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Elucidation of invasive andmetastatic mechanism in oral cancer for application to molecular based diagnosisand gene therapy

Research Project

Project/Area Number 21249088
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionHiroshima University

Principal Investigator

TAKATA Takashi  広島大学, 大学院・医歯薬保健学研究院, 教授 (10154783)

Co-Investigator(Kenkyū-buntansha) KUDO Yasusei  徳島大学, ヘルスバイオサイエンス研究部, 准教授 (50314753)
SINDOH Masanobu  北海道大学, 大学院・歯学研究科, 教授 (20162802)
HIDA Kyouko  北海道大学, 大学院・歯学研究科, 特任准教授 (40399952)
Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥45,630,000 (Direct Cost: ¥35,100,000、Indirect Cost: ¥10,530,000)
Fiscal Year 2012: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2011: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2010: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2009: ¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Keywords口腔癌 / 浸潤・転移 / microRNA / 浸潤 / 転移 / 血管新生 / 微小環境 / MMP10 / MMP13
Research Abstract

To elucidate invasive and metastatic mechanism in oral cancer for application to molecular based diagnosis and gene therapy, we conducted research in accordance with our projects. As a result, we identified Wnt5B and MMP10 as promoter of , microRNA-203 as suppressor of tumor invasion, Periostin as promoter of lymphangiogenesis, MMP-13 as promoter of angiogenesis. Additionally, we attempted to apply Periostin to Elisa for serum of oral cancer patients. Interestingly, we found upregulation of Periostin correlated with lymphonode metastasis status. Therefore, we showed Periostin could be a useful for molecular diagnostic marker in oral cancer.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (95 results)

All 2012 2011 2010 2009

All Journal Article (59 results) (of which Peer Reviewed: 46 results) Presentation (36 results)

  • [Journal Article] The 3D tissue microenvironment modulates DNA methylation and E-cadherin expression in squamous cell carcinoma2012

    • Author(s)
      Desrochers TM, Shamis Y, Alt-Holland A, Kudo Y, Takata T, Wang G, Jackson-Grusby L, Garlick JA.
    • Journal Title

      Epigenetics

      Volume: 7(1) Pages: 34-46

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear Aurora B and cytoplasmic Survivin expression is involved in lymph node metastasis of colorectal cancer2012

    • Author(s)
      Tuncel H, Shimamoto F, Kaneko H, Aoki E, Jikihara H, Nakai S, Takata T, Tatsuka M
    • Journal Title

      Oncology Let

      Volume: 3(5) Pages: 1109-1114

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Frequent increased gene copy number and high protein expression of tRNA (cytosine-5-)-methyltransferase (NSUN2) in human cancers.2012

    • Author(s)
      Okamoto M, Hirata S, Sato S, Koga S, Fujii M, Qi G, Ogawa I, Takata T, Shimamoto F, Tatsuka M
    • Journal Title

      DNA Cell Biol

      Volume: 31(5) Pages: 660-71

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Periostin Directly and Indirectly Promotes Tumor Lymphangiogenesis of Head and Neck Cancer.2012

    • Author(s)
      Kudo Y, Iizuka S, Yoshida M, Nguyen PT, Siriwardena BSMS, Tsunematsu T, Ohbayashi M, Ando T, Hatakeyama D, Shibata T, Koizumi K, Maeda M, Ishimaru N, Ogawa I, Takata T
    • Journal Title

      PLos ONE

      Volume: 7(8)

    • NAID

      120006714446

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Matrix metalloproteinase-13(MMP-13) directly and indirectly promotes tumor angiogenesis.2012

    • Author(s)
      Kudo.Y, Iizuka.S, Yoshida.M, Tsunematsu.T, Kondo T, Subarnbhesaj A, Deraz EM, Siriwardena SB, Tahara H, Ishimaru N, Ogawa I,Takata T
    • Journal Title

      J Biol Chem

      Volume: 287(46) Pages: 38716-28

    • NAID

      120006718351

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prostacyclin receptor in tumor endothelial cells promotes angiogenesis in an autocrine manner2012

    • Author(s)
      Osawa T, Ohga N, Hida Y, Kitayama K, Akiyama K, Onodera Y, Fujie M, Shinohara N, Nonomura K, Shindoh M, Hida K
    • Journal Title

      Cancer Sci

      Volume: 103(6) Pages: 1038-1044

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] Tumor-derived microvesicles induce proangiogenic phenotype in endothelial cells via endocytosis2012

    • Author(s)
      Kawamoto T, Ohga N, Akiyama K, Hirata N, Kitahara S, Maishi N., Osawa T., Yamamoto K., Kondoh M, Shindoh M, Hida Y, Hida K
    • Journal Title

      PLoS ONE

      Volume: 7(3)

    • NAID

      120005946706

    • Related Report
      2012 Final Research Report
  • [Journal Article] Biglycan is a specific marker and an autocrine angiogenic factor of tumour endothelial cells2012

    • Author(s)
      Yamamoto K, Ohga N, Hida Y, Maishi N, Kawamoto T, Kitayama K, Akiyama K, Osawa T, Kondoh M, Matsuda K, OnoderaY, Fujie M, Kaga K, Hirano S, Shinohara N, Shindoh M, Hida K
    • Journal Title

      Br J Cancer

      Volume: 106 Pages: 1214-1223

    • Related Report
      2012 Final Research Report
  • [Journal Article] CXCR7 : A novel tumor endothelial marker in renal cell carcinoma2012

    • Author(s)
      Maishi N, Ohga N, Hida Y, Akiyama K, Kitayama K, Osawa T, Onodera Y, Shinohara N, Nonomura K, Shindoh M, Hida K
    • Journal Title

      Pathol Int

      Volume: 62(5) Pages: 309-317

    • NAID

      10031185206

    • Related Report
      2012 Final Research Report
  • [Journal Article] Heterogeneity of Tumor Endothelial Cells: Comparison between Tumor Endothelial Cells Isolated from Highly Metastatic and Low Metastatic Tumors2012

    • Author(s)
      Ohga N, Ishikawa S, Maishi N, Akiyama K, Hida Y, Kawamoto T, Sadamoto Y, Osawa T,Yamamoto K,Kondoh M,Ohmura H,Shinohara N,Nonomura K,Shindoh M,Hida K
    • Journal Title

      Am J Pathol

      Volume: 180(3) Pages: 1294-1307

    • Related Report
      2012 Final Research Report
  • [Journal Article] Tumor endothelial cells acquire drug resistance by MDR1 upregulation via VEGF signaling in tumor microenvironment2012

    • Author(s)
      Akiyama K, Ohga N, Hida Y, Kawamoto T, Sadamoto Y., Ishikawa S, Maishi N, Akino T, Kondoh M, Matsuda A, Inoue N, Shindoh Mand Hida K
    • Journal Title

      Am J Pathol

      Volume: 180(3) Pages: 1283-1293

    • Related Report
      2012 Final Research Report
  • [Journal Article] Nuclear Aurora B and cytoplasmic Survivin expression is involed in lymph node metastasis of colorectal cancer2012

    • Author(s)
      Tuncel H, Shimamoto F, Kaneko H, Aoki E, Jikihara H, Nakai S, Takata T, et al.
    • Journal Title

      Oncology Letter

      Volume: 3(5) Pages: 1109-1114

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of receptor for hyaluronan-mediated motility (RHAMM) in MC3T3-E1 cells induces proliferation and differentiation through phosphorylation of ERK1/22012

    • Author(s)
      Hatano H, Shigeishi H, Kudo Y, Takata T 2012et al.
    • Journal Title

      J Bone Miner Metab

      Volume: 30(3) Pages: 293-303

    • NAID

      10031168780

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frequent increased gene copy number and high protein expression of tRNA (cytosine-5-)-methyltransferase (NSUN2) in human cancers2012

    • Author(s)
      Okamoto M, Hirata S, Sato S, Koga S Fujii M, Qi G, Ogawa I, Takata T, et al.
    • Journal Title

      DNA cell Biol

      Volume: 31(5) Pages: 660-671

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Periostin Directly and Indirectly Promotes Tumor Lymphangiogenesis of Head and Neck Cancer2012

    • Author(s)
      Kudo Y, Takata T et al.
    • Journal Title

      PLoS ONE

      Volume: 7(8)

    • NAID

      120006714446

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Matrix metalloproteinase-13 (MMP-13) directly and indirectly promotes tumor angiogenesis2012

    • Author(s)
      Kudo Y, Takata T et al.
    • Journal Title

      J Biol Chem

      Volume: 287(46) Pages: 38716-3828

    • NAID

      120006718351

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of Mesenchymal Cell Line Derived from Human Developing Odontoma2012

    • Author(s)
      Hatano H, Kudo Y, Takata T et al.
    • Journal Title

      Oral Diseases

      Volume: 18(8) Pages: 756-762

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of Receptor for Hyaluronan-Mediated Motility (RHAMM) in MC3T3-E1 induces the proliferation and differentiation through phosphorypation of ERK1/22012

    • Author(s)
      Hatano, H., Shigeishi, H., Kudo, Y., et al
    • Journal Title

      J Bone Miner Metabol

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor-derived microvesicles induce proangiogenic phenotype in endothelial cells via endocytosis2012

    • Author(s)
      Kawamoto T, Ohga N, Akiyama K, Hirata N, Kitahara S, Maishi N, Osawa T, et al
    • Journal Title

      PLoS ONE

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biglycan is a specific marker and an autocrine angiogenic factor of tumor endothelial cells2012

    • Author(s)
      Yamamoto K, Ohga N, Hida Y, Maishi N, Kawamoto T, Kitayama K, Akiyama K, Osawa T, Kondoh M, et al
    • Journal Title

      Br J Cancer

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heterogeneity of tumor endothelial cells : Comparison between tumor end othelial cells isolated from highly metastatic and low metastatic tumors2012

    • Author(s)
      Ohga N, Ishikawa S, Maishi N, Akiyama K, Hida Y, Kawamoto T, Sadamoto Y, Osawa T, Yamamoto K, et al
    • Journal Title

      Am J Pathol

      Volume: 180 Pages: 1294-1307

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor endothelial cells acquire drug resistance by MDR1 upregulation via VEGF signaling in tumor microenvironment2012

    • Author(s)
      Akiyama K, Ohga N, Hida Y, Kawamoto T, Sadamoto Y, Ishikawa S, Akino T, Kondoh M, Maishi N, Matsuda A, Inoue N, Shindoh M, Hida K
    • Journal Title

      Am J Pathol

      Volume: 180 Pages: 1283-1293

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclooxygenase-2 inhibition causes antiangiogenic effects on tumor end othelial and vascular progenitor cells2012

    • Author(s)
      Muraki C, Ohga N, Hida Y, Nishihara H, Kato Y, Tsuchiya K, Matsuda K, Totsuka Y, Shindoh M, Hida K
    • Journal Title

      Int J Cancer

      Volume: 130 Pages: 59-70

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MMP-10/stromelysin-2promotes invasion of head and neck cancer2011

    • Author(s)
      Deraz EM, Kudo Y, Yoshida M, Tani H, Tsunematsu, T, Siriwardena B.S.M.S, Kiekhaee MR, Qi G, Iizuka S, Ogawa, I, Campisi G, Lo Muzio L, Abiko Y, Kikuchi A, Takata T
    • Journal Title

      PLoS ONE

      Volume: 6(10)

    • NAID

      120005300499

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Incleased telomerase activity and hTERT expression in human salivary gland carcinomas2011

    • Author(s)
      Shigeishi H, Sugiyama M, Tahara H, Ono S, Bhawal UK, Okura M, Kogo M, Shinohara M, Shindoh M, Shintani S, Hamakawa H, Takata T, Kamata N
    • Journal Title

      Oncology Letter

      Volume: 2 Pages: 845-850

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] miR-22 represses cancer progression by inducing celular senescence2011

    • Author(s)
      Xu D, Takeshita F, Hino Y, Fukunaga S, Kudo Y, Tamaki A, Matsunaga J, Takahashi R, Takata T, Shimamoto A, Ochiya T, Tahara H
    • Journal Title

      J Cell Biol

      Volume: 193(2) Pages: 409-24

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] N-cadherin expression is involved in malignant behavior of head and neck cancer in relation to epithelial-mesenchymal transition2011

    • Author(s)
      Nguyen PT, Kudo Y, Yoshida M, Kamata N, Ogawa I, Takata T
    • Journal Title

      Histol Histopathol

      Volume: 26(2) Pages: 147-56

    • NAID

      120006727042

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] N-cadherin expression is correlated with metastasis of spindle cell carcinoma of head and neck region2011

    • Author(s)
      Nguyen PT, Kudo Y, Yoshida M, Iizuka S, Ogawa I, Takata T
    • Journal Title

      J Oral PatholMed

      Volume: 40(1) Pages: 77-82

    • NAID

      120006714448

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oncogenic role of RUNX3 in head and neck cancer2011

    • Author(s)
      Kudo Y, Tsunematsu T, Takata T
    • Journal Title

      J cell Biochem

      Volume: 112 Pages: 387-393

    • NAID

      120006714447

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cyclooxygenase-2 inhibition causes antiangiogenic effects on tumor endothelial and vascular progenitor cells2011

    • Author(s)
      Muraki C, Ohga N, Hida Y, Nishihara H, Kato Y, Tsuchiya K, Matsuda K,Totsuka Y, Shindoh M and Hida K
    • Journal Title

      Int J Cancer

      Volume: 130 Pages: 59-70

    • Related Report
      2012 Final Research Report
  • [Journal Article] HuR keeps an angiogenic switch on by stabilizing mRNA of VEGF and COX-2 in tumor endothelium2011

    • Author(s)
      Kurosu T, Ohga N, Hida Y, Maishi N, Akiyama K, Kakuguchi W, Kuroshima T, Kondo M., Akino T., Totsuka Y., Shindoh M,Higashino F and Hida K
    • Journal Title

      Br J Cancer

      Volume: 104(5) Pages: 819-829

    • Related Report
      2012 Final Research Report
  • [Journal Article] Phenotype of tumor lymphatic vessels is a prognostic factor in human tongue squamous cell carcinoma2011

    • Author(s)
      Nitta Y, Hida K, Kitamura T, Higashino F, Ohga N, Fukushima K, Shindoh M
    • Journal Title

      Oncol Lett

      Volume: 2(1) Pages: 79-83

    • Related Report
      2012 Final Research Report
  • [Journal Article] MMP-10/stromelysin-2 promotes invasion of head and neck cancer2011

    • Author(s)
      Deraz, E.M., Kudo, Y., et al
    • Journal Title

      PLoS ONE

      Volume: 6

    • NAID

      120005300499

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] miR-22 represses cancer progression by inducing cellular senescence2011

    • Author(s)
      Xu, D., Takeshita, F., Hino, Y., Fukunaga, S., Kudo, Y., et al
    • Journal Title

      J Cell Biol

      Volume: 193 Pages: 409-424

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered angiogenesis in the tumor microenvironment2011

    • Author(s)
      Hida K, Kawamoto T, Ohga N, Akiyama K, Hida Y, Shindoh M
    • Journal Title

      Pathol Int

      Volume: 61 Pages: 630-637

    • NAID

      10031185133

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Viral-mediated stabilization of AU-rich element containing raRNA contributes to cell transformation2011

    • Author(s)
      Kuroshima T, Aoyagi M, Yasuda M, Kitamura T, Jehung JP, Ishikawa M, Kitagawa Y, Totsuka Y, Shindoh M, Higashino F
    • Journal Title

      Oncogene

      Volume: 30 Pages: 2912-2920

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RANKL expression specifically observed in vivo promotes epithelial mesenchymal transition and tumor progression2011

    • Author(s)
      Yamada T, Tsuda M, Takahashi T, Kawaguchi H, Totsuka Y, Shindoh M, Ohba Y
    • Journal Title

      Am J Pathol

      Volume: 178 Pages: 2846-2857

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N-cadherin expression is involved in malignant behavior of head and neck cancer in relation to epithelial-mesenchymal transition.2011

    • Author(s)
      Nguyen PT, Kudo Y, Yoshida M, Kamata N, Ogawa I, Takata T.
    • Journal Title

      Histology and Histopathology

      Volume: 26(2) Pages: 147-156

    • NAID

      120006727042

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N-cadherin expression is correlated with metastasis of spindle cell carcinoma of head and neck region.2011

    • Author(s)
      Nguyen PT, Kudo Y, Yoshida M, Iizuka S, Ogawa I, Takata T.
    • Journal Title

      Journal of Oral Pathology and Medicine

      Volume: 40(1) Pages: 77-82

    • NAID

      120006714448

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oncogenic role of RUNX3 in head and neck cancer.2011

    • Author(s)
      Kudo Y, Tsunematsu T, Takata T
    • Journal Title

      Journal of Cellular Biochemistry

      Volume: 112(2) Pages: 387-393

    • NAID

      120006714447

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] miR-22 provides a direct link between cellular senescence and tumorigenesis.2011

    • Author(s)
      Xu, D., Takeshita, F., Hino, Y., Fukunaga, S., Kudo, Y., Tamaki, A., Matsunaga, J., Takahashi, R., Takata, T., Shimamoto, A., Ochiya, T., Tahara, H.
    • Journal Title

      Journal of Cellular Biology

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclooxygenase-2 inhibition causes antiangiogenic effects on tumor endothelial and vascular progenitor cells.2011

    • Author(s)
      Muraki C, Ohga N, Hida Y, Nishihara H, Kato Y, Tsuchiya K, Matsuda K, Totsuka Y, Shindoh M, Hida K.
    • Journal Title

      International Journal of Cancer

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Viral-mediated stabilization of AU-rich element containing mRNA contributes to cell transformation.2011

    • Author(s)
      Kuroshima T, Aoyagi M, Yasuda M, Kitamura T, Jehung JP, Ishikawa M, Kitagawa Y, Totsuka Y, Shindoh M, Higashino F.
    • Journal Title

      Oncogene

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HuR keeps an angiogenic switch on by stabilising mRNA of VEGF and COX-2 in tumour endothelium.2011

    • Author(s)
      Kurosu T, Ohga N, Hida Y, Maishi N, Akiyama K, Kakuguchi W, Kuroshima T, Kondo M, Akino T, Totsuka Y, Shindoh M, Higashino F, Hida K.
    • Journal Title

      British Journal of Cancer

      Volume: 104(5) Pages: 819-829

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear Survivin expression is correlated with malignant behaviors of head and neckcancer together with Aurora-B2010

    • Author(s)
      Qi G, Kudo Y, Ando T, Tsunematsu T, Shimizu N, Siriwardena S, Yoshida M, Keikhaee M, Ogawa I, Takata T
    • Journal Title

      Oral Oncol

      Volume: 46(4) Pages: 263-70

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Isolated tumor endothelial cells maintain specific character during long-term culture2010

    • Author(s)
      Matsuda K, Ohga N, Hida Y, Muraki C, Kurosu T, Tsuchiya K, Akino T., Shih SC, Totsuka Y, Klagsbrun M, Shindoh M and Hida K
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 394 Pages: 947-954

    • Related Report
      2012 Final Research Report
  • [Journal Article] Adrenomedullin antagonist suppresses tumor formation in renal cell carcinoma through inhibitory effects on tumor endothelial cells and endothelial progenitor mobilization2010

    • Author(s)
      Tsuchiya K, Hida K, Hida Y, Muraki C, Ohga N, Kondo T, Miseki T, Nakagawa K, Shindoh M, Harabayashi T., Shinohara N, Nonomura K and Kobayashi M
    • Journal Title

      Int J Oncol

      Volume: 36(6) Pages: 1379-1386

    • NAID

      120003370695

    • Related Report
      2012 Final Research Report
  • [Journal Article] A multiple primary carcinoma consisting of leukoplakia and SCC : a case report with p53 mutation analysis.2010

    • Author(s)
      Hassan NM, Tada M, Shindoh M, Hamada J, Kashiwazaki H, Shimo T, Ashikaga Y, Yamazaki Y, Sasaki A, Moriuchi T, Inoue N.
    • Journal Title

      Anticancer Research

      Volume: 30(11) Pages: 4773-4778

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adrenomedullin antagonist suppresses tumor formation in renal cell carcinoma through inhibitory effects on tumor endothelial cells and endothelial progenitor mobilization.2010

    • Author(s)
      Tsuchiya K, Hida K, Hida Y, Muraki C, Ohga N, Akino T, Kondo T, Miseki T, Nakagawa K, Shindoh M, Harabayashi T, Shinohara N, Nonomura K, Kobayashi M.
    • Journal Title

      International Journal of Oncology

      Volume: 36(6) Pages: 1379-1386

    • NAID

      120003370695

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HuR knockdown changes the oncogenic potential of oral cancer cells.2010

    • Author(s)
      Kakuguchi W, Kitamura T, Kuroshima T, Ishikawa M, Kitagawa Y, Totsuka Y, Shindoh M, Higashino F.
    • Journal Title

      Molecular Cancer Research

      Volume: 8(4) Pages: 520-528

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolated tumor endothelial cells maintain specific character during long-term culture.2010

    • Author(s)
      Matsuda K, Ohga N, Hida Y, Muraki C, Tsuchiya K, Kurosu T, Akino T, Shih SC, Totsuka Y, Klagsbrun M, Shindoh M, Hida K.
    • Journal Title

      Molecular Cancer Research

      Volume: 394(4) Pages: 947-954

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear Survivin expression is correlated with malignant behaviors of head and neck cancer together with Aurora-B2010

    • Author(s)
      Qi G, Kudo Y, Ando T, Tsunematsu T, Shimizu N, Siriwardena S, Yoshida M, Keikhaee M, Ogawa I, Takata T.
    • Journal Title

      Oral Oncology (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oncogenic role of nuclear accumulated Aurora-A.2009

    • Author(s)
      Tatsuka M, Sato S, Kanda A, Miki T, Kamata N, Kitajima S, Kudo Y, Takata T
    • Journal Title

      Mol Carcinogen

      Volume: 48 Pages: 810-820

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant β-catenin expression and adenomatous polyposis coli gene mutation in ameloblastoma and odontogenic carcinoma2009

    • Author(s)
      Siriwardena BS, Kudo Y, Ogawa I, Tilakaratne WM, Takata T
    • Journal Title

      Oral Oncol

      Volume: 45 Pages: 103-108

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] RUNX3 has an oncogenic role in head and neck cancer.2009

    • Author(s)
      Tsunematsu T, Kudo Y, Iizuka S, Ogawa I, Fujita T, Kurihara H, Abiko Y, Takata T
    • Journal Title

      PLoS ONE

      Volume: 4

    • NAID

      120006714449

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory Effects of Epigallocatechin-3 Gallate, a Polyphenol in Green Tea, on Tumor-Associated Endothelial Cells and Endothelial Progenitor Cells2009

    • Author(s)
      Ohga N, Hida K, Hida Y, Muraki C, Tsuchiya K,Matsuda K, Ohiro Y,Totsuka Y and Shindoh M
    • Journal Title

      Cancer Sci

      Volume: 100(10) Pages: 1963-1970

    • NAID

      10027196113

    • Related Report
      2012 Final Research Report
  • [Journal Article] Cytogenetic Abnormalities of Tumor-Associated Endothelial Cells in Human Malignant Tumor2009

    • Author(s)
      Akino T, Hida K,Hida Y, Tsuchiya K, Freedman D, Muraki C, Ohga N, Matsuda K, Harabayashi T, Shinohara N, Nonomura K,KlagsbrunM and Shindoh M
    • Journal Title

      Am J Pathol

      Volume: 175(6) Pages: 2657-2667

    • Related Report
      2012 Final Research Report
  • [Journal Article] Oncogenic role of nuclear accumulated Aurora-A2009

    • Author(s)
      Tatsuka M, Sato S, Kanda A, Miki T, Kamata N, Kitajima S, Kudo Y, Takata T.
    • Journal Title

      Molecular Carcinogenesis 48

      Pages: 810-820

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RUNX3 has an oncogenic role in head and neck cancer2009

    • Author(s)
      Tsunematsu T, Kudo Y, Iizuka S, Ogawa I, Fujita T, Kurihara H, Abiko Y, Takata T.
    • Journal Title

      PLoS ONE 4

    • NAID

      120006714449

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] FGFR-1 inhibitor PD173074 induces mesenchymal-epithelial tramsition through suppression of AP-1 in Head and Neck Squamous Cel Carcinoma2012

    • Author(s)
      Nguyen PT, Inubushi T, Tsunematsu T, Kudo Y, Kamata N, Ogawa I, Takata T
    • Organizer
      第23回日本臨床口腔病理学会・学術大会
    • Place of Presentation
      東京
    • Year and Date
      2012-08-30
    • Related Report
      2012 Final Research Report
  • [Presentation] FGFR-1 inhibitor PD173074 induces mesenchymal-epithelial tramsition through suppression of AP-1 in Head and Neck Squamous Cell Carcinoma2012

    • Author(s)
      Nguyen PT, Inubushi T, Tsunematsu T, Kudo Y, Kamata N, Ogawa I, Takata T
    • Organizer
      Cold Spring Harbor Meeting, Models & Mechanisms of Cancer
    • Place of Presentation
      New York, USA
    • Year and Date
      2012-08-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Identification of microRNA-203 as an invasion in oral cancer2012

    • Author(s)
      大林真理子, 吉田真希, 工藤保誠, 高田 隆
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] Ameloblastinの癌抑制遺伝子としての役割の解明2012

    • Author(s)
      安藤俊範,常松貴明,工藤保誠,小川郁子,宮内睦美, 高田 隆
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 細胞分裂期キナーゼAurora-AによるDNA複製調節機構2012

    • Author(s)
      常松貴明, 工藤保誠, 高田 隆
    • Organizer
      第101回日本病理学会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] The role as tumor suppressor gene and the expression of Ameloblastin in osteosarcoma2012

    • Author(s)
      安藤俊範,常松貴明,工藤保誠,小川郁子,宮内睦美,高田 隆
    • Organizer
      第66回日本口腔科学会
    • Place of Presentation
      広島
    • Related Report
      2012 Annual Research Report
  • [Presentation] The novel function of Ameloblastin as a tumor suppressor gene in osteosarcoma2012

    • Author(s)
      安藤俊範,常松貴明,工藤保誠, 小川郁子,宮内睦美,高田 隆
    • Organizer
      第45回広島大学歯学会
    • Place of Presentation
      広島
    • Related Report
      2012 Annual Research Report
  • [Presentation] FGFR-1 inhibitor PD173074 induces mesenchymal-epithelial tramsition through suppression of AP-1 in Head and Neck Squamous Cell Carcinoma2012

    • Author(s)
      Nguyen PT, Inubushi T, Tsunematsu T, Kudo Y, Kamata N, Ogawa I, Takata T
    • Organizer
      Cold Spring Harbor Meeting, Models & Mechanisms of Cancer
    • Place of Presentation
      New York (USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 分裂期キナーゼAurora-AによるDNAライセンス化抑制因子Gemininの安定化機構2012

    • Author(s)
      常松貴明, 工藤保誠, 高田 隆
    • Organizer
      第23回日本臨床口腔病理学会・学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] FGFR-1 inhibitor PD173074 induces mesenchymal-epithelial tramsition through suppression of AP-1 in Head and Neck Squamous Cell Carcinoma2012

    • Author(s)
      Nguyen PT, Inubushi T, Tsunematsu T, Kudo Y, Kamata N, Ogawa I, Takata T
    • Organizer
      第23回日本臨床口腔病理学会・学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification of microRNA-203 as an invasion in oral cancer2012

    • Author(s)
      大林真理子, 吉田真希, 工藤保誠, 高田 隆
    • Organizer
      第23回日本臨床口腔病理学会・学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 細胞分裂期におけるDNA複製因子Gemininのユビキチン分解機構とその新たな役割2012

    • Author(s)
      常松貴明, 工藤保誠, 高田 隆
    • Organizer
      第54回日本歯科基礎医学会学術大会
    • Place of Presentation
      郡山
    • Related Report
      2012 Annual Research Report
  • [Presentation] Geminin escapes from ubiquitin-mediated degradation by Aurora-A induced phosphorylation during mitosis2012

    • Author(s)
      常松 貴明, 工藤 保誠, 高田 隆
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] The Novel Tumor Suppressor Function Of Ameloblastin In Osteosarcoma2012

    • Author(s)
      Ando T, Tsunematsu T, Kudo Y, Ogawa I, Miyauchi M, Takata T
    • Organizer
      第60回国際歯科研究学会日本部会総会・学術大会(JADR)
    • Place of Presentation
      新潟
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification of novel invasion related molecules in oral cancer2011

    • Author(s)
      工藤保誠
    • Organizer
      第5回アジア口腔病理学会・第22回日本臨床口腔病理学会総会・学術大会
    • Place of Presentation
      福岡市(九州大学医学部)(招待講演)
    • Year and Date
      2011-08-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Identification of microRNA-203 as an inhibitor of invasion in oral cancer2011

    • Author(s)
      Obayashi M, Kudo Y, Yoshida M, Hino Y, Fukunaga S, Tahara H,Takata T
    • Organizer
      59th JADR Annual Meeting
    • Place of Presentation
      広島市
    • Related Report
      2012 Final Research Report
  • [Presentation] 口腔癌における浸潤抑制因子としてのmiR-203の同定2011

    • Author(s)
      大林真理子,工藤保誠,吉田真希,日野由美子,福永早央里,田原栄俊,高田 隆
    • Organizer
      第30回分子病理学研究会
    • Place of Presentation
      倉敷市
    • Related Report
      2012 Final Research Report
  • [Presentation] 頭頸部癌の浸潤に関わるmicroRNAの探索2010

    • Author(s)
      吉田真希, 工藤保誠, 高田隆
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 頭頸部扁平上皮癌におけるRUNX3の過剰発現機構2010

    • Author(s)
      常松貴明, 工藤保誠, 高田隆
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 口腔扁平上皮癌における転写因子RUNX3の発現制御機構とその役割2010

    • Author(s)
      常松貴明, 工藤保誠, 高田隆
    • Organizer
      先端歯学スクール2010
    • Place of Presentation
      三浦市
    • Year and Date
      2010-09-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Identification and characterization of new invasion relating molecules of head and neck squamous cell carcinoma2010

    • Author(s)
      工藤保誠
    • Organizer
      The 120th Anniversary of Siriraj Medical School Siriraj Scientific Congress
    • Place of Presentation
      バンコク市(タイ)(招待講演)
    • Year and Date
      2010-08-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Identification and characterization of new invasion relating molecules of head and neck squamous cell carcinoma2010

    • Author(s)
      Kudo Y
    • Organizer
      The 120th Anniversary of Siriraj Medical School Siriraj Scientific Congress
    • Place of Presentation
      バンコク,タイ
    • Year and Date
      2010-08-17
    • Related Report
      2012 Final Research Report
  • [Presentation] N-cadherin expression is involved in malignant behavior of head and neck cancer in relation to epithelial-mesenchymal transition2010

    • Author(s)
      Ohbayashi M, Nguyen PT, Kudo Y, Yoshida M, Miyauchi M, Ogawa I, Takata T.
    • Organizer
      15^<th> International Congress on Oral Patholofy and Medicine
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2010-08-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Runx3 has an Oncogenic role in head and neck cancer2010

    • Author(s)
      工藤保誠、常松貴明、高田隆
    • Organizer
      17^<th> RUNX Meeting
    • Place of Presentation
      広島市
    • Year and Date
      2010-07-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 口腔扁平上皮癌における転写因子RUNX3の発現制御機構とその役割2010

    • Author(s)
      常松貴明, 工藤保誠, 高田隆
    • Organizer
      第64回日本口腔科学会
    • Place of Presentation
      札幌市
    • Year and Date
      2010-06-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 口腔癌の浸潤に関与する microRNA の網羅的解析2010

    • Author(s)
      吉田真希、工藤保誠、高田 隆
    • Organizer
      第43回広島大学歯学会総会
    • Place of Presentation
      広島市
    • Year and Date
      2010-06-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 口腔癌の浸潤に関与するmicroRNAの網羅的解析2010

    • Author(s)
      吉田真希、工藤保誠、高田隆
    • Organizer
      第43回広島大学歯学会総会
    • Place of Presentation
      広島市
    • Year and Date
      2010-06-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 口腔扁平上皮癌におけるSurvivinとAurora-Bの過剰発現2010

    • Author(s)
      工藤保誠, 斉広塋, 小川郁子, 高田隆
    • Organizer
      第99回日本病理学会
    • Place of Presentation
      東京都
    • Year and Date
      2010-04-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] HSulf-1は頭頸部癌の浸潤を促進する2010

    • Author(s)
      吉田真希, 工藤保誠, 小川郁子, 高田隆
    • Organizer
      第99回日本病理学会
    • Place of Presentation
      東京都
    • Year and Date
      2010-04-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] N-cadherin expression is involved in malignant behavior of head and neck cancer in relation to epithelial-mesenchymal transition2010

    • Author(s)
      Ohbayashi M,Nguyen PT,Kudo Y, Yoshida M,Miyauchi M,Ogawa I,Takata T
    • Organizer
      15th International Congress on Oral Pathology and Medicine
    • Place of Presentation
      ソウル, 韓国
    • Related Report
      2012 Final Research Report
  • [Presentation] 頭頸部癌の浸潤に関わる microRNA の探索2010

    • Author(s)
      吉田真希,工藤保誠,高田 隆
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      大阪市
    • Related Report
      2012 Final Research Report
  • [Presentation] 口腔癌の浸潤における MMP-10 の役割2010

    • Author(s)
      工藤保誠,高田 隆
    • Organizer
      第64回日本口腔科学会
    • Place of Presentation
      札幌市
    • Related Report
      2012 Final Research Report
  • [Presentation] HSulf-1 は頭頸部癌の浸潤を促進する2010

    • Author(s)
      吉田真希,工藤保誠,小川郁子,高田 隆
    • Organizer
      第99回日本病理学会
    • Place of Presentation
      東京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Co-expression of nuclear Survivin and Aurora-B shows malignant behavior of head and neck cancer2009

    • Author(s)
      斉広塋, 工藤保誠, 安藤敏範, 吉田真希, 高田隆
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] HSulf-1 は頭頚部癌の浸潤を促進する2009

    • Author(s)
      吉田真希,工藤保誠, ヌーウィン・ティ・フーン・タオ,小川郁子, 高田 隆
    • Organizer
      第20回日本臨床口腔病理学会総会・学術大会
    • Place of Presentation
      札幌市
    • Related Report
      2012 Final Research Report
  • [Presentation] HSulf-1 promotes the invasion of head and neck cancer2009

    • Author(s)
      吉田真希,工藤保誠,小川郁子,高田 隆
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜市
    • Related Report
      2012 Final Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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