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Glutamate receptor dynamism in the brain functions and diseases

Research Project

Project/Area Number 21300118
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionNiigata University

Principal Investigator

SAKIMURA Kenji  新潟大学, 脳研究所, 教授 (40162325)

Co-Investigator(Kenkyū-buntansha) NATSUME Rie  新潟大学, 脳研究所, 技術職員 (60467082)
Co-Investigator(Renkei-kenkyūsha) ABE Manabu  新潟大学, 脳研究所, 准教授 (10334674)
YAMAZAKI Maya  新潟大学, 脳研究所, 助教 (70401768)
WATANABE Masahiko  北海道大学, 大学院・医学研究科, 教授 (70210945)
Research Collaborator KANO Masanobu  東京大学, 大学院・医学系研究科, 教授 (40185963)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2010: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2009: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywords分子 / 細胞神経科学 / ノックアウトマウス / 発生工学 / 神経科学 / グルタミン酸受容体 / シナプス伝達 / 神経脊髄炎 / 分子・細胞神経科学
Research Abstract

The objective of this study is to verify a working hypothesis that the expression and stability of glutamate receptors, including(further) transition to synapses and removal, are responsible for(are involved in) different modes of neuronal regulation depending on each kind of brain cells and regions, which transforms simple inputs into various types of outputs, thus underlying complex neuronal expressions. For this purpose, we established floxed mice of 4 AMPA-type-and 4 NMDA-type-glutamate receptors, as well as several kinds of synaptic functional molecules floxed mice. We also generated Cre-driver mice such as GAD67-Cre mouse. By inter-crossing these mice, we have clarified that a GluN2B subunit is crucial for synaptic functional expression of NMDA-type receptors in a CA3 area of hippocampus, and that TARPγ-2 andγ-7 are essential for the expression of AMPA type receptors in cerebellum. We have also shown that at developing synapses GluN2A and GluN2B suppress AMPA receptors in their own mode, by using a single-cell NMDA receptor subunit deleted mouse.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (84 results)

All 2012 2011 2010 2009 Other

All Journal Article (48 results) (of which Peer Reviewed: 48 results) Presentation (30 results) Remarks (4 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Ablation of NG2 Proteoglycan Leads to Deficits in Brown Fat Function and to Adult Onset Obesity2012

    • Author(s)
      Chang Y, She ZG, Sakimura K, Stallcup WB.
    • Journal Title

      PLoS One

      Volume: 7(1)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cav2. 1 in Cerebellar Purkinje Cells Regulates Competitive Excitatory Synaptic Wiring2012

    • Author(s)
      Miyazaki T, (他3名) Yamazaki M, Abe M, Kano M, Sakimura K, Watanabe M.
    • Journal Title

      J Neurosci

      Volume: 32(4) Pages: 1311-1328

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of synaptic plasticity by cerebrospinal fluid from anti-NMDA receptor encephalitis patients2012

    • Author(s)
      Zhang Q
    • Journal Title

      Neurobiol Dis.

      Volume: 45(1) Issue: 1 Pages: 610-615

    • DOI

      10.1016/j.nbd.2011.09.019

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ca <sub>v</sub>2.1 in cerebellar Purkinje cells regulates competitive excitatory synaptic wiring, cell survival, and cerebellar biochemical compartmentalization2012

    • Author(s)
      Miyazaki, Taisuke ; Yamasaki, Miwako ; Hashimoto, Kouichi, et
    • Journal Title

      Journal of Neuroscience

      Volume: 32 Issue: 4 Pages: 1311

    • DOI

      10.1523/jneurosci.2755-11.2012

    • NAID

      120005208889

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ablation of NG2 Proteoglycan Leads to Deficits in Brown Fat Function andto Adult Onset Obesity2012

    • Author(s)
      Chang Y
    • Journal Title

      PLoS One.

      Volume: 7(1) Issue: 1 Pages: e30637-e30637

    • DOI

      10.1371/journal.pone.0030637

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct Modes of AMPA Receptor Suppression at Developing Synapses by GluN2A and GluN2B : Single-Cell NMDA Receptor Subunit Deletion In Vivo2011

    • Author(s)
      Gray JA, (他3名) Sakimura K, Nicoll RA.
    • Journal Title

      Neuron

      Volume: 71(6) Pages: 1085-101

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Postsynaptic P/Q-type Ca2+channel in Purkinje cell mediates synaptic competition and elimination in developing cerebellum2011

    • Author(s)
      Hashimoto K, (他3名) Yamazaki M, Shin Hashimoto K, (他3名) Yamazaki M, Shin HS, Watanabe M, Sakimura K, Kano M.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 108(24) Pages: 9987-92

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular and morphological configuration for 2-arachidonoylglycerol-mediatedretrograde signaling at mossy cell-granule cell synapses in the dentate gyrus.2011

    • Author(s)
      Uchigashima M, Yamazaki M, (他2名) Sakimura K, Kano M, Watanabe M.
    • Journal Title

      J Neurosci

      Volume: 31(21) Pages: 7700-14

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tangential migration and proliferation of intermediate progenitors of GABAergic neurons in the mouse telencephalon2011

    • Author(s)
      Wu S, (他9名) Sakimura K, Kaneko T, Tamamaki N.
    • Journal Title

      Development

      Volume: 138(12) Pages: 2499-509

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glutamate receptorδ2 is essential for input pathway-dependent regulation of synaptic AMPAR contents in cerebellar purkinje cells2011

    • Author(s)
      Yamasaki M, , Abe M, Natsume R, (他4名) Mishina M, Sakimura K, Watanabe M.
    • Journal Title

      J Neurosci

      Volume: 31(9) Pages: 3362-3374

    • NAID

      120003295068

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] NG2 cells are uniformly distributed and NG2 is not required for barrel formation in the somatosensory cortex2011

    • Author(s)
      Hill RA, Natsume R, Sakimura K, Nishiyama A.
    • Journal Title

      Mol Cell Neurosci

      Volume: 46(4) Pages: 689-98

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus.2011

    • Author(s)
      Yoshida T, (他3名) Yamazaki M, Sakimura K, Kano M, Yoshioka M, Watanabe M.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 108(7) Pages: 3059-64

    • NAID

      10030575938

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus2011

    • Author(s)
      Yoshida, T.; Uchigashima, M.; Yamasaki, M., et al
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 108 Issue: 7 Pages: 3059

    • DOI

      10.1073/pnas.1012875108

    • NAID

      10030575938

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NG2 cells are uniformly distributed and NG2 is not required for barrel formation in the somatosensory cortex2011

    • Author(s)
      Hill RA
    • Journal Title

      Mol Cell Neurosci.

      Volume: 46(4) Pages: 689-98

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glutamate Receptor delta 2 Is Essential for Input Pathway-Dependent Regulation of Synaptic AMPAR Contents in Cerebellar Purkinje Cells2011

    • Author(s)
      Yamasaki, M.; Miyazaki, T.; Azechi, H., et al
    • Journal Title

      Journal of Neuroscience

      Volume: 31(9) Issue: 9 Pages: 3362-3374

    • DOI

      10.1523/jneurosci.5601-10.2011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal protease-activated receptor 1 drives synaptic retrograde signaling mediated by the endocannabinoid 2-arachidonoylglycerol2011

    • Author(s)
      Hashimotodani Y
    • Journal Title

      J Neurosci.

      Volume: 31 Issue: 8 Pages: 3104

    • DOI

      10.1523/jneurosci.6000-10.2011

    • NAID

      120002950596

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tangential migration and proliferation of intermediate progenitors of GABAergicneurons in the mouse telencephalon2011

    • Author(s)
      Wu S
    • Journal Title

      Development

      Volume: 138(12) Issue: 12 Pages: 2499-509

    • DOI

      10.1242/dev.063032

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular and morphological configuration for 2-Arachidonoylglycerol-mediated retrograde signaling at mossy cell-granule cell synapses in the dentate gyrus2011

    • Author(s)
      Uchigashima, M.; Yamazaki, M.; Yamasaki, M., et al
    • Journal Title

      Journal of Neuroscience

      Volume: 31 Issue: 21 Pages: 7700

    • DOI

      10.1523/jneurosci.5665-10.2011

    • NAID

      120003521155

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Postsynaptic P/Q-type Ca<sup>2+</sup> channel in Purkinje cell mediates synaptic competition and elimination in developing cerebellum2011

    • Author(s)
      Hashimoto, K.; Tsujita, M.; Miyazaki, T., et al
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 108 Issue: 24 Pages: 9987

    • DOI

      10.1073/pnas.1101488108

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical features of neuromyelitis optica in a large Japanese cohort : comparison between phenotypes2011

    • Author(s)
      Nagaishi A
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 82(12) Issue: 12 Pages: 1360-4

    • DOI

      10.1136/jnnp-2011-300403

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Basic leucine zipper transcription factor, ATF-like (BATF) regulates epigenetically and energetically effector CD8 T-cell differentiation via Sirt1 expression2011

    • Author(s)
      Kuroda S
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 108(36) Issue: 36 Pages: 14885-9

    • DOI

      10.1073/pnas.1105133108

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct Modes of AMPA Receptor Suppression at Developing Synapses by GluN2A and GluN2B : Single-Cell NMDA Receptor Subunit Deletion In Vivo2011

    • Author(s)
      Gray JA
    • Journal Title

      Neuron.

      Volume: 71(6) Issue: 6 Pages: 1085-101

    • DOI

      10.1016/j.neuron.2011.08.007

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glutamate receptor δ2 is essential for input pathway-dependent regulation of synaptic AMPAR contents in cerebellar purkinje cells.2011

    • Author(s)
      Yamasaki M, et al.
    • Journal Title

      J Neurosci.

      Volume: 31(9) Pages: 3362-3374

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal protease-activated receptor 1 drives synaptic retrograde signaling mediated by the endocannabinoid 2-arachidonoylglycerol.2011

    • Author(s)
      Hashimotodani Y, et al.
    • Journal Title

      J Neurosci.

      Volume: 31(8) Pages: 3104-3109

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ablation of Glutamate Receptor GluR{ delta} 2 in Adult Purkinje Cells Causes Multiple Innervation of Climbing Fibers by Inducing Aberrant Invasion to Parallel Fiber Innervation Territory2010

    • Author(s)
      Miyazaki T, (他2名) Sakimura K, Mishina M, Watanabe M.
    • Journal Title

      J Neurosci

      Volume: 30(45) Pages: 15196-15209

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Trans-Synaptic Interaction of GluRdelta2 and Neurexin through Cbln1 Mediates Synapse Formation in the Cerebellum2010

    • Author(s)
      Uemura T, (他6名) Sakimura K, Mishina M.
    • Journal Title

      Cell

      Volume: 141(6) Pages: 1068-79

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] TARPsγ-2 and-γ7 are essential for AMPA receptor expression in the cerebellum2010

    • Author(s)
      Yamazaki M, (他5名) Abe M, Natsume R, Takahashi M, Kano M, Sakimura K, Watanabe M.
    • Journal Title

      Eur J Neurosci

      Volume: 31(12) Pages: 2204-20

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission2010

    • Author(s)
      Tanimura A, Yamazaki M, (他3名) Abe M, Kita Y, Hashimoto K, Shimizu T, Watanabe M, Sakimura K, Kano M.
    • Journal Title

      Neuron

      Volume: 65(3) Pages: 320-327

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced immobilizing properties of isoflurane and nitrous oxide in mutant mice lacking theN-methyl-D-aspartate receptor GluRepsilonl subunit are caused by the secondary effects of gene knockout.2010

    • Author(s)
      Petrenko AB, et al.
    • Journal Title

      Anesth Analg.

      Volume: 110(2) Pages: 461-465

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TARPS γ-2 and γ-7 are essential for AMPA receptor expression in the cerebellum.2010

    • Author(s)
      Yamazaki M, et al
    • Journal Title

      Eur J Neurosci.

      Volume: 31(12) Pages: 2204-2220

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trans-Synaptic Interaction of GluRdelta2 and Neurexin through Cbin1 Mediates Synapse Formation in the Cerebellum.2010

    • Author(s)
      Uemura T, et al.
    • Journal Title

      Cell

      Volume: 141(6) Pages: 1068-1079

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] T-Type Calcium Channel Antagonists Suppress Tremor in Two Mouse Models of Essential Tremor.2010

    • Author(s)
      Handforth A, et al.
    • Journal Title

      Neuropharmacology

      Volume: 59 Pages: 380-387

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chondroitin sulfate N-Acetylgalactosaminyltransferase-1 is required for normal cartilage development.2010

    • Author(s)
      Watanabe Y, et al.
    • Journal Title

      Biochem J.

      Volume: 432(1) Pages: 47-55

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ablation of Glutamate Receptor GluR{delta}2 in Adult Purkinje Cells Causes Multiple Innervation of Climbing Fibers by Inducing Aberrant Invasion to Parallel Fiber Innervation Territory.2010

    • Author(s)
      Miyazaki T, et al.
    • Journal Title

      J Neurosci.

      Volume: 30(45) Pages: 15196-15209

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ionotropic Glutamate Receptor AMPA 1 as a Gene Influencing Ovulation Rate.2010

    • Author(s)
      Sugimoto M, et al.
    • Journal Title

      PLoS One.

      Volume: 5(11)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NG2 cells are uniformly distributed and NG2 is not required for barrel formationin the somatosensory cortex.2010

    • Author(s)
      Hill RA, et al.
    • Journal Title

      Mot Cell Neurosci.

      Volume: 46(4) Pages: 689-698

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced immobilizing properties of isoflurane and nitrous oxide in mutant mice lacking theN-methyl-D-aspartate receptor GluRepsilon1 subunit are caused by the secondary effects of gene knockout.2010

    • Author(s)
      Petrenko AB, et al.
    • Journal Title

      Anesth Analg. 110

      Pages: 461-465

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The endocannabinoid 2-Arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission.2010

    • Author(s)
      Tanimura A, et al.
    • Journal Title

      Neuron. 65(3)

      Pages: 320-327

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TARPs γ-2 and γ-7 are essential for AMPA receptor expression in the cerebellum.2010

    • Author(s)
      Yamazaki M, et al.
    • Journal Title

      Eur J Neurosci. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced immobilizing properties of isoflurane and nitrous oxide in mutant mice lacking theN-methyl-D-aspartate receptor GluRepsilon1 subunit are caused by the secondary effects of gene knockout2009

    • Author(s)
      Petrenko AB, (他2名) Sakimura K, Baba H.
    • Journal Title

      Anesth Analg

      Volume: 110(2) Pages: 461-5

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Subtypes of GABAergic neurons project axons in th neocortex2009

    • Author(s)
      Higo S, Akashi K, Sakimura K, and Tamamaki N
    • Journal Title

      Frontiers in Neuroanatomy

      Volume: 3(25)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] NMDA receptor GluN2B(GluR epsilon 2/NR2B) subunit is crucial for channel function, postsynaptic macromolecular organization, and actin cytoskeleton at hippocampal CA3 synapses2009

    • Author(s)
      Akashi K, (他4名) Abe M, Natsume R, Watanabe M, Sakimura K.
    • Journal Title

      J Neurosci

      Volume: 29(35) Pages: 10869-82

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of binding sites for anti-aquaporin 4 antibodies in patients with neuromyelitis optica.2009

    • Author(s)
      Tani T, et al.
    • Journal Title

      J Neuroimmunol. 211(1-2)

      Pages: 110-113

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activity-dependent glial swelling is impaired in aquaporin-4 knockout mice.2009

    • Author(s)
      Kitaura H, et al.
    • Journal Title

      Neurosci Res. 64(2)

      Pages: 208-212

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines.2009

    • Author(s)
      Hildebrand ME, et al.
    • Journal Title

      J Neurosci. 29(31)

      Pages: 9668-9682

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NMDA receptor GluN2B (GluR epsilon 2/NR2B) subunit is crucial for channel function, postsynaptic macromolecular organization, and actin cytoskeleton at hippocampal CA3 synapses.2009

    • Author(s)
      Akashi K, et al.
    • Journal Title

      J Neurosci. 29(35)

      Pages: 10869-10882

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Subtypes of GABAergic neurons project axons in th neocortex2009

    • Author(s)
      Higo S, et al.
    • Journal Title

      Frontiers in Neuroanatomy Vol.3

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathologic and immunologic profiles of a limited form of neuromyelitis optica with myelitis.2009

    • Author(s)
      Yanagawa K, et al.
    • Journal Title

      Neurology. 73(20)

      Pages: 1628-1637

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Systematic generation of gene manipulated mice using C57BL/6 ES cell RENKA2012

    • Author(s)
      Kenji Sakimura
    • Organizer
      第42回生理研国際シンポジウム
    • Place of Presentation
      愛知県岡崎市生理学研究所
    • Year and Date
      2012-03-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Systematic generation of gene manipulated mice using C57BL/6 ES cell RENKA2012

    • Author(s)
      Kenji Sakimura
    • Organizer
      第42回生理研国際シンポジウム
    • Place of Presentation
      生理学研究所(招待講演)
    • Year and Date
      2012-03-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規アルツハイマー病モデルマウスの構築と表現型解析2011

    • Author(s)
      堀田優子
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都市
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] カイニン酸受容体の定量的解析Quantitative analysis of kainate receptor subunits in the mouse brain2011

    • Author(s)
      渡辺和泉
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Quantitative analysis of Glutamate receptor subunits in the mouse brain. ISN(国際神経化学会)2011

    • Author(s)
      Sakimura K.
    • Organizer
      23rd. Biennial Meeting
    • Place of Presentation
      ギリシャ・アテネ
    • Year and Date
      2011-08-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Quantitative analysis of Glutamate receptor subunits in the mouse brain2011

    • Author(s)
      Sakimura, K.
    • Organizer
      ISN 23rd. Biennial Meeting
    • Place of Presentation
      ギリシャ・アテネ
    • Year and Date
      2011-08-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Transmembrane AMPA receptor regulatory protein g-8 is involved with the regulation of spontaneous activity and mental condition.2011

    • Author(s)
      Yamazaki M.
    • Organizer
      第8回IBRO
    • Place of Presentation
      イタリア・フィレンツェ
    • Year and Date
      2011-07-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Transmembrane AMPA receptor regulatory protein ・-8 is involved with the regulation of spontaneous activity and mental condition2011

    • Author(s)
      M.Yamazaki
    • Organizer
      第8回IBRO
    • Place of Presentation
      イタリア・フィンツェ
    • Year and Date
      2011-07-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] NMDA receptor GluN2B subunit is crucial for channel function, postsynaptic macromolecular organization, and regulation of actin cytoskeleton at hippocampal CA3 synapses.2010

    • Author(s)
      K. Akashi
    • Organizer
      NEUROSCIENCE2010
    • Place of Presentation
      アメリカ・サンディエゴ
    • Year and Date
      2010-11-16
    • Related Report
      2011 Final Research Report
  • [Presentation] NMDA receptor GluN2B subunit is crucial for channel function, postsyn aptic macromolecular organization, and regulation of actin cytoskeleton at hippocampal CA3 synapses.2010

    • Author(s)
      Akashi, K, et al.
    • Organizer
      NEUROSCIENCE2010
    • Place of Presentation
      アメリカ・サンディエゴ
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Loss of cerebellar granule cell AMPA receptors co0n tributes to ataxia in stargazer mice.2010

    • Author(s)
      M. Yamazaki
    • Organizer
      NEUROSCIENCE2010
    • Place of Presentation
      アメリカ・サンディエゴ
    • Year and Date
      2010-11-14
    • Related Report
      2011 Final Research Report
  • [Presentation] Loss of cerebellar granule cell AMPA receptors contributes to ataxia instargazer mice.2010

    • Author(s)
      Yamazaki, M., et al.
    • Organizer
      NEUROSCIENCE2010
    • Place of Presentation
      アメリカ・サンディエゴ
    • Year and Date
      2010-11-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] TARPγ2、γ7は小脳AMPA型グルタミン酸受容体の機能的構成成分であるTARPsγ-2 andγ-7 are functional components of cerebellar AMPA receptor.2010

    • Author(s)
      山崎真弥
    • Organizer
      第33回日本神経科学大会第53回日本神経化学会大会合同大会NEURO2010
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2010-09-03
    • Related Report
      2011 Final Research Report
  • [Presentation] TARP γ2、γ7は小脳AMPA型グルタミン酸受容体の機能的構成成分である2010

    • Author(s)
      山崎真弥, 他
    • Organizer
      第33回日本神経科学大会 第53回日本神経化学会大会合同大会NEURO2010
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] プルキンエ細胞選択的ノックアウトを用いた小脳AMPA受容体サブユニットの生理機能解析2010

    • Author(s)
      阿部学, 他
    • Organizer
      第33回日本神経科学大会 第53回日本神経化学会大会合同大会NEURO2010
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Transmembrane AMPA receptor regulatory protein gamma-2 and gamma-7 are essential for AMPA receptor complex.2010

    • Author(s)
      Yamazaki M.
    • Organizer
      FENS Forum2010
    • Place of Presentation
      オランダ・アムステルダム
    • Year and Date
      2010-07-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Transmembrane AMPA receptor regulatory protein gamma-2 and gamma-7 are essential for AMPA receptor complex.2010

    • Author(s)
      Yamazaki, M., et al.
    • Organizer
      FENS Forum 2010
    • Place of Presentation
      オランダ・アムステルダム
    • Year and Date
      2010-07-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] グルタミン酸受容体が担う脳機能:コンディショナルノックアウト法での解析2010

    • Author(s)
      崎村建司
    • Organizer
      2010日本生化学関東支部例会
    • Place of Presentation
      新潟県長岡市
    • Year and Date
      2010-05-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] ES細胞における相同組換え効率上昇法の開発2010

    • Author(s)
      阿部学, 他
    • Organizer
      第57回日本実験動物学会総会
    • Place of Presentation
      京都府京都市
    • Year and Date
      2010-05-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] ES細胞での相同組換え上昇に関する因子の同定2009

    • Author(s)
      八矢幸大
    • Organizer
      第32回 日本分子生物学会年会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Analysis of the physiological function of cerebellar AMPA receptor subunits using Purkinje cell-specific gene targeting system.2009

    • Author(s)
      M. Abe
    • Organizer
      NEUROSCIENCE2009
    • Place of Presentation
      アメリカシカゴ
    • Year and Date
      2009-10-17
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Composition of AMPA receptor subunits in the mouse brain ; Quantitative analysis of AMPA receptor subunits.2009

    • Author(s)
      H. Azechi
    • Organizer
      NEUROSCIENCE2009
    • Place of Presentation
      アメリカシカゴ
    • Year and Date
      2009-10-17
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] The analysis of 26S proteasome conditional knockout mice for a motor neuron degenerative model.2009

    • Author(s)
      Y.Tashiro
    • Organizer
      NEUROSCIENCE2009
    • Place of Presentation
      アメリカシカゴ
    • Year and Date
      2009-10-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウス脳AMPA受容体サブユニットの定量的解析2009

    • Author(s)
      畦地裕統
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] NMDA受容体GluRε2サブユニットはNMDA受容体活性に必須な分子であり、かつシナプス後肥厚の分子複合体の形成維持に関与する2009

    • Author(s)
      明石馨
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Stargazerマウスの運動失調は小脳顆粒細胞のAMPA方受容体が原因である2009

    • Author(s)
      山崎真弥
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 変異シンタキシン1A(R151G)ノックインマウスにおけるシナプス小胞輸送の解析2009

    • Author(s)
      渡邊裕美
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] MADA receptor Glum2B subunit is crucial for channel function and postsynaptic molecular organization at Hippocampal Ca3 synapses.2009

    • Author(s)
      Sakimura, K
    • Organizer
      ISN(国際神経化学会) 22 rd. Biennial Meeting
    • Place of Presentation
      韓国プサン市
    • Year and Date
      2009-08-25
    • Related Report
      2011 Final Research Report
  • [Presentation] MADA receptor GluN2B subunit is crucial for channel function and postsynaptic molecular organization at Hippocampal CA3 synapses.2009

    • Author(s)
      Sakimura, K
    • Organizer
      22nd Biennial Meeting of the International Society for Neurochemistry (ISN)
    • Place of Presentation
      韓国プサン市
    • Year and Date
      2009-08-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] The significanse of Syntaxin-1A-CaMK II interaction in synaptic Vesicle transportaition and mouse behavior.2009

    • Author(s)
      Yumi Watanabe
    • Organizer
      第52回日本神経化学会大会
    • Place of Presentation
      群馬県渋川市伊香保
    • Year and Date
      2009-06-21
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.bri.niigata-u.ac.jp/~cellular/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.bri.niigata-u.ac.jp/~cellular/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.bri.niigata-u.ac.ip/~cellular/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.bri.niigata-u.ac.jp/~cellular/

    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] ES細胞における相同組換え効率を改善する方法2010

    • Inventor(s)
      崎村建司、阿部学、八矢幸大
    • Industrial Property Rights Holder
      新潟大学
    • Industrial Property Number
      2010-228524
    • Filing Date
      2010-08-10
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] ES細胞における相同組換え効率を改善する方法2010

    • Inventor(s)
      崎村建司・阿部学・八矢幸大
    • Industrial Property Rights Holder
      国立大学法人 新潟大学
    • Industrial Property Number
      2010-228524
    • Filing Date
      2010-10-08
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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