| Budget Amount *help |
¥47,710,000 (Direct Cost: ¥36,700,000、Indirect Cost: ¥11,010,000)
Fiscal Year 2011: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2010: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2009: ¥22,230,000 (Direct Cost: ¥17,100,000、Indirect Cost: ¥5,130,000)
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| Research Abstract |
In collaboration with expert spinal surgeons in Japan, we collected～ 1, 600 samples from patients with lumbar disc herniation(LDH). We analyzed their clinical and radiographic phenotypes in detail and established clinical database for LDH. Using these samples and data, we performed various genetic analyses(candidate gene approach based on expression profile and computer-prediction, and genome-wide association study) and identified several highly associated SNPs for LDH susceptibility, including those in genes involved in development of vertebral disc and proteoglycan metabolism.
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