Study to identify viral genomic factors for severe dengue virus infections in Asia and Africa
| Project/Area Number |
21256004
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Virology
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| Research Institution | Nagasaki University |
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Principal Investigator |
MORITA Kouichi 長崎大学, 熱帯医学研究所, 教授 (40182240)
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| Co-Investigator(Kenkyū-buntansha) |
HASEBE Futoshi 長崎大学, 国際連携研究戦略本部, 教授 (20253693)
INOUE Shingo 長崎大学, 熱帯医学研究所, 助教 (00346925)
KUBO Toru 長崎大学, 熱帯医学研究所, 助教 (50444873)
YU Fuxun 長崎大学, 熱帯医学研究所, 助教 (30437842)
HAYASAKA Daisuke 長崎大学, 熱帯医学研究所, 助教 (10346926)
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| Co-Investigator(Renkei-kenkyūsha) |
HAMADA Tuyoshi 長崎大学, 先端計算研究センター, 准教授 (00443010)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥46,280,000 (Direct Cost: ¥35,600,000、Indirect Cost: ¥10,680,000)
Fiscal Year 2011: ¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2010: ¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2009: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
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| Keywords | デング出血熱 / 熱帯病 / 蚊媒介性 / 病原性 / デングウイルス / アジア・アフリカ / フラビウイルス感染 |
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| Research Abstract |
To identify viral genomic factors for severe dengue virus infections, we conducted field surveys in Asia and Africa. A number of severe dengue cases were confirmed among adult patients with primary infections, suggesting additional mechanism of severity on top of the antibody-dependent infection theory. Viral quasispecies were analyzed and showed different target cell tropism even with a single amino acid alternation on E-protein.
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Report
(4 results)
Research Products
(75 results)
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[Journal Article] Discovery of the First Insect Nidovirus, a Missing Evolutionary Link in the Emergence of the Largest RNA Virus Genomes2011
Author(s)
Nga PT, Parquet MC, Lauber C, Parida M, Nabeshima T, Yu F, Thuy NT, Inoue S, Ito T, Okamoto K, Ichinose A, Snijder EJ, Morita K, Gorbalenya AE
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Journal Title
PLoS Pathogens
Volume: 7(9)
NAID
Related Report
Peer Reviewed
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[Journal Article] Development of a rapid and comprehensive proteomics-based arboviruses detection system2010
Author(s)
Okamoto K, Endo Y, Inoue S, Nabeshima T, Nga PT, Guillermo PH, Yu F, Loan DP, Trang BM, Natividad FF, Hasebe F, Morita K
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Journal Title
J. Virol. Meth
Volume: Vol.167
Pages: 31-36
Related Report
Peer Reviewed
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[Journal Article] Isolation and characterization of two phenotypically distinct dengue type-2 virus isolates from the same dengue hemorrhagic Fever patient2009
Author(s)
Kinoshita H, Mathenge EG, Hung NT, Huong VT, Kumatori A, Yu F, Parquet MC, Inoue S, Matias RR, Natividad FF, Morita K, Hasebe F
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Journal Title
Jpn J Infect Dis
Volume: Vol.62(5)
Pages: 343-50
NAID
Related Report
Peer Reviewed
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