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Longitudinal study for neuro-degenerative diseases in Papua, Indonesia

Research Project

Project/Area Number 21256005
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Neurology
Research InstitutionResearch Institute for Humanity and Nature

Principal Investigator

OKUMIYA Kiyohito  総合地球環境学研究所, 研究部, 准教授 (20253346)

Co-Investigator(Kenkyū-buntansha) MATSUBAYASHI Kozo  京都大学, 東南アジア研究所, 教授 (70190494)
KUZUHARA Shigeki  鈴鹿医療科学大学, 保健衛生学部医療福祉学科, 教授 (70111383)
KOKUBO Yasumasa  三重大学, 医学(系)医学科(研究院), 講師 (60263000)
WADA Taizo  京都大学, 東南アジア研究所, 特任准教授 (90378646)
SAZ E Garcia Del (OSAKI Yasushi)  高知大学, 人文社会科学部門, 助教 (20294829)
SEGUCHI Harumichi  神戸女子大学, 健康福祉学部, 教授 (90030866)
TOMIMOTO Hidekazu  三重大学, 医学(系)医学科(研究院), 教授 (80324648)
YAMAUCHI Taro  北海道大学, 医学部保健科学研究院, 准教授 (70345049)
E.GARCIA delSaz  高知大学, 人文社会・教育科学系, 助教 (10294828)
Co-Investigator(Renkei-kenkyūsha) ONISHI Hideyuki  同志社女子大学, 現代社会学部, 准教授 (60414033)
Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥47,840,000 (Direct Cost: ¥36,800,000、Indirect Cost: ¥11,040,000)
Fiscal Year 2012: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2011: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2010: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2009: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Keywords神経変性疾 / パーキンソン症候 / 運動ニューロン疾患 / 筋萎縮性側索硬化症 / パーキンソン症候群 / 西ニューギニア地域
Research Abstract

We diagnosed 64 cases of neurological diseases consisting of 1) ALS; 17 cases of probable and definite ALS, 10 cases of possible ALS, including three cases with cognitive impairment (CI), 2) 13 cases of ALS and/or parkinsonism including five cases with CI, 3) 19 cases of parkinsonism including one case with CI, 4) 2 cases of poliomyeloradiculitis, 5)one case of Dopa responsive dystonia.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (182 results)

All 2013 2012 2011 2010 2009 Other

All Journal Article (95 results) (of which Peer Reviewed: 61 results) Presentation (70 results) Book (15 results) Remarks (2 results)

  • [Journal Article] 西ニューギニアの神経難病多発地域を歩く-第2報-辺境のジャングル・共同体・現代医学-2013

    • Author(s)
      平田温、奥宮清人、松林公蔵、稲村哲也、M.B.インドラジャヤ、葛原茂樹、石本恭子、木村友美、今井必生、陳蚊玲、瀬口春道、エヴァ・ガルシア・デル・サス、藤澤道子
    • Journal Title

      ヒマラヤ学誌

      Volume: 14 Pages: 217-227

    • NAID

      120005466236

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] インドネシア・パプア州低地バデにおける暮らしと文化-文化人類学と医療調査の連携を探る予備的研究-2013

    • Author(s)
      稲村哲也、木村友美、石本恭子、奥宮清人、平田温、松林公蔵、今井必生、陳蚊玲、葛原茂樹、瀬口春道、エヴァ・ガルシア、藤澤道子.
    • Journal Title

      ヒマラヤ学誌

      Volume: 14 Pages: 228-241

    • NAID

      120005466235

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 開発途上地域における糖尿病にみる健康教育の重要性-インドネシア・パプア州での症例より-2013

    • Author(s)
      木村友美、石本恭子、稲村哲也、陳政玲、今井必生、平田温、葛原茂樹、瀬口春道、エヴァ・ガルシア、藤澤道子、松林公蔵、奥宮清人
    • Journal Title

      ヒマラヤ学誌

      Volume: 14 Pages: 211-216

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term care prevention project in Japan2013

    • Author(s)
      Fukutomi E, Kimura Y, Wada T, Okumiya K, Nlatsubayashi K.
    • Journal Title

      Lancet

      Volume: 12 Pages: 381-381

    • Related Report
      2012 Final Research Report
  • [Journal Article] 西ニューギニアの神経難病多発地域を歩く―第2報―辺境のジャングル・共同体・現代医学―2013

    • Author(s)
      平田温、奥宮清人
    • Journal Title

      ヒマラヤ学誌

      Volume: 14 Pages: 217-227

    • NAID

      120005466236

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 開発途上地域における糖尿病にみる健康教育の重要性-インドネシア・パプア州での症例より-2013

    • Author(s)
      木村友美、奥宮清人
    • Journal Title

      ヒマラヤ学誌

      Volume: 14 Pages: 211-216

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] インドネシア・パプア州低地バデにおける暮らしと文化―文化人類学と医療調査の連携を探る予備的研究―2013

    • Author(s)
      稲村哲也、奥宮清人
    • Journal Title

      ヒマラヤ学誌

      Volume: 14 Pages: 228-241

    • NAID

      120005466235

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] VPS35 Mutation in Japanese Patients with Typical Parkinson’s Disease2013

    • Author(s)
      Ando M, Kokubo Y.
    • Journal Title

      Movement Disorders

      Volume: 15;27(11) Issue: 11 Pages: 175-182

    • DOI

      10.1002/mds.25145

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical features and a mutation with late onset of limb girdle muscular dystrophy 2B.2013

    • Author(s)
      Takahashi T, Kokubo Y.
    • Journal Title

      J Neurol Neurosurg Psychiatry.

      Volume: 71(7) Issue: 4 Pages: 433-440

    • DOI

      10.1136/jnnp-2011-301339

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] VPS35 mutation in Japanese patients with typical Parkinson' s disease2012

    • Author(s)
      Kokubo Y, Kuzuhara S
    • Journal Title

      Mov Disord

      Volume: 27(11) Pages: 1413-7

    • Related Report
      2012 Final Research Report
  • [Journal Article] Correlation of systolic blood pressure with age and body mass index in native Papuan populations2012

    • Author(s)
      Fujisawa M, Okumiya K
    • Journal Title

      Hypertens Res.

      Volume: 35(9) Issue: 9 Pages: 959-60

    • DOI

      10.1038/hr.2012.106

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] α-Synuclein pathology in the amyotrophic lateral sclerosis/parkinsonism dementia complex in the Kii Peninsula2012

    • Author(s)
      Kokubo Y, Kuzuhara S
    • Journal Title

      J Neuropathol Exp Neurol.

      Volume: 71(7) Pages: 625-30

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] VPS35 mutation in Japanese patients with typical Parkinson' s disease.2012

    • Author(s)
      Kokubo Y, Kuzuhara S,
    • Journal Title

      Mov Disord

      Volume: 27(11) Pages: 1413-7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analyses of the MAPT, PGRN, and C9orf72 mutations in Japanese patients with FTLD, PSP, and CBS2012

    • Author(s)
      Kokubo Y, Kuzuhara S
    • Journal Title

      Parkinsonism Relat Disord

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutational analysis of familial and sporadic amyotrophic lateral sclerosis with OPTN mutations in Japanese population2012

    • Author(s)
      Kokubo Y, Kuzuhara S
    • Journal Title

      Amyotroph Lateral Scler

      Volume: 13(6) Pages: 562-6

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] C90RF72 Repeat Expansion in Amyotrophic Lateral Sclerosis in the Kii Peninsula of Japan2012

    • Author(s)
      Kokubo Y, Kuzuhara S
    • Journal Title

      Arch Neurol

      Volume: 69(9) Pages: 1154-8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] An increase in ALS incidence on the Kii Peninsula, 1960-2009: a possible link to change in drinking water source2012

    • Author(s)
      Kokubo Y, Kuzuhara S
    • Journal Title

      Amyotroph Lateral Scler

      Volume: 13(4) Pages: 347-50

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] ALS-parkinsonism-dementia complex of Kii and other related diseases in Japan2012

    • Author(s)
      Kuzuhara S
    • Journal Title

      Parkinsonism Relat Disord

      Volume: Suppl 1

    • Related Report
      2012 Final Research Report
  • [Journal Article] Cardiac ^<123>I-meta-iodobenzylguanidine scintigraphy in patients with amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Kii peninsula, Japan2012

    • Author(s)
      Kokubo Y, Nomura Y, Morimoto S, Kuzuhara S
    • Journal Title

      Parkinsonism Relat Disord

      Volume: 18 Pages: 306-8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] <123>~I-meta-iodobenzylguanidine scintigraphy in patients with amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Kii peninsula, Japan2012

    • Author(s)
      Kokubo Y, Nomura Y, Morimoto S, Kuzuhara S
    • Journal Title

      Parkinsonism Relat Disord

      Volume: 18 Issue: 3 Pages: 306-8

    • DOI

      10.1016/j.parkreldis.2011.08.005

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] J-curve association between economic status and diabetes independent of functional disability in Japanese elderly.2012

    • Author(s)
      Okumiya K, Sakamoto R, Kimura Y, Ishimoto Y, Fukutomi E, Kasahara Y, et al.
    • Journal Title

      Geriatr Gerontol Int

      Volume: 12(4) Issue: 4 Pages: 755-6

    • DOI

      10.1111/j.1447-0594.2012.00854.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] α-Synuclein pathology in the amyotrophic lateral sclerosis/parkinsonism dementia complex in the Kii Peninsula, Japan.2012

    • Author(s)
      Kokubo Y
    • Journal Title

      J Neuropathol Exp Neurol

      Volume: 71(7) Issue: 7 Pages: 625-630

    • DOI

      10.1097/nen.0b013e31825b9680

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An increase in ALS incidence on the Kii Peninsula, 1960-2009: a possible link to change in drinking water source.2012

    • Author(s)
      Kihira T, Kokubo Y.
    • Journal Title

      Amyotroph Lateral Scler.

      Volume: 13(4) Issue: 4 Pages: 625-630

    • DOI

      10.3109/17482968.2012.674140

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C9ORF72 repeat expansion in amyotrophic lateral sclerosis in the Kii peninsula of Japan.2012

    • Author(s)
      Ishiura H, Kokubo Y.
    • Journal Title

      Arch Neurol.

      Volume: 69(9) Issue: 9 Pages: 1154-1158

    • DOI

      10.1001/archneurol.2012.1219

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Donepezil for demenia with Lewy bodies: a randomized, placebo-controlled trial.2012

    • Author(s)
      Mori Y, , Osaki Y.
    • Journal Title

      Ann Neurol

      Volume: 72 Issue: 1 Pages: 41-52

    • DOI

      10.1002/ana.23557

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] "Field medicine" : A new paradigm of geriatric medicine2012

    • Author(s)
      Matsubayashi K, Okumiya K
    • Journal Title

      Geriatr Gerontol Int

      Volume: 12 Issue: 1 Pages: 5-15

    • DOI

      10.1111/j.1447-0594.2011.00738.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel protein S gene mutation combined with protein S Tokushima mutation in a patient with superior sagittal sinus thrombosis2012

    • Author(s)
      Shindo A, Tomimoto H
    • Journal Title

      J Neurol

      Volume: 259(1) Issue: 1 Pages: 178-179

    • DOI

      10.1007/s00415-011-6122-x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PLA2G6 variant in Parkinson' s disease2011

    • Author(s)
      Kokubo Y, Kuzuhara S
    • Journal Title

      J Hum Genet

      Volume: 56 (5) Pages: 401-3

    • Related Report
      2012 Final Research Report
  • [Journal Article] Prevalence of Parkinson' s disease and atypical parkinsonian syndromes in a rural Japanese district2011

    • Author(s)
      0saki Y, Morita Y, Kuwahara T, Miyano I, Doi Y
    • Journal Title

      Acta Neurol Scand

      Volume: 124 (3) Pages: 182-7

    • Related Report
      2012 Final Research Report
  • [Journal Article]2011

    • Author(s)
      Yata K, Oikawa S, Sasaki R, Shindo A, Yang R, Murata M, Kanamaru K, Tomimoto H.
    • Journal Title

      Brain Res

      Volume: 1410 Pages: 12-23

    • Related Report
      2012 Final Research Report
  • [Journal Article] Angiogenic and vasoprotective effects of adrenomedullin on prevention of cognitive decline after chronic cerebral hypoperfusion in mice2011

    • Author(s)
      Tomimoto H
    • Journal Title

      Stroke

      Volume: 42(4) Issue: 4 Pages: 1122-8

    • DOI

      10.1161/strokeaha.110.603399

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] グアムと紀伊半島にみられるparkinsonism-ALS-dementia複合2011

    • Author(s)
      葛原茂樹
    • Journal Title

      日本臨牀(増刊号10認知症学下)

      Volume: 69 Pages: 455-460

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] 血管性パーキンソニズム2011

    • Author(s)
      葛原茂樹
    • Journal Title

      日本臨牀(増刊号10認知症学下)

      Volume: 69 Pages: 335-338

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] 牟婁病-紀伊ALS・パーキンソン・認知症複合(特集:続・日本人の発見した神経疾患)2011

    • Author(s)
      葛原茂樹
    • Journal Title

      Brain Nerve

      Volume: 63(2) Pages: 119-129

    • NAID

      40018721582

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] Controversyパーキンソン病の薬物治療はできるだけ早く始める方がよい2011

    • Author(s)
      大崎康史
    • Journal Title

      NO.MDSJ Letters

      Volume: 4 Pages: 1-3

    • Related Report
      2012 Final Research Report
  • [Journal Article] パーキンソン病患者のQOLと予後2011

    • Author(s)
      大崎康史
    • Journal Title

      CLINICAL NEURO SCIENCE

      Volume: 29 Pages: 514-515

    • Related Report
      2012 Final Research Report
  • [Journal Article] Strong association between polycythemia and glucose intolerance in older adults living at high altitudes in the Andes2011

    • Author(s)
      Okumiya K, Matsubayashi K
    • Journal Title

      J Am Geriatr Soc

      Volume: 59(10) Issue: 10 Pages: 1971-1973

    • DOI

      10.1111/j.1532-5415.2011.03610_8.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of socioeconomic globalization on health and aging in highlanders compared to lowlanders in Yunnan, China, and Kochi, Japan2011

    • Author(s)
      Okumiya K, Matsubayashi K
    • Journal Title

      Ecol Res

      Volume: 26 Issue: 6 Pages: 1027-1038

    • DOI

      10.1007/s11284-010-0784-1

    • NAID

      10030347613

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Field Medicine for reconsidering "Optimal Ageing"2011

    • Author(s)
      Matsubayashi K, Okumiya K
    • Journal Title

      J Am Geriatr Soc

      Volume: 59(8) Issue: 8 Pages: 1568-1570

    • DOI

      10.1111/j.1532-5415.2011.03528.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cardiac 123I-Meta-Iodobenzylguanidine Scintigraphy and Lew Body Pathology in a Patient with Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex of Kii, Japan2011

    • Author(s)
      Kokubo Y, Kuzuhara S
    • Journal Title

      Mov Disord

      Volume: 26(12) Issue: 12 Pages: 2300-2301

    • DOI

      10.1002/mds.23850

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PLA2G6 variant in Parkinson's disease2011

    • Author(s)
      Tomiyama H, Kokubo Y, Kuzuhara S
    • Journal Title

      J Hum Genet

      Volume: 56(5) Issue: 5 Pages: 401-403

    • DOI

      10.1038/jhg.2011.22

    • NAID

      10030659472

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of Parkinson's disease and atypical parkinsonian syndromes in a rural Japanese district2011

    • Author(s)
      Osaki, Y
    • Journal Title

      Acta Neurol Scand

      Volume: 124 Issue: 3 Pages: 182-187

    • DOI

      10.1111/j.1600-0404.2010.01442.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Controversyパーキンソン病の薬物治療はできるだけ早く始める方がよいNO2011

    • Author(s)
      大崎康史
    • Journal Title

      MDSJ Letters

      Volume: 4 Pages: 1-3

    • Related Report
      2011 Annual Research Report
  • [Journal Article] パーキンソン病患者のQOLと予後2011

    • Author(s)
      大崎康史
    • Journal Title

      CLINICAL NEUROSCIENCE

      Volume: 29 Pages: 514-515

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Astrocytic neuroprotection through induction of cytoprotective molecules ; a proteomic analysis of mutant P301S tau-transgenic mouse2011

    • Author(s)
      Yata K, Tomimoto H
    • Journal Title

      Brain Res

      Volume: 2(1410) Pages: 12-23

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] No evidence for pathogenic role of GIGYF2 mutation in Parkinson disease in .Tapanese patients2010

    • Author(s)
      Kokubo Y, Kuzuhara S
    • Journal Title

      Neurosci Lett

    • Related Report
      2012 Final Research Report
  • [Journal Article] Higher-dose glutathione therapy for Parkinson' s disease in Japan: is it really safe?2010

    • Author(s)
      Naito Y, Matsuo K, Kokubo Y, Narita Y, Tomimoto H
    • Journal Title

      Mov Disord.

      Volume: 25(7)

    • Related Report
      2012 Final Research Report
  • [Journal Article] Changes in the incidence and clinical features of ALS in the Koza, Kozagawa, and Kushimoto area of the Kii Peninsula--from the 1960s to the 2000s (follow-up study).2010

    • Author(s)
      Kokubo Y, Kuzuhara S
    • Journal Title

      Brain Nerve

      Volume: 62(1) Pages: 72-80

    • Related Report
      2012 Final Research Report
  • [Journal Article] No evidence for pathogenic role of GIGYF2 mutation in Parkinson disease in Japanese patients2010

    • Author(s)
      Kokubo Y, Kuzuhara S
    • Journal Title

      Neurosci Lett

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Painful neck on rotation: diagnostic significance for crowned dens syndrome2010

    • Author(s)
      Kuzuhara S
    • Journal Title

      J Neurol

      Volume: 257(1) Pages: 132-5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mood Disorders in the Community-Dwelling Elderly in Asia.2010

    • Author(s)
      Matsubayashi K, Okumiya K
    • Journal Title

      J Am Geriatr Soc

      Volume: 58 Pages: 213-214

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Strong association between polycythemia and glucose intolerance in elderly high-altitude dwellers in Asia.2010

    • Author(s)
      Okumiya K, Matsubayashi K
    • Journal Title

      J Am Geriatr Soc

      Volume: 58 Pages: 609-611

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Community-Based Geriatric Assessment and Preventive Intervention Lowered Medical Expenses for the Elderly.2010

    • Author(s)
      Matsubayashi K, Okumiya K
    • Journal Title

      J Am Geriatr Soc

      Volume: 58 Pages: 791-793

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diabetes mellitus and hypertension in elderly highlanders in Asia.2010

    • Author(s)
      Okumiya K, Matsubayashi K
    • Journal Title

      J Am Geriatr Soc

      Volume: 58 Pages: 1193-1195

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 痙性対麻痺におけるbacrofen持続髄注療法2010

    • Author(s)
      内藤寛、冨本秀和
    • Journal Title

      神経治療学

      Volume: 27(5) Pages: 689-695

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 発作の誘因としてValsarva負荷の関与が疑われた一過性全健忘の3症例;高磁場脳MRIを用いた検討2010

    • Author(s)
      坂井利行、冨本秀和
    • Journal Title

      臨床神経学

      Volume: 50(7) Pages: 473-477

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HTRA1変異と家族性虚血性脳小血管病の関連2010

    • Author(s)
      丹羽篤、冨本秀和
    • Journal Title

      分子脳血管病

      Volume: 9 Pages: 104-106

    • Related Report
      2010 Annual Research Report
  • [Journal Article] No evidence for pathogenic role of GIGYF2 mutation in Parkinson disease in Japanese patients Neuroscience Letters2010

    • Author(s)
      LinLi, Kokubo Y, Kuzuhara S
    • Journal Title

      Neuroscience Letters

      Volume: 479 Pages: 245-248

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Higher-dose glutathione therapy for Parkinson's disease in Japan : is it really safe?2010

    • Author(s)
      Naito Y, Kokubo Y, Tomimoto H.
    • Journal Title

      Mov Disord.

      Volume: May15;25(7) Pages: 962-963

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in the incidence and clinical features of ALS in the Koza, Kozagawa, and Kushimoto area of the Kii Peninsula-from the 1960s to the 2000s(follow-up study)2010

    • Author(s)
      Kihira T, Kokubo Y, Kuzuhara S.
    • Journal Title

      Brain Nerve.

      Volume: Jan;62(1) Pages: 72-80

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of Parkinson' s disease and atypical parkinsonian syndromesin a rural Japanese district.2010

    • Author(s)
      Osaki Y
    • Journal Title

      Acta Neurol Scand

      Volume: 10

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Strong Association Between Polycythemia and Glucose Intolerance in Elderly high-altitude dwellers in Asia2010

    • Author(s)
      Okumiya Kiyohoto
    • Journal Title

      J Am Geriatr Soc 58

      Pages: 609-611

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mood Disorders in the Community-Dwelling Elderly in Asia2010

    • Author(s)
      松林公蔵
    • Journal Title

      J Am Geriatr Soc 58

      Pages: 213-214

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 奄美・加計呂麻島の環境認識に関わる第二次調査概報2010

    • Author(s)
      大西秀之
    • Journal Title

      現代社会フォーラム 6号

      Pages: 89-108

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 17th Symposium on the Treatment of Parkinson' s Disease. September 27, 2008, Tokyo. Foreword2009

    • Author(s)
      Kuzuhara S, Takahashi R
    • Journal Title

      J Neurol

      Volume: 256 Suppl 3 Pages: 269-269

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Juvenile muscular atrophy of the distal upper extremity (hirayama disease) in two lanky look-alike brothers2009

    • Author(s)
      Kajikawa H, Kokubo Y, Taniguchi A, Naito Y, Kuzuhara S
    • Journal Title

      Neurologist

      Volume: 15 (4) Pages: 220-2

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      Satoh M, Takeda K, Kuzuhara S. Agraphia in intellectually normal Japanese patients with ALS: omission of kana letters
    • Journal Title

      J Neurol

      Volume: 256(9) Pages: 1455-60

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuro-Sweet disease:report of the first autopsy case.2009

    • Author(s)
      Kokubo Y
    • Journal Title

      BMJ Case Rep

      Volume: pii

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-N-methyl‐D‐aspartate receptor-related grave but reversible encephalitis with ovarian teratoma in 2 Japanese women presenting with excellent recovery without tumor resection2009

    • Author(s)
      Kokubo Y
    • Journal Title

      Eur Neurol

      Volume: 61 Pages: 50-1

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased oxidative stress in patients with amyotrophic lateral sclerosis/Parkinsonism-dementia complex in the Kii peninsula2009

    • Author(s)
      Morimoto S, Kuzuhara S, Kokubo Y
    • Journal Title

      Japan. Mov Disord

      Volume: 24(l) Pages: 123-6

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Research Committee on the Neurodegenerative Diseases of Japan. Age at onset influences on wide-ranged clinical features of sporadic amyotrophic lateral sclerosis2009

    • Author(s)
      Kuzuhara S
    • Journal Title

      J Neurol Sci

      Volume: 15;276(1-2) Pages: 163-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cross sectional and longitudinal studies of three-dimensional stereotactic surface projection SPECT analysis in Parkinson' s disease2009

    • Author(s)
      0saki Y, Morita Y, Fukumoto M, Akagi N, Yoshida S, Doi Y
    • Journal Title

      Mov Disord

      Volume: 24(10) Issue: 10 Pages: 1475-80

    • DOI

      10.1002/mds.22623

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] パーキンソン病初期治療における薬剤選択2009

    • Author(s)
      大崎康史
    • Journal Title

      Medico

      Volume: 40 Pages: 9-11

    • Related Report
      2012 Final Research Report
  • [Journal Article] 紀伊半島・グアム・ニューギニアのALS/パーキンソン・認知症複合2009

    • Author(s)
      葛原茂樹
    • Journal Title

      神経心理学

      Volume: 48 Pages: 625-633

    • Related Report
      2012 Final Research Report
  • [Journal Article] パーキンソン病をめぐる最近の話題と治療の進歩2009

    • Author(s)
      葛原茂樹
    • Journal Title

      日本内科学会雑誌

      Volume: 98 Pages: 57-66

    • NAID

      10024935282

    • Related Report
      2012 Final Research Report
  • [Journal Article] 目で見るパーキンソン病診療の進歩2009

    • Author(s)
      葛原茂樹
    • Journal Title

      日本医事新報

      Volume: 4460 Pages: 65-68

    • Related Report
      2012 Final Research Report
  • [Journal Article] Comprehensive Geriatric Assessment of elderly highlanders in Qinghai, China II : The association of polycythemia with life-style related diseases among the three ethnics2009

    • Author(s)
      Okumiya Kiyohoto
    • Journal Title

      Geriatr Gerontol Int 4

      Pages: 342-351

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive geriatric assessment of elderly highlanders in Qinhai, China I : Acticvities of daily living, quality of life and metabolic syndrome2009

    • Author(s)
      松林公蔵
    • Journal Title

      Geriatr Gerontol Int 4

      Pages: 333-341

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changing attitudes of elderly Japanese toward disease2009

    • Author(s)
      松林公蔵
    • Journal Title

      J Am Geriatr Soc. 57

      Pages: 1732-1733

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Twenty-one-item Fall Risk Index Predicts Falls in Community-dwelling Japanese Elderly2009

    • Author(s)
      Wada Taizo
    • Journal Title

      J Am Geriatr Soc 57

      Pages: 2369-2371

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A validation exercise on the new criteria for multiple system atrophy2009

    • Author(s)
      Osaki Yasushi
    • Journal Title

      Mov Disord 24

      Pages: 2272-2276

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cross sectional and longitudinal studies of three-dimensional stereotactic surface projection SPECT analysis in Parkinson's disease2009

    • Author(s)
      Osaki Yasushi
    • Journal Title

      Mov Disord 24

      Pages: 1475-1480

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] パーキンソン病初期治療における薬剤選択2009

    • Author(s)
      大崎康史
    • Journal Title

      Medico 40

      Pages: 9-11

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 紀伊半島・グアム・ニューギニアのALS/パーキンソン・認知症複合2009

    • Author(s)
      葛原茂樹
    • Journal Title

      神経心理学 25

      Pages: 182-191

    • Related Report
      2009 Annual Research Report
  • [Journal Article] ALS研究の最近の進歩:ALSとTDP-432009

    • Author(s)
      葛原茂樹
    • Journal Title

      臨床神経学 48

      Pages: 625-633

    • NAID

      10022594094

    • Related Report
      2009 Annual Research Report
  • [Journal Article] パーキンソン病をめぐる最近の話題と治療の進歩2009

    • Author(s)
      葛原茂樹
    • Journal Title

      日本内科学会雑誌 98

      Pages: 57-66

    • NAID

      10024935282

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 目で見るパーキンソン病 診療の進歩2009

    • Author(s)
      葛原茂樹
    • Journal Title

      日本医事新報 4460

      Pages: 65-68

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 地域における転倒の実態2009

    • Author(s)
      松林公蔵
    • Journal Title

      Geriatric Medicine 47

      Pages: 689-692

    • Related Report
      2009 Annual Research Report
  • [Journal Article] メタボリックシンドロームは転倒の危険因子か?2009

    • Author(s)
      和田泰三
    • Journal Title

      Geriatric Medicine 47

      Pages: 707-709

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 高齢者のQOL2009

    • Author(s)
      松林公蔵
    • Journal Title

      日本医師会雑誌 138

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      大崎康史
    • Journal Title

      「Q59」『パーキンソン病診療Q&A 110』(中外医学社)

      Pages: 178-179

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      小久保康昌
    • Journal Title

      「パーキンソン認知症複合(グアム島、紀伊半島)」『パーキンソン病 基礎・臨床研究のアップデート』(日本臨床)

      Pages: 259-263

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      Onishi Hideyuki
    • Journal Title

      "Living Hours and Activities." An Illustrated Eco-history of the Mekong River Basin(Akimichi, Tomoya(ed))(White Lotus)

      Pages: 109-110

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      Matsubayashi Kozo
    • Journal Title

      "Demographic transition and the elderly." An Illustrated Eco-history of the Mekong River Basin(Akimichi, Tomoya(ed))(White Lotus)

      Pages: 118-120

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      Okumiya Kiyohoto
    • Journal Title

      "Diabetes Mellitus" An Illustrated Eco-history of the Mekong River Basin(Akimichi, Tomoya(ed))(White Lotus)

      Pages: 113-114

    • Related Report
      2009 Annual Research Report
  • [Presentation] 西ニューギニア地域における神経変性疾患の実態に関する縦断的研究2013

    • Author(s)
      奥宮清人
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] No association between ATXN2 (SCA2) CAG repeat expansion and amyotrophic lateral sclerosis /parkinsonism-dementia complex of the Kii peninsula, Japan2012

    • Author(s)
      Tomiyama H, Kokubo Y
    • Organizer
      ASHG (American Society of Human Genetics) annual meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2012-11-06
    • Related Report
      2012 Final Research Report
  • [Presentation] The Asp620Asn mutation of VPS35 in Japanese patients with typical Parkinson disease.2012

    • Author(s)
      Ando M, Kokubo Y
    • Organizer
      ASHG (American Society of Human Genetics) annual meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2012-11-06
    • Related Report
      2012 Final Research Report
  • [Presentation] VPS35 Asp620Asn mutation in Japanese patients with Parkinson disease2012

    • Author(s)
      Ando M, Kokubo Y
    • Organizer
      7TH ANNUAL GEO-PD MEETING
    • Place of Presentation
      SEOUL, SOUTH KOREA
    • Year and Date
      2012-10-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Analyses of the MAPT, PGRN, and C9orf72 mutations in Japanese patients with FTLD, PSP, and CBS.2012

    • Author(s)
      Ogaki K, Kokubo Y
    • Organizer
      7TH ANNUAL GEO-PD MEETING
    • Place of Presentation
      SEOUL, SOUTH KOREA
    • Year and Date
      2012-10-08
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Alfa-Synuclein pathology of amyotrophic lateral sclerosis/parkinsonism-dementia complex in the Kii Peninsula, Japan2012

    • Author(s)
      Kokubo Y, Kuzuhara S
    • Organizer
      8th International Conference on Frontotemporal Dementias
    • Place of Presentation
      Manchester, UK
    • Year and Date
      2012-09-05
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Immunochemical Study Western blotting of tauopathy in ALS/ Parkinson Dementia Complex (PDC), Kii ,Japan2012

    • Author(s)
      Morimoto S, Kokubo Y
    • Organizer
      27th AANP (American Association of Neuropathologists) conference
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2012-06-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Changing patterns of amyotrophic lateral sclerosis(ALS) and parkinsonism-dementia complex (PDC) of the Kii peninsula in Japan,2012

    • Author(s)
      Kuzuhara S, Kokubo Y
    • Organizer
      13th Asian Oceanian Congress of Neurology,
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2012-06-04
    • Related Report
      2012 Final Research Report
  • [Presentation] Neutron activation analysis of trace elements in scalp hair from ALS patients and residents of the Kii Peninsula, Japan2012

    • Author(s)
      Kihira T, Kokubo Y
    • Organizer
      23RD INTERNATIONAL SYMPOSIUM ON ALS/MND
    • Place of Presentation
      Chicago, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] 紀伊半島の筋萎縮性側索硬化症/パーキンソン認知症複合患者におけるedaravon投与の効果2012

    • Author(s)
      小久保康昌
    • Organizer
      第30回 神経医治療学会総会
    • Place of Presentation
      北九州市、福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] VPS35 Asp620Asn mutation in Japanese patients with Parkinson disease.2012

    • Author(s)
      Ando M, Kokubo Y.
    • Organizer
      7TH ANNUAL GEO-PD MEETING
    • Place of Presentation
      SEOUL, SOUTH KOREA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Changing patterns of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC) of the Kii peninsula in Japan2012

    • Author(s)
      Kuzuhara S
    • Organizer
      13th Asian Oceanian Congress of Neurology
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2012 Annual Research Report
  • [Presentation] Neutron activation analysis of trace elements in scalp hair from ALS patients and residents of the Kii Peninsula, Japan2012

    • Author(s)
      Kihira T, Kokubo Y.
    • Organizer
      23RD INTERNATIONAL SYMPOSIUM ON ALS/MND
    • Place of Presentation
      Chicago, USA.
    • Related Report
      2012 Annual Research Report
  • [Presentation] No association between ATXN2 (SCA2) CAG repeat expansion and amyotrophic lateral sclerosis /parkinsonism-dementia complex of the Kii peninsula, Japan2012

    • Author(s)
      Tomiyama H, Kokubo Y.
    • Organizer
      ASHG(American Society of Human Genetics)annual meeting
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] The Asp620Asn mutation of VPS35 in Japanese patients with typical Parkinson disease.2012

    • Author(s)
      Ando M, Kokubo Y.
    • Organizer
      ASHG(American Society of Human Genetics)annual meeting
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] 日本人75例(FTLD、PSP、CBS)におけるMAPT、PGRNおよびC9orf72の 遺伝子解析2012

    • Author(s)
      本井ゆみ子, 小久保康昌.
    • Organizer
      31回日本認知症学会
    • Place of Presentation
      つくば市、茨城県
    • Related Report
      2012 Annual Research Report
  • [Presentation] Immunochemical Study Western blotting of tauopathy in ALS/ Parkinson Dementia Complex (PDC), Kii ,Japan2012

    • Author(s)
      Morimoto S, Kokubo Y.
    • Organizer
      27th AANP(American Association of Neuropathologists) conference
    • Place of Presentation
      Chicago, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] 紀伊半島の筋萎縮性側索硬化症/パーキンソン認知症複合(牟婁病:KiiALS/PDC)ー現状と課題ー2012

    • Author(s)
      小久保康昌.
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 紀伊筋萎縮性側索硬化症・パーキンソニズム認知症複合(ALS/PDC)の全ゲノム配列解析による疾患遺伝子の探索2012

    • Author(s)
      石浦浩之、小久保康昌.
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] パーキンソン病患者のHR-QOL---大学病院外来と疫学調査の比較から2012

    • Author(s)
      大崎康史
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] パーキンソン病患者の痛みに関するアンケート調査から2012

    • Author(s)
      森田ゆかり、大崎康史
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 大脳白質病変と認知症・認知障害2011

    • Author(s)
      冨本秀和
    • Organizer
      第30回日本認知症学会学術集会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-11-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] パーキンソン類縁疾患とパーキンソン病のMRI2011

    • Author(s)
      大崎康史
    • Organizer
      MDSJ第5回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 皮質下血管性認知症;認知症疾患における位置づけ2011

    • Author(s)
      冨本秀和
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] シクロスポリンとIVIGが有効であった免疫介在性壊死性ミオパチーの1例2011

    • Author(s)
      松尾皇、大崎康史
    • Organizer
      第129回日本神経学会東海北陸地方会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-03-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Predictors of increase in severity among Japanese amyotrophic lateral sclerosis patients by discriminant analysis2011

    • Author(s)
      Okamoto K, Kuzuhara S, Kokubo Y
    • Organizer
      22th International Symposium on ALS/MND
    • Place of Presentation
      Sydoney, Australia
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Neuropsychological study of patients with amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kiipeninsula of Japan2011

    • Author(s)
      SHINDO A, Kuzuhara S, KokuboY
    • Organizer
      22th International Symposium on ALS/MND
    • Place of Presentation
      Sydoney, Australia
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Research Consortium of Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex of the Kii Peninsula of Japan2011

    • Author(s)
      Kokubo Y, Kuzuhara S
    • Organizer
      ICAD 2011
    • Place of Presentation
      Paris, France
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Parkinson' s disease subtypes based on an epidemiological cohort in a rural Japanese district: a cluster analysis2011

    • Author(s)
      Osaki Y
    • Organizer
      5th International Congress of Parkinson' s Disease & Movement Disorders
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2012 Final Research Report
  • [Presentation] 紀伊半島の筋萎縮性側索硬化症/パーキンソン認知症複合におけるバイオマーカーの検討-脳脊髄液中タウ,リン酸タウ,Aβの解析-2011

    • Author(s)
      小久保康昌、葛原茂樹
    • Organizer
      第30回日本認知症学会
    • Place of Presentation
      タワーホール船堀
    • Related Report
      2011 Annual Research Report
  • [Presentation] パーキンソン病におけるPLA2G6変異の意義2011

    • Author(s)
      吉野浩代、小久保康昌、葛原茂樹
    • Organizer
      第56回日本人類遺伝学会大会
    • Place of Presentation
      千葉幕張メッセ
    • Related Report
      2011 Annual Research Report
  • [Presentation] 紀伊半島のALS/PDCにおけるバイオマーカーの検討-脳脊髄液中タウ、リン酸化タウ、Aβの解析2011

    • Author(s)
      小久保康昌、葛原茂樹
    • Organizer
      第5回MDSJコングレス
    • Place of Presentation
      品川プリンスホテル
    • Related Report
      2011 Annual Research Report
  • [Presentation] FTDP-17が疑われた日本人患者75症例におけるPGRNとMAPT遺伝子解析2011

    • Author(s)
      大垣光太郎、小久保康昌、葛原茂樹
    • Organizer
      第5回MDSJコングレス
    • Place of Presentation
      品川プリンスホテル
    • Related Report
      2011 Annual Research Report
  • [Presentation] PLA2G6 in patients with Parkinson's disease/frontotemporal type of dementia2011

    • Author(s)
      Tomiyama H, Kokubo Y, Kuzuhara S
    • Organizer
      国際人類遺伝学会議(ICHG2011)/米国人類遺伝学会(ASHG)大会
    • Place of Presentation
      カナダ・モントリオール
    • Related Report
      2011 Annual Research Report
  • [Presentation] 人工呼吸器装着するも、経口摂取で13年生存した紀伊ALSの1例2011

    • Author(s)
      小久保康昌、葛原茂樹
    • Organizer
      第52回日本神経病理学会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] パーキンソン病におけるPLA2G6変異の意義2011

    • Author(s)
      吉野浩代、小久保康昌、葛原茂樹
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] 筋萎縮性側索硬化症発症関連要因解明に関する症例対照研究2011

    • Author(s)
      岡本和士、小久保康昌、葛原茂樹
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] FTDP-17が疑われた日本人75症例におけるPGRNとMAPT遺伝子解析2011

    • Author(s)
      大垣光太郎、小久保康昌、葛原茂樹
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      品川プリンスホテル
    • Related Report
      2011 Annual Research Report
  • [Presentation] 大島地区でのALS疫学的調査-第1報-2011

    • Author(s)
      紀平為子、小久保康昌、葛原茂樹
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] Parkinson's disease subtypes based on an epidemiological cohort in a rural Japanese district : a cluster analysis2011

    • Author(s)
      Osaki Y
    • Organizer
      5th International Congress of Parkinson's Disease & Movement Disorders
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2011 Annual Research Report
  • [Presentation] 地域におけるパーキンソン病のサブタイプ---クラスター解析から2011

    • Author(s)
      森田ゆかり、大崎康史
    • Organizer
      第52回日本神経学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] 多系統萎縮症のQOLと影響因子に関する検討2011

    • Author(s)
      徳永純、大崎康史
    • Organizer
      第52回日本神経学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] Significance of cortical SAH as a putative marker tor cerebral amyloid angiopathy in patients with cognitive impairment2011

    • Author(s)
      Tomimoto H.
    • Organizer
      VasCog 2011
    • Place of Presentation
      Lille France
    • Related Report
      2011 Annual Research Report
  • [Presentation] In vivo detection of cortical microinfarction with ultrahigh-field MRI in subjects with cognitive impairment2011

    • Author(s)
      Li Y, Tomimoto H
    • Organizer
      VasCog 2011
    • Place of Presentation
      Lille France
    • Related Report
      2011 Annual Research Report
  • [Presentation] Controvercy CN1.パーキンソン病の薬物治療はできるだけ早く始める方がよい NO2010

    • Author(s)
      大崎康史
    • Organizer
      MDSJ第4回学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Prevalence of Parkinson' s disease and atypical parkinsonian syndromes in a rural Japan2010

    • Author(s)
      Osaki Y
    • Organizer
      14^<th> Congress of the European Federation of Neurological Societies
    • Place of Presentation
      Geneva, Switzerland
    • Year and Date
      2010-09-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Prevalence of Parkinson' s disease and atypical parkinsonian syndromesin a rural Japan.2010

    • Author(s)
      Osaki Y
    • Organizer
      14^<th> Congress of the European Federation of Neurological Societies.
    • Place of Presentation
      Geneva, Switzerland.
    • Year and Date
      2010-09-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 紀伊ALS/PDCにおけるOPTN蛋白の神経病理学的検討2010

    • Author(s)
      森本悟, 小久保康昌, 葛原茂樹
    • Organizer
      ALS/ALSD/FTLDUのサマーワークショップ
    • Place of Presentation
      東京都健康長寿医療センター研究所
    • Year and Date
      2010-08-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 一地域におけるパーキンソン病の有病率-男女差についての検討2010

    • Author(s)
      大崎康史
    • Organizer
      第51回日本神経学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 一地域におけるパーキンソン病のQOL-PDQ-39を用いた検討2010

    • Author(s)
      森田ゆかり、大崎康史
    • Organizer
      第51回日本神経学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Amyotrophic lateral sclerosis (ALS)and parkinsoniam-dementia complex (PDC) of the Kii peninsula of Japan. Clinical and neuropathological review2010

    • Author(s)
      Kokubo Y
    • Organizer
      NeuroTalk-2010
    • Place of Presentation
      Singapore EXPO・Singapore
    • Related Report
      2012 Final Research Report
  • [Presentation] A Biological Marker of Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex of The Kii Peninsula Of Japan.-Analysis of Cerebrospinal Fluid Phosphorylated Tau2010

    • Author(s)
      Kokubo Y. Kuzuhara S
    • Organizer
      7th International Conference on Frontotemporal Dementias
    • Place of Presentation
      Indianapolis, USA.
    • Related Report
      2012 Final Research Report
  • [Presentation] W県内筋萎縮性側索硬化症多発地における発症率の推移と環境要因の検討2010

    • Author(s)
      紀平為子、小久保康昌、葛原茂樹
    • Organizer
      第51回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 紀伊ALS/PDCのMRI所見:VSRAD plusを用いた解2010

    • Author(s)
      小久保康昌、葛原茂樹
    • Organizer
      第51回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 筋萎縮性側索硬化症発症関連要因解明に関する症例対策研究2010

    • Author(s)
      岡本和士、小久保康昌
    • Organizer
      特定疾患の疫学に関する研究班
    • Place of Presentation
      埼玉医科大学かわごえクリニック
    • Related Report
      2010 Annual Research Report
  • [Presentation] Amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex(PDC) of the Kii peninsula of Japan.Clinical and neuropathological review.2010

    • Author(s)
      Kokubo Y
    • Organizer
      NeuroTalk-2010
    • Place of Presentation
      Singapore EXPO・Singapore
    • Related Report
      2010 Annual Research Report
  • [Presentation] A Biological Marker of Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex of The Kii Peninsula Of Japan.-Analysis of Cerebrospinal Fluid Phosphorylated Tau-2010

    • Author(s)
      Kokubo Y.Kuzuhara S
    • Organizer
      7th International Conference on Frontotemporal Dementias
    • Place of Presentation
      Indianapolis, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] FTDP-17が疑われた日本人71症例におけるMAPT、PGRN遺伝子解析2010

    • Author(s)
      大垣光太郎、小久保康昌、葛原茂樹
    • Organizer
      第4回MDSJ
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] 日本人パーキンソン病患者におけるGIGYF2の変異解析2010

    • Author(s)
      李林、小久保康昌、葛原茂樹
    • Organizer
      第4回MDSJ
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] 孤発性パーキンソン病におけるPLA2G6 p.P806R2010

    • Author(s)
      富山弘幸、小久保康昌、葛原茂樹
    • Organizer
      第4回MDSJ
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] パーキンソン病におけるPLA2G6 p.P806R2010

    • Author(s)
      富山弘幸、小久保康昌、葛原茂樹
    • Organizer
      日本人類遺伝学会総会
    • Place of Presentation
      大宮
    • Related Report
      2010 Annual Research Report
  • [Presentation] 人工呼吸器を装着するも、経口摂取で13年と生存した紀伊ALSの1例2010

    • Author(s)
      小久保康昌、葛原茂樹
    • Organizer
      第38回臨床神経病懇話会
    • Place of Presentation
      山口
    • Related Report
      2010 Annual Research Report
  • [Presentation] 筋萎縮性側索硬化症発症関連要因解明に関する症例対照研究2010

    • Author(s)
      岡本和士、小久保康昌
    • Organizer
      特定疾患の疫学に関する研究班
    • Place of Presentation
      埼玉医科大学かわごえクリニック
    • Related Report
      2010 Annual Research Report
  • [Presentation] 紀伊半島の筋萎縮性側索硬化症/パーキンソン認知症複合におけるバイオマーカーの検討-脳脊髄液中リン酸化タウの解析2010

    • Author(s)
      小久保康昌、葛原茂樹
    • Organizer
      平成22年度厚労省神経変性疾患調査研究班
    • Place of Presentation
      東京都市センターホテル5階オリオン
    • Related Report
      2010 Annual Research Report
  • [Presentation] 紀伊半島ALS症例の神経原線維変化の分布2010

    • Author(s)
      葛原茂樹、小久保康昌
    • Organizer
      平成22年度厚労省神経変性疾患調査研究班
    • Place of Presentation
      東京都市センターホテル5階オリオン
    • Related Report
      2010 Annual Research Report
  • [Presentation] Formation of the Ainu Subsistence Strategy by Economic and Political In fluences from the Mainland Japan2009

    • Author(s)
      Onishi Hideyuki
    • Organizer
      International Convention of Asia Scholars 6
    • Place of Presentation
      Daejeon Convention Center, Daejeon, Korea
    • Year and Date
      2009-08-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Parkinson's disease in a rural Japan2009

    • Author(s)
      Osaki Yasushi
    • Organizer
      13^<ra> International Congress of Parkinson's disease & Movement Disorders
    • Place of Presentation
      Paris
    • Related Report
      2009 Annual Research Report
  • [Presentation] Atypical parkinsonism in a rural Japan2009

    • Author(s)
      Osaki Yasushi
    • Organizer
      13^<rd> International Congress of Parkinson's disease & Movement Disorders
    • Place of Presentation
      Paris
    • Related Report
      2009 Annual Research Report
  • [Presentation] 抗SRP抗体陽性壊死性ミオパチーの3例

    • Author(s)
      丹羽 篤、小久保康昌
    • Organizer
      神経病理学会東海北陸地方会
    • Place of Presentation
      金沢、石川県
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高度な白質病変を伴った紀伊筋萎縮性側索硬化症・・パーキンソン病認知症複合の一剖検例

    • Author(s)
      森本悟、小久保康昌
    • Organizer
      関東神経病理懇話会(KNPN )
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Book] 今日の神経疾患治療指針 第2版2013

    • Author(s)
      大崎康史
    • Publisher
      西村書店
    • Related Report
      2012 Final Research Report
  • [Book] 続・生老病死のエコロジー:ヒマラヤ・アンデスに生きる-身体・こころ・時間2013

    • Author(s)
      奥宮清人
    • Publisher
      昭和堂
    • Related Report
      2012 Annual Research Report
  • [Book] 高所と健康・病気 -低酸素適応と生活変化-2013

    • Author(s)
      奥宮清人
    • Total Pages
      171
    • Publisher
      西村書店
    • Related Report
      2012 Annual Research Report
  • [Book] 今日の神経疾患治療指針 第2版2013

    • Author(s)
      大崎康史
    • Publisher
      医学書院
    • Related Report
      2012 Annual Research Report
  • [Book] Amyotrophic Lateral Sclerosis and the Frontotemporal Dementias2012

    • Author(s)
      Kuzuhara S, Kokubo Y
    • Publisher
      Oxford University Press
    • Related Report
      2012 Final Research Report
  • [Book] 「パーキンソン病」北徹監修健康長寿学大事典-EBMからQOLまで-2012

    • Author(s)
      奥宮清人
    • Publisher
      西村書店,
    • Related Report
      2012 Final Research Report
  • [Book] Amyotrophic Lateral Sclerosis and the Frontotemporal Dementias2012

    • Author(s)
      Kuzuhara S, Kokubo Y.
    • Publisher
      Oxford University Press
    • Related Report
      2012 Annual Research Report
  • [Book] 健康長寿学大事典2012

    • Author(s)
      奥宮清人
    • Publisher
      西村書店
    • Related Report
      2012 Annual Research Report
  • [Book] ガイドラインサポートブックパーキンソン病2011

    • Author(s)
      大崎康史
    • Publisher
      医薬ジャーナル社
    • Related Report
      2012 Final Research Report
  • [Book] 神経科用薬、治療薬マニュアル20112011

    • Author(s)
      葛原茂樹(高久史麿、矢崎義雄監修)
    • Publisher
      医学書院
    • Related Report
      2012 Final Research Report
  • [Book] ガイドラインサポートブック パーキンソン病2011

    • Author(s)
      大崎康史
    • Publisher
      医薬ジャーナル社
    • Related Report
      2011 Annual Research Report
  • [Book] 神経科用薬、治療薬マニュアル20112011

    • Author(s)
      葛原茂樹(高久史麿、矢崎義雄監修)
    • Publisher
      医学書院、東京
    • Related Report
      2011 Annual Research Report
  • [Book] 生老病死のエコロジー:チベット・ヒマラヤに生きる2011

    • Author(s)
      奥宮清人
    • Publisher
      昭和堂
    • Related Report
      2011 Annual Research Report
  • [Book] 「Q59」『パーキンソン病診療Q&A110』2009

    • Author(s)
      大崎康史
    • Publisher
      中外医学社
    • Related Report
      2012 Final Research Report
  • [Book] 「パーキンソン認知症複合(グアム島、紀伊半島)」『パーキンソン病基礎・臨床研究のアップデート』2009

    • Author(s)
      小久保康昌
    • Publisher
      日本臨床
    • Related Report
      2012 Final Research Report
  • [Remarks] 紀伊半島の筋萎縮性側索硬化症/パーキンソン認知症複合ー牟婁病ー

    • URL

      http://square.umin.ac.jp/ALS-PDC/access.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://square.umin.ac.jp/ALS-PDC/access.html

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2019-07-29  

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