Magnetic stem/progenitor cell targeting for tissue regeneration through the angiogenesis

• Project/Area Number: 21249079
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Hiroshima University
• Principal Investigator: OCHI Mitsuo 広島大学, 大学院・医歯薬保健学研究院, 教授 (70177244)
• Co-Investigator(Kenkyū-buntansha): YASUNAGA Yuji 広島大学, 大学院・医歯薬保健学研究院, 寄附講座教授 (40253075) ; ASAHARA Takayuki 東海大学, 医学部, 教授 (20246200) ; ADACHI Nobuo 広島大学, 病院, 准教授 (30294383) ; KAMEI Naosuke 広島大学, 病院, 病院助教 (70444685) ; NAKASA Tomoyuki 広島大学, 病院, 病院助教 (60467769)
• Co-Investigator(Renkei-kenkyūsha): ASAHARA Hiroshi 東京医科歯科大学, 大学院・医歯薬学総合研究科, 教授 (70294460)
• Project Period (FY): 2009 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥47,580,000 (Direct Cost: ¥36,600,000、Indirect Cost: ¥10,980,000); Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2010: ¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000); Fiscal Year 2009: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
• Keywords: 移植・再生医療 / 再生医学 / 細胞・組織

Research Abstract

We performed the basic research about tissue regeneration using magnetic targeting of bone marrow mesenchymal stem cells or endothelial progenitor cells in muscloskeletal and spinal cord injury models. Magnetic cell targeting enhanced the effect of cell transplantation on the tissue repair in all injury models. We suspected that magnetic cell targeting contributed the tissue repair by promoting accumulation, adhesion and proliferation of transplanted cells.

Research Products

• [Journal Article] Articular cartilage repair with magnetic mesenchymal stem cells (2013)
  • Author(s): Goki Kamei, Mitsuo Ochi et al
  • Journal Title: American Journal of Sports Medicine Volume: (in press)
  • NAID: 40020306221
  • Peer Reviewed
• [Journal Article] A new distraction arthroplasty device using magnetic force; a cadaveric study. (2013)
  • Author(s): Goki Kamei, Mitsuo Ochi et al
  • Journal Title: Clinical Biomechanics Volume: (in press)
  • Peer Reviewed
• [Journal Article] Magnetic Targeting of Human Peripheral Blood CD133(+) Cells for Skeletal Muscle Regeneration. (2013)
  • Author(s): Shingo Ohkawa, Mitsuo Ochi et al
  • Journal Title: Tissue Engineering Part C: Methods Volume: (in press)
  • Peer Reviewed
• [Journal Article] Ex-vivo expanded human blood-derived CD133(+) cells promote repair of injured spinal cord. (2013)
  • Author(s): Naosuke Kamei, Mitsuo Ochi
  • Journal Title: Journal of the Neurological Sciences Volume: 328 Pages: 41-50
  • Peer Reviewed
• [Journal Article] In vivo bioluminescence imaging of magnetically targeted bone marrow-derived mesenchymal stem cells in skeletal muscle injury model. (2013)
  • Author(s): Akihiro Nakabayashi, Naosuke Kamei, Mitsuo Ochi et al
  • Journal Title: Journal of Orthopaedic Research Volume: 31 Pages: 754-759
  • Peer Reviewed
• [Journal Article] Articular cartilage repair with magnetic mesenchymal stem cells (2013)
  • Author(s): Goki Kamei, Mitsuo Ochi
  • Journal Title: American Journal of Sports Medicine Volume: in press
  • NAID: 40020306221
  • Peer Reviewed
• [Journal Article] A new distraction arthroplasty device using magnetic force; a cadaveric study (2013)
  • Author(s): Goki Kamei, Mitsuo Ochi
  • Journal Title: Clinical Biomechanics Volume: in press
  • Peer Reviewed
• [Journal Article] Ex-vivo expanded human blood-derived CD133(+) cells promote repair of injured spinal cord (2013)
  • Author(s): Naosuke Kamei, Mitsuo Ochi
  • Journal Title: Journal of the Neurological Sciences Volume: in press Issue: 1-2 Pages: 41-50
  • DOI: 10.1016/j.jns.2013.02.013
  • Peer Reviewed
• [Journal Article] Magnetic Targeting of Human Peripheral Blood CD133(+) Cells for Skeletal Muscle Regeneration (2013)
  • Author(s): Shingo Ohkawa, Mitsuo Ochi
  • Journal Title: Tissue Engineering Part C: Methods Volume: in press
  • Peer Reviewed
• [Journal Article] Overexpression of microRNA-223 in rheumatoid arthritis synovium controls osteoclast differentiation (2013)
  • Author(s): Hayatoshi Shibuya, Mitsuo Ochi
  • Journal Title: Modern Rheumatology Volume: in press
  • NAID: 10031189161
  • Peer Reviewed
• [Journal Article] In vivo bioluminescence imaging of magnetically targeted bone marrow-derived mesenchymal stem cells in skeletal muscle injury model (2013)
  • Author(s): Nakabayashi A, Mitsuo Ochi
  • Journal Title: Journal of Orthopaedic Research Volume: 31 Issue: 5 Pages: 754-759
  • DOI: 10.1002/jor.22282
  • Peer Reviewed
• [Journal Article] In vivo bioluminescence imaging of transplanted bone marrow mesenchymal stromal cells using a magnetic delivery system in a rat fracture model. (2012)
  • Author(s): Akira Kodama, Naosuke Kamei, Mitsuo Ochi et al
  • Journal Title: Journal of Bone & Joint Surgery, British Volume: 94 Pages: 998-1006
  • Peer Reviewed
• [Journal Article] The effect of intra-articular injection of microRNA-210 on ligament healing in a rat model. (2012)
  • Author(s): Takeshi Shoji, Tomoyuki Nakasa, Naosuke Kamei, Nobuo Adachi, Mitsuo Ochi et al
  • Journal Title: Am J Sports Med Volume: 40 Pages: 2470-2478
  • Peer Reviewed
• [Journal Article] The therapeutic potential of ex vivo expanded CD133+ cells derived from human peripheral blood for peripheral nerve injuries. (2012)
  • Author(s): Shin Ohtsubo, Naosuke Kamei, MitsuoOchi et al
  • Journal Title: Journal of Neurosurgery Volume: 117 Pages: 787-794
  • Peer Reviewed
• [Journal Article] Magnetic field-based delivery of human CD133+ cells promotes functional recovery after ratspinal cord injury. (2012)
  • Author(s): Yuki Fujioka, Naosuke Kamei, Mitsuo Ochi et al
  • Journal Title: Spine Volume: 37
  • Peer Reviewed
• [Journal Article] Angiogenic microRNA-210 is present in cells surrounding osteonecrosis. (2012)
  • Author(s): Keiichiro Yamasaki, Tomoyuki Nakasa, Yuji Yasunaga, Mitsuo Ochi et al
  • Journal Title: Journal of Orthopaedic Research Volume: 30 Pages: 2012-2012
  • Peer Reviewed
• [Journal Article] The effect of intra-articular injection of microRNA-210 on ligament healing in a rat model (2012)
  • Author(s): Takeshi shoji, Mitsuo Ochi
  • Journal Title: American Journal of Sports Medicine Volume: 40 Issue: 11 Pages: 2470-2478
  • DOI: 10.1177/0363546512458894
  • Peer Reviewed
• [Journal Article] The therapeutic potential of ex vivo expanded CD133+ cells derived from human peripheral blood for peripheral nerve injuries (2012)
  • Author(s): Shin Ohtsubo, Mitsuo Ochi
  • Journal Title: Journal of Neurosurgery Volume: 117 Issue: 4 Pages: 787-794
  • DOI: 10.3171/2012.7.jns111503
  • Peer Reviewed
• [Journal Article] In vivo bioluminescence imaging of transplanted bone marrow mesenchymal stromal cells using a magnetic delivery system in a rat fracture model (2012)
  • Author(s): Akira Kodama, Mitsuo Ochi
  • Journal Title: Journal of Bone and Joint Surgery - British Volume Volume: 94 Issue: 7 Pages: 998-1006
  • DOI: 10.1302/0301-620x.94b7.28521
  • Peer Reviewed
• [Journal Article] Rotator cuff regeneration using a bioabsorbable material with bone marrow-derived mesenchymal stem cells in a rabbit model (2012)
  • Author(s): Shin Yokoya, Mitsuo Ochi
  • Journal Title: American Journal of Sports Medicine Volume: 40 Issue: 6 Pages: 1259-1268
  • DOI: 10.1177/0363546512442343
  • Peer Reviewed
• [Journal Article] Angiogenic microRNA-210 is present in cells surrounding osteonecrosis (2012)
  • Author(s): Keiichiro Yamasaki, Mitsuo Ochi
  • Journal Title: Journal of Orthopaedic Research Volume: 30 Issue: 8 Pages: 1263-1270
  • DOI: 10.1002/jor.22079
  • Peer Reviewed
• [Journal Article] Magnetic Field-based Delivery of Human CD133 Positive Cells Promotes Functional Recovery Following Rat Spinal Cord Injury (2012)
  • Author(s): Fujioka Y, Kamei N, Ochi M
  • Journal Title: Spine Volume: (in press) Issue: 13 Pages: E768-E777
  • DOI: 10.1097/brs.0b013e318246d59c
  • Peer Reviewed
• [Journal Article] Changes in microRNA expression in peripheral mononuclear cells according to the progression of osteoarthritis (2012)
  • Author(s): Okuhara A, Nakasa T, Adachi N, Ochi M
  • Journal Title: Mod Rheumatol Volume: (in press) Issue: 3 Pages: 446-457
  • DOI: 10.1007/s10165-011-0536-2
  • NAID: 10030782427
  • Peer Reviewed
• [Journal Article] The inhibitory effect of microRNA-146a expression on bone destruction in collagen-induced arthritis (2011)
  • Author(s): Nakasa T, Ochi M
  • Journal Title: Arthritis Rheum Volume: 63 Issue: 6 Pages: 1582-1590
  • DOI: 10.1002/art.30321
  • Peer Reviewed
• [Journal Article] Articular cartilage repair using an intr a-articular magnet and synovium-derived cells (2011)
  • Author(s): Hori J, Ochi M
  • Journal Title: J Orthop Res Volume: 29 Issue: 4 Pages: 531-538
  • DOI: 10.1002/jor.21267
  • Peer Reviewed
• [Journal Article] MicroRNA-223 expression in neutrophils in the early phase of secondary damage after spinal cord injury (2011)
  • Author(s): Izumi B, Nakasa T, Kamei N, Ochi M
  • Journal Title: Neurosci Lett Volume: 492 Issue: 2 Pages: 114-118
  • DOI: 10.1016/j.neulet.2011.01.068
  • Peer Reviewed
• [Journal Article] Therapeutic effects with magnetic targeting of bone marrow stromal cells in a rat spinal cord injury model (2011)
  • Author(s): Sasaki H, Ochi M
  • Journal Title: Spine Volume: 36 Issue: 12 Pages: 933-938
  • DOI: 10.1097/brs.0b013e3181eb9fb0
  • NAID: 10030714568
  • Peer Reviewed
• [Journal Article] Prevention of osteonecrosis by intravenous administration of human peripheral blood-derived CD34-positive cells in a rat osteonecrosis model (2011)
  • Author(s): Terayama H, Yasunaga Y, Ochi M
  • Journal Title: J Tissue Eng Regen Med Volume: 5 Issue: 1 Pages: 32-40
  • DOI: 10.1002/term.285
  • Peer Reviewed
• [Journal Article] Articular cartilage repair using an intra-articular magnet and synovium-derived cells (2011)
  • Author(s): Junji Hori, Mitsuo Ochi
  • Journal Title: J Orthop Res Volume: (in press)
  • Peer Reviewed
• [Journal Article] Therapeutic effects with magnetic targeting of bone marrow stromal cells in a rat spinal cord injury model (2011)
  • Author(s): Hirofumi Sasaki, Mitsuo Ochi
  • Journal Title: Spine Volume: (in press)
  • NAID: 10030714568
  • Peer Reviewed
• [Journal Article] Micro RNA in Arthritis (2011)
  • Author(s): Tomoyuki Nakasa, Mitsuo Ochi
  • Journal Title: Physiol Genomics Volume: (in press)
  • Peer Reviewed
• [Journal Article] Enhancement of bone formation in an experimental bony defect using ferumoxide-labelled mesenchymal stromal cells and a magnetic targeting system (2010)
  • Author(s): Seigo Oshima, Mitsuo Ochi
  • Journal Title: J Bone Joint Surg Br Volume: 92 Pages: 1606-1613
  • Peer Reviewed
• [Journal Article] CD133+ cells from human umbilical cord blood reduce cortical damage and promote axonal growth in neonatal rat organ co-cultures exposed to hypoxia (2010)
  • Author(s): Norifumi Tanaka, Naosuke Kamei, Mitsuo Ochi
  • Journal Title: Int J Dev Neurosci Volume: 28 Pages: 581-587
  • NAID: 120002753660
  • Peer Reviewed
• [Journal Article] Silencing microRNA-34a inhibits chondrocyte apoptosis in a rat osteoarthritis model in vitro (2010)
  • Author(s): Muhamand M Abouheif, Tomoyuki Nakasa, Mitsuo Ochi
  • Journal Title: Rheumatology Volume: 49 Pages: 2054-2060
  • Peer Reviewed
• [Journal Article] Efficacy of bone marrow mononuclear cells to promote bone regeneration compared with isolated CD34+ cells from the same volume of aspirate (2010)
  • Author(s): Shinji Yasuhara, Mitsuo Ochi
  • Journal Title: Artif Organs Volume: 34 Pages: 594-599
  • Peer Reviewed
• [Journal Article] The effect of microRNA-21 on proliferation and matrix synthesis of chondrocytes embedded in atelocollagen gel (2010)
  • Author(s): Wilat Kongcharoensombat, Tomoyuki Nakasa, Nobuo Adachi, Mitsuo Ochi
  • Journal Title: Knee Surg Sports Traumatol Arthrosc Volume: 18 Pages: 1679-1684
  • Peer Reviewed
• [Journal Article] Bone-marrow-derived mononuclear cells with a porous hydroxyapatite scaffold for the treatment of osteonecrosis of the femoral head : a preliminary study (2010)
  • Author(s): Takuma Yamasaki, Mitsuo Ochi
  • Journal Title: J Bone Joint Surg Br Volume: 92 Pages: 337-341
  • Peer Reviewed
• [Journal Article] The effect of an external magnetic force on cell adhesion and proliferation of magnetically labeled mesenchymal stem cells (2010)
  • Author(s): Toshio Nakamae, Nobuo Adachi, Yomoyuki Nakasa, Mitsuo Ochi
  • Journal Title: Sports Med Arthrosc Rehabil Ther Technol Volume: 2 Pages: 5-5
  • Peer Reviewed
• [Journal Article] The effects of CD133-positive cells to a nonvascularized fasciocutaneous free graft in the rat model (2009)
  • Author(s): Misa Nakanishi, Takayuki Asahara, Mitsuo Ochi, et al.
  • Journal Title: Ann Plast Surg 63 Pages: 331-335
  • Peer Reviewed
• [Journal Article] Acceleration of skeletal muscle regeneration in a rat skeletal muscle injury model by local injection of human peripheral blood-derived CD133-positive cells (2009)
  • Author(s): Ming Shi, Naosuke Kamei, Tomoyuki Nakasa, Takayuki Asahara, Mitsuo Ochi, et al.
  • Journal Title: Stem Cells 27 Pages: 949-960
  • Peer Reviewed
• [Journal Article] Augmentation of degenerated human cartilage in vitro using magnetically labeled mesenchymal stem cells and an external magnetic device (2009)
  • Author(s): Takaaki Kobayashi, Mitsuo Ochi, et al.
  • Journal Title: Arthroscopy 25 Pages: 1435-1441
  • Peer Reviewed
• [Journal Article] Regeneration of peripheral nerve after transplantation of CD133(+) cells derived from human peripheral blood (2009)
  • Author(s): Yasumu Kijima, Naosuke Kamei, Takayuki Asahara, Mitsuo Ochi, et al.
  • Journal Title: J Neurosurg 110 Pages: 758-767
  • Peer Reviewed
• [Journal Article] Challenging for cartilage repair (2009)
  • Author(s): Mitsuo Ochi
  • Journal Title: Sports Medicine, Arthroscopy Rehabilitation, Therapy & Technology 1 Pages: 13-13
  • Peer Reviewed
• [Journal Article] Administration of human peripheral blood-derived CD133+ cells accelerates functional recovery in a rat spinal cord injury model (2009)
  • Author(s): Hirofumi Sasaki, Naosuke Kamei, Takayuki Asahara, Mitsuo Ochi, et al.
  • Journal Title: Spine 34 Pages: 249-254
  • NAID: 10027238220
  • Peer Reviewed
• [Presentation] Distraction arthroplasty と磁気ターゲティングシステムを用いた変形性膝関節症治療 (2013)
  • Author(s): 亀井 豪 器, 越 智 光 夫
  • Organizer: 第12回日本再生医療学会総会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2013-03-21
• [Presentation] 磁気誘導を用いた軟骨の再生 (2013)
  • Author(s): 越智光夫
  • Organizer: 平成 25 年電気学会全国大会
  • Place of Presentation: 名古屋大学(名古屋市)
  • Year and Date: 2013-03-20
• [Presentation] 膝関節のスポーツ外傷・障害 (2013)
  • Author(s): 越智光夫
  • Organizer: 朝日医学・医療セミナー
  • Place of Presentation: 電気ビルみらいホール(福岡市)
  • Year and Date: 2013-03-09
• [Presentation] 膝関節の生物学的再建 (2013)
  • Author(s): 越智光夫
  • Organizer: 福島県整形外科学術講演会
  • Place of Presentation: ホテルサンルートプラザ福島(福島市)
  • Year and Date: 2013-03-06
• [Presentation] 運動器の再生医療 (2013)
  • Author(s): 越智光夫
  • Organizer: 日本再生医療学会エデュケーショナルセミナー
  • Place of Presentation: 六本木ヒルズ(東京)
  • Year and Date: 2013-02-26
• [Presentation] Distraction arthroplastyと磁気ターゲティングシステムを用いた変形性膝関節症治療 (2013)
  • Author(s): 亀井豪器，越智光夫
  • Organizer: 第12回日本再生医療学会総会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Invited
• [Presentation] The future treatment of osteoarthritis (2012)
  • Author(s): Mitsuo Ochi
  • Organizer: The 18th National Congress of Indonesian Orthopaedic Association
  • Place of Presentation: Jakarta, Indonesia
  • Year and Date: 2012-11-21
• [Presentation] Past, present and future for cartilage repair (2012)
  • Author(s): Mitsuo Ochi
  • Organizer: The 7th International Congress of Chinese Orthopaedic Association
  • Place of Presentation: Beijing, China
  • Year and Date: 2012-11-15
• [Presentation] Cartilage repair; treatment options and outcomes (2012)
  • Author(s): Mitsuo Ochi
  • Organizer: Congress of Arthroscopy and Sports Medicine
  • Place of Presentation: Jaipur, India
  • Year and Date: 2012-11-08
• [Presentation] Biological reconstruction of the knee joint (2012)
  • Author(s): Mitsuo Ochi
  • Organizer: Annual Fall Meeting of Korean Orthopaedic Association
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2012-10-19
• [Presentation] Cartilage repair by cell therapy; Past, Present and Future (2012)
  • Author(s): Mitsuo Ochi
  • Organizer: Seminar in National Taiwan University
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2012-08-24
• [Presentation] Distraction arthroplasty in cartilage repair (2012)
  • Author(s): Mitsuo Ochi
  • Organizer: The 15th ESSKA CONGRESS
  • Place of Presentation: Geneva, Switzerland
  • Year and Date: 2012-05-02
• [Presentation] Emerging technology for cartilage repair (2012)
  • Author(s): Mitsuo Ochi
  • Organizer: The 9th IFOSMA & 22nd Chinese Endoscopy
  • Place of Presentation: Shanghai, China
  • Year and Date: 2012-04-26
• [Presentation] Magnetic delivered human CD133+ cells promote functional recovery in the rat spinal cord injury (2012)
  • Author(s): Fujioka Y, Kamei N, Ochi M
  • Organizer: 2012 Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: Moscone Convention Center. San Francisco, USA
  • Year and Date: 2012-02-04
• [Presentation] Magnetic targeting of human peripheral blood CD133+ cells promotes skeletal muscle regeneration (2012)
  • Author(s): Ohkawa S, Kamei N, Adachi N, Ochi M
  • Organizer: 2012 Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: Moscone Convention Center. San Francisco, USA
  • Year and Date: 2012-02-04
• [Presentation] Administration of microRNA-210 promotes spinal cord regeneration (2012)
  • Author(s): Ujigo S, Kamei N, Nakasa T, Ochi M
  • Organizer: 2012 Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: Moscone Convention Center. San Francisco, USA
  • Year and Date: 2012-02-04
• [Presentation] Contribution of endogenous endothelial progenitor cells to neovascularization and astrogliosis in spinal cord injury (2012)
  • Author(s): Kamei N, Ochi M
  • Organizer: 2012 Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: Moscone Convention Center. San Francisco, USA
  • Year and Date: 2012-02-04
• [Presentation] n Vivo Bioluminescence Imaging of Magnetically Targeted Bone Marrow Mesenchymal Stromal Cells Delivery with External Magnetic Force in Bone Fracture Models (2012)
  • Author(s): Kodama A, Kamei N, Ochi M
  • Organizer: 2012 Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: Moscone Convention Center. San Francisco, USA
  • Year and Date: 2012-02-04
• [Presentation] In vivo imaging of magnetic targeted bone marrow mesenchymal stem cells in skeletal muscle injury models (2012)
  • Author(s): Nakabayashi A, Kamei N, Ochi M
  • Organizer: 2012 Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: Moscone Convention Center. San Francisco, USA
  • Year and Date: 2012-02-04
• [Presentation] Spinal Cord Regeneration through the vasculogenesis (2012)
  • Author(s): Naosuke Kamei, Mitsuo Ochi
  • Organizer: The 18th National Congress of Indonesian Orthopaedic Association
  • Place of Presentation: Jakarta, Indonesia
  • Invited
• [Presentation] Cartilage repair –treatment options and outcomes (2012)
  • Author(s): Mitsuo Ochi
  • Organizer: Congress of Arthroscopy and Sports Medicine
  • Place of Presentation: Jaipur, India
  • Invited
• [Presentation] ヒト末梢血由来CD133陽性細胞の磁気ターゲティングによる骨格筋再生 (2012)
  • Author(s): 大川新吾，越智光夫
  • Organizer: 第27回日本整形外科学会基礎学術集会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
• [Presentation] 骨格筋損傷における磁気ターゲティングされた骨髄間葉系幹細胞のin vivoイメージング (2012)
  • Author(s): 中林昭裕，越智光夫
  • Organizer: 第27回日本整形外科学会基礎学術集会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
• [Presentation] 脊髄損傷に対する新たな血管再生治療 (2012)
  • Author(s): 亀井直輔，越智光夫
  • Organizer: 第27回日本整形外科学会基礎学術集会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
  • Invited
• [Presentation] 軟骨の再生医療 (2012)
  • Author(s): 越智光夫
  • Organizer: 第11回日本再生医療学会総会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Invited
• [Presentation] 骨髄間葉系細胞の磁気ターゲティングによる骨癒合促進：in vivoイメージングを用いた移植細胞の動態解析 (2012)
  • Author(s): 児玉祥，越智光夫
  • Organizer: 第11回日本再生医療学会総会
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Presentation] Distraction arthroplasty in cartilage repair (2012)
  • Author(s): Mitsuo Ochi
  • Organizer: The 15th ESSKA CONGRESS
  • Place of Presentation: Geneva, Switzerland
  • Invited
• [Presentation] 脊髄損傷に対する血管再生治療 (2011)
  • Author(s): 亀井直輔, 越智光夫
  • Organizer: 第46回日本脊髄障害医学会
  • Place of Presentation: 関西空港会議場(泉佐野市)(招待講演)
  • Year and Date: 2011-11-18
• [Presentation] Challenging of repairing large cartilage defects (2011)
  • Author(s): Ochi M
  • Organizer: The Annual Meeting of the Israel Society of Sports Medicine l & The 28th International Jerusalem Symposium on Sports Medicine
  • Place of Presentation: Kfar Hamaccabiah Hotel. Ramat Gan, Israel(招待講演)
  • Year and Date: 2011-11-03
• [Presentation] 骨髄間葉系幹細胞の磁気ターゲティングによる骨再生促進:in vivoイメージングを用いた移植細胞の動態解析 (2011)
  • Author(s): 児玉祥, 亀井直輔, 越智光夫
  • Organizer: 第26回日本整形外科学会基礎学術集会
  • Place of Presentation: ベイシア文化ホール(前橋市)
  • Year and Date: 2011-10-20
• [Presentation] 脊髄損傷に対するヒト末梢血由来CD133陽性細胞移植と外磁場デリバリーの効果 (2011)
  • Author(s): 藤岡悠樹, 亀井直輔, 越智光夫
  • Organizer: 第26回日本整形外科学会基礎学術集会
  • Place of Presentation: ベイシア文化ホール(前橋市)
  • Year and Date: 2011-10-20
• [Presentation] 骨格筋損傷における磁気ターゲティングされた骨髄間葉系幹細胞のin vivoイメージング (2011)
  • Author(s): 中林昭裕, 亀井直輔, 越智光夫
  • Organizer: 第26回日本整形外科学会基礎学術集会
  • Place of Presentation: ベイシア文化ホール(前橋市)
  • Year and Date: 2011-10-20
• [Presentation] 磁気標識したヒト間葉系幹細胞を用いた細胞導入と筋損傷修復に関する研究-磁気ターゲティングシステムを用いて- (2011)
  • Author(s): 大島誠吾, 亀井直輔, 中佐智幸, 安永裕司, 越智光夫
  • Organizer: 第26回日本整形外科学会基礎学術集会
  • Place of Presentation: ベイシア文化ホール(前橋市)
  • Year and Date: 2011-10-20
• [Presentation] ヒト末梢血由来CD133陽性細胞の磁気ターゲティングによる骨格筋再生 (2011)
  • Author(s): 大川新吾, 亀井直輔, 越智光夫
  • Organizer: 第26回日本整形外科学会基礎学術集会
  • Place of Presentation: ベイシア文化ホール(前橋市)
  • Year and Date: 2011-10-20
• [Presentation] 血管新生を介した脊髄再生治療の開発 (2011)
  • Author(s): 亀井直輔
  • Organizer: 第26回日本整形外科学会基礎学術集会
  • Place of Presentation: ベイシア文化ホール(前橋市)(招待講演)
  • Year and Date: 2011-10-20
• [Presentation] MicroRNA-210 as a novel therapy for spinal cord injury (2011)
  • Author(s): Hikmat Hadoush, 亀井直輔, 越智光夫
  • Organizer: 第26回日本整形外科学会基礎学術集会
  • Place of Presentation: ベイシア文化ホール(前橋市)
  • Year and Date: 2011-10-20
• [Presentation] Cartilage Repair-Past, Present and Future- (2011)
  • Author(s): Ochi M
  • Organizer: The 2nd Meeting of ACTO第2回アジア細胞治療学会
  • Place of Presentation: フェニックス・シーガイア・リゾート(宮崎市)(招待講演)
  • Year and Date: 2011-10-19
• [Presentation] Meniscus transplantation for articular cartilage defects in the knee joint (2011)
  • Author(s): Ochi M
  • Organizer: 34th Annual Scientific Meeting
  • Place of Presentation: Grand Copthorne Waterfront Hotel. Singapore(招待講演)
  • Year and Date: 2011-10-13
• [Presentation] 脊髄損傷に対するヒト末梢血由来CD133陽性細胞移植と外磁場デリバリーの効果 (2011)
  • Author(s): 藤岡悠樹, 亀井直輔, 越智光夫
  • Organizer: 第30回日本運動器移植・再生医学研究会
  • Place of Presentation: 福岡国際会議場(福岡市)
  • Year and Date: 2011-09-25
• [Presentation] 血管新生マイクロRNAによる脊髄再生 (2011)
  • Author(s): 亀井直輔, 中佐智幸, 越智光夫
  • Organizer: 第30回日本運動器移植・再生医学研究会
  • Place of Presentation: 福岡国際会議場(福岡市)
  • Year and Date: 2011-09-25
• [Presentation] Present Status and Future of Cartilage Repair (2011)
  • Author(s): 越智光夫
  • Organizer: 3rd JOSKAS 2011
  • Place of Presentation: 札幌コンベンションセンター(札幌市)(招待講演)
  • Year and Date: 2011-09-25
• [Presentation] Present status and future direction of cartilage repair (2011)
  • Author(s): Ochi M
  • Organizer: The 3rd International Cartilage and Osteoarthritis Symposium(ICOA 2011)
  • Place of Presentation: Ramada Plaza Suwon Hotel. Suwon, Korea(招待講演)
  • Year and Date: 2011-07-04
• [Presentation] 大学病院のこの4年と運動器の再生医療 (2011)
  • Author(s): 越智光夫
  • Organizer: 平成23年度広島大学循環器内科同門会総会
  • Place of Presentation: ホテルグランヴィア広島(広島市)(招待講演)
  • Year and Date: 2011-06-12
• [Presentation] Novel approaches to prevent or treat, osteoarthritis of the knee (2011)
  • Author(s): Ochi M
  • Organizer: 8th BIENNIAL ISAKOS CONGEESS
  • Place of Presentation: Riocentro Convention Center. Rio de Janeiro, Brazil(招待講演)
  • Year and Date: 2011-05-19
• [Presentation] Cartilage repair with magnetically labeled mesenchymal Stromal cells (2011)
  • Author(s): Ochi M
  • Organizer: 8th BIENNIAL ISAKOS CONGRESS
  • Place of Presentation: Riocentro Convention Center. Rio de Janeiro, Brazil(招待講演)
  • Year and Date: 2011-05-19
• [Presentation] 膝関節生物学的再建術 (2011)
  • Author(s): 越智光夫
  • Organizer: 第38回昭和大学整形外科支部総会
  • Place of Presentation: 東京都(招待講演)
  • Year and Date: 2011-03-12
• [Presentation] 新たな骨格筋再生治療の開発 (2011)
  • Author(s): 亀井直輔
  • Organizer: 第10回日本再生医療学会総会
  • Place of Presentation: 東京都(招待講演)
  • Year and Date: 2011-03-02
• [Presentation] 変形性膝関節症 その治療と予防-再生医療を中心に- (2011)
  • Author(s): 越智光夫
  • Organizer: 第3回長崎骨関節炎症セミナー
  • Place of Presentation: 長崎市(招待講演)
  • Year and Date: 2011-02-23
• [Presentation] Challenging of repairing large cartilage defects with minimally invasive technique (2011)
  • Author(s): Mitsuo Ochi
  • Organizer: 第5回GCOE国際シンポジウム 臨床経験からみた軟骨再生研究 -国際比較と近未来-
  • Place of Presentation: 東京都(招待講演)
  • Year and Date: 2011-02-03
• [Presentation] 運動器再生医療の現状と未来への挑戦 (2011)
  • Author(s): 亀井直輔
  • Organizer: 豊見城中央病院 院内講演会
  • Place of Presentation: 沖縄県 豊見城市(招待講演)
  • Year and Date: 2011-02-03
• [Presentation] Challenging of repairing large cartilage defects with minimally invasive technique (2010)
  • Author(s): Mitsuo Ochi
  • Organizer: 6th Meeting of The European Federation of National Associations of Orthopaedie Sports Traumatalogy
  • Place of Presentation: Brussels, Belgium(招待講演)
  • Year and Date: 2010-11-25
• [Presentation] 運動器疾患の再生医療 -広島大学発、近未来の治療法- (2010)
  • Author(s): 越智光夫
  • Organizer: 第43回霞祭
  • Place of Presentation: 広島市(招待講演)
  • Year and Date: 2010-11-13
• [Presentation] Cartilage Repair with Cell Delivery Using Magnetic Field and Distraction (2010)
  • Author(s): Mitsuo Ochi
  • Organizer: 7th Combined Meeting of the Orthopaedic Research Societies
  • Place of Presentation: Kyoto, Japan(招待講演)
  • Year and Date: 2010-10-19
• [Presentation] 磁場を利用した運動器の再生医療 (2010)
  • Author(s): 越智光夫
  • Organizer: 第25回日本整形外科学会基礎学術集会
  • Place of Presentation: 京都市(招待講演)
  • Year and Date: 2010-10-14
• [Presentation] 第二世代自家培養軟骨細胞移植による軟骨再生 (2010)
  • Author(s): 安達伸生
  • Organizer: 第25回日本整形外科学会基礎学術集会
  • Place of Presentation: 京都市(招待講演)
  • Year and Date: 2010-10-14
• [Presentation] Vascular nicheを利用した脊髄再生アプローチ (2010)
  • Author(s): 亀井直輔
  • Organizer: 第25回日本整形外科学会基礎学術集会
  • Place of Presentation: 京都市(招待講演)
  • Year and Date: 2010-10-14
• [Presentation] Challenge of repairing large cartilage defects with minimally invasive technique (2010)
  • Author(s): Mitsuo Ochi
  • Organizer: International Cartilage Repair Society 2010
  • Place of Presentation: Barcelona, Spain(招待講演)
  • Year and Date: 2010-09-27
• [Presentation] 軟骨修夏的過去、現在与未来 (2010)
  • Author(s): Mitso Ochi
  • Organizer: Shanghai 6th People's Hospital
  • Place of Presentation: Shanghai, China(招待講演)
  • Year and Date: 2010-08-23
• [Presentation] 膝関節疾患の臨床と軟骨再生医療 (2010)
  • Author(s): 越智光夫
  • Organizer: 富士フィルム株式会社社内講演会
  • Place of Presentation: 小田原市(招待講演)
  • Year and Date: 2010-07-23
• [Presentation] 運動器疾患に対する再生医療の実際 (2010)
  • Author(s): 越智光夫
  • Organizer: 第12回日本口腔顔面外傷学会総会・学術総会
  • Place of Presentation: 広島市(招待講演)
  • Year and Date: 2010-07-17
• [Presentation] 膝関節再建術2010 (2010)
  • Author(s): 越智光夫
  • Organizer: 第10回西はりま整形外科懇話会
  • Place of Presentation: 相生市(招待講演)
  • Year and Date: 2010-07-10
• [Presentation] 膝関節再建術-プロ選手を含む- (2010)
  • Author(s): 越智光夫
  • Organizer: 第6回広島ベイサイド骨・関節セミナー
  • Place of Presentation: 広島市(招待講演)
  • Year and Date: 2010-07-08
• [Presentation] Cartilage Repair-2010 Update (2010)
  • Author(s): Mitso Ochi
  • Organizer: 第7回アジア・オセアニア整形外科スポーツ医学会
  • Place of Presentation: 沖縄県宜野湾市(招待講演)
  • Year and Date: 2010-07-02
• [Presentation] 運動器再生医療の現状と課題 (2010)
  • Author(s): 安達伸生
  • Organizer: 第5回未来医療市民公開シンポジウム
  • Place of Presentation: 大阪市(招待講演)
  • Year and Date: 2010-06-23
• [Presentation] Advancements in treatment of cartilage lesions (2010)
  • Author(s): Mitso Ochi
  • Organizer: Ioannina University Visiting Professor
  • Place of Presentation: Ioannina, Greece(招待講演)
  • Year and Date: 2010-06-07
• [Presentation] 関節軟骨の再建術 (2010)
  • Author(s): 越智光夫
  • Organizer: 第83回日本整形外科学会学術総会
  • Place of Presentation: 東京都(招待講演)
  • Year and Date: 2010-05-28
• [Presentation] シンポジウム:膝関節軟骨欠損から変形性関節症まで (2010)
  • Author(s): 越智光夫
  • Organizer: 第83回日本整形外科学会学術総会
  • Place of Presentation: 東京都(招待講演)
  • Year and Date: 2010-05-28
• [Presentation] Past, Present and Future of Cartilage Repair (2010)
  • Author(s): Mitsuo Ochi
  • Organizer: POSNA Annual Meeting
  • Place of Presentation: Hawaii, USA(招待講演)
  • Year and Date: 2010-05-06
• [Presentation] My novel technique to repair articular cartilage defects (2010)
  • Author(s): Mitsuo Ochi
  • Organizer: POSNA Annual Meeting
  • Place of Presentation: Hawaii, USA(招待講演)
  • Year and Date: 2010-05-06
• [Presentation] 運動器の再生医療 -臨床応用の視点から- (2010)
  • Author(s): 越智光夫
  • Organizer: 第118回北海道整形災害外科学会
  • Place of Presentation: 札幌市
  • Year and Date: 2010-01-30
• [Presentation] (SOA Opening Lecture) Past, Present and Future of Cartilage Repair (2009)
  • Author(s): 越智光夫
  • Organizer: Singapore Orthopaedic Association 32nd Annual Scientific Meeting
  • Place of Presentation: Singapore
  • Year and Date: 2009-11-18
• [Presentation] Cell therapy using CD133+ cells from human peripheral blood for nerve (2009)
  • Author(s): 越智光夫
  • Organizer: 18th Sunderland meeting
  • Place of Presentation: Shanghai, China
  • Year and Date: 2009-11-02
• [Presentation] 再生医療 (2009)
  • Author(s): 越智光夫
  • Organizer: 広島西医療センター新棟完成記念講演会
  • Place of Presentation: 大竹市
  • Year and Date: 2009-10-07
• [Presentation] Cartilage repair (2009)
  • Author(s): 越智光夫
  • Organizer: The Prague Arthroscopy Symposium On Cartilage Surgery
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 2009-09-18
• [Presentation] 膝関節外科 現在から未来へ (2009)
  • Author(s): 越智光夫
  • Organizer: 第42回獨整会公開学術講演会
  • Place of Presentation: 宇都宮市
  • Year and Date: 2009-09-09
• [Presentation] (Keynote Lecture) Cartilage Repair with Emerging Technology (2009)
  • Author(s): 越智光夫
  • Organizer: The 2nd World Congress of Tissue Engineering and Regenerative Medicine
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-09-02
• [Presentation] 運動器の再生医療2009 (2009)
  • Author(s): 越智光夫
  • Organizer: 広島臨床骨関節研究会
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-08-07
• [Presentation] 運動器の再生医学 (2009)
  • Author(s): 越智光夫
  • Organizer: 広島大学原爆放射線医科学研究所血液内科開講50周年記念講演会
  • Place of Presentation: 広島市
  • Year and Date: 2009-07-18
• [Presentation] 運動器への再生医療2009 (2009)
  • Author(s): 越智光夫
  • Organizer: 第1回日本関節鏡・膝・スポーツ整形外科学会
  • Place of Presentation: 札幌市
  • Year and Date: 2009-06-27
• [Presentation] 運動器疾患の再生医療 (2009)
  • Author(s): 越智光夫
  • Organizer: 第55回岡山大学大学院整形外科学講座開講記念会
  • Place of Presentation: 岡山市
  • Year and Date: 2009-06-13
• [Presentation] Regenerative Medicine in Orthopaedics (2009)
  • Author(s): 越智光夫
  • Organizer: International sports medicine meeting of the Chinese Association of Sports Medicine
  • Place of Presentation: Qingdao, China
  • Year and Date: 2009-06-12
• [Presentation] Articular Cartilage Repair with Emerging Technology (2009)
  • Author(s): 越智光夫
  • Organizer: Second Annual Augustus Thorndike, M.D. Visiting Lecture
  • Place of Presentation: Boston, U.S.A.
  • Year and Date: 2009-05-21
• [Presentation] (Instructional Course Lectures) Therapy for chondral lesions-from bench to bedside (2009)
  • Author(s): 越智光夫
  • Organizer: 7th BIENNIAL ISAKOS CONGRESS
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2009-04-08
• [Presentation] (APOSSM Special Presentation) Recent advancements in cartilage repair (2009)
  • Author(s): 越智光夫
  • Organizer: 7th BIENNIAL ISAKOS CONGRESS
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2009-04-05
• [Presentation] 磁気誘導を用いた軟骨の再生
  • Author(s): 越智光夫
  • Organizer: 平成25年電気学会全国大会
  • Place of Presentation: 名古屋大学（名古屋市）
  • Invited
• [Presentation] 運動器の再生医療
  • Author(s): 越智光夫
  • Organizer: 日本再生医療学会エデュケーショナルセミナー
  • Place of Presentation: 六本木ヒルズ(東京都)
  • Invited
• [Presentation] 膝関節外科への取り組み
  • Author(s): 越智光夫
  • Organizer: 沖縄関節外科研究会
  • Place of Presentation: 沖縄ハーバービューホテルクラウンプラザ(沖縄市)
  • Invited
• [Presentation] 変形性膝関節症の病態と治療
  • Author(s): 越智光夫
  • Organizer: 八重山地区膝関節セミナー
  • Place of Presentation: ホテル日航八重山(石垣市)
  • Invited
• [Presentation] 変形性膝関節症の病態と治療
  • Author(s): 越智光夫
  • Organizer: 世羅郡医師会講演会
  • Place of Presentation: 公立世羅中央病院(広島県世羅郡)
  • Invited
• [Presentation] 関節軟骨再生へのチャレンジ
  • Author(s): 越智光夫
  • Organizer: 愛光学園60周年記念講演会
  • Place of Presentation: 松山全日空ホテル(松山市)
  • Invited
• [Presentation] Cartilage repair by cell therapy –Past, Present and Future-
  • Author(s): Mituso Ochi
  • Organizer: Seminar in National Taiwan University
  • Place of Presentation: Taipei, Taiwan
  • Invited
• [Presentation] 変形性膝関節症の病態と治療
  • Author(s): 越智光夫
  • Organizer: 第11回北海道整形外科教育フォーラム
  • Place of Presentation: 京王プラザホテル札幌（札幌市）
  • Invited
• [Presentation] 膝関節外科の進歩
  • Author(s): 越智光夫
  • Organizer: 第9回東葛関節鏡研究会
  • Place of Presentation: ホテルザマンハッタン海浜幕張(千葉市)
  • Invited
• [Book] 先進医療 NAVIGATOR(5.磁性化幹細胞,CD133 陽性 細胞と外磁場装置を用いた再生医療) (2013)
  • Author(s): 亀井豪器, 越智光夫
  • Total Pages: 189
  • Publisher: 日本医学出版
• [Book] 再生医療叢書 6 骨格系(11.骨格筋の再生) (2013)
  • Author(s): 亀井直輔,越智光夫
  • Total Pages: 181
  • Publisher: 朝倉書店
• [Book] 先進医療NAVIGATOR（5.磁性化幹細胞,CD133陽性細胞と外磁場装置を用いた再生医療） (2013)
  • Author(s): 亀井豪器, 越智光夫
  • Total Pages: 190
  • Publisher: 日本医学出版
• [Book] 再生医療叢書6 骨格系（11.骨格筋の再生） (2012)
  • Author(s): 亀井直輔，越智光夫
  • Total Pages: 181
  • Publisher: 朝倉書店
• [Patent(Industrial Property Rights)] 創外固定器および固定器セット (2012)
  • Inventor(s): 越智光夫, 青木雅昭
  • Industrial Property Rights Holder: 越智光夫, 青木雅昭
  • Industrial Property Number: 2012-135636
  • Filing Date: 2012-06-15
• [Patent(Industrial Property Rights)] 磁気誘導システムとその動作方法 (2012)
  • Inventor(s): 村上雅人, 越智光夫
  • Industrial Property Rights Holder: 村上雅人, 越智光夫
  • Industrial Property Number: 2011-537331
  • Filing Date: 2012-04-20
• [Patent(Industrial Property Rights)] 磁気誘導装置,磁気誘導システム (2009)
  • Inventor(s): 越智光夫,村上雅人
  • Industrial Property Rights Holder: 越智光夫
  • Industrial Property Number: 2009-244942
  • Filing Date: 2009-10-23
• [Patent(Industrial Property Rights)] 磁気誘導装置, 磁気誘導システム (2009)
  • Inventor(s): 越智光夫, 村上雅人
  • Industrial Property Rights Holder: 越智光夫
  • Industrial Property Number: 2009-244942
  • Filing Date: 2009-10-23