Genetic studies on molecular and functional basis for dendrite maintenance.

• Project/Area Number: 21300143
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Osaka Bioscience Institute (2010-2011); National Institute of Genetics (2009)
• Principal Investigator: EMOTO Kazuo 公益財団法人大阪バイオサイエンス研究所, 神経細胞生物学部門, 研究部長 (80300953)
• Co-Investigator(Kenkyū-buntansha): YASUNAGA Kei-ichiro 大阪バイオサイエンス研究所, 研究員 (20534572) ; KANAMORI Rei 大阪バイオサイエンス研究所, 研究員 (50534575)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000); Fiscal Year 2011: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000); Fiscal Year 2010: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000); Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 分子 / 細胞神経科学 / 樹状突起 / ショウジョウバエ / 感覚ニューロン / RNAi / ライブイメージング / 細胞外マトリックス / Hippoキナーゼ / NDRキナーゼ / リモデリング / 受容領域 / 神経疾患

Research Abstract

Developing neurons establish their unique dendritic fields for sampling appropriate inputs from particular places. By using Drosophila sensory neurons as a model system, we have studies how neurons specify and maintain their unique dendritic fields. We have progressed our understanding on the functional mechanisms of the NDR-Hippo kinase signaling pathway in dendrite maintenance.

Research Products

• [Journal Article] Signaling mechanisms that coordinate the development and maintenance of dendritic fields (2012)
  • Author(s): Emoto, K.
  • Journal Title: Curr, Opin. Neurobiol Volume: 22 Pages: 1-7
  • Peer Reviewed
• [Journal Article] Neural functions of matrix metalloproteinases : plasticity, neurogenesis, and disease (2012)
  • Author(s): Fujioka, H., Dairyo, Y., Yasunaga, K and Emoto, K.
  • Journal Title: Biochem. Res. Int Volume: 789083(2012) Pages: 1-1
  • Peer Reviewed
• [Journal Article] Different levels of the TRIM protein Asap regulate distinct axonal projections of Drosophila sensory neurons. (2011)
  • Author(s): Morikawa, R., Kanamori, T., Yasunaga, K., and Emoto, K.
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 108 Pages: 19389-19394
  • Peer Reviewed
• [Journal Article] The growing role of the Hippo-NDR kinase signaling in neuronal development and disease (2011)
  • Author(s): Emoto, K.
  • Journal Title: J. Biochem Volume: 150 Pages: 133-141
  • NAID: 10030586649
  • Peer Reviewed
• [Journal Article] Dendrite remodeling in development and disease (2011)
  • Author(s): Emoto, K.
  • Journal Title: Dev. Growth Differ Volume: 53 Pages: 277-286
  • NAID: 10028202226
  • Peer Reviewed
• [Journal Article] Hippo pathwayが制御する多彩な細胞機能 (2011)
  • Author(s): 藤岡洋美・泉あやか・榎本和生
  • Journal Title: 細胞工学特集Hippo Pathway:癌・細胞死・再生の新たな鍵を握る器官サイズ制御シグナル Volume: 30 Pages: 918-922
• [Journal Article] 神経入力による脳神経回路の成熟と疾患 (2011)
  • Author(s): 古泉博之・榎本和生
  • Journal Title: ファルマシア Volume: 47 Pages: 306-310
  • NAID: 110009900924
• [Journal Article] The growing role of the Hippo-NDR kinase signaling in neuronal development and disease (2011)
  • Author(s): Emoto, K.
  • Journal Title: J.Biochem. Volume: 150 Issue: 2 Pages: 133-141
  • DOI: 10.1093/jb/mvr080
  • NAID: 10030586649
  • Peer Reviewed
• [Journal Article] Dendrite remodeling in development and disease (2011)
  • Author(s): Emoto, K.
  • Journal Title: Dev.Growth Differ. Volume: 53 Issue: 3 Pages: 277-286
  • DOI: 10.1111/j.1440-169x.2010.01242.x
  • NAID: 10028202226
  • Peer Reviewed
• [Journal Article] Different levels of the tripartite motif protein Asap regulate distinct axonal projections of Drosophila sensory neurons (2011)
  • Author(s): Morikawa, et al
  • Journal Title: Proc.Natl.Acad.Sci.USA Volume: 108 Issue: 48 Pages: 19389-19394
  • DOI: 10.1073/pnas.1109843108
  • Peer Reviewed
• [Journal Article] Dendrite reshaping of adult Drosophila sensory neurons requires matrix metalloproteinasemediated modification of the basement membranes (2010)
  • Author(s): Yasunaga, K., Kanamori T., Morikawa, R., Suzuki, E., and Emoto, K.
  • Journal Title: Dev. Cell Volume: 18 Pages: 621-632
  • Peer Reviewed
• [Journal Article] The Drosophila Furry protein interacts with Trc and is highly mobile in vivo (2010)
  • Author(s): Fang, X., Lu, Q., Emoto, K., and Adler, P. N.
  • Journal Title: BMC Dev. Biol Pages: 10-40
  • Peer Reviewed
• [Journal Article] 樹状突起リモデリングを規定する細胞外マトリックス分解機構 (2010)
  • Author(s): 安永桂一郎・榎本和生
  • Journal Title: 細胞工学 Volume: 29 Pages: 480-481
• [Journal Article] 神経ネットワーク再編の鍵を握る細胞外マトリックス分解機構 (2010)
  • Author(s): 榎本和生
  • Journal Title: 生化学「特集:細胞外プロテオリシス研究の最前線」 Volume: 82 Pages: 972-978
  • NAID: 10027502887
• [Journal Article] 記憶・学習の形成と維持を司るエピジェネティック機構 (2010)
  • Author(s): 榎本和生
  • Journal Title: 医学のあゆみ「特集:エピゲノム研究最前線」 Volume: 235 Pages: 1051-1055
• [Journal Article] Dendrite reshaping of adult Drosophila sensory neurons requires matrix metallopr oteinase-mediated modification of the basement membranes. (2010)
  • Author(s): Yasunaga, et al.
  • Journal Title: Developmental Cell Volume: 18 Pages: 621-632
  • Peer Reviewed
• [Journal Article] The Drosophila Furry protein interacts with Trc and is highly mobile in vivo. (2010)
  • Author(s): Fang, et al.
  • Journal Title: BMC Developmental Biology Volume: 10 Pages: 40-40
  • Peer Reviewed
• [Journal Article] 神経ネットワーク再編の鍵を握る細胞外マトリックス分解機構 (2010)
  • Author(s): 榎本和生
  • Journal Title: 生化学 Volume: 82 Pages: 972-978
  • NAID: 10027502887
• [Journal Article] The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signaling pathway (2009)
  • Author(s): Koike-Kumagai, M., Yasunaga, K., Morikawa, R., Kanamori T., and Emoto, K.
  • Journal Title: EMBO J. Volume: 28 Pages: 3879-3892
  • Peer Reviewed
• [Journal Article] The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signaling pathway (2009)
  • Author(s): Koike-Kumagai, et al.
  • Journal Title: The EMBO Journal 28 Pages: 3783-3784
  • Peer Reviewed
• [Journal Article] Impaired retrograde membrane traffic in a mutant CHO cell defective in phosphatidylserine synthesis
  • Author(s): Lee, S., Uchida, Y., Emoto, K., Umeda, M., Kuge, O., Taguchi, T., and Arai, H.
  • Journal Title: Genes Cells Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Salt-inducible kinase 1 regulates E-cadherin expression and intercellular junction stability
  • Author(s): Enelinga, K., Briona, L., Pintob, V., Pinhob, M. J., Mochizuki, N., Emoto, K., S. Patricio, and Bertorelloa, A. M.
  • Journal Title: FASEB J Volume: (印刷中)
  • Peer Reviewed
• [Presentation] The Hippo signaling pathway in dendrite control (2011)
  • Author(s): 榎本和生
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-14
• [Presentation] Molecular and cellular basis for dendrite development (2011)
  • Author(s): Emoto, K.
  • Organizer: Cold Spring Harbor Meeting Asia
  • Place of Presentation: Suzhou, China
  • Year and Date: 2011-10-21
• [Presentation] Control of dendritic fields by the TOR signaling pathway (2011)
  • Author(s): 榎本和生
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-15
• [Presentation] Control of dendritic fields in sensory neurons by TOR signaling (2010)
  • Author(s): Kazuo Emoto
  • Organizer: 日本生化学会分子生物学会合同大会(BMB2010)
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-12-10
• [Presentation] The TRIM protein Asap regulates axon patterning of Drosophila sensory neurons through modulating the Netrin signaling pathway (2010)
  • Author(s): 森川麗・榎本和生
  • Organizer: 第33回日本分子生物学会第83回日本生化学会合同年会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-08
• [Presentation] Dendrite reshaping in adult Drosophila sensory neurons requires matrix metalloproteinase-mediated modification of the basement membranes (2010)
  • Author(s): 安永桂一郎・金森崇裕・榎本和生
  • Organizer: 第33回日本分子生物学会第83回日本生化学会合同年会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-08
• [Presentation] KIAA0319, a dyslexia-associated gene, induces abnormal branching of neurites (2010)
  • Author(s): 田頭大志・石井萌・森川麗・松田幸江、木谷友次朗・馬場敦・月田早智子・榎本和生・服部光治
  • Organizer: 第33回日本神経科学会
  • Place of Presentation: 神戸市神戸国際会議場
  • Year and Date: 2010-09-02
• [Presentation] The TRIM protein Asap is a critical determinant in axon patterning of Drosophila sensory neurons (2010)
  • Author(s): 森川麗・榎本和生
  • Organizer: 第33回日本神経科学会
  • Place of Presentation: 神戸市神戸国際会議場
  • Year and Date: 2010-09-02
• [Presentation] Dendrite reshaping in adult Drosophila sensory neurons (2010)
  • Author(s): 安永桂一郎・鈴木えみ子・榎本和生
  • Organizer: 第43回日本発生生物学会
  • Place of Presentation: 京都市京都国際会議場
  • Year and Date: 2010-06-20
• [Presentation] ニューロン樹状突起の形成と維持を制御する Hippo シグナリング (2009)
  • Author(s): 榎本和生
  • Organizer: 第82回日本生化学会年会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2009-10-24
• [Book] Hippo pathwayの多彩な細胞機能 (2011)
  • Author(s): 藤岡洋美・泉あやか・榎本和生
  • Total Pages: 8
  • Publisher: 学研バイオメディカル秀潤社(細胞工学)
• [Remarks]
  • URL: http://www.obi.or.jp/