| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2009: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
|
|---|
| Research Abstract |
A remarkable feature of neuronal wiring is its specificity. The subcellular organization of glutamatergic and GABAergic inputs along Purkinje neurons is essential for information processing in cerebellum. In this study, we demonstrated that RBP-J promotes the neurogenesis of stellate and basket cells : two sets of inhibitory neurons that innervate selectively dendrites and axonal initial segments of Purkinje neurons, respectively. In addition. I found that climbing fibers(CF_s) that innervate proximal dendrites of Purkinje neurons in zebrin II immunoreactive(Z+) zones have a higher release probability than CFs in Z-zones.
|
