Chromatin dynamics in regulation of activity-dependent transcription in neurons.
| Project/Area Number |
21300123
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Neuroscience in general
|
|---|
| Research Institution | Nara Institute of Science and Technology |
|---|
Principal Investigator |
NAKASHIMA Kinichi 奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授 (80302892)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKIZAWA Takumi 群馬大学, 大学院・医学系研究科, 准教授 (30531115)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2009: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
|
|---|
| Keywords | ニューロン / クロマチン / 転写 / 神経活動依存性転写 / コアヒストン / クロマチンダイナミクス / エピジェネティクス / 転写応答 / Bdnf |
|---|
| Research Abstract |
We have identified two different types of genes induced in a neuronal activity-dependent manner ; one is immediately expressed while the other expressed lately. We examined differences in chromatin modifications in two groups of genes and analyzed dynamic behavior of chromatin related proteins which are assumedly involved in activity-dependent transcription. We found that chromatin modifications, recruitment of RNA polymerase II and the negative elongation factor are different between the two groups. These results demonstrate molecular basis for temporal regulation of activity-dependent genes.
|
Report
(4 results)
Research Products
(102 results)
-
-
[Journal Article] Role of GLI2 in the growth of human osteosarcoma2011
Author(s)
Nagao, H., Ijiri, K., Hirotsu, M., Ishidou, Y., Yamamoto, T., Nagano, S., Takizawa, T., Nakashima, K., Komiya, S. & Setoguchi, T.
-
Journal Title
J Pathol
Volume: 224
Pages: 169-179
Related Report
Peer Reviewed
-
-
[Journal Article] Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus.2010
Author(s)
Mira H., Andreu Z., Suh H., Lie D.C., Jessberger S., Consiglio A., San Emeterio J., Hortiguela R., Marques-Torrejon M.A., Nakashima K., Colak D., Gotz M., Farinas I., Gage F.H.
-
Journal Title
Cell Stem Cell
Volume: 7
Pages: 78-89
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Book] Regulatory networks in stem cells2009
Author(s)
Suzuki A, Raya A, Kawakami Y, Morita M, Matsui T, Nakashima K, Gage FH, Rodriguez-Esteban C, Izpisua Belmonte JC
Total Pages
21
Publisher
Humana Press(In press)
Related Report
-
-
