Chromatin dynamics in regulation of activity-dependent transcription in neurons.

• Project/Area Number: 21300123
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: Nara Institute of Science and Technology
• Principal Investigator: NAKASHIMA Kinichi 奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授 (80302892)
• Co-Investigator(Kenkyū-buntansha): TAKIZAWA Takumi 群馬大学, 大学院・医学系研究科, 准教授 (30531115)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000); Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2010: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2009: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
• Keywords: ニューロン / クロマチン / 転写 / 神経活動依存性転写 / コアヒストン / クロマチンダイナミクス / エピジェネティクス / 転写応答 / Bdnf

Research Abstract

We have identified two different types of genes induced in a neuronal activity-dependent manner ; one is immediately expressed while the other expressed lately. We examined differences in chromatin modifications in two groups of genes and analyzed dynamic behavior of chromatin related proteins which are assumedly involved in activity-dependent transcription. We found that chromatin modifications, recruitment of RNA polymerase II and the negative elongation factor are different between the two groups. These results demonstrate molecular basis for temporal regulation of activity-dependent genes.

Research Products

• [Journal Article] Chromatin immunoprecipitation in mouse hippocampal cells and tissues (2012)
  • Author(s): Sailaja, BS., Takizawa, T., Meshorer, E.
  • Journal Title: Methods Mol Biol Volume: 809 Pages: 353-64
  • Peer Reviewed
• [Journal Article] Role of GLI2 in the growth of human osteosarcoma (2011)
  • Author(s): Nagao, H., Ijiri, K., Hirotsu, M., Ishidou, Y., Yamamoto, T., Nagano, S., Takizawa, T., Nakashima, K., Komiya, S. & Setoguchi, T.
  • Journal Title: J Pathol Volume: 224 Pages: 169-179
  • Peer Reviewed
• [Journal Article] L1 retrotransposition in neurons is modulated by MeCP2. (2010)
  • Author(s): Muotri A.R., Marchetto M.C., Coufal N.G., Oefner R., Yeo G., Nakashima K., Gage F.H.
  • Journal Title: Nature Volume: 468 Pages: 443-446
  • Peer Reviewed
• [Journal Article] Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus. (2010)
  • Author(s): Mira H., Andreu Z., Suh H., Lie D.C., Jessberger S., Consiglio A., San Emeterio J., Hortiguela R., Marques-Torrejon M.A., Nakashima K., Colak D., Gotz M., Farinas I., Gage F.H.
  • Journal Title: Cell Stem Cell Volume: 7 Pages: 78-89
  • Peer Reviewed
• [Journal Article] BMP-induced REST regulates the establishment and maintenance of astrocytic identity. (2010)
  • Author(s): Kohyama J., Sanosaka T., Tokunaga A., Takatsuka E., Tsujimura K., Okano H., Nakashima K.
  • Journal Title: Journal of Cell Biology Volume: 189 Pages: 159-170
  • Peer Reviewed
• [Journal Article] Chromatin remodeling in neural stem cell differentiation. (2010)
  • Author(s): Juliandi B., Abematsu M., Nakashima K.
  • Journal Title: Current Opinion in Neurobiology Volume: 20 Pages: 408-415
  • Peer Reviewed
• [Journal Article] Epigenetic regulation in neural stem cell differentiation. (2010)
  • Author(s): Juliandi B., Abematsu M., Nakashima K.
  • Journal Title: Development, Growth, Differentiation Volume: 52 Pages: 493-504
  • NAID: 10027565372
  • Peer Reviewed
• [Journal Article] Neurons derived from transplanted neural stem cells restore disrupted neuronal circuitry in a mouse model of spinal cord injury. (2010)
  • Author(s): Abematsu M., Tsujimura K., Yamano M., Saito M., Kohno K., Kohyama J., Namihira M., Komiya S., Nakashima K.
  • Journal Title: Journal of Clinical Investigation Volume: 120 Pages: 3255-3266
  • Peer Reviewed
• [Journal Article] BMP-induced REST regulates the establishment and maintenance of (2010)
  • Author(s): Kohyama J, Sanosaka T, Tokunaga A, Takatsuka E, Tsujimura K, Okano H, Nakashima K
  • Journal Title: Jouranl of Cell Biology (In press)
  • Peer Reviewed
• [Journal Article] Epigenetic regulation in neural stem cell differentiation (2010)
  • Author(s): Juliandi B, Abematsu M, Nakashima K
  • Journal Title: Development, Growth & Differentiation 189(In press)
  • NAID: 10027565372
  • Peer Reviewed
• [Journal Article] Neuronal differentiation of neural precursor cells is promoted by the methyl-CpG-binding protein MeCP2. (2009)
  • Author(s): Tsujimura K, Abematsu M, Kohyama J, Namihira M, Nakashima K
  • Journal Title: Experimental neurology 219 Pages: 104-111
  • Peer Reviewed
• [Journal Article] Astrocyte differectiation of neural precursor cells in enhanced by retinoic acid through a change in epigenetic modification. (2009)
  • Author(s): Asano H, Aonuma M, Sanosaka T, Kohyama J, Namihira M, Nakashima K
  • Journal Title: Stem cells (Dayton, Ohio) 27 Pages: 2744-2752
  • Peer Reviewed
• [Journal Article] Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis. (2009)
  • Author(s): Kuwabara T, Hsieh J, Muotri A, Yeo G, Warashina M, Lie DC, Moore L, Nakashima K, Asashima M, Gage FH
  • Journal Title: Nature neuroscience 12 Pages: 1097-1105
  • Peer Reviewed
• [Presentation] 神経幹細胞の性質変換に伴う遺伝子座の核内配置の変動 (2011)
  • Author(s): 伊藤謙治、中島欽一、荒川浩一、滝沢琢己
  • Organizer: 第58回北関東医学会総会
  • Place of Presentation: 前橋市
  • Year and Date: 2011-09-29
• [Presentation] Epigenetics関連技術である細胞核構造解析とその毒性学的研究への適用の可能性 (2011)
  • Author(s): 滝沢琢己
  • Organizer: 第38回日本トキシコロジー学会,学術年会
  • Place of Presentation: 横浜市
  • Year and Date: 2011-07-11
• [Presentation] Epigenetics関連技術である細胞核構造解析とその毒性学的研究への適用の可能性 (2011)
  • Author(s): 滝沢琢己
  • Organizer: 第38回日本トキシコロジー学会学術年会
  • Place of Presentation: 横浜市
  • Year and Date: 2011-07-11
• [Presentation] 神経幹細胞性質変換に伴う遺伝子座の核内配置の変動解析 (2011)
  • Author(s): 伊藤謙治、中島欽一、荒川浩一、滝沢琢己
  • Organizer: 第5回日本エピジェネティクス研究会年会
  • Place of Presentation: 熊本市
  • Year and Date: 2011-05-19
• [Presentation] Identification and Spatio-temporal Regulation of Distinct Classes of Activity-dependent Genes in Post-mitotic Neurons (2011)
  • Author(s): Takumi Takizawa
  • Organizer: International Symposium on the Physicochemical Field for Genetic Activities
  • Place of Presentation: 兵庫県
  • Year and Date: 2011-01-24
• [Presentation] Identification and Spatio-temporal Regulation of Distinct Classes of Activity-dependent Genes in Post-mitotic Neurons (2011)
  • Author(s): 滝沢琢己
  • Organizer: International Symposium on the Physicochemical Field for Genetic Activities
  • Place of Presentation: 淡路市
  • Year and Date: 2011-01-24
• [Presentation] Analysis of DNA methylation-independent regulatory mechanisms of astrocyte specific gene expression in embryonic stem cells(ESCs) (2010)
  • Author(s): 裏山悟司、滝沢琢己、神山淳、中島欽一
  • Organizer: BMB2010
  • Place of Presentation: 兵庫県
  • Year and Date: 2010-12-07
• [Presentation] 神経系細胞における遺伝子座核内配置 (2010)
  • Author(s): 滝沢琢己
  • Organizer: BMB2010
  • Place of Presentation: 兵庫県
  • Year and Date: 2010-12-07
• [Presentation] 神経系細胞における遺伝子座核内配置 (2010)
  • Author(s): 滝沢琢己
  • Organizer: BMB2010
  • Place of Presentation: 神戸市
  • Year and Date: 2010-12-07
• [Presentation] Hypoxic condition facilitates Notch-induced DNA demethylation of astrocytic genes, resulting in the enhancedastrocyte differentiation of neural precursor cells (2010)
  • Author(s): 武藤哲司、中島欽一
  • Organizer: BMB2010
  • Place of Presentation: 神戸市
  • Year and Date: 2010-12-07
• [Presentation] Rett症候群原因遺伝子産物MeCP2の新規機能解析 (2010)
  • Author(s): 鈴木暁也、辻村啓太、中島欽一
  • Organizer: BMB2010
  • Place of Presentation: 神戸市
  • Year and Date: 2010-12-07
• [Presentation] Analysis of DNA methylation-independent regulatory mechanisms of astrocyte specific gene expression in embryonic stem cells (ESCs) (2010)
  • Author(s): 裏山悟司、滝沢琢己、神山淳、中島欽一
  • Organizer: BMB2010
  • Place of Presentation: 神戸市
  • Year and Date: 2010-12-07
• [Presentation] 抗てんかん薬バルプロ酸のエピジェネティックな作用とその応用 (2010)
  • Author(s): 中島欽一
  • Organizer: 第3回Stroke Science Academy
  • Place of Presentation: 福岡市
  • Year and Date: 2010-12-03
• [Presentation] 神経幹細胞制御におけるヒストン脱アセチル化酵素阻害剤の影響とその影響 (2010)
  • Author(s): 中島欽一
  • Organizer: 大阪大学蛋白質研究所セミナー
  • Place of Presentation: 大阪市
  • Year and Date: 2010-11-25
• [Presentation] Spatiotemporal regulation of activity dependent genes in post-mitotic neurons (2010)
  • Author(s): Takiazawa, T., Takagi M., Itoh K., Nakashima K.
  • Organizer: 40^<th> Annual Meeting NEUROSCIENCE2010
  • Place of Presentation: San Diego
  • Year and Date: 2010-11-13
• [Presentation] Analysis of DNA methylation independent reguylatory mechanisums of astrocyte specific gene expression in embryonic stem cells (2010)
  • Author(s): Urayama S., Takizawa T., Hori Y., Kohyama J., Nakashima K.
  • Organizer: 40^<th> Annual Meeting NEUROSCIENCE2010
  • Place of Presentation: San Diego
  • Year and Date: 2010-11-13
• [Presentation] The effects of histone deacetylaseinhibition on cortical development (2010)
  • Author(s): Berry J., Tsujimura K, Abematsu M., Kohyama J., Nakashima K.
  • Organizer: 40^<th> Annual Meeting NEUROSCIENCE2010
  • Place of Presentation: San Diego USA
  • Year and Date: 2010-11-13
• [Presentation] Hypoxic condition facilitates Notch induced DNA demethylation of astrocytic genes, resulting in the enhanced astrocyte differentiation of neural precursor cells in response to the astrocyte inducing cytokine LIF (2010)
  • Author(s): Mutoh T., Nakashima K.
  • Organizer: 40^<th> Annual Meeting NEUROSCIENCE2010
  • Place of Presentation: San Diego USA
  • Year and Date: 2010-11-13
• [Presentation] Analysis of DNA methylation independent reguylatory mechanisums of astrocyte specific gene expression in embryonic stem cells (2010)
  • Author(s): Urayama S., Takizawa T., Hori Y, Kohyama J., Nakashima K.
  • Organizer: 40^<th> Annual Meeting NEUROSCIENCE2010
  • Place of Presentation: San Diego USA
  • Year and Date: 2010-11-13
• [Presentation] Protemic identification of co-facors for the methyl-CpG binding protein, MeCP2 (2010)
  • Author(s): Tsujimura K., Fukao M., Fujiwara R., Suzuki A., Nakashima K.
  • Organizer: 40^<th> Annual Meeting NEUROSCIENCE2010
  • Place of Presentation: San Diego USA
  • Year and Date: 2010-11-13
• [Presentation] Meningeal cells express astrocyte inducing cytokines in the developing mouse brain (2010)
  • Author(s): Sanosaka T., Namihira M., Takizawa T., Nakashima K.
  • Organizer: 40^<th> Annual Meeting NEUROSCIENCE2010
  • Place of Presentation: San Diego USA
  • Year and Date: 2010-11-13
• [Presentation] Epigenetic regulation of transplanted neural stem cells reconstructed injured spinal cord (2010)
  • Author(s): Abemstsu M., Tsujimura K., Yamano M., Saito M., Kohno K., Kohyama J., Namihira M.,Komiya, S., Nakashima K.
  • Organizer: 40^<th> Annual Meeting NEUROSCIENCE2010
  • Place of Presentation: San Diego USA
  • Year and Date: 2010-11-13
• [Presentation] Spatiotemporal regulation of activity dependent genes in post-mitotic neurons (2010)
  • Author(s): Takiazawa, T., Takagi M., Itoh K., Nakashima K.
  • Organizer: 40^<th> Annual Meeting NEUROSCIENCE2010
  • Place of Presentation: San Diego USA
  • Year and Date: 2010-11-13
• [Presentation] Meningeal Cells Induce Astrocyte Differentiation of Neural Stem Cells (2010)
  • Author(s): 佐野坂司、波平昌一、滝沢琢己、中島欽一
  • Organizer: The 29^<th> NAITO CONFERENCE ON GLIA WORLD
  • Place of Presentation: 神奈川県
  • Year and Date: 2010-10-05
• [Presentation] Astrocyte Differentiation Mediated by Cytokines' Signaling (2010)
  • Author(s): 中島欽一
  • Organizer: The 29^<th> NAITO CONFERENCE ON GLIA WORLD
  • Place of Presentation: 神奈川県三浦郡葉山町
  • Year and Date: 2010-10-05
• [Presentation] Np95 Regulates Astrogliogenesis in the Developing Cerebral Cort (2010)
  • Author(s): 武藤哲司、古関庸子、武藤正弘、古関明彦、中島欽一
  • Organizer: The 29^<th> NAITO CONFERENCE ON GLIA WORLD
  • Place of Presentation: 神奈川県三浦郡葉山町
  • Year and Date: 2010-10-05
• [Presentation] Meningeal Cells Induce Astrocyte Differentiation of Neural Stem Cells (2010)
  • Author(s): 佐野坂司、波平昌一、滝沢琢己、中島欽一
  • Organizer: The 29^<th> NAITO CONFERENCE ON GLIA WORLD
  • Place of Presentation: 神奈川県三浦郡葉山町
  • Year and Date: 2010-10-05
• [Presentation] 抗てんかん薬バルプロ酸の神経系における良い作用と悪い作用 (2010)
  • Author(s): 中島欽一、Juliandi B.
  • Organizer: 日本遺伝学会第82回大会
  • Place of Presentation: 札幌市
  • Year and Date: 2010-09-20
• [Presentation] アストロサイト分化誘導性サイトカイン発現細胞の同定 (2010)
  • Author(s): 佐野坂司、波平昌一、滝沢琢己、中島欽一
  • Organizer: Neuro2010
  • Place of Presentation: 兵庫県
  • Year and Date: 2010-09-02
• [Presentation] 神経活動依存性遺伝子発現の時空間制御 (2010)
  • Author(s): 滝沢琢己、高木美智、笹岡寛敏、伊藤謙治、中島欽一
  • Organizer: Neuro2010
  • Place of Presentation: 兵庫県
  • Year and Date: 2010-09-02
• [Presentation] 神経活動依存性遺伝子発現の時空間制御 (2010)
  • Author(s): 滝沢琢己、高木美智、笹岡寛敏、伊藤謙治、中島欽一
  • Organizer: Neuro2010
  • Place of Presentation: 神戸市
  • Year and Date: 2010-09-02
• [Presentation] アストロサイト分化における小胞体ストレス応答の役割 (2010)
  • Author(s): 齋藤敦、落合希実子、村上智彦、佐野坂司、中島欽一
  • Organizer: Neuro2010
  • Place of Presentation: 神戸市
  • Year and Date: 2010-09-02
• [Presentation] アストロサイト分化誘導性サイトカイン発現細胞の同定 (2010)
  • Author(s): 佐野坂司、波平昌一、滝沢琢己、中島欽一
  • Organizer: Neuro2010
  • Place of Presentation: 神戸市
  • Year and Date: 2010-09-02
• [Presentation] メチル化DNA結合タンパク質MeCP2の相互作用因子解析 (2010)
  • Author(s): 辻村啓太、鈴木暁也、深尾陽一郎、藤原正幸、中島欽一
  • Organizer: Neuro2010
  • Place of Presentation: 神戸市
  • Year and Date: 2010-09-02
• [Presentation] Prenatal HDAC inhibition affects adult hippocampal neurogenesis (2010)
  • Author(s): Juliandi B., Tanemura K., Abematsu M., Igarashi K., Kanno J., Nakashima K.
  • Organizer: Neuro2010
  • Place of Presentation: 神戸市
  • Year and Date: 2010-09-02
• [Presentation] Neurons derived from transplanted neural stem cells reconstruct disrupted neuronal circuits in the injured mouse spinal cord. (2010)
  • Author(s): Nakashima K.
  • Organizer: 2010 Shanghai Summer Stem Cell Symposium
  • Place of Presentation: Shanghai
  • Year and Date: 2010-08-09
• [Presentation] 発生期脳における神経幹細胞のアストロサイトへの分化能獲得および分化誘導機構 (2010)
  • Author(s): 中島欽一
  • Organizer: 第50回日本先天異常学会学術集会
  • Place of Presentation: 淡路市
  • Year and Date: 2010-07-08
• [Presentation] 胚性幹細胞におけるGFAP遺伝子の発現制御機構の解析 (2010)
  • Author(s): 裏山悟司、滝沢琢己、堀由貴奈、神山淳、中島欽一
  • Organizer: 日本分子生物学会第10,回春季シンポジウム
  • Place of Presentation: 宮城県
  • Year and Date: 2010-06-08
• [Presentation] 胚性幹細胞におけるGFAP遺伝子の発現制御機構の解析 (2010)
  • Author(s): 裏山悟司、滝沢琢己、堀由貴奈、神山淳、中島欽一
  • Organizer: 日本分子生物学会 第10回春季シンポジウム
  • Place of Presentation: 宮城県宮城郡松島町
  • Year and Date: 2010-06-08
• [Presentation] Spatiotemporal regulation of activity dependent gene expression in post-mitotic neurons (2010)
  • Author(s): Takagi M., Sasaoka H., Itoh K., Kimura H., Nakashima K., Takizawa T.
  • Organizer: The 75^<th> Cold Spring Harbor Symposium
  • Place of Presentation: New York
  • Year and Date: 2010-06-02
• [Presentation] Spatiotemporal regulation of activity dependent gene expression in post-mitotic neurons. (2010)
  • Author(s): Takagi M., Sasaoka H., Itoh K., Kimura H., Nakashima K., Takizawa T.
  • Organizer: The 75^<th> Cold Spring Harbor Symposium
  • Place of Presentation: New York USA
  • Year and Date: 2010-06-02
• [Presentation] HDAC阻害剤を用いた神経幹細胞制御による損傷脊髄新規治療法 (2010)
  • Author(s): 中島欽一
  • Organizer: 日本エピジェネティクス研究会第4回年会
  • Place of Presentation: 米子市
  • Year and Date: 2010-05-28
• [Presentation] 成体海馬ニューロン新生におけるNP95の役割 (2010)
  • Author(s): 武藤哲司、武藤正弘、古関庸子、古関明彦、中島欽一
  • Organizer: 日本エピジェネティクス研究会第4回年会
  • Place of Presentation: 米子市
  • Year and Date: 2010-05-28
• [Presentation] メチル化DNA結合タンパク質MeCP2の新規相互作用因子の探索 (2010)
  • Author(s): 辻村啓太、鈴木暁也、藤原正幸、深尾洋一朗、中島欽一
  • Organizer: 日本エピジェネティクス研究会第4回年会
  • Place of Presentation: 米子市
  • Year and Date: 2010-05-28
• [Presentation] 移植神経幹細胞由来ニューロンによる脊髄損傷治療 (2010)
  • Author(s): 中島欽一
  • Organizer: 神経組織の成長・再生・移植研究会 第25回学術集会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-05-22
• [Presentation] Oxygen tension can control the DNA methylation status of GFAP promoter through Notch signaling and allows propagation and maturation of neuronal progenitor (2010)
  • Author(s): 武藤哲司、中島欽一
  • Organizer: 第8回幹細胞シンポジウム
  • Place of Presentation: 淡路市
  • Year and Date: 2010-05-13
• [Presentation] The role of histone acetylation on cortical development (2010)
  • Author(s): Juliandi B.、辻村啓太、〓松昌彦、神山淳、中島欽一
  • Organizer: 第8回幹細胞シンポジウム
  • Place of Presentation: 淡路市
  • Year and Date: 2010-05-13
• [Presentation] Rett症候群原因遺伝子産物MeCP2の機能解析 (2010)
  • Author(s): 辻村啓太, 鈴木暁也, 中島欽一
  • Organizer: 第4回神経発生討論会
  • Place of Presentation: 岡崎
  • Year and Date: 2010-03-19
• [Presentation] ニューロン活動依存的に発現する遺伝子の核内空間配置解析 (2009)
  • Author(s): 高木美智, 滝沢琢己, 笹岡寛敏, 中島欽一
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜市
  • Year and Date: 2009-12-09
• [Presentation] Analysis of chromatin modifications and trascriptional regulations of activity-dependent genes in post-mitotic neurons (2009)
  • Author(s): 笹岡寛敏, 滝沢琢己, 木村宏, 中島欽一
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜市
  • Year and Date: 2009-12-09
• [Presentation] A source of astrocyte-inducing cytokines in the developing mouse brain (2009)
  • Author(s): 佐野坂司, 犬伏浩規, 神山淳, 滝沢琢己, 中島欽一
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜市
  • Year and Date: 2009-12-09
• [Presentation] Analysis of DNA methylation-independent regulatory mechanisms of astrocyte specific gene expression (2009)
  • Author(s): 裏山悟司, 滝沢琢己, 堀由貴奈, 神山淳, 中島欽一
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜市
  • Year and Date: 2009-12-09
• [Presentation] Astrocyte-specific genes are generally demethylated in neural precursor cells prior to astrocytic differentiation (2009)
  • Author(s): 畑田出穂, 波平昌一, 森田純代, 堀居拓郎, 木村美香, 中島欽一
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜市
  • Year and Date: 2009-12-09
• [Presentation] レチノイン酸誘導製ヒストンアセチル化による神経幹細胞のアストロサイト分化促進機構 (2009)
  • Author(s): 浅野弘嗣, 青沼真, 佐野坂司, 神山淳, 波平昌一, 中島欽一
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜市
  • Year and Date: 2009-12-09
• [Presentation] The Role of Histone Acetylation on Cortical Development (2009)
  • Author(s): Berry J, Tsujimura K, Abematsu M, Kohyama J, Nakashima K
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜市
  • Year and Date: 2009-12-09
• [Presentation] Mechanism in sequential differentiation of neural stem cells mediated by neuron-stem cell interaction (2009)
  • Author(s): Nakashima K
  • Organizer: The 1st International Global COE Symposium
  • Place of Presentation: 仙台
  • Year and Date: 2009-12-07
• [Presentation] The spatio-temporal regulation of activity-dependent genes in post-mitotic neurons (2009)
  • Author(s): Takizawa T, Sasaoka H, Takagi M, Kimura H, Nakashima K.
  • Organizer: The 4th International Workshop on Cell Regulations in Division and Arrest
  • Place of Presentation: 沖縄
  • Year and Date: 2009-11-29
• [Presentation] ニューロンでの遺伝子発現におけるエピジェネティック修飾の解析 (2009)
  • Author(s): 笹岡寛敏, 滝沢琢己, 木村宏, 中島欽一
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸市
  • Year and Date: 2009-10-23
• [Presentation] ニューロン活動依存的に発現する遺伝子の核内空間配置解析 (2009)
  • Author(s): 高木美智, 笹岡寛敏, 滝沢琢己, 中島欽一
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸市
  • Year and Date: 2009-10-23
• [Presentation] 神経幹細胞のアストロサイト分化能獲得を制御するエピジェネティクス機構 (2009)
  • Author(s): Sanosaka T, Namihira M, Kohyama J, Semi K, Taga T, Nakashima K
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋市
  • Year and Date: 2009-09-16
• [Presentation] 移植神経幹細胞のエピジェネティック制御による損傷脊髄再生治療 (2009)
  • Author(s): あべ松昌彦, 辻村啓太, 山野真利子, 斉藤美知子, 河野憲二, 神山淳, 波平昌一, 小宮節郎, 中島欽一
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋市
  • Year and Date: 2009-09-16
• [Presentation] 脊髄損傷に対するエピジェネティック治療 (2009)
  • Author(s): Nakashima K
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋市
  • Year and Date: 2009-09-16
• [Presentation] 胎仔期HDAC阻害剤暴露によるマウス脳内環境変化で誘発される成体期行動以上と原因解明 (2009)
  • Author(s): 中島欽一
  • Organizer: シンポジウム「脳を巡る環境-遺伝子相互作用の分子基盤」
  • Place of Presentation: 東京都
  • Year and Date: 2009-08-29
• [Presentation] Mechanism for sequential acquisition of differentiation potential of neural stem cells (2009)
  • Author(s): Nakashima K
  • Organizer: The 22th Biennial Meeting of the ISN/APSN 2009
  • Place of Presentation: Busan, Korea
  • Year and Date: 2009-08-23
• [Presentation] Sequencial differentiation of neural stem cells into neuron first and then astrocyte (2009)
  • Author(s): 蝉克憲, 波平昌一, 神山淳, 佐野坂司, 中島欽一
  • Organizer: 第4回Notchシグナル研究会
  • Place of Presentation: 三島市
  • Year and Date: 2009-07-30
• [Presentation] Epigenetic Regulations for Neural Cell Differentiation and Plasticity (2009)
  • Author(s): Nakashima K
  • Organizer: Lasker/IRRF Intiative for Innovation in Vision Research
  • Place of Presentation: Woods Hole, USA
  • Year and Date: 2009-07-13
• [Presentation] DYNAMIC CHANGES IN DNA METHYLATION AND SPATIAL POSITIONING OF AN ASTROCYTE SPECIFIC GENE, GFAP DURING ASTROCYTE DIFFERENTIATION (2009)
  • Author(s): Takizawa T, Taga T, Misteli T, Nakashima K.
  • Organizer: ISSCR 7th Annual Meeting
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2009-07-08
• [Presentation] REGULATION OF NEURAL CELL DIFFERENTIATION PLASTICITY IN ADULT CENTRAL NERVOUS SYSTEM (2009)
  • Author(s): Kohyama J, Tsujimura K, Kirikae I, Abematsu M, Takebayashi H, Nakashima K
  • Organizer: ISSCR 7th Annual Meeting
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2009-07-08
• [Presentation] COMMITTED NEURONAL PRECURSORS CONFER ASTROCYTE-DIFFERENTIATION POTENTIAL ON NEURAL STEM CELLS THROUGH NOTCH SIGNAL MEDIATED DNA DEMETHYLATION DURING MOUSE BRAIN DEVELOMENT (2009)
  • Author(s): Sanosaka T, Namihira M, Kohyama J, Semi K, Benjamin D, Taga T, Nakashima K
  • Organizer: ISSCR 7th Annual Meeting
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2009-07-08
• [Presentation] RETINOIC ACID-INDUCED CHROMATIN REMODELING PROMOTES ASTROCYTE DIFFERENTIATION OF NEURAL STEM CELLS (2009)
  • Author(s): Asano H, Namihira M, Kohyama J, Aonuma M, Sanosaka T, Nakashima K
  • Organizer: ISSCR 7th Annual Meeting
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2009-07-08
• [Presentation] DYNAMIC CHANGES IN DNA METHYLATION AND SPATIAL POSITIONING OF AN ASTROCYTE SPECIFIC CENE, GFAP DURING ASTROCYTE DIFFERENTIATION (2009)
  • Author(s): Takizawa T, Taga T, Misteli T, Nakashima K
  • Organizer: ISSCR 7th Annual Meeting
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2009-07-08
• [Presentation] Allele-specific nuclear positioning of the monoallelically expressed astrocyte marker GFAP (2009)
  • Author(s): Takizawa T, Nakashima K, Gudla RP, Lockett S, Misteli T.
  • Organizer: 第24回内藤コンファレンス
  • Place of Presentation: 札幌市
  • Year and Date: 2009-06-23
• [Presentation] Committed nueronal precursors confer astrocyte-differentiation potential on neural stem cells through Notch-signal mediated DNA demethylation during mouse brain development (2009)
  • Author(s): Semi K, Namihira M, Kohyama J, Sanosaka T, Nakashima K
  • Organizer: 第24回内藤コンファレンス
  • Place of Presentation: 札幌市
  • Year and Date: 2009-06-23
• [Presentation] アストロサイト特異的遺伝子GFAP発現制御に関するDNAメチル化と遺伝子座核内配置 (2009)
  • Author(s): 滝沢琢己
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 渋川市
  • Year and Date: 2009-06-22
• [Presentation] 神経幹細胞が生み出す細胞の順番付けの仕組み (2009)
  • Author(s): 中島欽一
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 渋川市
  • Year and Date: 2009-06-22
• [Presentation] メチル化DNA結合タンパク質による神経系細胞の分化・可塑性制御 (2009)
  • Author(s): 中島欽一
  • Organizer: 神経組織の成長・再生・移植研究会 (GRT) 第24回学術集会
  • Place of Presentation: 渋川市
  • Year and Date: 2009-06-21
• [Presentation] Neuro-to-gliogenic switch triggered by Notch-induced demethylation in neural stem cells (2009)
  • Author(s): Nakashima K
  • Organizer: CREST Neuroscience International Symposium
  • Place of Presentation: 淡路市
  • Year and Date: 2009-06-02
• [Presentation] ニューロンでの遺伝子発現におけるエピジェネティック修飾の解析 (2009)
  • Author(s): 笹岡寛敏, 滝沢琢己, 中島欽一
  • Organizer: 第3回日本エピジェネティクス研究会年会
  • Place of Presentation: 東京都
  • Year and Date: 2009-05-22
• [Presentation] アストロサイト特異的遺伝子GFAPの核内配置と転写活性 (2009)
  • Author(s): 滝沢琢己, Tom Misteli, 中島欽一
  • Organizer: 第3回日本エピジェネティクス研究会年会
  • Place of Presentation: 東京都
  • Year and Date: 2009-05-22
• [Presentation] メチル化DNA結合タンパク質MeCP2によるニューロン分化誘導機構と中枢神経系 (2009)
  • Author(s): 辻村啓太, 松昌彦, 神山淳, 波平昌一, 中島欽一
  • Organizer: 第3回日本エピジェネティクス研究会年会
  • Place of Presentation: 東京都
  • Year and Date: 2009-05-22
• [Presentation] Committed nueronal precursors confer astrocyte-differentiation potential on neural stem cells through Notch-signal mediated DNA demethylation during mouse brain development (2009)
  • Author(s): Semi K, Namihira M, Kohyama J, Sanosaka T, Nakashima K
  • Organizer: 第7回幹細胞シンポジウム
  • Place of Presentation: 東京都
  • Year and Date: 2009-05-15
• [Book] "ゲノムDNAの核内配置と遺伝子発現制御"生化学 (2010)
  • Author(s): 滝沢琢己, 高木美智, 笹岡寛敏
• [Book] Handbook of epigenetics : The new molecular and medical genetics (2010)
  • Author(s): Juliandi B, Abematsu M, Nakashima K
  • Total Pages: 14
  • Publisher: Elsevier
• [Book] The new molecular and medical genetics (2010)
  • Author(s): Juliandi B, Abematsu M, Nakashima K
  • Publisher: Elsevier(In press)
• [Book] "神経系細胞における核内機能ドメイン配置"実験医学 (2009)
  • Author(s): 滝沢琢己, 中島欽一
• [Book] "神経系におけるゲノム核内配置" Clinical Neuroscience (2009)
  • Author(s): 滝沢琢己
• [Book] Regulatory networks in stem cells (2009)
  • Author(s): Suzuki A, Raya A, Kawakami Y, Morita M, Matsui T, Nakashima K, Gage FH, Rodriguez-Esteban C, Izpisua Belmonte JC
  • Total Pages: 21
  • Publisher: Humana Press(In press)
• [Remarks]
  • URL: http://bsw3.naist.jp/courses/courses203.html
• [Remarks]
  • URL: http://www.naist.jp/pressrelease/detail_j/topics/1290/