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Neuroimaging and Neuropsychological studies on neural basis of episodic memory

Research Project

Project/Area Number 21300101
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cognitive science
Research InstitutionTohoku University

Principal Investigator

FUJII Toshikatsu  東北大学, 大学院・医学系研究科, 准教授 (70271913)

Co-Investigator(Renkei-kenkyūsha) ABE Nobuhito  東北大学, 大学院・医学系研究科, 助教 (90507922)
MUGIKURA Shunji  東北大学, 大学病院, 助教 (20375017)
MORI Etsuro  東北大学, 大学院・医学系研究科, 教授 (30368477)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Keywords脳認知科学 / エピソード記憶 / 文脈記憶 / 内側側頭葉 / 前頭前野 / 脳機能画像法 / 神経心理学 / 認知神経科学 / PET / fMRI
Research Abstract

The functions of various brain areas on the encoding and retrieval of episodic memory have been studied intensely, yet the specific contribution of each brain area has not been elucidated. The purpose of the present study was to identify neural networks that support event memory itself, temporal context memory, spatial context memory, and source memory. For this purpose, we employed both neuroimaging and neuropsychological studies. The results showed (1)the influence of prefrontal activity on medial temporal lobe activity during the retrieval of episodic memory,(2)the crucial role of the medial temporal lobe in the retrieval of source memory, and (3)the differential roles of subregions within the medial temporal lobe in episodic memory.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (54 results)

All 2012 2011 2010 2009

All Journal Article (23 results) (of which Peer Reviewed: 21 results) Presentation (18 results) Book (13 results)

  • [Journal Article] Changing the criteria for old/new recognition judgments can modulate activity in the anterior hippocampus2012

    • Author(s)
      Hashimoto R, Abe N, Ueno A, Fujii T, Takahashi S, Mori E.
    • Journal Title

      Hippocampus

      Volume: 22 Pages: 141-148

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effects of aging and Alzheimer's disease on associative recognition memory2011

    • Author(s)
      Hanaki R, Abe N, Fujii T, Ueno A, Nishio Y, Hiraoka, K Shimomura T, Iizuka O, Shinohara M, Hirayama K, Mori E.
    • Journal Title

      Neurological Sciences

      Volume: 32 Pages: 1115-1122

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neural basis of pleasant and unpleasant emotions induced by social reputation2011

    • Author(s)
      Ito A, Fujii T, Ueno A, Koseki Y, Tashiro M, Mori E.
    • Journal Title

      Neuroreport

      Volume: 22 Pages: 679-683

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of the dorsolateral prefrontal cortex in deception when remembering neutral and emotional events2011

    • Author(s)
      Ito A, Abe N, Fujii T, Ueno A, Koseki Y, Hashimoto R, Mugikura S, Takahashi S, Mori E.
    • Journal Title

      Neuroscience Research

      Volume: 69 Pages: 121-128

    • NAID

      10028190577

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] False item recognition in patients with Alzheimer's disease2011

    • Author(s)
      Abe N, Fujii T, Nishio Y, Iizuka O, Kanno S, Kikuchi H, Takagi M, Hiraoka K, Yamasaki H, Choi H, Hirayama K, Shinohara M, Mori E.
    • Journal Title

      Neuropsychologia

      Volume: 49 Pages: 1897-1902

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Small gray matter volume in orbitofrontal cortex in Prader-Willi syndrome : a voxel-based MRI study2011

    • Author(s)
      Ogura K, Fujii T, Abe N, Hosokai Y, Shinohara M, Takahashi S, Mori E.
    • Journal Title

      Human Brain Mapping

      Volume: 32 Pages: 1059-1066

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prader-Willi症候群における行動異常の介護者に対する質問紙による評価:妥当性の検討2011

    • Author(s)
      篠原真弓, 小倉加恵子, 藤井俊勝, 平山和美, 大野耕策, 森悦朗
    • Journal Title

      神経心理

      Volume: 27 Pages: 54-63

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 記憶とは2011

    • Author(s)
      藤井俊勝
    • Journal Title

      Clinical Neuroscience

      Volume: 29 Pages: 144-147

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] The role of the dorsolateral prefrontal cortex in deception when remembe ring neutral and emotional events2011

    • Author(s)
      Ito A, Abe N, Fujii T, Ueno A, Koseki Y, Hashimoto R, Mugikura S, Takahashi S, Mori E
    • Journal Title

      Neuroscience Research

      Volume: 69(2) Issue: 2 Pages: 121-128

    • DOI

      10.1016/j.neures.2010.11.001

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Right temporal-lobe contribution to the retrieval of family relationships in person identification2010

    • Author(s)
      Abe N, Fujii T, Ueno A, Shigemune Y, Suzuki M, Tashiro M, Mori E.
    • Journal Title

      Neuroscience Letters

      Volume: 486 Pages: 10-13

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neural correlates of forgiveness for moral transgressions involving deception2010

    • Author(s)
      Hayashi A, Abe N, Ueno A, Shigemune Y, Mori E, Tashiro M, Fujii T.
    • Journal Title

      Brain Research

      Volume: 1332 Pages: 90-99

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hippocampal activation associated with successful external source monitoring2010

    • Author(s)
      Mugikura S, Abe N, Suzuki M, Ueno A, Higano S, Takahashi S, Fujii T.
    • Journal Title

      Neuropsychologia

      Volume: 48 Pages: 1543-1550

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of emotion and reward motivation on neural correlates of episodic memory encoding : a PET study2010

    • Author(s)
      Shigemune Y, Abe N, Suzuki M, Ueno A, Mori E, Tashiro M, Itoh M, Fujii T.
    • Journal Title

      Neuroscience Research

      Volume: 67 Pages: 72-79

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Memory repression : brain mechanisms underlying dissociative amnesia2010

    • Author(s)
      Kikuchi H, Fujii T, Abe N, Suzuki M, Takagi M, Mugikura S, Takahashi S, Mori E.
    • Journal Title

      Journal of Cognitive Neuroscience

      Volume: 22 Pages: 602-613

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systematic retinotopic reaching error vectors in unilateral optic ataxia2010

    • Author(s)
      Blangero A, Ota H, Rossetti Y, Fujii T, Ohtake H, Tabuchi M, Vighetto A, Yamadori A, Vindras P, Pisella L.
    • Journal Title

      Cortex

      Volume: 46 Pages: 77-93

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 文字処理過程における運動覚の役割-左頭頂葉損傷による失読失書例の検討2010

    • Author(s)
      遠藤佳子, 鈴木匡子, 平山和美, 藤井俊勝, 隈部俊宏, 森悦朗
    • Journal Title

      脳神経

      Volume: 62 Pages: 991-996

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Do parkinsonian patients have trouble telling lies? The neurobiological basis of deceptive behavior2009

    • Author(s)
      Abe N, Fujii T, Hirayama K, Takeda A, Hosokai Y, Ishioka T, Nishio Y, Suzuki K, Itoyama Y, Takahashi S, Fukuda H, Mori E.
    • Journal Title

      Brain

      Volume: 132 Pages: 1386-1395

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reactivation of medial temporal lobe and human V5/MT+ during the retrieval of motion information : a PET study2009

    • Author(s)
      Ueno A, Abe N, Suzuki M, Shigemune Y, Hirayama K, Mori E, Tashiro M, Itoh M, Fujii T.
    • Journal Title

      Brain Research

      Volume: 1285 Pages: 127-134

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative analysis of donepezil binding to acetylcholinesterase using positron emission tomography and [5-(11)C-methoxy] donepezil2009

    • Author(s)
      Hiraoka K, Okamura N, Funaki Y, Watanuki S, Tashiro M, Kato M, Hayashi A, Hosokai Y, Yamasaki H, Fujii T, Mori E, Yanai K, Watabe H.
    • Journal Title

      Neuroimage

      Volume: 46 Pages: 616-623

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Do parkinsonian patients have trouble telling lies? the neurobiological basis of deceptive behavior2009

    • Author(s)
      Abe, et al.
    • Journal Title

      Brain 132

      Pages: 1386-1395

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reactivation of medial temporal lobe and human V5/MT+ during the retrieval of motion information : a PET study2009

    • Author(s)
      Ueno, et al.
    • Journal Title

      Brain Research 1285

      Pages: 127-134

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative analysis of donepezil binding to acetylcholinesterase using positron emission tomography and [5-11C-methoxy] donepezil2009

    • Author(s)
      Hiraoka, et al.
    • Journal Title

      Neuroimage 46

      Pages: 616-623

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      Fujii T, Suzuki M
    • Journal Title

      Episodic memory. The Encyclopedia of Neuroscience(Binder MC, Hirokawa N, Windhorst U (eds))(Springer)

    • Related Report
      2009 Annual Research Report
  • [Presentation] Hippocampal activity during recollection of different contextual information : an fMRI study2012

    • Author(s)
      Suzuki M, Okuda J, Fujii T.
    • Organizer
      10th Tsukuba International Conference on Memory
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] 記憶と嘘2011

    • Author(s)
      藤井俊勝
    • Organizer
      玉川大学脳科学リテラシー部門第10回研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Reactivation Hypothesis in Episodic Memory : from the Findings of Neuroimaging Studies2011

    • Author(s)
      Ueno A, Okuda J, Fujii T.
    • Organizer
      The 3^<rd> International Conference on Cognitive Neurodynamics
    • Place of Presentation
      Niseko, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Correlated brain activations during formation of memory for future plans2011

    • Author(s)
      Okuda J, Suzuki M, Fujii T.
    • Organizer
      The 3^<rd> International Conference on Cognitive Neurodynamics
    • Place of Presentation
      Niseko, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Distinct brain activations predicting the choice of likes and dislikes2011

    • Author(s)
      Ueno A, Ito A, Koseki Y, Hayashi A, Mori E, Matsue Y, Fujii T.
    • Organizer
      International Neuropsychological Society, 39th Annual Meeting
    • Place of Presentation
      Boston, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Dissociating areas for novelty detection and for episodic encoding within the human medial temporal lobe2011

    • Author(s)
      Koseki Y, Ito A, Abe N, Ueno A, Hayashi A, Mori E, Sung Y, Matsue Y, Fujii T.
    • Organizer
      International Neuropsychological Society, 39th Annual Meeting
    • Place of Presentation
      Boston, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] False recollection and recognition : an event-related fMRI study2011

    • Author(s)
      Abe N, Fujii T, Suzuki M, Ueno A, Shigemune Y, Mugikura S, Takahashi S, Mori E.
    • Organizer
      International Neuropsychological Society, 39th Annual Meeting
    • Place of Presentation
      Boston, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] The role of dorsolateral prefrontal cortex in deception for emotional and neutral events2011

    • Author(s)
      Ito A, Abe N, Fujii T, Ueno A, Koseki Y, Hashimoto R, Mugikura S, Takahashi S, Mori E.
    • Organizer
      International Neuropsychological Society, 39th Annual Meeting
    • Place of Presentation
      Boston, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Neural correlates of moral judgment about anti-and pro-social lying2011

    • Author(s)
      Hayashi A, Abe N, Fujii T, Ito A, Ueno A, Koseki Y, Mugikura S, Takahashi S, Mori E.
    • Organizer
      International Neuropsychological Society, 39th Annual Meeting
    • Place of Presentation
      Boston, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] An fMRI study on dissociative amnesia2010

    • Author(s)
      Toshikatsu Fujii
    • Organizer
      Neurotalk 2010
    • Place of Presentation
      Singapore, Singapore
    • Year and Date
      2010-06-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 記憶障害のみかた2009

    • Author(s)
      藤井俊勝
    • Organizer
      第14回日本神経精神医学会教育講演
    • Place of Presentation
      仙台
    • Year and Date
      2009-11-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 嘘とだましの神経メカニズム2009

    • Author(s)
      藤井俊勝
    • Organizer
      日本学術会議神経関係3分科会合同市民公開シンポジウム「社会性の脳科学」
    • Place of Presentation
      東京
    • Year and Date
      2009-10-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] 記憶とその障害2009

    • Author(s)
      藤井俊勝
    • Organizer
      第33回日本高次脳機能障害学会教育セミナー
    • Place of Presentation
      札幌
    • Year and Date
      2009-10-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高次脳機能の神経機能画像研究2009

    • Author(s)
      藤井俊勝
    • Organizer
      第50回日本神経学会総会シンポジウム「神経機能画像の進歩」
    • Place of Presentation
      仙台
    • Year and Date
      2009-05-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Right temporal lobe activity associated with the retrieval of family relationships in person identification : a positron emmision tomography study2009

    • Author(s)
      Abe N, Ueno A, Shigemune Y, Suzuki M, Mori E, Tashiro M, Fujii T.
    • Organizer
      15th Annual meeting of the Organization for Human Brain Mapping
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Reactivation of medial temporal lobe and visual association areas during the retrieval of visual information : a positron emmision tomography study2009

    • Author(s)
      Ueno A, Abe N, Suzuki M, Shigemune Y, Hirayama K, Mori E, Tashiro M, Itoh M, Fujii T.
    • Organizer
      15th Annual meeting of the Organization for Human Brain Mapping
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Amygdala activity associated with unpleasant emotion induced by social appraisal : a PET study2009

    • Author(s)
      Ito A, Abe N, Ueno A, Koseki Y, Mori E, Tashiro M, Fujii T.
    • Organizer
      15th Annual meeting of the Organization for Human Brain Mapping
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] The brain empathic responses modulated by the affective link between self and others : a PET study2009

    • Author(s)
      Koseki Y, Abe N, Ueno A, Ito A, Mori E, Tashiro M, Fujii T.
    • Organizer
      15th Annual meeting of the Organization for Human Brain Mapping
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2011 Final Research Report
  • [Book] 社会脳科学の展望-脳から社会をみる2012

    • Author(s)
      阿部修士, 藤井俊勝
    • Publisher
      新曜社
    • Related Report
      2011 Final Research Report
  • [Book] 社会脳科学の展望-脳から社会をみる2012

    • Author(s)
      奥田次郎, 藤井俊勝
    • Publisher
      新曜社
    • Related Report
      2011 Final Research Report
  • [Book] 展望する脳.社会脳シリーズ第1巻「社会神経科学の展望-脳から社会をみる」(苧阪直行編)2012

    • Author(s)
      奥田次郎, 藤井俊勝
    • Publisher
      新曜社
    • Related Report
      2011 Annual Research Report
  • [Book] 嘘をつく脳.社会脳シリーズ第1巻「社会神経科学の展望-脳から社会をみる」(苧阪直行編)2012

    • Author(s)
      阿部修士, 藤井俊勝
    • Publisher
      新曜社
    • Related Report
      2011 Annual Research Report
  • [Book] 記憶. ストレス科学辞典2011

    • Author(s)
      藤井俊勝
    • Publisher
      実務教育
    • Related Report
      2011 Final Research Report
  • [Book] 記憶.ストレス科学辞典(日本ストレス学会、財団法人パブリックヘルスリサーチセンター監修)2011

    • Author(s)
      藤井俊勝, 他
    • Publisher
      実務教育出版
    • Related Report
      2011 Annual Research Report
  • [Book] 記憶障害. 脳卒中症候学2010

    • Author(s)
      藤井俊勝, 阿部修士, 森悦朗
    • Publisher
      西村書店
    • Related Report
      2011 Final Research Report
  • [Book] 嘘とだまし. よくわかる認知科学2010

    • Author(s)
      藤井俊勝
    • Publisher
      ミネルヴァ書房
    • Related Report
      2011 Final Research Report
  • [Book] Perforating branches of the anterior communicating artery : anatomy and infarction2010

    • Author(s)
      Fujii Toshikatsu
    • Related Report
      2011 Final Research Report
  • [Book] Perforating branches of the anterior communicating artery : anatomy and infarction. In : Neurovascular Imaging : MRI & Microangiography(Takahashi S (ed))2010

    • Author(s)
      Fujii T
    • Publisher
      Springer
    • Related Report
      2010 Annual Research Report
  • [Book] 嘘とだまし.よくわかる認知科学(乾敏郎,川口潤,吉川左紀子編)2010

    • Author(s)
      藤井俊勝
    • Publisher
      ミネルヴァ書房
    • Related Report
      2010 Annual Research Report
  • [Book] 記憶障害.脳卒中症候学(田川皓一編)2010

    • Author(s)
      藤井俊勝, 阿部修士, 森悦朗
    • Publisher
      西村書店
    • Related Report
      2010 Annual Research Report
  • [Book] Episodic memory2009

    • Author(s)
      Fujii Toshikatsu, Suzuki Maki
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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