| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2009: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Research Abstract |
SNAP-25 is a presynaptic protein essential for neurotransmitter release from presynaptic nerve terminals. SNAP-25 is phosphorylated at Ser^<187> in protein kinase-dependent manner. We found that the phosphorylation SNAP-25 was regulated by protein phosphatase 2A, and played essential roles in the PKC-dependent regulation of dopamine release from presynaptic nerve terminals, and in the suppression of epilepsy during early postnatal period.
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