Development of statistical methodology for analyses of chemical compounds for drug discovery in chemical biology

• Project/Area Number: 21300109
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Statistical science
• Research Institution: 公益財団法人がん研究会 (2011); Japanese Foundation For Cancer Research (2009-2010)
• Principal Investigator: MATSUURA Masaaki 公益財団法人がん研究会, がん研究所がんゲノム研究部, 部長 (40173794)
• Co-Investigator(Kenkyū-buntansha): HOSHIKAWA Yutaka 公益財団法人がん研究会, がん研究所がんゲノム研究部, 研究員 (80280626) ; MIYATA Satoshi 公益財団法人がん研究会, ゲノムセンター, 研究員 (60360343) ; USHIJIMA Masaru 公益財団法人がん研究会, ゲノムセンター, 研究員 (60328565) ; ISOMURA Minoru 島根大学, 医学部・病態病理学講座, 講師 (40272497) ; HARA Toshihide 東京理科大学, 理工学部・情報科学科, 助教 (30579769)
• Co-Investigator(Renkei-kenkyūsha): YAMORI Takao 公益財団法人がん研究会, がん化学療法センター分子薬理部, 部長 (60200854) ; DAN Shingo 公益財団法人がん研究会, がん化学療法センター分子薬理部, 研究員 (70332202)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000); Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2009: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
• Keywords: 統計数学 / バイオインフォマティクス / 創薬 / 生体生命情報学 / ケミカルバイオロジー

Research Abstract

We developed a statistical methodology to find optimal compounds for drug discovery, using JFCR-39 cell line panel.

Research Products

• [Journal Article] Hyperactivation of 4E-binding protein 1 as a mediator of biguanide-in duced cyto toxicity during glucose deprivation (2012)
  • Author(s): Matsuo J, Tsukumo Y, Saito S, Tsukahara S, Sakurai J, Sato S, Kondo H, Ushijima M, Matsuura M, Watanabe T, Tomida A
  • Journal Title: Mol Cancer Ther Volume: 11(5) Issue: 5 Pages: 1082-1091
  • DOI: 10.1158/1535-7163.mct-11-0871
  • Peer Reviewed
• [Journal Article] ASCL1-coexpression profiling but not single gene expression profiling defines lung adenocarcinomas of neuroendocrine nature with poor prognosis (2012)
  • Author(s): Fujiwara T, Hiramatsu M, Isagawa T, Ninomiya H, Inamura K, Ishikawa S, Ushijima M, Matsuura M, Jones M. H., Shimane M, Nomura H, Ishikawa, Y, Aburatani H
  • Journal Title: Lung Cancer Volume: 75(1) Pages: 119-125
  • URL: http://www.sciencedirect.com/science/article/pii/S016950021100328X
  • Peer Reviewed
• [Journal Article] Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency (2012)
  • Author(s): Wang L, et al.(Isomura M 25人中14番目)
  • Journal Title: Genome research Volume: 22 Pages: 208-219
  • URL: http://www.genome.org/cgi/doi/10.1101/gr.123109.111
  • Peer Reviewed
• [Journal Article] Prospective randomized phase II study determines the clinical usefulness of genetic biomarkers for sensitivity to primary chemotherapy with paclitaxel in breast cancer (2011)
  • Author(s): Ito Y, Nagasaki K, Miki Y, Iwase T, Akiyama F, Matsuura M, Horii R, Makita M, Tokudome N, Ushijima M, Yoshimoto M, Takahashi S, Noda T, Hatake K
  • Journal Title: Cancer Science Volume: 102 Issue: 1 Pages: 130-136
  • DOI: 10.1111/j.1349-7006.2010.01740.x
  • NAID: 10029288759
  • Peer Reviewed
• [Journal Article] Alcoholics show reduced telomere length in the oesophagus (2011)
  • Author(s): Aida J, Yokoyama A, Izumiyama N, Nakamura K, Ishikawa N, Poon SS, Fujiwara M, Sawabe M, Matsuura M, Arai T, Takubo K
  • Journal Title: Journal of Pathology Volume: 223 Pages: 410-416
  • Peer Reviewed
• [Journal Article] Prospective randomized phase II study determines the clinical usefulness of genetic biomarkers for sensitivity to primary chemotherapy with paclitaxel in breast cancer. (2011)
  • Author(s): Ito Y, Nagasaki K, Miki Y, Iwase T, Akiyama F, Matsuura M, Horii R, Makita M, Tokudome N, Ushijima M, Yoshimoto M, Takahashi S, Noda T, Hatake K.
  • Journal Title: Cancer Science Volume: 102 Pages: 130-136
  • NAID: 10029288759
  • Peer Reviewed
• [Journal Article] Alcoholics show reduced telomere length in the oesophagus. (2011)
  • Author(s): Aida J, Yokoyama A, Izumiyama N, Nakamura K, Ishikawa N, Poon SS, Fujiwara M, Sawabe M, Matsuura M, Arai T, Takubo K.
  • Journal Title: Journal of Pathology Volume: 223 Pages: 410-416
  • Peer Reviewed
• [Journal Article] Mathematical description of drug movement into tumor with EPR effect and estimation of its configuration for DDS (2010)
  • Author(s): Hara, T., Iriyama, S., Makino, K., Terada, H. and Ohya, M.
  • Journal Title: Colloids Surf B Biointerfaces Volume: 75 Pages: 42-46
  • URL: http://dx.doi.org/10.1016/j.colsurfb.2009.08.013
  • Peer Reviewed
• [Journal Article] Common and discriminative clinicopathological features between breast cancers with pathological complete response or progressive disease in response to neoadjuvant chemotherapy (2010)
  • Author(s): Osako T, Horii R, Matsuura M, Ogiya A, Domoto K, Miyagi Y, Takahashi S, Ito Y, Iwase T, Akiyama F
  • Journal Title: J. Cancer Res. Clin. Oncol Volume: 136(2) Issue: 2 Pages: 233-241
  • DOI: 10.1007/s00432-009-0654-9
  • Peer Reviewed
• [Journal Article] Common and discriminative clinicopathological features between breast cancers with pathological complete response or progressive disease in response to neoadjuvant chemotherapy (2010)
  • Author(s): Osako T, Horii R, Matsuura M, Ogiya A, Domoto K, Miyagi Y, Takahashi S, Ito Y, Iwase T, Akiyama F
  • Journal Title: J.Cancer Res.Clin.Oncol. 136(2) Pages: 233-241
  • Peer Reviewed
• [Journal Article] Predictive factors for efficacy of capecitabine in heavily pretreated patients with metastatic breast cancer (2009)
  • Author(s): Osako T, Ito Y, Ushijima M, Takahashi S, Tokudome N, Sugihara T, Iwase T, Matsuura M, Hatake K
  • Journal Title: Cancer Chemother. Pharmacol Volume: 63 Pages: 865-871
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/18670777
  • Peer Reviewed
• [Journal Article] Predictive factors for efficacy of capecitabine in heavily pretreated patients with metastatic breast cancer (2009)
  • Author(s): Osako T, Ito Y, Ushijima M, Takahashi S, Tokudome N, Sugihara T, Iwase T, Matsuura M, Hatake K.
  • Journal Title: Cancer Chemother.Pharmacol. 63(5) Pages: 865-871
  • Peer Reviewed
• [Presentation] イメージング質量分析データに対するソフトウェアの開発 (2011)
  • Author(s): 牛嶋大、瀬藤光利、松浦正明
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 名古屋(国際会議場)
  • Year and Date: 2011-10-04
• [Presentation] Some mathematical techniques to study life sciences (2011)
  • Author(s): Hara, T. Ohya, M
  • Organizer: 32^<nd> International Conference on Quantum Probability and Related Topics
  • Place of Presentation: Levico Terme, Italy
  • Year and Date: 2011-06-02
• [Presentation] 少数サンプルから癌化学療法の副作用に関連するSNPを同定する方法の開発 (2010)
  • Author(s): 磯村実,松浦正明,野田哲生,三木義男
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] Statistical issues on the use of Connectivity Map (2009)
  • Author(s): 牛嶋大,宮田敏,松浦正明
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-03
• [Book] バイオインフォマティクス (2009)
  • Author(s): 松浦正明
  • Publisher: 南江堂
• [Book] マイクロアレイデータの解析における統計処理 (2009)
  • Author(s): 宮田敏,牛嶋大,松浦正明
  • Publisher: 金芳堂
• [Book] 「バイオインフォマティクス」新臨床腫瘍学:がん薬物療法専門医のために 改訂第2版 (2009)
  • Author(s): 松浦正明
  • Total Pages: 4
  • Publisher: 南江堂
• [Book] 「マイクロアレイデータの解析における統計処理」がん分子標的治療研究実践マニュアル (2009)
  • Author(s): 宮田敏, 牛嶋大, 松浦正明
  • Total Pages: 7
  • Publisher: 金芳堂