| Project/Area Number |
21256004
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Virology
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| Research Institution | Nagasaki University |
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Principal Investigator |
MORITA Kouichi 長崎大学, 熱帯医学研究所, 教授 (40182240)
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| Co-Investigator(Kenkyū-buntansha) |
HASEBE Futoshi 長崎大学, 国際連携研究戦略本部, 教授 (20253693)
INOUE Shingo 長崎大学, 熱帯医学研究所, 助教 (00346925)
KUBO Toru 長崎大学, 熱帯医学研究所, 助教 (50444873)
YU Fuxun 長崎大学, 熱帯医学研究所, 助教 (30437842)
HAYASAKA Daisuke 長崎大学, 熱帯医学研究所, 助教 (10346926)
|
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| Co-Investigator(Renkei-kenkyūsha) |
HAMADA Tuyoshi 長崎大学, 先端計算研究センター, 准教授 (00443010)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥46,280,000 (Direct Cost: ¥35,600,000、Indirect Cost: ¥10,680,000)
Fiscal Year 2011: ¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2010: ¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2009: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
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| Keywords | デング出血熱 / 熱帯病 / 蚊媒介性 / 病原性 / デングウイルス / アジア・アフリカ / フラビウイルス感染 |
|---|
| Research Abstract |
To identify viral genomic factors for severe dengue virus infections, we conducted field surveys in Asia and Africa. A number of severe dengue cases were confirmed among adult patients with primary infections, suggesting additional mechanism of severity on top of the antibody-dependent infection theory. Viral quasispecies were analyzed and showed different target cell tropism even with a single amino acid alternation on E-protein.
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