• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Immunotherapeutic analysis using newly established murine models for Sjogren' s syndrome

Research Project

Project/Area Number 21249090
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionThe University of Tokushima

Principal Investigator

HAYASHI Yoshio  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 客員教授 (00127854)

Co-Investigator(Kenkyū-buntansha) ARAKAKI Rieko  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (40231120)
YAMADA Akiko  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (70452646)
ISHIMARU Naozumi  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (60314879)
新垣 理恵子  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (00193061)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥46,150,000 (Direct Cost: ¥35,500,000、Indirect Cost: ¥10,650,000)
Fiscal Year 2011: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2010: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2009: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Keywordsシェーグレン症候群 / 自己免疫疾患 / 治療法開発 / RbAp48 / CCR7 / エストロゲン / アロマターゼ / RNA干渉 / カテプシンL
Research Abstract

We reported that transgenic(TG) expression of RbAp48, and CCR7 knockout(KO) mice resulted in the development of autoimmune exocrinopathy resembling Sjogren' s syndrome. CD4^+ T cell-mediated autoimmune lesions were aggravated with age, in association with autoantibody productions. We obtained evidences that salivary epithelial cells can produce interferon-γand interleukin-18, which activates interferon regulatory factor-1(IRF-1), and class II transactivator(CIITA). Regulatory T(Treg) cells were significantly retained in the lymph nodes of CCR7KO mice, and failed to patrol within the exocrine organs to protect autoimmunity. The gene targeting for RbAp48 with application of in vivo siRNA administration prevented autoimmune lesions. These results indicate a novel immunocompetent role of epithelial cells, resulting in loss of local tolerance prior to developing gender-based autoimmunity.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (79 results)

All 2012 2011 2010 2009

All Journal Article (36 results) (of which Peer Reviewed: 26 results) Presentation (42 results) Book (1 results)

  • [Journal Article] CCR7 with S1P1signaling through AP-1 for migration of Foxp3+ regulatory T-cells control autoimmune exocrinopathy2012

    • Author(s)
      Ishimaru N, Yamada A, Nitta T, Arakaki R, Lipp M, Takahama Y, Hayashi Y
    • Journal Title

      Am. J. Pathol

      Volume: 180 Pages: 199-208

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] CCR7 with S1P1 signaling through AP-1 fir nugratuib if Foxp3+ reguratory T-cell controls autoimmune exocrinopathy2012

    • Author(s)
      Ishimaru N, 他
    • Journal Title

      Am J Pathol

      Volume: 180 Pages: 199-208

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atelocollagen-mediated systemic administration of myostatin-targeting siRNA improves muscular atrophy in caveolin-3-deficient mice2011

    • Author(s)
      Kawakami E, Kinouchi N, Adachi T, Ohsawa Y, Ishimaru N, Ohuchi H, Sunada Y, Hayashi Y, Noji S
    • Journal Title

      Dev Growth Differ

      Volume: 53(1) Pages: 48-54

    • NAID

      10027899274

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel DC therapy with manipulation of MKK6 gene on Nickel allergy in mice2011

    • Author(s)
      Watanabe M, Ishimaru N, Ashrin MN, Arakaki R, Yamada A, Ichikawa T, Hayashi Y
    • Journal Title

      PLoS One

      Volume: 6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development2011

    • Author(s)
      Lei Y, Mat Ripen A, Ishimaru N, Ohigashi I, Nagasawa T, Jeker L, Bosl M, Hollander GA, Hayashi Y, de Waal Malefyt R, Nitta T, Takahama Y
    • Journal Title

      J. Exp. Med

      Volume: 208 Pages: 383-394

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sjogren症候群2011

    • Author(s)
      林良夫、新垣理恵子、石丸直澄
    • Journal Title

      日本内科学会雑誌

      Volume: 100 Pages: 1262-1268

    • NAID

      10029097111

    • Related Report
      2011 Final Research Report
  • [Journal Article] RANKLとFasによる免疫応答の制御2011

    • Author(s)
      石丸直澄、井澤俊、林良夫
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 55 Pages: 142-147

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] Autoimmune disease : Sjogren's syndrome2011

    • Author(s)
      Hayashi Y, 他
    • Journal Title

      Nihon Naika Gakkai Zasshi

      Volume: 10 Pages: 1262-1268

    • Related Report
      2011 Annual Research Report
  • [Journal Article] novel DC therapy with manipulation of MKK6 gene on nickel allergy in mic2011

    • Author(s)
      Watanabe M, 他
    • Journal Title

      Plos One

      Volume: 6

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aire-dependent production of XCL1 medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development.2011

    • Author(s)
      Lei Y, Ripin AM, 他
    • Journal Title

      J Exp Med

      Volume: 208 Pages: 383-394

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In situ patrolling of regulatory T cells is essential for protecting autoimmune exocrinopaty2010

    • Author(s)
      Ishimaru N, Nitta T, Arakaki R, Yamada A, Lipp M, Takahama Y, Hayashi Y
    • Journal Title

      PLoS One

      Volume: 5(1)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cathepsin L inhibition prevents murine autoimmune diabetes via suppression of CD8+ T cell activity2010

    • Author(s)
      Yamada A, Ishimaru N, Arakaki R, Katunuma N, Hayashi Y
    • Journal Title

      PLoS One

      Volume: 5(9)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inflammatory disease and cancer with a decrease in Kupffer cell numbers in Nucling-knockout mice2010

    • Author(s)
      Sakai T, Liu L, Teng X, Ishimaru N, Tran NH, Kim SM, Sano N, Hayashi Y, Kaji R, Fukui K.
    • Journal Title

      Int. J. Cancer

      Volume: 126 Pages: 1079-1094

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunotherapeutic target in estrogen deficiency-dependent Sjogren' s syndrome-related manifestations2010

    • Author(s)
      Arakaki R, Ishimaru N, Hayashi Y
    • Journal Title

      Immunotherapy

      Volume: 2(3) Pages: 339-346

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 新生児におけるダイオキシンへの暴露と自己免疫病の発生2010

    • Author(s)
      石丸直澄、小橋真之、山田安希子、新垣理恵子、林良夫
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 53(1) Pages: 92-96

    • Related Report
      2011 Final Research Report
  • [Journal Article] Immunotherapeutic targets in estrogen deficiency-dependent Sjogren's syndrome-related manifestations.2010

    • Author(s)
      Arakaki R, 他
    • Journal Title

      Immunotherapy

      Volume: 2 Pages: 339-346

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Delivery of small interfering RNA with a synthetic collagen poly (Pro-Hyp-Gly) for gene silencing in vitro and in vivo.2010

    • Author(s)
      Adachi T, 他
    • Journal Title

      Dev Growth Differ

      Volume: 52 Pages: 693-699

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cathepsin L inhibition prevents murine autoimmune diabetes via suppression of CD8+ T cell activity.2010

    • Author(s)
      Yamada A, 他
    • Journal Title

      PLoS One

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atelocollagen-mediated systemic ad2010

    • Author(s)
      Kawakami E, 他
    • Journal Title

      PLoS One

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In situ patrolling of regulatory T cells is essential for protecting autoimmune exocrinopathy2010

    • Author(s)
      Ishimaru N, 他
    • Journal Title

      PLoS One 5

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inflammatory disease and cancer with a decrease in Kupffer cell numbers in Nucline-knockout mice.2010

    • Author(s)
      Sakai T, 他
    • Journal Title

      Int J Cancer 126

      Pages: 1079-1094

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of plasmacytoid dendritic cells(pDCs) for aberrant class II expression in the exocrine glands from estrogen-deficient mice of healthy background2009

    • Author(s)
      Arakaki R, Nagaoka A, Ishimaru N, Yamada A, Yoshida S, Hayashi Y
    • Journal Title

      Am. J. Pathol

      Volume: 174 Pages: 1715-1724

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neonatal explosure to low dose 2, 3, 7, 8-tetrachlorodibenzo-p-diozin causes autoimmunity due to the disruption of T cell tolerance2009

    • Author(s)
      Ishimaru N, Takagi A, Kohashi M, Yamada A, Arakaki R, Kanno J, Hayashi Y.
    • Journal Title

      J. Immunol

      Volume: 182 Pages: 6576-6586

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of fractalkine as accelerating factor on the autoimmune exocrinopathy in mice2009

    • Author(s)
      Tsubota K, Nishiyama T, Mishima K, Inoue H, Doi T, Hattori Y, Kodama T, Higuchi A, Hayashi Y, Saito I
    • Journal Title

      Invest. Ophthalmol. Vis. Sci

      Volume: 50 Pages: 4753-4760

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Real-time in vivo imaging of p16Ink4a reveals cross talk with p532009

    • Author(s)
      Yamakoshi K, Takahashi A, Hirota F, Nakayama R, Ishimaru N, Kubo Y, Mann DJ, Ohmura M, Hirao A, Saya H, Arase S, Hayashi Y, Nakao K, Matsumoto M, Ohtani N, Hara E.
    • Journal Title

      J. Cell Biol

      Volume: 186 Pages: 393-407

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] YKL-40 secreted from adipose tissue inhibits degradation of type I collagen2009

    • Author(s)
      Iwata T, Kuwajima M, Sukeno A, Ishimaru N, Hayashi Y, Wabitsch M, Mizusawa N, Itakura M, Yoshimoto K.
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 388 Pages: 511-516

    • NAID

      120005708871

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ダイオキシンによる免疫異常2009

    • Author(s)
      石丸直澄、林良夫
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 51(1) Pages: 60-65

    • NAID

      40016464327

    • Related Report
      2011 Final Research Report
  • [Journal Article] 炎症性腸疾患におけるレギュラトリーT細胞2009

    • Author(s)
      石丸直澄、林良夫
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 51(3) Pages: 301-306

    • NAID

      40016608905

    • Related Report
      2011 Final Research Report
  • [Journal Article] Sjogren症候群の発症とエストロゲン2009

    • Author(s)
      石丸直澄、林良夫
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 51(4) Pages: 431-437

    • NAID

      40016880980

    • Related Report
      2011 Final Research Report
  • [Journal Article] RANKLとFasシグナルクロストークによる樹状細胞の機能調節機構2009

    • Author(s)
      井澤俊、石丸直澄、田中英二、林良夫
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 52(5) Pages: 471-477

    • Related Report
      2011 Final Research Report
  • [Journal Article] シェーグレン症候群2009

    • Author(s)
      林良夫、石丸直澄、新垣理恵子
    • Journal Title

      感染・炎症・免疫

      Volume: 39 Pages: 80-82

    • Related Report
      2011 Final Research Report
  • [Journal Article] Thymoproteasome shapes immunocompetent repertoire of CD8(+)T cells2009

    • Author(s)
      Nitta T, 他
    • Journal Title

      Immunity 32

      Pages: 29-40

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Real-time in vivo imaging of p16Ink4a reveals cross talk with p53.2009

    • Author(s)
      Yamakoshi K, 他
    • Journal Title

      J Cell Biol 186

      Pages: 393-407

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] YKL-40 secreted from adipose tissue inhibits degradation of type I collagen.2009

    • Author(s)
      Iwata T, 他
    • Journal Title

      Biochem Biophys Res Commun 388

      Pages: 511-516

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neonatal exposure to low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin causes autoimmunity due to the disruption of T cell tolerance.2009

    • Author(s)
      Ishimaru N, 他
    • Journal Title

      J Immunol 182

      Pages: 6578-6586

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of plasmacytoid dendritic cells for aberrant class II expression in exocrine glands from estrogen-deficient mice of healthy back ground.2009

    • Author(s)
      Arakaki R, 他
    • Journal Title

      Am J Pathol 174

      Pages: 1715-1725

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] A novel role of NFkB relB in bone remodeling2011

    • Author(s)
      Masahiro Hiasa
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Year and Date
      2011-12-28
    • Related Report
      2011 Final Research Report
  • [Presentation] In vivo T cell apoptosis via interaction with CD11b+ macrophages in Fas-deficient host2011

    • Author(s)
      Ritsuko Oura
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Year and Date
      2011-11-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Hyperfunctions of osteoclasts in pathogenesis of rheumatoid arthritis in MRL/ lpr mice2011

    • Author(s)
      Kazuma Matsumoto
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Year and Date
      2011-11-28
    • Related Report
      2011 Final Research Report
  • [Presentation] A critical role of aromatase in the pathogenesis of Sjuogren' s syndrome2011

    • Author(s)
      Akihiko Iwasa
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Year and Date
      2011-11-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Th17 cells on the development of Sjogren' s syndrome in estrogen deficient NOD mice2011

    • Author(s)
      Rieko Arakaki
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Year and Date
      2011-11-28
    • Related Report
      2011 Final Research Report
  • [Presentation] The role of Th17 cell on the development of Sjogren's syndrome in estrogen deficient NOD mice2011

    • Author(s)
      新垣理恵子, 他
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Year and Date
      2011-11-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] A critical role of aromatase in the pathogenesis of Sjogren's syndrome2011

    • Author(s)
      岩浅亮彦, 他
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Year and Date
      2011-11-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] In vivo T cell apoptosis via interaction with CD11b+ macrophages in Fasdeficient host2011

    • Author(s)
      大浦律子, 他
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Year and Date
      2011-11-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Analysis of Immune Responess to Metal using Murine Nickel Allergy Model2011

    • Author(s)
      Ashrin Meinar Nur, 他
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Year and Date
      2011-11-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] A novel role of NFkB relB in bone remodeling2011

    • Author(s)
      Masahiro Hiasa, 他
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Year and Date
      2011-11-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Hyperfunctions of osteoclasts in pathogenesis of rheumatoid arthritis in MRL/lpr mice2011

    • Author(s)
      Kazuma Matsumoto, 他
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Year and Date
      2011-11-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Analysis of Immune Responses to Metal using Murine Nickel Allergy Model2011

    • Author(s)
      Meinar Nur Ashrin
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Year and Date
      2011-11-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 自己免疫疾患の病態におけるメモリーCD8陽性T細胞の役割2011

    • Author(s)
      石丸直澄
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-04-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 関節リウマチ病態における破骨細胞を介したT細胞活性化機構の解析2011

    • Author(s)
      松本一真
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-04-28
    • Related Report
      2011 Final Research Report
  • [Presentation] エストロジェン欠乏によって誘導されるシェーグレン症候群病態増強へのTh17細胞の関与2011

    • Author(s)
      新垣理恵子
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-04-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 自己免疫疾患の病態におけるメモリーCD8陽性T細胞の役割2011

    • Author(s)
      石丸直澄, 他
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      パシフィコ横浜(千葉県)
    • Year and Date
      2011-04-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] エストロジェン欠乏によって誘導されるシェーグレン症候群病態増強へのTh17細胞の関与2011

    • Author(s)
      新垣理恵子, 他
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      パシフィコ横浜(千葉県)
    • Year and Date
      2011-04-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 関節リウマチ病態における破骨細胞を介したT細胞活性化機序の解析2011

    • Author(s)
      松本一真, 他
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      パシフィコ横浜(千葉県)
    • Year and Date
      2011-04-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 関節リウマチモデルマウスおける破骨細胞の機能解析2011

    • Author(s)
      松本一真, 他
    • Organizer
      第29回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2011-04-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 低用量ダイオキシンの新生仔期投与による自己免疫病変の誘導2010

    • Author(s)
      小橋真之
    • Organizer
      第39回日本免疫学会総会学術集会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2010-12-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 自己免疫疾患におけるアロマターゼの役割2010

    • Author(s)
      右丸直澄
    • Organizer
      第18回ステロイドホルモン学会学術集会
    • Place of Presentation
      WINC AICHI(名古屋市)
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Critical Signaling Pathway via CCR7 of Foxp3+CD25+CD4+ Regulatory T Cells for the Egress from Lymph Nodes2010

    • Author(s)
      石丸直澄
    • Organizer
      第14回国際免疫学会議
    • Place of Presentation
      神戸ポートピアホテル、神戸国際展示場(神戸市)
    • Year and Date
      2010-08-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Fas-independent apoptosis of T cells via DCs controls autoimmune arthritis2010

    • Author(s)
      松本一真
    • Organizer
      第14回国際免疫学会議
    • Place of Presentation
      神戸ポートピアホテル、神戸国際展示場(神戸市)
    • Year and Date
      2010-08-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Rapid T cell death via interaction with CD11b+ macrophages in Fas-deficient host2010

    • Author(s)
      大浦律子
    • Organizer
      第14回国際免疫学会議
    • Place of Presentation
      神戸ポートピアホテル、神戸国際展示場(神戸市)
    • Year and Date
      2010-08-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Atelocollagen-mediated Systemic Administration of Myostatin siRNA Improves Muscular Dystrophy2010

    • Author(s)
      N.KINOUCHI
    • Organizer
      IADR 88th General Session and Exhibition 2010 Barcelona
    • Place of Presentation
      CCIB(Barcelona))
    • Year and Date
      2010-07-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Rapid peripheral T cell death in Fas-deficient mice2010

    • Author(s)
      R.OURA
    • Organizer
      IADR 88th General Session and Exhibition 2010 Barcelona
    • Place of Presentation
      CCIB(Barcelona)
    • Year and Date
      2010-07-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Special Processed Collagen-mediated Application of Myostatin-siRNA for Muscular Atrophy Diseases2010

    • Author(s)
      E.KAWAKAMI
    • Organizer
      IADR 88th General Session and Exhibition 2010 Barcelona
    • Place of Presentation
      CCIB(Barcelona)
    • Year and Date
      2010-07-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] シェーグレン症候群における調節性T細胞の役割2010

    • Author(s)
      石丸直澄
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2010-04-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] I型糖尿病モデルマウスにおけるカテプシンL特異的阻害剤を用いた治療効果の検討2010

    • Author(s)
      山田安希子
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京都新宿医)
    • Year and Date
      2010-04-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウス関節炎モデル樹状細胞のRANKL/FASシグナルを介した免疫抑制効果2010

    • Author(s)
      松本一真
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2010-04-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] エストロゲン欠乏依存的に唾液腺に誘導される膵ラ氏島アミロイドポリペプチドの機能とその意義2010

    • Author(s)
      新垣理恵子
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2010-04-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Neonatal exposure to low-dose 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin(TCDD) causes autoimmuiny in salivary glands due to the disruption of T cell tolerance2009

    • Author(s)
      Ishimaru N
    • Organizer
      The 11^<th> International Symposium on Exocrine Secretion Program and Abstract p. 8
    • Place of Presentation
      KOBE
    • Year and Date
      2009-12-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Immunoregulatory effect via RANKL and Fas signaling of dendritic cells in murine autoimmune arthritis models2009

    • Author(s)
      松本一真
    • Organizer
      第39回日本免疫学会総会学術集会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2009-12-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 低用量ダイオキシンの新生児期投与による自己免疫病変への誘導2009

    • Author(s)
      小橋真之
    • Organizer
      第39回日本免疫学会総会学術集会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2009-12-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] I型糖尿病モデルマウスにおけるカテプシンL特異的阻害剤を介した治療学的解析2009

    • Author(s)
      山田安希子
    • Organizer
      第39回日本免疫学会総会学術集会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2009-12-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] In situ patrolling of regulatory T cells is essential for protecting organ-specific autoimmunity.2009

    • Author(s)
      石丸直澄
    • Organizer
      第39回日本免疫学会総会学術集会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2009-12-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] エストロゲン欠乏によって唾液腺に誘導されるislet amyloid poly peptideの機能とその意義2009

    • Author(s)
      新垣理恵子
    • Organizer
      第39回日本免疫学会総会学術集会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2009-12-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Fas/NF-kBを介したマクロファージによる免疫調節機構2009

    • Author(s)
      大浦律子
    • Organizer
      第39回日本免疫学会総会学術集会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2009-12-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Salivary Gland and Autoimmunity2009

    • Author(s)
      Hayashi Y.
    • Organizer
      第11回The International Symposium on Exocrine Secretion(ISES)
    • Place of Presentation
      Tokushima University
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] I型糖尿病モデルマウスにおけるカテプシンLを介した治療学的解析2009

    • Author(s)
      山田安希子
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2009-05-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Local Toleranceの破綻による臓器特異的自己免疫疾患の発症機序2009

    • Author(s)
      石丸直澄
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2009-05-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] エストロゲン欠乏によって唾液腺に誘導される樹状細胞の同定とその機能2009

    • Author(s)
      新垣理恵子
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2009-05-03
    • Related Report
      2009 Annual Research Report
  • [Book] Handbook on Immunosenescence Basic understanding and clinical applications2009

    • Author(s)
      Hayashi Y.
    • Total Pages
      1652
    • Publisher
      Springer Netherlands
    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi