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Development of statistical methodology for analyses of chemical compounds for drug discovery in chemical biology

Research Project

Project/Area Number 21300109
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Statistical science
Research Institution公益財団法人がん研究会 (2011)
Japanese Foundation For Cancer Research (2009-2010)

Principal Investigator

MATSUURA Masaaki  公益財団法人がん研究会, がん研究所がんゲノム研究部, 部長 (40173794)

Co-Investigator(Kenkyū-buntansha) HOSHIKAWA Yutaka  公益財団法人がん研究会, がん研究所がんゲノム研究部, 研究員 (80280626)
MIYATA Satoshi  公益財団法人がん研究会, ゲノムセンター, 研究員 (60360343)
USHIJIMA Masaru  公益財団法人がん研究会, ゲノムセンター, 研究員 (60328565)
ISOMURA Minoru  島根大学, 医学部・病態病理学講座, 講師 (40272497)
HARA Toshihide  東京理科大学, 理工学部・情報科学科, 助教 (30579769)
Co-Investigator(Renkei-kenkyūsha) YAMORI Takao  公益財団法人がん研究会, がん化学療法センター分子薬理部, 部長 (60200854)
DAN Shingo  公益財団法人がん研究会, がん化学療法センター分子薬理部, 研究員 (70332202)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Keywords統計数学 / バイオインフォマティクス / 創薬 / 生体生命情報学 / ケミカルバイオロジー
Research Abstract

We developed a statistical methodology to find optimal compounds for drug discovery, using JFCR-39 cell line panel.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (20 results)

All 2012 2011 2010 2009

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (4 results) Book (4 results)

  • [Journal Article] Hyperactivation of 4E-binding protein 1 as a mediator of biguanide-in duced cyto toxicity during glucose deprivation2012

    • Author(s)
      Matsuo J, Tsukumo Y, Saito S, Tsukahara S, Sakurai J, Sato S, Kondo H, Ushijima M, Matsuura M, Watanabe T, Tomida A
    • Journal Title

      Mol Cancer Ther

      Volume: 11(5) Issue: 5 Pages: 1082-1091

    • DOI

      10.1158/1535-7163.mct-11-0871

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ASCL1-coexpression profiling but not single gene expression profiling defines lung adenocarcinomas of neuroendocrine nature with poor prognosis2012

    • Author(s)
      Fujiwara T, Hiramatsu M, Isagawa T, Ninomiya H, Inamura K, Ishikawa S, Ushijima M, Matsuura M, Jones M. H., Shimane M, Nomura H, Ishikawa, Y, Aburatani H
    • Journal Title

      Lung Cancer

      Volume: 75(1) Pages: 119-125

    • URL

      http://www.sciencedirect.com/science/article/pii/S016950021100328X

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency2012

    • Author(s)
      Wang L, et al.(Isomura M 25人中14番目)
    • Journal Title

      Genome research

      Volume: 22 Pages: 208-219

    • URL

      http://www.genome.org/cgi/doi/10.1101/gr.123109.111

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prospective randomized phase II study determines the clinical usefulness of genetic biomarkers for sensitivity to primary chemotherapy with paclitaxel in breast cancer2011

    • Author(s)
      Ito Y, Nagasaki K, Miki Y, Iwase T, Akiyama F, Matsuura M, Horii R, Makita M, Tokudome N, Ushijima M, Yoshimoto M, Takahashi S, Noda T, Hatake K
    • Journal Title

      Cancer Science

      Volume: 102 Issue: 1 Pages: 130-136

    • DOI

      10.1111/j.1349-7006.2010.01740.x

    • NAID

      10029288759

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alcoholics show reduced telomere length in the oesophagus2011

    • Author(s)
      Aida J, Yokoyama A, Izumiyama N, Nakamura K, Ishikawa N, Poon SS, Fujiwara M, Sawabe M, Matsuura M, Arai T, Takubo K
    • Journal Title

      Journal of Pathology

      Volume: 223 Pages: 410-416

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prospective randomized phase II study determines the clinical usefulness of genetic biomarkers for sensitivity to primary chemotherapy with paclitaxel in breast cancer.2011

    • Author(s)
      Ito Y, Nagasaki K, Miki Y, Iwase T, Akiyama F, Matsuura M, Horii R, Makita M, Tokudome N, Ushijima M, Yoshimoto M, Takahashi S, Noda T, Hatake K.
    • Journal Title

      Cancer Science

      Volume: 102 Pages: 130-136

    • NAID

      10029288759

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alcoholics show reduced telomere length in the oesophagus.2011

    • Author(s)
      Aida J, Yokoyama A, Izumiyama N, Nakamura K, Ishikawa N, Poon SS, Fujiwara M, Sawabe M, Matsuura M, Arai T, Takubo K.
    • Journal Title

      Journal of Pathology

      Volume: 223 Pages: 410-416

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mathematical description of drug movement into tumor with EPR effect and estimation of its configuration for DDS2010

    • Author(s)
      Hara, T., Iriyama, S., Makino, K., Terada, H. and Ohya, M.
    • Journal Title

      Colloids Surf B Biointerfaces

      Volume: 75 Pages: 42-46

    • URL

      http://dx.doi.org/10.1016/j.colsurfb.2009.08.013

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Common and discriminative clinicopathological features between breast cancers with pathological complete response or progressive disease in response to neoadjuvant chemotherapy2010

    • Author(s)
      Osako T, Horii R, Matsuura M, Ogiya A, Domoto K, Miyagi Y, Takahashi S, Ito Y, Iwase T, Akiyama F
    • Journal Title

      J. Cancer Res. Clin. Oncol

      Volume: 136(2) Issue: 2 Pages: 233-241

    • DOI

      10.1007/s00432-009-0654-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Common and discriminative clinicopathological features between breast cancers with pathological complete response or progressive disease in response to neoadjuvant chemotherapy2010

    • Author(s)
      Osako T, Horii R, Matsuura M, Ogiya A, Domoto K, Miyagi Y, Takahashi S, Ito Y, Iwase T, Akiyama F
    • Journal Title

      J.Cancer Res.Clin.Oncol. 136(2)

      Pages: 233-241

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predictive factors for efficacy of capecitabine in heavily pretreated patients with metastatic breast cancer2009

    • Author(s)
      Osako T, Ito Y, Ushijima M, Takahashi S, Tokudome N, Sugihara T, Iwase T, Matsuura M, Hatake K
    • Journal Title

      Cancer Chemother. Pharmacol

      Volume: 63 Pages: 865-871

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/18670777

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Predictive factors for efficacy of capecitabine in heavily pretreated patients with metastatic breast cancer2009

    • Author(s)
      Osako T, Ito Y, Ushijima M, Takahashi S, Tokudome N, Sugihara T, Iwase T, Matsuura M, Hatake K.
    • Journal Title

      Cancer Chemother.Pharmacol. 63(5)

      Pages: 865-871

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] イメージング質量分析データに対するソフトウェアの開発2011

    • Author(s)
      牛嶋大、瀬藤光利、松浦正明
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋(国際会議場)
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Some mathematical techniques to study life sciences2011

    • Author(s)
      Hara, T. Ohya, M
    • Organizer
      32^<nd> International Conference on Quantum Probability and Related Topics
    • Place of Presentation
      Levico Terme, Italy
    • Year and Date
      2011-06-02
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 少数サンプルから癌化学療法の副作用に関連するSNPを同定する方法の開発2010

    • Author(s)
      磯村実,松浦正明,野田哲生,三木義男
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Statistical issues on the use of Connectivity Map2009

    • Author(s)
      牛嶋大,宮田敏,松浦正明
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-03
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Book] バイオインフォマティクス2009

    • Author(s)
      松浦正明
    • Publisher
      南江堂
    • Related Report
      2011 Final Research Report
  • [Book] マイクロアレイデータの解析における統計処理2009

    • Author(s)
      宮田敏,牛嶋大,松浦正明
    • Publisher
      金芳堂
    • Related Report
      2011 Final Research Report
  • [Book] 「バイオインフォマティクス」新臨床腫瘍学:がん薬物療法専門医のために 改訂第2版2009

    • Author(s)
      松浦正明
    • Total Pages
      4
    • Publisher
      南江堂
    • Related Report
      2009 Annual Research Report
  • [Book] 「マイクロアレイデータの解析における統計処理」がん分子標的治療研究実践マニュアル2009

    • Author(s)
      宮田敏, 牛嶋大, 松浦正明
    • Total Pages
      7
    • Publisher
      金芳堂
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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