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A study for the generation mechanism and physiological relevance of left-right asymmetry of the brain

Research Project

Project/Area Number 21300125
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionKyushu University

Principal Investigator

ITO Isao  九州大学, 大学院・理学研究院, 准教授 (20183741)

Co-Investigator(Kenkyū-buntansha) WATANABE Shigeru  慶応義塾大学, 文学部, 教授 (30051907)
SAKATA Shougo  広島大学, 総合科学研究科, 教授 (50153888)
野村 政壽  九州大学, 大学病院, 講師 (30315080)
Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Keywords分子・細胞神経科学 / 脳の左右差 / 海馬 / 神経回路 / NMDA受容体 / 行動解析
Research Abstract

How is brain asymmetry generated? What is the meaning of brain asymmetry in higher-order brain functions? To address these fundamental questions, we conducted electrophysiological and behavioral studies using several strains of mutant mice. We found that a protein, known to be important in cellular immunity, was critical for the generation of asymmetrical neuronal circuitry in the brain. The transgenic mice lacking this protein showed deficits in the retention of spatial memory.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (37 results)

All 2013 2012 2011 2010 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (18 results) (of which Invited: 2 results) Book (2 results) Remarks (5 results)

  • [Journal Article] Hippocampal theta wave activity during configural and non-configural tasks in rats2013

    • Author(s)
      Sakimoto, Y., Hattori, M., Takeda, K., Okada, K.& Sakata, S
    • Journal Title

      Experimental Brain Research

      Volume: 225 Pages: 177-185

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neural activity in the hippocampus during conflict resolution2013

    • Author(s)
      Sakimoto Y, Okada K, Hattori M, Takeda K, Sakata S
    • Journal Title

      Behavioural Brain Research

      Volume: 237 Pages: 1-6

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hippocampal theta wave activity during configural and non-configural tasks in rats.2013

    • Author(s)
      Sakimoto, Y., Hattori, M., Takeda, K., Okada, K. & Sakata, S.
    • Journal Title

      Experimental Brain Research

      Volume: 225 Pages: 177-185

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neural activity in the hippocampus during conflict resolution.2013

    • Author(s)
      Sakimoto Y, Okada K, Hattori M, Takeda K, Sakata S.
    • Journal Title

      Behavioural Brain Research

      Volume: 237 Pages: 1-6

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mice recognize the center of an enclosure2012

    • Author(s)
      Inoue,N., Watanabe,S
    • Journal Title

      Behavioral Processes

      Volume: 91 Pages: 141-144

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of ischemia on spatial learning in mice2012

    • Author(s)
      Watanabe,S., Utsuki,N
    • Journal Title

      ARLS Series of Advanced Study of Logic and Sensibility

      Volume: 5 Pages: 7-14

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mice recognize the center of an enclosure.2012

    • Author(s)
      Inoue,N., Watanabe,S.
    • Journal Title

      Behavioral Processes

      Volume: 91 Pages: 141-144

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of ischemia on spatial learning in mice2012

    • Author(s)
      Watanabe,S., Utsuki,N
    • Journal Title

      CARLS Series of Advanced Study of Logic and Sensibility

      Volume: 5 Pages: 7-14

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive behavioural study of GluR4 knockout mice: implication in cognitive function2011

    • Author(s)
      Sagata N.Ito I.
    • Journal Title

      Genes Brain and Behavior

      Volume: 9 Pages: 899-909

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive behavioural study of GluR4 knockout mice : implication in cognitive function2011

    • Author(s)
      N.Sagata, 他
    • Journal Title

      Genes Brain and Behavior

      Volume: 9 Pages: 899-909

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Left-right asymmetry defect in the hippocampal circuitry impairs spatial learning and working memory in ivmice2010

    • Author(s)
      Goto K, Kurashima R., Gokan H, Inoue N., Ito I., Watanabe S
    • Journal Title

      PLoS ONE

      Volume: 5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Left-right asymmetry defect in the hippocampal circuitry impairs spatial learning and working memory in iv mice.2010

    • Author(s)
      K.Goto, et al
    • Journal Title

      PLoS ONE

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] MHC クラス1は海馬の非対称性形成に関与する2012

    • Author(s)
      川原愛子、伊藤 功(他 9 名)
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-19
    • Related Report
      2012 Final Research Report
  • [Presentation] A comparison of hippocampal theta activity between configural and non-configural tasks2012

    • Author(s)
      Sakimoto, Y. & Sakata, S
    • Organizer
      16th biennial scientific meeting of the International Society for Comparative Psychology
    • Place of Presentation
      Spain (Jaen)
    • Year and Date
      2012-09-12
    • Related Report
      2012 Final Research Report
  • [Presentation] Major histocompatibility complex class I molecules regulate asymmetry in hippocampal circuitry2012

    • Author(s)
      I. Ito
    • Organizer
      16th biennial scientific meeting of the International Society for Comparative Psychology
    • Place of Presentation
      Spain (Jaen)
    • Year and Date
      2012-09-12
    • Related Report
      2012 Final Research Report
  • [Presentation] MHC-Iは海馬神経回路の非対称性形成に関与する2012

    • Author(s)
      川原愛子, 他
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本市総合体育館(長野)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] マウス海馬の左右非対称性2012

    • Author(s)
      伊藤 功
    • Organizer
      第153回獣医学会学術集会
    • Place of Presentation
      埼玉
    • Year and Date
      2012-03-27
    • Related Report
      2012 Final Research Report
  • [Presentation] マウス海馬の左右非対称性2012

    • Author(s)
      伊藤功
    • Organizer
      第153回獣医学会学術集会
    • Place of Presentation
      大宮ソニックシティ(埼玉)(招待講演)
    • Year and Date
      2012-03-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] マウス海馬神経回路の非対称性2012

    • Author(s)
      伊藤功
    • Organizer
      第228回川崎医学会講演会
    • Place of Presentation
      川崎医科大学(岡山)(招待講演)
    • Year and Date
      2012-02-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] MHC-I は海馬神経回路の非対称性形成に関与する2012

    • Author(s)
      川原愛子、伊藤 功 (他 5 名)
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本市
    • Related Report
      2012 Final Research Report
  • [Presentation] A comparison of hippocampal theta activity between configural and non-configural tasks.2012

    • Author(s)
      Sakimoto, Y. & Sakata, S.
    • Organizer
      16th biennial scientific meeting of the International Society for Comparative Psychology
    • Place of Presentation
      Spain (Jaen)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Major histocompatibility complex class I molecules regulate asymmetry in hippocampal circuitry2012

    • Author(s)
      I. Ito
    • Organizer
      2nd Joint meeting of the Spanish Society for Comparative Psychology and the International Society for Comparative Psychology.
    • Place of Presentation
      Spain (Jaen)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Molecular mechanisms of behavioral abnormalities of knockout mice of Grm3, a candidate for schizophrenia susceptibility2011

    • Author(s)
      藤岡竜太, 他
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 統合失調症関連遺伝子AMPA受容体GluR4遺伝子のノックアウトマウスの作製と解析2011

    • Author(s)
      岩城明子, 他
    • Organizer
      第56回日本人類遺伝学会大会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 海馬神経回路の非対称性形成に関与するシグナル分子の探索2011

    • Author(s)
      川原愛子, 他
    • Organizer
      第62回西日本生理学会
    • Place of Presentation
      佐賀大学医学部(佐賀)
    • Year and Date
      2011-10-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Molecular Asymmetry in Mouse Hippocampal Circuitry2010

    • Author(s)
      I. Ito
    • Organizer
      THEINTERNATIONAL SOCIETY FOR COMPARATIVE PSYCHOLOGY
    • Place of Presentation
      兵庫
    • Year and Date
      2010-05-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Molecular Asymmetry in Mouse Hippocampal Circuitry2010

    • Author(s)
      Isao ITO
    • Organizer
      THE INTERNATIONAL SOCIETY FOR COMPARATIVE PSYCHOLOGY
    • Place of Presentation
      兵庫
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] MHCクラス1は海馬の非対称性形成に関与する

    • Author(s)
      川原愛子、倉内翔太郎、深田優子、Jose Martinez-Hernandez、八木橋輝美、板谷祐也、章瑠依、深田正紀、Rafael Lujan、 重本隆一、伊藤功
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] 統合失調症関連遺伝子GRM3のノックアウトマウスにおける行動異常とその分子機構の解析

    • Author(s)
      藤岡 竜太、二井 偉暢、岩城 明子、柴田 篤志、伊藤 功、北市 清幸、 野村 政壽、服部 聡子、高雄 啓三、宮川 剛、服巻 保幸
    • Organizer
      第57回日本人類遺伝学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウスにおけるピーク法の学習過程の検討

    • Author(s)
      坂田省吾
    • Organizer
      中国四国心理学会第68回大会
    • Place of Presentation
      福山大学
    • Related Report
      2012 Annual Research Report
  • [Book] Comparative Cognition: Experimental Exploration of Animal Intelligence 、 What " and " Where " analysis and flexibility in avian visual cognition2013

    • Author(s)
      Watanabe, S
    • Total Pages
      387
    • Publisher
      Oxford University Press
    • Related Report
      2012 Final Research Report
  • [Book] Comparative Cognition: Experimental Exploration of Animal Intelligence.2013

    • Author(s)
      Watanabe,S
    • Total Pages
      387
    • Publisher
      “What” and “Where” analysis and flexibility in avian visual cognition.
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://seibutsu.biology.kyushu-u.ac.jp/~neurosci/index.html

    • Related Report
      2012 Final Research Report
  • [Remarks] 九州大学理学研究院生物科学部門生体物理化学研究室伊藤グループ

    • URL

      http://seibutsu.biology.kyushu-u.ac.jp/~neurosci/index.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://seibutsu.biology.kyushu-u.ac.jp/~neurosci/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://seibutsu.biology.kyushu-u.ac.jp/-neurosci/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://seibutsu.biology.kyushu-u.ac.jp/~neurosci/

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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