Input responsiveness of neuronal circuits and its modulation by neurotransmitters.

• Project/Area Number: 21300127
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: National Institute for Physiological Sciences
• Principal Investigator: IMOTO Keiji 生理学研究所, 生体情報研究系, 教授 (00176512)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2009: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
• Keywords: 神経回路 / シナプス伝達 / フィードフォワード抑制 / ダイナミッククランプ / てんかん / 神経細胞 / シナプス / 入力タイミング / 神経調節因子 / 欠伸発作 / 深部脳刺激 / パッチクランプ / HCNチャネル / シミュレーション / in vivo記録

Research Abstract

We investigated timing dependency of two synaptic inputs to layer 4 neurons projecting from thalamus using patch clamp recording from brain slice preparations. The optimal timing of quasi-simultaneous inputs is modulated by neuromodulators. This switching-like behavior of the circuit may be a neuronal correlate of switching of attention and wakefulness. We also investigated the role of the basal ganglia in absence epilepsy using calcium channel-mutant mice, which are used as a model animal for epilepsy. We found functional activity of hyperpolarization-activated cation channel is reduced in the subthalamic nucleus. The reduction enhanced excitability of subthalamic neurons, which resulted in prolongation of abnormal rhythmic activity of absence epilepsy.

Research Products

• [Journal Article] Rewiring of afferent fibers in the somatosensory thalamus of mice caused by peripheral sensory nerve transection. (2012)
  • Author(s): Takeuchi Y, Yamasaki M, Nagumo Y, Imoto K, Watanabe M, Miyata M
  • Journal Title: J Neurosci Volume: (in press)
  • Peer Reviewed
• [Journal Article] In vivo patch-clamp recording from locus coeruleus neurones in the rat brainstem (2012)
  • Author(s): Sugiyama D, Hur SW, Pickering AE, Kase D, Kim SJ, Kawamata M, Imoto K, Furue H
  • Journal Title: J Physiol Volume: (in press)
  • NAID: 120007108244
  • Peer Reviewed
• [Journal Article] Roles of the subthalamic nucleus and subthalamic HCN channels in absence seizures (2012)
  • Author(s): Kase D, Inoue T, Imoto K
  • Journal Title: Journal of Neurophysiology Volume: 107 Issue: 1 Pages: 393-406
  • DOI: 10.1152/jn.00937.2010
  • Peer Reviewed
• [Journal Article] In vivo patch-clamp recording from locus coeruleus neurons in the rat brainstem (2012)
  • Author(s): Sugiyama D, Hur SW, Pickering AE, Kase D, Kim SJ, Kawamata M, Imoto K, Furue H
  • Journal Title: Journal of Physiology Volume: (in press) Issue: 10 Pages: 2225-2231
  • DOI: 10.1113/jphysiol.2011.226407
  • NAID: 120007108244
  • Peer Reviewed
• [Journal Article] Roles of the subthalamic nucleus and subthalamic HCN channels in absence seizures (2011)
  • Author(s): Kase D, Inoue T, Imoto K
  • Journal Title: J Neurophysiol Volume: 107 Pages: 393-406
  • Peer Reviewed
• [Journal Article] Synapse-and subtype-speciifc modulaton of synaptic transmission by nicotinic acetylcholine receptor in the ventrobasal thalamus (2011)
  • Author(s): Nagumo Y, Takeuchi Y, Imoto K, Miyata M
  • Journal Title: Neurosci Res Volume: 69 Pages: 203-213
  • Peer Reviewed
• [Journal Article] Synapse and subtype-speciifc modulaton of synaptic transmission by nicotinic acetylcholine receptor in the ventrobasal thalamus. (2011)
  • Author(s): Nagumo Y, et al.
  • Journal Title: Neuroscience Research Volume: 69 Pages: 203-213
  • Peer Reviewed
• [Journal Article] Bone cancer induces a unique central sensitization through synaptic changes in a wide area of the spinal cord (2010)
  • Author(s): Yanagisawa Y, Furue H, Kawamata T, Uta D, Yamamoto J, Furuse S, Katafuchi T, Imoto K, Iwamoto Y and Yoshimura M
  • Journal Title: Mol Pain Volume: 6 Pages: 38-38
  • Peer Reviewed
• [Journal Article] TRPA1-expressing primary afferents synapse with a morphologically identified subclass of substantia gelatinosa neurons in the adult rat spinal cord (2010)
  • Author(s): Uta D, Furue H, Pickering AE, Rashid MH, Mizuguchi-Takase H, Katafuchi T, Imoto K, Yoshimura M
  • Journal Title: Eur J Neurosci Volume: 31 Pages: 1960-1973
  • Peer Reviewed
• [Journal Article] Developmental characteristics of dendritic spines in the dentate gyrus of Fmr1 knockout mice (2010)
  • Author(s): Grossman AW, Aldridge GM, Lee KJ, Zeman MK, Jun CS, Azam HS, Arii T, Imoto K, Greenough WT, Rhyu IJ
  • Journal Title: Brain Res Volume: 1355 Pages: 221-227
  • Peer Reviewed
• [Journal Article] Glutamate transporter EAAT4 in Purkinje cells controls intersynaptic diffusion of climbing fiber transmitter mediating inhibition of GABA release from interneurons (2010)
  • Author(s): Satake S, Song S-Y, Konishi S, Imoto K
  • Journal Title: Eur J Neurosci Volume: 32 Pages: 1843-1853
  • Peer Reviewed
• [Journal Article] Bone cancer induces a unique central sensitization through synaptic changes in a wide area of the spinal cord. (2010)
  • Author(s): Yanagisawa Y, et al.
  • Journal Title: Molecular Pain Volume: 6 Pages: 38-38
  • Peer Reviewed
• [Journal Article] TRPA1-expressing primary afferents synapse with a morphologically identified subclass of substantia gelatinosa neurons in the adult rat spinal cord. (2010)
  • Author(s): Uta D, et al.
  • Journal Title: European Journal of Neuroscience Volume: 31 Pages: 1960-1973
  • Peer Reviewed
• [Journal Article] Developmental characteristics of dendritic spines in the dentate gyrus of Fmrl knockout mice. (2010)
  • Author(s): Grossman AW, et al.
  • Journal Title: Brain Research Volume: 1355 Pages: 1843-1853
  • Peer Reviewed
• [Journal Article] Glutamate transporter EAAT4 in Purkinje cells controls intersynaptic diffusion of climbing fiber transmitter mediating inhibition of GABA release from interneurons. (2010)
  • Author(s): Satake S, et al
  • Journal Title: European Journal of Neuroscience Volume: 32 Pages: 1843-1853
  • Peer Reviewed
• [Journal Article] Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system (2009)
  • Author(s): Shiuchi T, Haque MS, Okamoto S, Inoue T, Kageyama H, Lee S, Toda C, Suzuki A, Bachman ES, Kim YB, Sakurai T, Yanagisawa M, Shioda S, Imoto K, Minokoshi Y
  • Journal Title: Cell Metab Volume: 10 Pages: 466-480
  • Peer Reviewed
• [Journal Article] Latent genetic backgrounds and molecular pathogenesis in drug-induced long-QT syndrome (2009)
  • Author(s): Itoh H, Sakaguchi T, Ding WG, Watanabe E, Watanabe I, Nishio Y, Makiyama T, Ohno S, Akao M, Higashi Y, Zenda N, Kubota T, Mori C, Okajima K, Haruna T, Miyamoto A, Kawamura M, Ishida K, Nagaoka I, Oka Y, Nakazawa Y, Yao T, Jo H, Sugimoto Y, Ashihara T, Hayashi H, Ito M, Imoto K, Matsuura H, Horie M.
  • Journal Title: Circ Arrhythm Electrophysiol Volume: 2 Pages: 511-23
  • Peer Reviewed
• [Journal Article] Kinase-dead knock-in mouse reveals an essential role of CaMKII-alpha kinase activity in dendritic spine enlargement, LTP and learning (2009)
  • Author(s): Yamagata Y, Kobayashi S, Umeda T, Inoue A, Sakagami H, Fukaya M, Watanabe M, Hatanaka N, Totsuka M, Yagi T, Obata K, Imoto K, Yanagawa Y, Manabe T, Okabe S
  • Journal Title: J Neurosci Volume: 29 Pages: 7607-7618
  • Peer Reviewed
• [Journal Article] Kinase-dead knock-in mouse reveals an essential role of CaMKII-alpha kinase activity in dendritic spine enlargement, LTP and learning (2009)
  • Author(s): Yamagata Y, et al.
  • Journal Title: Journal of Neuroscience 29 Pages: 7607-7618
  • Peer Reviewed
• [Journal Article] Latent genetic backgrounds and molecular pathogenesis in druginduced long-QT syndrome (2009)
  • Author(s): Itoh H, et al.
  • Journal Title: Circulation Arrhythm Electrophysiol 2 Pages: 511-523
  • Peer Reviewed
• [Journal Article] Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system (2009)
  • Author(s): Shiuchi T, et al.
  • Journal Title: Cell Metabolism 10 Pages: 466-480
  • Peer Reviewed
• [Journal Article] Rewiring of afferent fibers in the somatosensory thalamus of mice caused by peripheral sensory nerve transection
  • Author(s): Takeuchi Y, Yamasaki M, Nagumo Y, Imoto K, Watanabe M, Miyata M
  • Journal Title: Journal of Neuroscience Volume: (in press)
  • Peer Reviewed
• [Presentation] 変異イオンチャネルのマルコフ過程パラメータ迅速最適化法 (2012)
  • Author(s): 井本敬二,伊藤英樹
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: (長野県)長野県松本文化会館
  • Year and Date: 2012-03-31
• [Presentation] 下部尿路機能の中枢性制御機構解明のためのin vivoパッチクランプ法の開発 (2012)
  • Author(s): 箱崎敦志,井本敬二,林勧生,河谷正仁,古江秀昌
  • Organizer: 第9回日本生理学会大会
  • Place of Presentation: (長野県)長野県松本文化会館
  • Year and Date: 2012-03-31
• [Presentation] 下部尿路機能の中枢性制御機構解明のためのin vivoパッチクランプ法の開発 (2012)
  • Author(s): 箱崎敦志, 井本敬二, 林勧生, 河谷正仁, 古江秀昌
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 長野県松本文化会館(長野県)
  • Year and Date: 2012-03-31
• [Presentation] 変異イオンチャネルのマルコフ過程パラメータ迅速最適化法 (2012)
  • Author(s): 井本敬二, 伊藤英樹
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 長野県松本文化会館(長野県)
  • Year and Date: 2012-03-31
• [Presentation] In vivoパッチクランプ記録法を用いた成熟ラット脊髄後角ニューロンにおける興奮性シナプス伝達に関する痒み物質セロトニンの皮膚投与における効果について (2012)
  • Author(s): 歌大介,後藤義,安藤嗣修,倉石泰,井本敬二,古江秀昌
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: (長野県)長野県松本文化会館
  • Year and Date: 2012-03-29
• [Presentation] ラット脳幹青斑核からのin vivoパッチクランプ記録 (2012)
  • Author(s): 杉山大介,井本敬二,川真田樹人,古江秀昌
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: (長野県)長野県松本文化会館
  • Year and Date: 2012-03-29
• [Presentation] ラット脳幹青斑核からのin vivoパッチクランプ記録 (2012)
  • Author(s): 杉山大介, 井本敬二, 川真田樹人, 古江秀昌
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 長野県松本文化会館(長野県)
  • Year and Date: 2012-03-29
• [Presentation] In vivoパッチクランプ記録法を用いた成熟ラット脊髄後角ニューロンにおける興奮性シナプス伝達に関する痒み物質セロトニンの皮膚投与における効果について (2012)
  • Author(s): 歌大介, 後藤義, 安藤嗣修, 倉石泰, 井本敬二, 古江秀昌
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 長野県松本文化会館(長野県)
  • Year and Date: 2012-03-29
• [Presentation] In vivo whole-cell patch-clamp analysis of synaptic responses evoked in locus coeruleus neurons in the rat brainstem (2011)
  • Author(s): Sugiyama D, Imoto K, Pickering AE, Kawamata M, Furue H
  • Organizer: Neuroscience 2011
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-11-16
• [Presentation] In vivo patch-clamp analysis of pruriceptive and nociceptive synaptic transmission in the adult rat spinal dorsal horn (2011)
  • Author(s): Uta D, Gotoh Y, Andoh T, Kuraishi Y, Imoto K, Furue H
  • Organizer: Neuroscience 2011
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-11-16
• [Presentation] Systemic injection of alpha-2 adrenergic agonist enhances inhibitory synaptic transmission in the rat superficial dorsal horn in vivo (2011)
  • Author(s): Funai Y, Nishikawa K, Mori T, Asada A, Imoto K, Furue H
  • Organizer: Neuroscience 2011
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-11-16
• [Presentation] Systemic injection of alpha-2 adrenergic agonist enhances inhibitory synaptic transmission in the rat superficial dorsal horn in vivo (2011)
  • Author(s): Funai Y, Nishikawa K, Mori T, Asada A, Imoto K, Furue H
  • Organizer: Neuroscience 2011
  • Place of Presentation: Washington Convention Center (アメリカ合衆国)
  • Year and Date: 2011-11-16
• [Presentation] In vivo patch-clamp analysis of pruriceptive and nociceptive synaptic transmission in the adult rat spinal dorsal horn (2011)
  • Author(s): Uta D, Gotoh Y, Andoh T, Kuraishi Y, Imoto K, Furue H
  • Organizer: Neuroscience 2011
  • Place of Presentation: Washington Convention Center(アメリカ合衆国)
  • Year and Date: 2011-11-16
• [Presentation] In vivo whole-cell patch-clamp analysis of synaptic responses evoked in locus coeruleus neurons in the rat brainstem (2011)
  • Author(s): Sugiyama D, Imoto K, Pickering AE, Kawamata M, Furne H
  • Organizer: Neuroscience 2011
  • Place of Presentation: Washington Convention Center(アメリカ合衆国)
  • Year and Date: 2011-11-16
• [Presentation] Inhibitory synaptic transmission from the substantia nigra parsreticulata in the murine ventral medial thalamus (2011)
  • Author(s): Kase D, Imoto K
  • Organizer: Neuroscience 2011
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-11-12
• [Presentation] Inhibitory synaptic transmission from the substantia nigra parsreticulata in the murine ventral medial thalamus (2011)
  • Author(s): Kase D, Imoto K
  • Organizer: Neuroscience 2011
  • Place of Presentation: Washington Convention Center (アメリカ合衆国)
  • Year and Date: 2011-11-12
• [Presentation] In vivo patch-clamp recording analysis of serotonin-induced itching on synaptic transmission in substantia gelatinosa neurons (2011)
  • Author(s): Uta D, Gotoh Y, Andoh T, Kuraishi Y, Imoto K, Furue H
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: (神奈川県)横浜パシフィコ
  • Year and Date: 2011-09-17
• [Presentation] In vivo patch-clamp recording analysis of serotonin-induced itching on synaptic transmission in substantia gelatinosa neurons (2011)
  • Author(s): Uta D, Gotoh Y, Andoh T, Kuraishi Y, Imoto K, Furue H
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-17
• [Presentation] Motivation-based modeling of learning behavior with scheduled reinforcement (2011)
  • Author(s): Shishido E, Imoto K
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: (神奈川県)横浜パシフィコ
  • Year and Date: 2011-09-16
• [Presentation] Diversity in the presynaptic potentiation of excitatory neurotransmission from granule cells to molecular-layer interneurons in rat cerebellar cortex (2011)
  • Author(s): Satake S, Imoto K
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: (神奈川県)横浜パシフィコ
  • Year and Date: 2011-09-16
• [Presentation] Diversity in the presynaptic potentiation of excitatory neurotransmission from granule cells to molecular-layer interneurons in rat cerebellar cortex (2011)
  • Author(s): Satake S, Imoto K
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-16
• [Presentation] Motivation-based modeling of learning behavior with scheduled reinforcement (2011)
  • Author(s): Shishido E, Imoto K
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-16
• [Presentation] GABAergic inhibitory synaptic transmission from substantia nigra pars reticulata in murine ventral medial thalamus (2011)
  • Author(s): Kase D, Imoto K
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: (神奈川県)横浜パシフィコ
  • Year and Date: 2011-09-15
• [Presentation] Contribution of kinase activity of Ca^<2+>/calmodulin-dependent protein kinase IIαto hippocampus-and amygdala-dependent memory formation (2011)
  • Author(s): Yamagata Y, Yanagawa Y, Imoto K
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: (神奈川県)横浜パシフィコ
  • Year and Date: 2011-09-15
• [Presentation] Contribution of kinase activity of Ca^<2+>/calmodulin-dependent protein kinase IIα to hippocampus- and amygdala-dependent memory formation (2011)
  • Author(s): Yamagata Y, Yanagawa Y, Imoto K
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-15
• [Presentation] GABAergic inhibitory synaptic transmission from substantia nigra pars reticulata in murine ventral medial thalamus (2011)
  • Author(s): Kase D, Imoto K
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-15
• [Presentation] How important is the kinase activity of Ca2+/calmodulin-dependent protein kinase IIαin hippocampus-and amygdala-dependent memory (2010)
  • Author(s): Yamagata Y, Yanagawa Y, Imoto K
  • Organizer: Neuroscience2010
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-11-16
• [Presentation] How important is the kinase activity of Ca^<2+>/calmodulin-dependent protein kinase IIα in hippocampus and amygdala-dependent memory. (2010)
  • Author(s): Yamagata Y, et al.
  • Organizer: Neuroscience 2010
  • Place of Presentation: サンディエゴコンベンションセンター(アメリカ合衆国)
  • Year and Date: 2010-11-16
• [Presentation] The plastic changes of spinal excitatory synaptic transmission in a murine model of cancer-induced bone pain (2010)
  • Author(s): Yanagisawa Y, Furue H, Kawamata T, Uta D, Imoto K, Iwamoto Y, Yoshimura M
  • Organizer: Neuroscience2010
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-11-14
• [Presentation] The plastic changes of spinal excitatory synaptic transmission in a murine model of cancer-induced bone pain. (2010)
  • Author(s): Yanagisawa Y, et al.
  • Organizer: Neuroscience 2010
  • Place of Presentation: サンディエゴコンベンションセンター(アメリカ合衆国)
  • Year and Date: 2010-11-14
• [Presentation] エタノールはラット小脳異種シナプス間拡散性クロストークを阻害する (2010)
  • Author(s): 佐竹伸一郎, 井本敬二
  • Organizer: 日本動物学会第81回大会
  • Place of Presentation: 東京大学駒場キャンパス(東京)
  • Year and Date: 2010-09-25
• [Presentation] Peripheral nerve transection-induced remodeling of afferent synapses in the somatosensory thalamus of mice (2010)
  • Author(s): Takeuchi Y, Nagumo Y, Katayama Y, Imoto K, Kawakami Y, Miyata M
  • Organizer: Neuro2010
  • Place of Presentation: (兵庫県)神戸コンベンションセンター
  • Year and Date: 2010-09-04
• [Presentation] Peripheral nerve transection-induced remodeling of afferent synapses in the somatosensory thalamus of mice. (2010)
  • Author(s): Takeuchi Y, et al.
  • Organizer: Neuro 2010
  • Place of Presentation: 神戸コンベンションセンター(兵庫)
  • Year and Date: 2010-09-04
• [Presentation] Firing pattern of substantia gelatinosa neurons receiving TRPA1-expressing afferents in adult rat spinal dorsal horn (2010)
  • Author(s): Uta D, Imoto K, Furue H
  • Organizer: Neuro2010
  • Place of Presentation: (兵庫県)神戸コンベンションセンター
  • Year and Date: 2010-09-03
• [Presentation] Firing pattern of substantia gelatinosa neurons receiving TRPA1-expressing afferents in adult rat spinal dorsal horn. (2010)
  • Author(s): Uta D, et al.
  • Organizer: Neuro 2010
  • Place of Presentation: 神戸コンベンションセンター(兵庫)
  • Year and Date: 2010-09-03
• [Presentation] Electrical and pharmacological modulations of subthalamic nucleus activity bidirectionally affect absence seizures in tottering mice (2010)
  • Author(s): Kase D, Inoue T, Imoto K
  • Organizer: Neuro2010
  • Place of Presentation: (兵庫県)神戸コンベンションセンター
  • Year and Date: 2010-09-02
• [Presentation] In vivo patch-clamp analysis of synaptic responses evoked in the rat locus coeruleus neurons (2010)
  • Author(s): Sugiyama D, Imoto K, Kawamata M, Furue H
  • Organizer: Neuro2010
  • Place of Presentation: (兵庫県)神戸コンベンションセンター
  • Year and Date: 2010-09-02
• [Presentation] Ethanol suppresses climbing fiber-induced presynaptic inhibition of GABAergic transmission at cerebellar interneuron-Purkinje cell synapses (2010)
  • Author(s): Satake S, Imoto K
  • Organizer: Neuro2010
  • Place of Presentation: 神戸コンベンションセンター
  • Year and Date: 2010-09-02
• [Presentation] Role of kinase activity of Ca2+/calmodulin-dependent protein kinase IIαin hippocampus-and amygdala-dependent memory (2010)
  • Author(s): Yamagata Y, Yanagawa Y, Imoto KQ
  • Organizer: Neuro2010
  • Place of Presentation: (兵庫県)神戸コンベンションセンター
  • Year and Date: 2010-09-02
• [Presentation] Multiple signal processing in a single local circuit (2010)
  • Author(s): Inoue T, Katsu T, Imoto K
  • Organizer: Neuro2010
  • Place of Presentation: (兵庫県)神戸コンベンションセンター
  • Year and Date: 2010-09-02
• [Presentation] Multiple signal processing in a single local circuit. (2010)
  • Author(s): Inoue T, et al.
  • Organizer: Neuro 2010
  • Place of Presentation: 神戸コンベンションセンター(兵庫)
  • Year and Date: 2010-09-02
• [Presentation] Role of kinase activity of Cat^<2+>/calmodulin-dependent protein kinase IIα in hippocampus and amygdala-dependent memory. (2010)
  • Author(s): Yamagata Y, et al.
  • Organizer: Neuro 2010
  • Place of Presentation: 神戸コンベンションセンター(兵庫)
  • Year and Date: 2010-09-02
• [Presentation] Ethanol suppresses climbing fiber-induced presynaptic inhibition of GAB Aergic transmission at cerebellar interneuron-Purkinje cell synapses. (2010)
  • Author(s): Satake S, et al.
  • Organizer: Neuro 2010
  • Place of Presentation: 神戸コンベンションセンター(兵庫)
  • Year and Date: 2010-09-02
• [Presentation] Electrical and pharmacological modulations of subthalamic nucleus activity bidirectionally affect absence seizures in tottering mice. (2010)
  • Author(s): Kase D, et al.
  • Organizer: Neurn 2010
  • Place of Presentation: 神戸コンベンションセンター(兵庫)
  • Year and Date: 2010-09-02
• [Presentation] In vivo patch-clamp analysis of synaptic responses evoked in the rat loc us coeruleus neurons. (2010)
  • Author(s): Sugiyama D, et al
  • Organizer: Neuro 2010
  • Place of Presentation: 神戸コンベンションセンター(兵庫)
  • Year and Date: 2010-09-02
• [Presentation] ラット後根神経節細胞Naチャネルに対する各局所麻酔薬の効果について (2010)
  • Author(s): 歌大介,井本敬二,古江秀昌
  • Organizer: 第32回日本疼痛学会
  • Place of Presentation: (京都府)国立京都国際会館
  • Year and Date: 2010-07-02
• [Presentation] ラット脳幹青斑核からのin vivoパッチクランプ記録法の開発 (2010)
  • Author(s): 杉山大介,井本敬二,川真田樹人,古江秀昌
  • Organizer: 第32回疼痛学会
  • Place of Presentation: (京都府)国立京都国際会館
  • Year and Date: 2010-07-02
• [Presentation] がん性疼痛モデルにおける疼痛関連行動の変化と脊髄興奮入力の可塑的変化 (2010)
  • Author(s): 柳澤義和,古江秀昌,川股知之,井本敬二,吉村恵
  • Organizer: 第32回疼痛学会
  • Place of Presentation: (京都府)国立京都国際会館
  • Year and Date: 2010-07-02
• [Presentation] がん性疾痛モデルにおける疹痛関連行動の変化と脊髄興奮性入力の可塑的変化 (2010)
  • Author(s): 柳澤義和, 他
  • Organizer: 第32回日本痺痛学会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2010-07-02
• [Presentation] ラット脳幹青斑核からのin vivoパッチクランプ記録法の開発 (2010)
  • Author(s): 杉山大介, 他
  • Organizer: 第32回日本痺痛学会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2010-07-02
• [Presentation] ラット後根神経節細胞Naチャネルに対する各局所麻酔薬の効果について (2010)
  • Author(s): 歌大介, 他
  • Organizer: 第32回日本疾痛学会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2010-07-02
• [Presentation] カルシウムチャネルと神経疾患 (2010)
  • Author(s): 井本敬二
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: (岡山県)岡山コンベンションセンター
  • Year and Date: 2010-03-29
• [Presentation] カルシウムチャネルと神経疾患 (2010)
  • Author(s): 井本敬二
  • Organizer: 日本薬学会第103年会
  • Place of Presentation: (岡山県)岡山コンベンションセンター
  • Year and Date: 2010-03-29
• [Presentation] Electrophysiological and morphological analysis of the actions of TRPA1 and TRPV1 agonists on synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord (2009)
  • Author(s): Uta D, Furue H, Imoto K, Yoshimura M
  • Organizer: The 3rd KU/YU-NIPS International Collaborative Symposium
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-10-31
• [Presentation] Electrophysiological and morphological analysis of the actions of TRPA1 and TRPV1 agonists on synaptic transmission in substantia gelatinosa neurons of the adult rat spinalcord (2009)
  • Author(s): Uta D, et al.
  • Organizer: The 3rd KU/YU-NIPS International Collaborative Symposium
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-10-31
• [Presentation] Actions of TRPA1 and TRPV1 agonists on synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord (2009)
  • Author(s): Uta D, Furue H, Imoto K, Yoshimura M
  • Organizer: The 39th Annual Meeting of Society for Neuroscience
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-10-21
• [Presentation] Peritoneum incision, but not skin and muscle incision, increases spontaneous firing rate of spinal dorsal neurons (2009)
  • Author(s): Sugiyama D, Furue H, Imoto K, Tanaka S, Kawamata M
  • Organizer: The 39th Annual Meeting of Society for Neuroscience
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-10-21
• [Presentation] Basal ganglia contribute to the maintenance of epileptic rhythms in absence epilepsy (2009)
  • Author(s): KaseD, Inoue T, Imoto K
  • Organizer: The 39th Annual Meeting of Society for Neuroscience
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-10-21
• [Presentation] Enhancement of excitatory synaptic transmission in the substantia gelatinosa of the spinal cord in a mouse model of bone cancer pain (2009)
  • Author(s): Yanagisawa Y, Furue H, Kawamata T, Uta D, Iwamoto Y, Imoto K, Yoshimura M
  • Organizer: The 39th Annual Meeting of Society for Neuroscience
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-10-17
• [Presentation] 大脳基底核回路は欠神発作のリズム維持に関与する (2009)
  • Author(s): 加勢大輔,井上剛,井本敬二
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: (愛知県)名古屋国際会議場
  • Year and Date: 2009-09-18
• [Presentation] Changes in nociceptive behaviors and spinal excitatory synaptic transmission in a murine model of cancer-induced bone pain (2009)
  • Author(s): Yanagisawa Y, Furue H, Kawamata T, Imoto K, Iwamoto Y, Yoshimura M
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: (愛知県)名古屋国際会議場
  • Year and Date: 2009-09-17
• [Presentation] Kinase activity of CaMKIIa is essential for structural, functional and behavioral expression of synaptic memory (2009)
  • Author(s): Yamagata Y, Kobayashi S, Umeda T, Inoue A, Sakagami H, Fukaya M, Watanabe M, Hatanaka N, Totsuka M, Yagi T, Obata K, Imoto K, Yanagawa Y, Manabe T, Okabe S
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: (愛知県)名古屋国際会議場
  • Year and Date: 2009-09-17
• [Presentation] Effects of TRPA1 and TRPV1 agonists on synaptic transmission in morphologically distinct cell types in substantia gelatinosa of the rat spinal cord (2009)
  • Author(s): Uta D, Furue H, Imoto K, Yoshimura M
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: (愛知県)名古屋国際会議場
  • Year and Date: 2009-09-17
• [Presentation] Contribution of peritoneum incision to generation of spontaneous activity in rat spinal dorsal horn neurons (2009)
  • Author(s): Sugiyama D, Furue H, Imoto K Kawamata M
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: (愛知県)名古屋国際会議場
  • Year and Date: 2009-09-17
• [Presentation] Gi/o共役型受容体が仲介するシナプス前抑制における多様性 (2009)
  • Author(s): 佐竹伸一郎,井本敬二
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: (愛知県)名古屋国際会議場
  • Year and Date: 2009-09-17
• [Presentation] Inflammation triggers noxious synaptic alteration in the rat spinal dorsal horn in vivo (2009)
  • Author(s): Furue H, Imoto K, Yoshimura M
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: (愛知県)名古屋国際会議場
  • Year and Date: 2009-09-17
• [Presentation] G_i/o共役型受容体が仲介するシナプス前抑制における多様性 (2009)
  • Author(s): 佐竹伸一郎, 井本敬二
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: (愛知県)名古屋国際会議場
  • Year and Date: 2009-09-17
• [Presentation] 腹膜切開による脊髄後角ニューロンの自発性発火の増加 (2009)
  • Author(s): 杉山大介, 他
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: (愛知県)名古屋国際会議場
  • Year and Date: 2009-09-17
• [Presentation] Kinase activity of CaMKIIα is essential for structural, functional and behavioral expression of synaptic memory (2009)
  • Author(s): Yamagata Y, et al.
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: (愛知県)名古屋国際会議場
  • Year and Date: 2009-09-17
• [Presentation] Roles of the basal ganglia in rhythm generation of the absence epilepsy (2009)
  • Author(s): Kase D, Inoue T, Imoto K
  • Organizer: 36回国際生理学会大会・第86回日本生理学会大会
  • Place of Presentation: (京都府)国立京都国際会館
  • Year and Date: 2009-08-01
• [Presentation] Roles of the basal ganglia in rhythm generation of the absence epilepsy (2009)
  • Author(s): Kase D, et al.
  • Organizer: 第36回国際生理学会大会・第86回日本生理学会大会
  • Place of Presentation: (京都府)国立京都国際会館
  • Year and Date: 2009-08-01
• [Presentation] Multiple and Ca_v2 channel subtype-dependent forms of paired-pulse facilitation at cerebellar granule cell-interneuron synapses (2009)
  • Author(s): Satake S, Inoue T, Imoto K
  • Organizer: 第36回国際生理学会大会・第86回日本生理学会大会
  • Place of Presentation: (京都府)国立京都国際会館
  • Year and Date: 2009-07-29
• [Presentation] Multiple and Cav2 channel subtype-dependent forms of paired-pulse facilitation at cerebellar granule cell-interneuron synapses (2009)
  • Author(s): 佐竹伸一郎, et al.
  • Organizer: 第36回国際生理学会大会・第86回日本生理学会大会
  • Place of Presentation: (京都府)国立京都国際会館
  • Year and Date: 2009-07-29
• [Presentation] The role of kinase activity of Ca^<2+>/calmodulin-dependent protein kinase II in hippocampal synaptic plasticity and learning (2009)
  • Author(s): Yamagata Y, Kobayashi S, Umeda T, Inoue A, Sakagami H, Fukaya M, Watanabe M, Hatanaka N, Totsuka M, Yagi T, Obata K, Imoto K, Yanagawa Y, Manabe T, Okabe S
  • Organizer: 第36回国際生理学会大会・第86回日本生理学会大会
  • Place of Presentation: (京都府)国立京都国際会館
  • Year and Date: 2009-07-28
• [Presentation] The role of kinase activity of Ca2+/calmodulin-dependent protein kinase II in hippocampal synaptic plasticity and learning (2009)
  • Author(s): Yamagata Y, et al.
  • Organizer: 第36回国際生理学会大会・第86回日本生理学会大会
  • Place of Presentation: (京都府)国立京都国際会館
  • Year and Date: 2009-07-28
• [Remarks]
  • URL: http://www.nips.ac.jp/huinfo/
• [Remarks]
  • URL: http://www.nips.ac.jp/huinfo/