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Mechanisms of neural circuit formation in the ventral telencephalon

Research Project

Project/Area Number 21300124
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionKochi University

Principal Investigator

HIRANO Shinji  高知大学, 教育研究部・医療学系, 准教授 (80222248)

Co-Investigator(Kenkyū-buntansha) YURI Kazunari  高知大学, 教育研究部・医療学系, 教授 (10220534)
Research Collaborator TAKEICHI Masatoshi  理化学研究所, 発生再生科学総合研究センター, グループディレクター
MASUBA Aya  高知大学, 総合人間自然科学研究科, 大学院生
ASAHINA Hiromichi  高知大学, 総合人間自然科学研究科, 大学院生
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2011: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywords神経科学 / 脳・神経 / 発生分化 / 神経回路 / 細胞接着分子 / カドヘリン / 細胞接着
Research Abstract

To reveal molecular mechanisms of neural circuit formation in the ventral telencephalon, we tried to prove importance of striatal axons and to find novel axon guidance molecules in this region. Due to technical problems, we failed to perform experiments on striatal axons. On the other hand, we could show that PlexinA1 and Semaphorin6D did not play major roles in formation of internal capsule and that distribution of protocadherin 9 protein coincided with certain neural circuits, such as auditory system.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (8 results)

All 2012 2010 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results) Remarks (2 results)

  • [Journal Article] Cadherins in brain morphogenesis and wiring2012

    • Author(s)
      Hirano S, Takeichi M
    • Journal Title

      Physiol. Rev

      Volume: 92(2) Pages: 597-634

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cadherins in brain morphogenesis and wiring2012

    • Author(s)
      Shinji Hirano, Masatoshi Takeichi
    • Journal Title

      Physiological Reviews

      Volume: 92 Pages: 597-634

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 神経回路形成におけるプレキシンA1とセマフォリン6Dの役割2010

    • Author(s)
      増場亜弥、朝比奈大道、須藤文和、熊ノ郷淳、平野伸二、由利和也
    • Organizer
      第33回分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Related Report
      2011 Final Research Report
  • [Presentation] マウス脳におけるプロトカドヘリン9の分布2010

    • Author(s)
      朝比奈大道、増場亜弥、竹市雅俊、平野伸二、由利和也
    • Organizer
      第33回分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Related Report
      2011 Final Research Report
  • [Presentation] 神経回路形成におけるプレキシンA1とセマフォリン6Dの役割2010

    • Author(s)
      増場亜弥、朝比奈大道、須藤文和、熊ノ郷淳、平野伸二、由利和也
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウス脳におけるプロトカドヘリン9の分布2010

    • Author(s)
      朝比奈大道、増場亜弥、竹市雅俊、平野伸二、由利和也
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.kochi-ms.ac.jp/~ff_antm1/Research.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.kochi-ms.ac.jp/~ff_antm1/Research.html

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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