• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis of non-olfactory sensory pathways that are necessary for the olfactory associative learning of the Drosophila mushroom body

Research Project

Project/Area Number 21300117
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionThe University of Tokyo

Principal Investigator

ITO Kei  東京大学, 分子細胞生物学研究所, 准教授 (00311192)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2009: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Keywordsショウジョウバエ / 嗅覚系 / 味覚系 / 投射神経 / 情報の統合 / 学習記憶 / GAL4エンハンサートラップ / LexAエンハンサートラップ
Research Abstract

The mushroom body is known to be an important center for associative olfactory memory in the insect brain. To understand the neural pathways of information other than the olfactory signals toward this center, we first analyzed the organization of the primary gustatory center, whose structure was hardly known despite the importance of gustatory information in associative olfactory learning. We also analyzed the neural connections of the brain regions that receive the arborizations of the input/output neurons of the mushroom body. By systematically labeling neurons according to cell lineage, we found that no neurons from the gustatory, auditory and visual centers directly project to these regions and that there are distinct regions that receive the projections from putative higher-associative centers.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (29 results)

All 2012 2011 2010 2009 Other

All Journal Article (14 results) (of which Peer Reviewed: 7 results) Presentation (13 results) Remarks (2 results)

  • [Journal Article] Chromatin modification of Notch targets in olfactory receptor neurondiversification2012

    • Author(s)
      Endo, K., Karim, M. R., Taniguchi, H., Krejci, A., Kinameri, E., Siebert, M., Ito, K., Bray, S. J., Moore, A. W.
    • Journal Title

      Nat Neurosci(15)

      Pages: 224-233

    • Related Report
      2011 Final Research Report
  • [Journal Article] Chromatin modification of Notch targets in olfactory receptor neuron diversification2012

    • Author(s)
      Endo, K., Karim, M.R., Taniguchi, H., Krejci, A., Kinameri, E., Siebert, M., Ito, K., Bray, S.J., Moore, A.W.
    • Journal Title

      Nat Neurosci

      Volume: 15 Issue: 2 Pages: 224-233

    • DOI

      10.1038/nn.2998

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Flybrain neuron database : acomprehensive database system of theDrosophila brain neurons2011

    • Author(s)
      Shinomiya, K., Matsuda, K., Oishi, T., Otsuna, H., and Ito, K.
    • Journal Title

      J Comp Neurol(519)

      Pages: 807-833

    • Related Report
      2011 Final Research Report
  • [Journal Article] Mushroom body efferent neurons responsiblefor aversive olfactory memory retrieval in Drosophila2011

    • Author(s)
      Sejourne, J., Placais, P. Y., Aso, Y., Siwanowicz, I., Trannoy, S., Thoma, V., Tedjakumala, S. R., Rubin, G. M., Tchenio, P., Ito, K., Isabel, G., Tanimoto, H., Preat, T.
    • Journal Title

      Nat Neurosci(14)

      Pages: 903-910

    • Related Report
      2011 Final Research Report
  • [Journal Article] Flybrain neuron database : a comprehensive database system of the Drosophila brain neurons2011

    • Author(s)
      Shinomiya, K., Matsuda, K., Oishi, T., Otsuna, H., Ito, K.
    • Journal Title

      J Comp Neurol

      Volume: 519 Issue: 5 Pages: 807-833

    • DOI

      10.1002/cne.22540

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mushroom body efferent neurons responsible for aversive olfactory memory retrieval in Drosophila2011

    • Author(s)
      Sejourne, J., Placais, P.Y., Aso, Y., Siwanowicz, I., Trannoy, S., Thoma, V., Tedjakumala, S.R., Rubin, G.M., Tchenio, P., Ito, K., Isabel, G., Tanimoto, H., Preat, T.
    • Journal Title

      Nat Neurosci

      Volume: 14 Issue: 7 Pages: 903-910

    • DOI

      10.1038/nn.2846

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neural architectureof the primary gustatory center of Drosophilamelanogaster visualized with GAL4 and LexA enhancer-trap systems2010

    • Author(s)
      Miyazaki, T. and Ito, K.
    • Journal Title

      J Comp Neurol(518)

      Pages: 4147-418

    • Related Report
      2011 Final Research Report
  • [Journal Article] Specific dopaminergic neurons for the formation of labile aversive memory2010

    • Author(s)
      Aso, Y., Siwanowicz, I., Bracker, L., Ito, K., Kitamoto, T., and Tanimoto, H.
    • Journal Title

      Curr Biol(20)

      Pages: 1445-1451

    • Related Report
      2011 Final Research Report
  • [Journal Article] Neural architecture of the primary gustatory center of Drosophila melanogaster visualized with GAL4 and LexA enhancer-trap systems.2010

    • Author(s)
      Miyazaki, T., Ito, K.
    • Journal Title

      J Comp Neurol

      Volume: 518 Pages: 4147-4181

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Specific dopaminergic neurons for the formation of labile aversive memory.2010

    • Author(s)
      Aso, Y., Siwanowicz, I., Bracker, L., Ito, K., Kitamoto, T., Tanimoto, H.
    • Journal Title

      Cuff Biol

      Volume: 20 Pages: 1445-1451

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GABA-mediated neural connections in the Drosophila antennal lobe2009

    • Author(s)
      Okada, R., Awasaki, T. and Ito, K.
    • Journal Title

      J Comp Neurol(514)

      Pages: 74-91

    • Related Report
      2011 Final Research Report
  • [Journal Article] Odor-evoked neural oscillations in Drosophila are mediated by widely branching interneurons2009

    • Author(s)
      Tanaka, N. K., Ito, K. and Stopfer, M.
    • Journal Title

      J Neurosci29

      Pages: 8595-2603

    • Related Report
      2011 Final Research Report
  • [Journal Article] GABA-mediated neural connections in the Drosophila antennal lobe2009

    • Author(s)
      Okada, R., Awasaki, T., Ito, K
    • Journal Title

      J Comp Neurol 514

      Pages: 74-91

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Odor-evoked neural oscillations in Drosophila are mediated by widely branching interneurons2009

    • Author(s)
      Tanaka, N.K., Ito, K., Stopfer, M
    • Journal Title

      J Neurosci 29

      Pages: 8595-603

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Olfactory Receptor Neuron Identity is Diversified by the Drosophila Evi1/Prdm16 Homologue Hamlet that Mediates Chromatin Modification at Notch-Target Loci2011

    • Author(s)
      遠藤啓太, MD Rezaul Karim, Alena Krejci, Emi Kinameri, Hiroaki Taniguchi, Matthias Siebert,伊藤啓, Sarah J. Bray, Adrian W. Moore
    • Organizer
      第44回発生生物学会大会
    • Place of Presentation
      沖縄コンベンションセンター
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Olfactory Receptor Neurons are Diversified by the Prdm Protein Hamlet that Mediates Chromatin Modification at Notch-Target Loci2011

    • Author(s)
      遠藤啓太, MD Rezaul Karim, Alena Krejci, Emi Kinameri, Hiroaki Taniguchi, Matthias Siebert,伊藤啓, Sarah J. Bray, Adrian W. Moore
    • Organizer
      1st Asia-Pacific Drosophila Research Conference
    • Place of Presentation
      台湾・台北・Chientan Youth Activity Center
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Projectome mapping of neural circuits in the Drosophila brain based on the neuroblast lineages2011

    • Author(s)
      伊藤正芳,遠藤啓太,伊藤啓
    • Organizer
      第44回日本発生生物学会大会
    • Place of Presentation
      沖縄・沖縄コンベンションセンター
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Projectome Analysis of the Lineage-Dependent Neural Circuits in the Drosophila Brain2011

    • Author(s)
      伊藤正芳,遠藤啓太,伊藤啓
    • Organizer
      1st Asia-Pacific Drosophila Research Conference
    • Place of Presentation
      台湾・台北・Chientan Youth Activity Center
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Projectome Mapping of the Lineage-Dependent Neural Circuits in the Drosophila Brain2011

    • Author(s)
      伊藤正芳,遠藤啓太,伊藤啓
    • Organizer
      2011Cold Spring Harbor Laboratory Meeting on Neurobiology of Drosophila
    • Place of Presentation
      米・コールドスプリングハーバー
    • Related Report
      2011 Final Research Report
  • [Presentation] Projectome Mapping of the Lineage-Dependent Neural Circuits in the Drosophila Brain2011

    • Author(s)
      Masayoshi Ito, Keita Endo, Kei Ito
    • Organizer
      2011 Cold Spring Harbor Laboratory Meeting on Neurobiology of Drosophila
    • Place of Presentation
      米・コールドスプリングハーバー
    • Related Report
      2011 Annual Research Report
  • [Presentation] Neural Structure of the Drosophila primary gustatory center revealed with GAL4 and LexA enhancer-trap systems2010

    • Author(s)
      宮崎隆明、伊藤啓
    • Organizer
      Functional Neurobiology in Minibrains : FromFlies to Robots and Back Again
    • Place of Presentation
      スペイン・サン・フェリウ・デ・ギホルス
    • Related Report
      2011 Final Research Report
  • [Presentation] Systematic analysis of the projection map of the primary gustatory center using two enhancer-trap systems in Drosophila melanogaster2010

    • Author(s)
      宮崎隆明、伊藤啓
    • Organizer
      第48回日本生物物理学会年会
    • Place of Presentation
      仙台・東北大学川内キャンパス
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Comprehensive analysis of the neural network in Drosophila brain on the neuroblast lineages2010

    • Author(s)
      伊藤正芳、遠藤啓太、伊藤啓
    • Organizer
      第43回日本発生生物学会年会
    • Place of Presentation
      京都・京都大学
    • Related Report
      2011 Final Research Report
  • [Presentation] Understanding the brain composition from the viewpoint of cell lineage2010

    • Author(s)
      伊藤啓、遠藤啓太、粟崎健、伊藤正芳
    • Organizer
      第43回日本発生生物学会年会
    • Place of Presentation
      京都・京都大学
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Neural Structure of the Drosophila primary gustatory center revealed with GAL4 and LexA enhancer-trap systems2010

    • Author(s)
      宮崎隆明、伊藤啓
    • Organizer
      Functional Neurobiology in Minibrains : From Flies to Robots and Back Again
    • Place of Presentation
      スペイン・サン・フェリウ・デ・ギホルス
    • Related Report
      2010 Annual Research Report
  • [Presentation] Comprehensive analysis of the neural network in Drosophila brain on the neuroblast lineages2010

    • Author(s)
      伊藤正芳、遠藤啓太、伊藤啓
    • Organizer
      第43回・本発生生物学会年会
    • Place of Presentation
      京都・京都大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] Systematic mapping of the primary gustatory center in the Drosophila brain2009

    • Author(s)
      伊藤啓,宮崎隆明
    • Organizer
      European Society for Insect Taste and Olfaction Meeting
    • Place of Presentation
      イタリア・サルジニア
    • Year and Date
      2009-09-23
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Remarks]

    • URL

      http://ndb.flybrain.org

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://ndb.flybrain.org

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi