究科, 助教 (20527999)
Co-Investigator(Renkei-kenkyūsha) SEKIGUCHI Kiyotoshi  大阪大学, 蛋白質研究所, 教授 (50187845)
KANEDA Yasufumi  大阪大学, 医学系研究科, 教授 (10177537)
TAMAI Katsuto  大阪大学, 医学系研究科, 寄附講座教授 (20236730)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥47,580,000 (Direct Cost: ¥36,600,000、Indirect Cost: ¥10,980,000)
Fiscal Year 2011: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2010: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2009: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
KeywordsiPS細胞 / 心筋細胞 / 細胞シート / 心不全 / 再生医学 / 細胞・組織 / 生体材料 / 生体分子 / 生体機能利用 / 心筋再生 / 幹細胞誘導因子 / 細胞外マトリックス
Research Abstract

We developed the new cell-free device for sever heart failure by restructuring of artificial stem cell niche using extracellular matrixes and stem cell recruitment/differentiation factors

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (13 results)

All 2011 2010

All Presentation (13 results)

  • [Presentation] 心不全における再生医療の現況2011

    • Author(s)
      宮川繁
    • Organizer
      日本人工臓器学会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-11-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Combined Therapy of Skeletal Myoblast Cell-Sheet Transplantation with Administration of Prostacycline Agonist Makes Left Ventricular Reverse Remodeling on the Impaired Myocardium in Rapid-Pacing Induced End-stage Heart Failure in Canine Heart2011

    • Author(s)
      Shirasaka T
    • Organizer
      American Heart Association
    • Place of Presentation
      アメリカ
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 心不全に対する治療戦略2011

    • Author(s)
      澤芳樹
    • Organizer
      心臓大血管外科懇話会
    • Place of Presentation
      鹿児島(招待講演)
    • Year and Date
      2011-11-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 重症心不全に対する複合治療2011

    • Author(s)
      澤芳樹
    • Organizer
      日本心不全学会学術集会
    • Place of Presentation
      鹿児島(招待講演)
    • Year and Date
      2011-10-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] 近未来の心不全戦略2011

    • Author(s)
      澤 芳樹
    • Organizer
      JSPS「再生医療の実用化」に関する研究開発専門委員会主催シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-07-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 虚血性心筋症に対する再生型治療の現状と展望2011

    • Author(s)
      宮川繁
    • Organizer
      日本冠動脈外科学会学術大会
    • Place of Presentation
      長野(招待講演)
    • Year and Date
      2011-07-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 心不全の克服に向けて ~人工心臓・心臓移植 そして再生医療~2011

    • Author(s)
      澤 芳樹
    • Organizer
      愛媛心臓病研究会
    • Place of Presentation
      愛媛
    • Year and Date
      2011-06-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Cardiac Regenerative Therapy2010

    • Author(s)
      澤芳樹
    • Organizer
      International Surgical Symposium 2nd West China-CUHK Surgical Forumm
    • Place of Presentation
      中国・香港(招待講演)
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 重症心不全治療のみらい2010

    • Author(s)
      澤 芳樹
    • Organizer
      日本人工臓器学会
    • Place of Presentation
      宮城
    • Year and Date
      2010-11-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Stem Cell Therapy for Severe Heart Failure2010

    • Author(s)
      Yoshiki Sawa
    • Organizer
      国際細胞治療学会アジア太平洋地域学会
    • Place of Presentation
      宮崎
    • Year and Date
      2010-10-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 骨格筋芽細胞を用いた心不全治療2010

    • Author(s)
      澤 芳樹
    • Organizer
      日本心臓病学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-17
    • Related Report
      2011 Final Research Report
  • [Presentation] 心筋再生治療の現状と未来2010

    • Author(s)
      澤 芳樹
    • Organizer
      日本循環制御医学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-05-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 心筋再生治療の現状と展望2010

    • Author(s)
      澤 芳樹
    • Organizer
      日本医工学治療学会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-02
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2018-02-02  

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