Roles of fatty acids and fatty acid binding proteins for regulating proliferation and differentiation of neural stem cells

• Project/Area Number: 21300115
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: Tohoku University
• Principal Investigator: OSUMI Noriko 東北大学, 大学院・医学系研究科, 教授 (00220343)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000); Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2009: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
• Keywords: 神経幹細胞 / 高度不飽和脂肪酸 / アラキドン酸 / ドコサヘキサエン酸 / 脂肪酸結合タンパク質 / 細胞増殖 / 細胞分化 / Fabp7 / ニューロスフェア / Fabp5

Research Abstract

Neurosphere assays using neural stem cells (NSCs)derived from the wild type rat embryo revealed that arachidonic acid (ARA)and docosahexanoic acid (DHA)regulate proliferation and differentiation of NSCs in a stage-dependent manner (Sakayori et al., 2011). From neurosphere assays using NSCs derived from mice deficient for fatty acid binding protein 7 (Fabp7), it is shown that Fabp7 is required for proliferation and differentiation of NSCs (in prep).

Research Products

• [Journal Article] Differential Proliferation Rhythm of Neural Progenitor and Oligodendrocyte Precursor Cells in the Young Adult Hippocampus (2011)
  • Author(s): Matsumoto, Y., Tsunekawa, Y., Nomura, T., Suto, F., Matsumata, M., Tsuchiya, S., and Osumi, N.
  • Journal Title: PLoS ONE Volume: 6(11)
  • Peer Reviewed
• [Journal Article] Distinctive effects of arachidonic acid and docosahexaenoic acid on neural stem/progenitor cells (2011)
  • Author(s): Sakayori, N., Maekawa, M., Numayama-Tsuruta, K., Katura, T., Moriya, T. and Osumi, N.
  • Journal Title: Genes Cells Volume: 16(7) Pages: 778-790
  • Peer Reviewed
• [Journal Article] Differential Proliferation Rhythm of Neural Progenitor and Oligodendrocyte Precursor Cells in the Young Adult Hippocampus (2011)
  • Author(s): Matsumoto, Y., Tsunekawa, Y., Nomura, T., Suto, F., Matsumata, M., Tsuchiya, S., Osumi, N.
  • Journal Title: PLoS ONE Volume: 6(11) Issue: 11 Pages: e27628-e27628
  • DOI: 10.1371/journal.pone.0027628
  • Peer Reviewed
• [Journal Article] Excessive ingestion of long-chain polyunsaturated fatty acids during developmental stage causes strain-and sex-dependent eye abnormalities in mice (2010)
  • Author(s): Maekawa, M., Iwayama, Y., Watanabe, A., Nozaki, Y., Ohnishi, T., Ohba, H., Toyoshima, M., Hamazaki, K., Osumi, N., Aruga, J. and Yoshikawa, T.
  • Journal Title: Biochem Biophys Res Commun Volume: 402(2) Pages: 431-437
  • Peer Reviewed
• [Journal Article] Impaired hippocampal neurogenesis and vascular formation in ephrin-A5-deficient mice (2010)
  • Author(s): Hara, Y., Nomura, T., Yoshizaki, K., Jonas Frisen, J., and Osumi, N.
  • Journal Title: Stem Cells Volume: 28(5) Pages: 974-983
  • Peer Reviewed
• [Journal Article] Polymorphism screening of brain-expressed FABPs7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects (2010)
  • Author(s): Maekawa, M., Iwayama, Y., Arai, R., Nakamura, K., Ohnishi, T., Toyota, T., Tsujii, M., Okazaki, Y., Osumi, N., Owada, Y., Mori, N. and Yoshikawa, T.
  • Journal Title: J Hum Genet Volume: 55(2) Pages: 127-130
  • Peer Reviewed
• [Journal Article] Impaired hippocampal neurogenesis and vascular formation in ephrin-A5-def icient mice. (2010)
  • Author(s): Hara, Y., Nomura, T., Yoshizaki, K., Jonas Frisen, J., Osumi, N.
  • Journal Title: Stem Cells Volume: 28 Pages: 1974-983
  • Peer Reviewed
• [Journal Article] Giant Subependymoma Developed in a Patient with Aniridia: Analyses of PAX6 and Tumor-relevant Genes. (2010)
  • Author(s): Maekawa, M., Fujisawa, H., Iwayama, Y., Tamase, A., Toyota, T., Osumi, N., Yoshikawa, T.
  • Journal Title: Brain Pathol Volume: 20 Pages: 1033-1041
  • Peer Reviewed
• [Journal Article] Excessive ingestion of long-chain polyunsaturated fatty acids during developmental stage causes strain-and sex-dependent eye abnormalities in mice. (2010)
  • Author(s): Maekawa, M., Iwayama, Y., Watanabe, A., Nozaki, Y., Ohnishi, T., Ohba, H., Toyoshima, M., Hamazaki, K., Osumi, N., Aruga, J., Yoshikawa, T.
  • Journal Title: Biochem Biophys Res Commun. Volume: 402 Pages: 431-437
  • Peer Reviewed
• [Journal Article] 脂肪酸シグナル・神経新生・精神疾患 (2010)
  • Author(s): 大隅典子
  • Journal Title: 日本神経精神薬理学雑誌Jpn.J.Neuropsychopharmacol. Volume: 30 Pages: 141-148
• [Journal Article] 脂肪酸とこころの発達 (2010)
  • Author(s): 松本葉子、大隅典子
  • Journal Title: 小児科 Volume: 51 Pages: 1155-1161
• [Journal Article] Polymorphism screening of brain-expressed FABP7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects. (2010)
  • Author(s): Maekawa M, Iwayama Y, Arai R, Nakamura K, Ohnishi T, Toyota T, Tsujii M, Okazaki Y, Osumi N, Owada Y, Mori N, Yoshikawa T
  • Journal Title: Journal of human genetics 55 Pages: 127-130
  • Peer Reviewed
• [Journal Article] Downstream genes of Pax6 revealed by comprehensive transcriptome profiling in the developing rat hindbrain. (2010)
  • Author(s): Numayama-Tsuruta K, Arai Y, Takahashi M, Sasaki-Hoshino M, Funatsu N, Nakamura S, Osumi N
  • Journal Title: BMC developmental biology 10 Pages: 6-6
  • Peer Reviewed
• [Journal Article] A novel missense mutation (Leu46Val)of PAX6 found in an autistic patient (2009)
  • Author(s): Maekawa, M., Iwayama, Y., Nakamura, K., Sato, M., Toyota, T., Ohnishi, T., Yamada, K., Miyachi, T., Tsujii, M., Hattori, E., M aekawa, N., Osumi, N., Mori, N. and Yoshikawa, T.
  • Journal Title: Neurosci Lett Volume: 462(3) Pages: 267-271
  • Peer Reviewed
• [Journal Article] Arachidonic acid drives postnatal neurogenesis and elicits a beneficial effect on prepulse inhibition, a biological trait of psychiatric illnesses (2009)
  • Author(s): Maekawa, M., Takashima, N., Matsumata, M., Ikegami, S., Kontani, M., Hara, Y., Kawashima, H., Owada, Y., Kiso, Y., Yoshikawa, T., Inokuchi, K. and Osumi, N.
  • Journal Title: PloS One Volume: 4(4)
  • Peer Reviewed
• [Journal Article] Reelin, radial fibers and cortical evolution : insights from comparative analysis of the mammalian and avian telencephalon. (2009)
  • Author(s): Nomura T, Hattori M, Osumi N
  • Journal Title: Development, growth & differentiation 51 Pages: 287-297
  • Peer Reviewed
• [Journal Article] Arachidonic acid drives postnatal neurogenesis and elicits a beneficial effect on prepulse inhibition, a biological trait of psychiatric illnesses. (2009)
  • Author(s): Maekawa M, Takashima N, Matsumata M, Ikegami S, Kontani M, Hara Y, Kawashima H, Owada Y, Kiso Y, Yoshikawa T, Inokuchi K, Osumi N
  • Journal Title: PLoS ONE 4
  • Peer Reviewed
• [Journal Article] A novel missense mutation(Leu46Val)of PAX6 found in an autistic patient. (2009)
  • Author(s): Maekawa M, Iwayama Y, Nakamura K, Sato M, Toyota T, Ohnishi T, Yamada K, Miyachi T, Tsujii M, Hattori E, Maekawa N, Osumi N, Mori N, Yoshikawa T
  • Journal Title: Neuroscience letters 462 Pages: 267-271
  • Peer Reviewed
• [Journal Article] Pax6 mutant rat as a model for autism spectrum disorder. (2009)
  • Author(s): Osumi N
  • Journal Title: Neurosci Res 65 Pages: 27-27
• [Journal Article] The effect of arachidonic acid and docosahexaenoic acid in neural stem/progenitor cells. (2009)
  • Author(s): Sakayori N, Numayama-Tsuruta K, Osumi N
  • Journal Title: Neurosci Res 65 Pages: 155-155
• [Journal Article] (2009)
  • Author(s): 酒寄信幸, 大隅典子
  • Journal Title: 最新医学増刊号 幹細胞研究の最新の進歩(後編)-組織幹細胞-(神経幹細胞と発生)
• [Presentation] Impact of postnatal and adult neurogenesis on animal behavior (2011)
  • Author(s): Osumi, N.
  • Organizer: The 3rd International Conference on Cognitive Neurodynamics
  • Place of Presentation: 北海道・ニセコ
  • Year and Date: 2011-06-12
• [Presentation] Impact of postnatal and adult neurogenesis on animal behavior (2011)
  • Author(s): Osumi, N.
  • Organizer: ICCN (The 3rd International Conference on Cognitive Neurodynamics)
  • Place of Presentation: 北海道・ニセコ
  • Year and Date: 2011-06-12
• [Presentation] Molecular and cellular mechanisms of mammalian cortical neurogenesis based on the morphology of radial progenitor cells (2011)
  • Author(s): Osumi, N.
  • Organizer: Cortical Development Conference 2011
  • Place of Presentation: ギリシャ・ハニア
  • Year and Date: 2011-05-19
• [Presentation] Neurogenesis-Its implication in and application for mental diseases (2011)
  • Author(s): Osumi, N.
  • Organizer: Cold Spring Harbor Asia Francis Crick Neurobiology Symposium
  • Place of Presentation: 中国・蘇州
  • Year and Date: 2011-04-17
• [Presentation] Neurogenesis-Its implication in and application for mental diseases (2011)
  • Author(s): Osumi, N.
  • Organizer: Cold Spring Harbor Asia Francis Crick Neurobioloey Symposium
  • Place of Presentation: 中国・蘇州
  • Year and Date: 2011-04-17
• [Presentation] 神経系前駆細胞の増殖と分化に対するアラキドン酸とドコサヘキサエン酸の効果の解析 (2010)
  • Author(s): 酒寄信幸、前川素子、松股美穂、沼山恵子、若松義雄、大隅典子
  • Organizer: 第33回日本分子生物学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-10
• [Presentation] The effects of arachidonic acid and docosahexaenoic acid on neural stem/progenitor cells (2010)
  • Author(s): Sakayori, N., Maekawa, M., Numayama-Tsuruta, K. and Osumi, N.
  • Organizer: Society of Neuroscience 40th Annual Meeting, Neuroscience 2010
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2010-11-14
• [Presentation] The effects of arachidonic acid and docosahexaenoic acid on neural stem/progenitor cells. (2010)
  • Author(s): Sakayori, N., Maekawa, M., Numayama-Tsuruta, K., Osumi, N.
  • Organizer: Society of Neuroscience 40th Annual Meeting, Neuroscience 2010
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2010-11-14
• [Presentation] 脂肪酸シグナルと神経新生～精神疾患病態への関与 (2010)
  • Author(s): 大隅典子
  • Organizer: 第18回日本精神行動遺伝医学会
  • Place of Presentation: 仙台
  • Year and Date: 2010-09-18
• [Presentation] 脂肪酸・グナ・レと神経生～精神囎病態への関与 (2010)
  • Author(s): 大隅典子
  • Organizer: 第18回日本精神行動遺伝医学会
  • Place of Presentation: 仙台
  • Year and Date: 2010-09-18
• [Presentation] 海馬歯状回の神経新生における脂肪酸シグナルの役割 (2010)
  • Author(s): 大隅典子
  • Organizer: 第20回日本臨床精神神経薬理学会・第40回日本神経精神薬理学会合同年会
  • Place of Presentation: 仙台
  • Year and Date: 2010-09-16
• [Presentation] 神経系前駆細胞の増殖と分化に対するアラキドン酸とDHAの効果の解析 (2010)
  • Author(s): 酒寄信幸, 松股美穂, 前川素子, 新井洋子, 大隅典子
  • Organizer: 第6回「必須脂肪酸と健康」研究会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-08
• [Presentation] 神経系前駆細胞の増殖と分化におけるアラキドン酸とドコサヘキサエン酸の効果の解析 (2010)
  • Author(s): 酒寄信幸、前川素子、沼山恵子、大隅典子
  • Organizer: 第33回日本神経科学大会Neuro2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-03
• [Presentation] The role of FABPs in postnatal hippocampal neurogenesis and function (2010)
  • Author(s): Matsumata, M., Maekawa, M., Arime, Y., Owada, Y., Sora, I., Yoshikawa, T. and Osumi, N.
  • Organizer: 第33回日本神経科学大会 Neuro2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-02
• [Presentation] The role of FABPs in postnatal hippocampal neurogenesis and function. (2010)
  • Author(s): Matsumata, M., Maekawa, M., Arime, Y., Owada, Y., Sore, I., Yoshikawa, T., Osumi, N.
  • Organizer: 第33回日本神経科学大学Neuro2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-02
• [Presentation] 成体マウス海馬の神経新生及び機能における脂肪酸結合タンパク質FABPの役割 (2010)
  • Author(s): 松股美穂、前川素子、有銘預世布、大和田祐二、曽良一郎、吉川武男、大隅典子
  • Organizer: 日本分子生物学会第10回春期シンポジウム
  • Place of Presentation: 松島
  • Year and Date: 2010-06-07
• [Presentation] The effect of arachidonic acid and docosahexaenoic acid in neural stem/progenitor cells. (2010)
  • Author(s): 酒寄信幸、前川素子、沼山恵子、大隅典子
  • Organizer: 日本分子生物学会第10回春期シンポジウム
  • Place of Presentation: 松島
  • Year and Date: 2010-06-07
• [Presentation] The effects of arachidonic acid and docosahexaenoic acid on neural stem/progenitor cells (2010)
  • Author(s): Osumi, N.
  • Organizer: 9th Conference of the International Society for the Study of Fatty Acids and Lipids (ISSFAL)
  • Place of Presentation: Maastricht, Netherlands
  • Year and Date: 2010-05-31
• [Presentation] The effects of arachidonic acid and docosahexaenoic acid on neural stem/progenitor cells. (2010)
  • Author(s): Osumi, N.
  • Organizer: 9th Conference of the International Society for the Study of Fatty Acids and Lipids (ISSFAL)
  • Place of Presentation: Maastricht ? Netherlands
  • Year and Date: 2010-05-31
• [Presentation] Fatty acid signals in neurogenesis : for potential prevention and treatment of psyichiatric diseases (2010)
  • Author(s): Osumi, N.
  • Organizer: Adult Neurogenesis : Structure and Function
  • Place of Presentation: Frauenchiemsee, Germany
  • Year and Date: 2010-05-28
• [Presentation] Fatty acid signals in neurogenesis : for potential prevention and treatment of psyichiatric diseases. (2010)
  • Author(s): Osumi, N.
  • Organizer: Adult Neurogenesis : Structure and Function
  • Place of Presentation: Germany? Frauenchiemsee
  • Year and Date: 2010-05-28
• [Presentation] 海馬神経新生および感覚運動フィルター機構における脂肪酸シグナルの役割 (2010)
  • Author(s): 大隅典了、松股美穂、酒寄信幸
  • Organizer: 第64回日本栄養・食糧学会大会
  • Place of Presentation: 徳島
  • Year and Date: 2010-05-23
• [Presentation] 神経系前駆細胞におけるアラキドン酸とドコサヘキサエン酸の効果の解析 (2010)
  • Author(s): 酒寄信幸、大隅典子
  • Organizer: 第8回幹細胞シンポジウム
  • Place of Presentation: 淡路島
  • Year and Date: 2010-05-13
• [Presentation] Spatiotemporal Post-Transcriptional Regulation of Cyclin D2 mRNA Induces Asymmetrical Cell Fates in Neuroepithelial Cells and Self-Organization of Corticogenesis. (2010)
  • Author(s): 大隅典子
  • Organizer: The 56th NIBB Conference Neocortical Organization
  • Place of Presentation: 岡崎
  • Year and Date: 2010-03-12
• [Presentation] 脂肪酸シクナル、神経新生、精神疾患 (2010)
  • Author(s): 大隅典子
  • Organizer: 日本神経精神薬理学会、日本薬理学会、日本薬学会東海支部主催 第48回「脳の医学・生物学研究会」
  • Place of Presentation: 名古屋
  • Year and Date: 2010-02-20
• [Presentation] Molecular mechanisms of neurogenesis, a key event in development and maintenance of the brain. (2009)
  • Author(s): 大隅典子
  • Organizer: Construction and Reconstruction of the Brain.
  • Place of Presentation: 淡路
  • Year and Date: 2009-10-08
• [Presentation] Pax6変異ラット:自閉症スペクトラムモデルとしての可能性. (2009)
  • Author(s): 大隅典子
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-18
• [Presentation] 神経系前駆細胞の増殖と分化におけるアラキドン酸とドコサヘキサエン酸の効果の解析 (2009)
  • Author(s): 酒寄信幸, 沼山恵子, 大隅典子
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-17
• [Presentation] The Effects of Fatty Acids on Neural Stem Cells. (2009)
  • Author(s): 酒寄信幸, 大隅典子
  • Organizer: Tohoku University -Lyon Summer School 2009.
  • Place of Presentation: Lyon, France
  • Year and Date: 2009-09-10
• [Presentation] Roles of fatty acid binding proteins and polyunsaturated fatty acids in hippocampal neurogenesis (2009)
  • Author(s): Osumi, N.
  • Organizer: 6th International Society of Developmental Biologists Congress 2009
  • Place of Presentation: Edinburgh, UK
  • Year and Date: 2009-09-08
• [Presentation] ROLES OF FATTY ACID BINDING PROTEINS AND POLYUNSATURATED FATTY ACIDS IN HIPPOCAMPAL NEUROGENESIS. (2009)
  • Author(s): 大隅典子
  • Organizer: 16th International Society of Developmental Biologists Congress 2009
  • Place of Presentation: Scotland, UK
  • Year and Date: 2009-09-08
• [Presentation] THE EFFECT OF ARACHIDONIC ACID AND DOCOSAHEXAENOIC ACID ON NEURAL STEM/PROGENITOR CELLS. (2009)
  • Author(s): 酒寄信幸, 沼山恵子, 大隅典子
  • Organizer: The 2nd Brain Science Summer Retreat in Sendai.
  • Place of Presentation: 仙台
  • Year and Date: 2009-07-25
• [Presentation] 神経新生の低下と精神疾患発症の脆弱性. (2009)
  • Author(s): 大隅典子
  • Organizer: 神経組織の成長・再生・移植研究会 第24回学術集会.
  • Place of Presentation: 渋川
  • Year and Date: 2009-06-21
• [Presentation] Fatty acid signals in neurogenesis : for potential prevention and treatment of psychiatric diseases (2009)
  • Author(s): Osumi, N.
  • Organizer: Neurogenesis 2009 Hippocampal neurogenesis : Its implication in neural functions and mental diseases
  • Place of Presentation: 淡路
  • Year and Date: 2009-06-02
• [Presentation] THE EFFECT OF ARACHIDONIC ACID AND DOCOSAHEXAENOIC ACID ON NEURAL STEM/PROGENITOR CELLS. (2009)
  • Author(s): 酒寄信幸, 沼山恵子, 大隅典子
  • Organizer: Neurogenesis2009 Hippocampal neurogenesis : Its implication in neural functions and mental diseases.
  • Place of Presentation: 淡路
  • Year and Date: 2009-06-02
• [Presentation] Fatty acid signals in neurogenesis : for potential prevention and treatment of psychiatric diseases. (2009)
  • Author(s): 大隅典子
  • Organizer: Neurogenesis2009 Hippocampal neurogenesis : Its implication in neural functions and mental diseases.
  • Place of Presentation: 淡路
  • Year and Date: 2009-06-02
• [Presentation] Fatty acid signals in neurogenesis and their application. (2009)
  • Author(s): 大隅典子
  • Organizer: 第4回iCeMS国際シンポジウム "Integrated Physical/Chemical Biology of the Cell : from Genes to Membrane Systems"
  • Place of Presentation: 京都
  • Year and Date: 2009-05-27
• [Presentation] Decreased Neurogenesis as a Risk Factor for Mental Diseases. (2009)
  • Author(s): 大隅典子
  • Organizer: Wiring the Brain 2009.
  • Place of Presentation: Limerick, Ireland
  • Year and Date: 2009-04-24
• [Presentation] Fatty acid signals in neurogenesis : for potential prevention and treatment for mental illnesses. (2009)
  • Author(s): 大隅典子
  • Organizer: Institut Multidisciplinaire de Biochimie des Lipides.
  • Place of Presentation: Lyon, France
  • Year and Date: 2009-04-20
• [Book] Eds. Tatsunori, S., Kazunobu, S., Jack M. Parent and Arturo Alvarez-Buylla (2011)
  • Author(s): Osumi, N. and Nannan, G.
  • Publisher: springer
• [Book] Impaired Neurogenesis as a Risk Factor for Schizophrenia and Related Mental Diseases (2011)
  • Author(s): Osumi, N., Nannan, G
  • Publisher: Springer (Eds. Tatsunori, S., Kazunobu, S., Jack M.Parent and Arturo Alvarez-Buylla)
• [Book] 「シリーズ朝倉<言語の可能性>第4巻 言語と生物学」 第5章言語の遺伝学的基盤 (2010)
  • Author(s): 大隅典子
  • Publisher: 朝館店
• [Book] 生命の科学 (2010)
  • Author(s): 大隅典子
  • Total Pages: 7
  • Publisher: 統合失調症関連モデル動物.
• [Book] アンチ・エイジング医学-日本抗加齢医学会雑誌 (2009)
  • Author(s): 大隅典子
  • Total Pages: 5
  • Publisher: アラキドン酸による神経新生向上効果.
• [Book] 学術の動向 (2009)
  • Author(s): 大隅典子
  • Total Pages: 5
  • Publisher: 脳に内在する神経幹細胞の活性化
• [Book] 領域架橋型シンポジウムシリーズ 平成20年度 第4回～第6回 報告書 (2009)
  • Author(s): 大隅典子
  • Total Pages: 5
  • Publisher: 神経新生のメカニズム:遺伝的要因と環境的要因.
• [Remarks]
  • URL: http://www.dev-neurobio.med.tohoku.ac.jp/en/