Studies on the role(s) of renin-angiotensin system in the pathogenesis of Alzheimer disease

• Project/Area Number: 21300145
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: National Center for Geriatrics and Gerontology
• Principal Investigator: MICHIKAWA Makoto 独立行政法人国立長寿医療研究センター, アルツハイマー病研究部, 部長 (40270912)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000); Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2009: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
• Keywords: 精神・神経疾患の病態と治療 / アルツハイマー病 / 蛋白分解酵素 / 治療 / レニン・アンギオテンシン / アンギオテンシン変換酵素 / アミロイドベータ蛋白 / 慢性脳虚血

Research Abstract

We found that angiotensin-converting enzyme(ACE) converts Aβ42 to Aβ40 and that angiotensin II receptor mediates metabolism of Alzheimer disease-related molecules. This study was designed to clarify the involvement of renin-angiotensin system in the pathogenesis of Alzheimer disease.

Research Products

• [Journal Article] Heparan Sulfate Subdomains that are Degraded by Sulf Accumulate in Cerebral Amyloid s Plaques of Alzheimer's Disease : Evidence from Mouse Models and Patients (2012)
  • Author(s): Hosono-Fukao T, Ohtake-Niimi S, Hoshino H, Akatsu H, Hossain M, Nishitsuji K, van Kuppevelt, Kimata K, Michikawa M, Wyss-Coray T, Uchimura K.
  • Journal Title: Am J Pathol Volume: 180(5) Pages: 2056-2067
• [Journal Article] Lipoprotein lipase is a novel Aβ-binding protein that promotes glycosaminoglycan-dependent cellular uptake of Aβin astrocytes (2011)
  • Author(s): Nishitsuji K, Hosono T, Uchimura K, Michikawa M.
  • Journal Title: J. Biol. Chem Volume: 286 Pages: 6393-6401
• [Journal Article] Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain-barrier model (2011)
  • Author(s): Nishitsuji K, Hosono T, Nakamura T, Bu G, Michikawa M.
  • Journal Title: Biol. Chem Volume: 286(20) Pages: 17536-17542
• [Journal Article] The dissociation of Aβfrom lipoprotein in cerebrospinal fluid from Alzheimer's disease accelerates Aβ42 assembly (2011)
  • Author(s): Takamura A, Kawarabayashi T, Yokoseki T, Shibata M, Morishima-Kawashima M, Saito Y, Murayama S, Ihara Y, Abe K, Shoji M, Michikawa M, Matsubara E.
  • Journal Title: J. Neurosci. Res Volume: 6 Pages: 815-821
• [Journal Article] Extracellular and intraneuronal HMW-Aβoligomers represent a molecular basis of memory loss in Alzheimer's disease model mouse (2011)
  • Author(s): Takamura A, Okamoto Y, Kawarabayashi T, Yokoseki T, Shibata M, Mouri A, Nabeshima T, Sun H, Abe K, Shoji M, Yanagisawa K, Michikawa M, Matsubara E.
  • Journal Title: Mol. Neurodegener Volume: 6 Pages: 20-20
• [Journal Article] Higher activity of peripheral blood angiotensin-converting enzyme is associated with later-onset of Alzheimer's disease. (2011)
  • Author(s): Akatsu H, Ogawa N, Kanesaka T, Hori A, Yamamoto T, Matsukawa N, Michikawa M.
  • Journal Title: J. Neurol. Sci Volume: 300 Pages: 67-73
• [Journal Article] ER-stress-inducible Herp, facilitates the degradation f immature nicastrin (2011)
  • Author(s): Marutani T, Maeda T, Tanabe C, Zou K, Araki W, Kokame K, Michikawa M, Komano H.
  • Journal Title: Biochim. Biophys. Acta Volume: 1810 Pages: 790-8
• [Journal Article] RB4CD12 epitope expression and heparan sulfate disaccharide composition in brain vasculature. (2011)
  • Author(s): Hosono-Fukao T, Ohtake-Niimi S, Nishitsuji K, Hossain M, van Kuppevelt TH, Michikawa M, Uchimura K.
  • Journal Title: J. Neurosci. Res Volume: 89 Pages: 1840-8
• [Journal Article] Beta-amyloid increases the expression level of ATBF1 responsible for death in cultured cortical neurons (2011)
  • Author(s): Jung C-G, Uhm K-O, Miura Y, Hosono T, Horike H, Khanna K K, Michikawa M.
  • Journal Title: Mol Neurodegener Volume: 6 Pages: 47-47
• [Journal Article] Lipoprotein lipase is a novel Aβ-binding protein that promotes glycosaminoglycan-dependent cellular uptake of Aβ in astrocytes (2011)
  • Author(s): Nishitsuji K, Hosono T, Uchimura K, Michikawa M
  • Journal Title: J.Biol.Chem Volume: 286 Issue: 8 Pages: 6393-6401
  • DOI: 10.1074/jbc.m110.172106
  • Peer Reviewed
• [Journal Article] Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain-barrier model (2011)
  • Author(s): Nishitsuji K, Hosono T, Nakamura T, Bu G, Michikawa M
  • Journal Title: J.Biol.Chem Volume: 286 Issue: 20 Pages: 17536-17542
  • DOI: 10.1074/jbc.m111.225532
  • Peer Reviewed
• [Journal Article] Association between cognitive function and plasma lipids of the elderly after controlling for apolipoprotein E genotype (2011)
  • Author(s): Yasuno F, Tanimukai S, Sasaki M, Hidaka S, Ikejima C, Yamashita F, Kodama C, Mizukami K, Michikawa M, Asada T
  • Journal Title: Am.J.Geriat.Psychiat Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] The dissociation of Aβ from lipoprotein in cerebrospinal fluid from Alzheimer's disease accelerates Aβ42 assembly (2011)
  • Author(s): Takamura A, Kawarabayashi T, Yokoseki T, Shibata M, Morishima-Kawashima M, Saito Y, Murayama S, Ihara Y, Abe K, Shoji M, Michikawa M, Matsubara E
  • Journal Title: J.Neurosci.Res. Volume: 6 Pages: 815-821
  • Peer Reviewed
• [Journal Article] Extracellular and intraneuronal HMW-Aβ oligomers represent a molecular basis of memory loss in Alzheimer's disease model mouse (2011)
  • Author(s): Takamura A, Okamoto Y, Kawarabayashi T, Yokoseki T, Shibata M, Mouri A, Nabeshima T, Sun H, Abe K, Shoji M, Yanagisawa K, Michikawa M, Matsubara E
  • Journal Title: Mol.Neurodegener. Volume: 6 Pages: 20-35
  • Peer Reviewed
• [Journal Article] Higher activity of peripheral blood angiotensin-converting enzyme is associated with later-onset of Alzheimer's disease (2011)
  • Author(s): Akatsu H, Ogawa N, Kanesaka T, Hori A, Yamamoto T, Matsukawa N, Michikawa M
  • Journal Title: J.Neurol.Sci Volume: 300 Issue: 1-2 Pages: 67-73
  • DOI: 10.1016/j.jns.2010.09.030
  • Peer Reviewed
• [Journal Article] ER-stress-indudcile Herp, facilitates the degradation of immature nicastrin (2011)
  • Author(s): Marutani T, Maeda T, Tanabe C, Zou K, Araki W, Kokame K, Michikawa M, Komano H
  • Journal Title: Biochim.Biophys.Acta Volume: 1810 Pages: 790-798
  • Peer Reviewed
• [Journal Article] RB4CD12 epitope expression and heparan sulfate disaccharide composition in brain vasculature (2011)
  • Author(s): Hosono-Fukao T, Ohtake-Niimi S, Nishitsuji K, Hossain M, van Kuppevelt TH, Michikawa M, Uchimura K
  • Journal Title: J.Neurosd.Res. Volume: 89 Pages: 1840-1848
  • Peer Reviewed
• [Journal Article] Beta-amyloid increases the expression level of ATBF1 responsible for death in cultured cortical neurons (2011)
  • Author(s): Jung C-G, Uhm K-O, Miura Y, Hosono T, Horike H, Khanna K K, Michikawa M
  • Journal Title: Mol Neurodegener Volume: 6 Pages: 47-58
  • Peer Reviewed
• [Journal Article] Extracellular and intraneuronal HMW-Aβ oligomers represent a molecular basis of memory loss in Alzheimer'sdisease model mouse. (2011)
  • Author(s): Takamura A, Okamoto Y, Kawarabayashi T, Yokoseki T, Shibata M, Mouri A, Nabeshima T, Sun H, Abe K, Shoji M, Yanagisawa K, Michikawa M, Matsubara E.
  • Journal Title: Mol.Neurodegener. Volume: 6:20 Pages: 1-16
  • Peer Reviewed
• [Journal Article] Higher activity of peripheral blood angiotensin-converting enzyme is associated with later-onset of Alzheimer's disease. (2011)
  • Author(s): Akatsu H, Ogawa N, Kanesaka T, Hori A, Yamamoto T, Matsukawa N, Michikawa M
  • Journal Title: J.Neurol.Sci. Volume: 300 Pages: 67-73
  • Peer Reviewed
• [Journal Article] Lipoprotein lipase is a novel Aβ-binding protein that promotes glycosaminoglycan-dependent cellular uptake of Aβ in astrocytes. (2011)
  • Author(s): Nishitsuji K, Hosono T, Uchimura K, Michikawa M.
  • Journal Title: J.Biol.Chem. Volume: 286 Pages: 6393-6401
  • Peer Reviewed
• [Journal Article] Association between cognitive function and plasma lipids of the elderly after controlling for apolipoprotein E genotype. (2011)
  • Author(s): Yasuno F, Tanimukai S, Sasaki M, Hidaka S, Ikejima C, Yamashita F, Kodama C, Mizukami K, Michikawa M, Asada T.
  • Journal Title: Am.J.Geriat.Psychiat. Volume: (In press)
  • Peer Reviewed
• [Journal Article] The dissociation of Aβ from lipoprotein in cerebrospinal fluid from Alzheimer's disease accelerates Aβ42 assembly. (2011)
  • Author(s): Takamura A, Kawarabayashi T, Yokoseki T, Shibata M, Morishima-Kawashima M, Saito Y, Murayama S, Ihara Y, Abe K, Shoji M, Michikawa M, Matsubara E.
  • Journal Title: J.Neurosci.Res. Volume: (In press)
  • Peer Reviewed
• [Journal Article] Homocysteine, another risk factor for Alzheimer's disease, impairs apolipoprotein E3 function (2010)
  • Author(s): Minagawa H, Watanabe A, Akatsu H, Adachi K, Ohtsuka C, Terayama Y, Hosono T, Takahashi S, Wakita H, Jung C-G, Komano H, Michikawa M.
  • Journal Title: J. Biol. Chem Volume: 285 Pages: 38382-38388
• [Journal Article] Honokiol increases ABCA1 expression level by activating retinoid X receptorβ (2010)
  • Author(s): Jung C-G, Horike H, Cha B-Y, Uhm K-O, Yamauchi R, Yamaguchi T, Hosono T, Iida K, Woo J-T, Michikawa M
  • Journal Title: Biol. Pharm. Bull Volume: 33 Pages: 1105-1111
• [Journal Article] Homocysteine, another risk factor for Alzheimer's disease, impairs apolipoprotein E3 function. (2010)
  • Author(s): Minagawa H, Watanabe A, Akatsu H, Adachi K, Ohtsuka C, Terayama Y, Hosono T, Takahashi S, Wakita H, Jung C-G, Komano H, Michikawa M.
  • Journal Title: J.Biol.Chem. Volume: 285 Pages: 38382-38388
  • Peer Reviewed
• [Journal Article] Honokiol increases ABCA1 expression level by activating retinoid X receptor β. (2010)
  • Author(s): Jung C-G, Horike H, Cha B-Y, Uhm K-O, Yamauchi R, Yamaguchi T, Hosono T, Iida K, Woo J-T, Michikawa M.
  • Journal Title: Biol.Pharm.Bull Volume: 33 Pages: 1105-1111
  • Peer Reviewed
• [Journal Article] アルツハイマー病分子病態とアポリポ蛋白E (2010)
  • Author(s): 道川誠
  • Journal Title: 医療の広場 Volume: 50巻 Pages: 4-5
  • NAID: 40018890647
• [Journal Article] アポリポ蛋白Eとアルツハイマー病 (2010)
  • Author(s): 道川誠
  • Journal Title: Clinical Neuroscience Volume: 28巻 Pages: 992-995
• [Journal Article] アンギオテンシン変換酵素の新しい顔:Aβ変換酵素 (2010)
  • Author(s): ゾウクン、道川誠、駒野宏人
  • Journal Title: 生化学 Volume: 82巻 Pages: 1120-1124
  • NAID: 10027880213
• [Journal Article] 脳のレニンアンギオテンシン系とアミロイドβ蛋白質代謝 (2010)
  • Author(s): 道川誠
  • Journal Title: Dementia Japan Volume: 24巻 Pages: 419-423
• [Journal Article] Apolipoprotein E4(1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells (2009)
  • Author(s): Nakamura T, Watanabe A, Fujino T, Hosono T, and Michikawa M
  • Journal Title: Mol. Neurodegener Volume: 4 Pages: 35-35
• [Journal Article] Microglia activated with toll-like receptor 9 ligand CpG attenuate oligomeric amyloid-βneurotoxicity in vitro and in vivo models of Alzheimer's disease (2009)
  • Author(s): Doi Y, Mizuno T, Maki Y, Jin S, Mizoguchi H, Ikeyama M, Doi M, Michikawa M, Takeuchi H, and Suzumura A.
  • Journal Title: Am. J. Pathol Volume: 175 Pages: 2121-2132
• [Journal Article] An E3 ubiquitin ligase, synoviolin is involved in the degradation of immature nicastrin, and regulates the production of amyloidβ-protein (2009)
  • Author(s): Maeda T, Marutani T, Zou K, Araki W, Yagishita N, Yamamoto Y, Amano T, Michikawa M, Nakajima T, and Komano H.
  • Journal Title: FEBS J Volume: 276 Pages: 5832-5840
• [Journal Article] Aβ42-to-Aβ40-and angiotensin-converting activities in different domain of angiotensin-converting enzyme (2009)
  • Author(s): Zou K, Maeda T, Oba R, Komano H, and Michikawa M
  • Journal Title: Biol. Chem Volume: 284 Pages: 31914-31920
• [Journal Article] Bioactive TGF-βcan associate with lipoproteins and is enriched in those containing apolipoprotein E3 (2009)
  • Author(s): Tesseur I, Brecht W, Corn J, Gong J-S, Yanagisawa K, Michikawa M, Weisgraber K, Huang Y, and Wyss-Coray T.
  • Journal Title: J. Neurochem Volume: 110(4) Pages: 1254-1262
• [Journal Article] Mechanism underlying apolipoprotein E isoform-dependent lipid efflux from neural cells in culture (2009)
  • Author(s): Minagawa H, Gong J-S, Jung C-G, Watanabe A, Lund-Katz S, Phillips M C, Saito H, Michikawa M.
  • Journal Title: J. Neurosci. Res Volume: 87 Pages: 2498-2508
• [Journal Article] Apolipoprotein E4(1-272)fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells. (2009)
  • Author(s): Nakamura T, Watanabe A, Fujino T, Hosono T, Michikawa M
  • Journal Title: Mol.Neurodegener. 4 Pages: 1-11
  • Peer Reviewed
• [Journal Article] Microglia activated with toll-like receptor 9 ligand CpG attenuate oligomeric amyloid-β neurotoxicity in vitro and invivo models of Alzheimer's disease. (2009)
  • Author(s): Doi Y, Mizuno T, Maki Y, Jin S, Mizoguchi H, Ikeyama M, Doi M, Michikawa M, Takeuchi H, Suzumura A
  • Journal Title: Am.J.Pathol. 175 Pages: 2121-2132
  • Peer Reviewed
• [Journal Article] An E3 ubiquitin ligase, Synoviolin is involved in the degradation of immature Nicastrin, and regulates the production of amyloid b-protein. (2009)
  • Author(s): Maeda T, Marutani T, Zou K, Araki W, Yagishita N, Yamamoto Y, Amano T, Michikawa M, Nakajima T, Komano H.
  • Journal Title: FEBS J 276 Pages: 5832-58401
  • Peer Reviewed
• [Journal Article] Aβ42-to-Aβ40- and angiotensin- converting activities in different domain of angiotensin-converting enzyme (2009)
  • Author(s): Zou K, Maeda T, Oba R, Komano H, Michikawa M
  • Journal Title: J.Biol.Chem. 284 Pages: 31914-31920
  • Peer Reviewed
• [Journal Article] Bioactive TGF-β can associate with lipoproteins and is enriched in those containing apolipoprotein E3 (2009)
  • Author(s): Tesseur I, Brecht W, Corn J, Gong J-S, Yanagisawa K, Michikawa M, Weisgraber K, Huang Y, Wyss-Coray T.
  • Journal Title: J.Neurochem 110 Pages: 1254-1262
  • Peer Reviewed
• [Journal Article] Mechanism underlying apolipoprotein E isoform-dependent lipid efflux from neural cells in culture. (2009)
  • Author(s): Minagawa K, Gong J-S, Jung C-G, Watanabe A, Lund-Katz S, Phillips M C, Saito H, Michikawa M.
  • Journal Title: J.Neurosci.Res 87 Pages: 2498-2508
  • Peer Reviewed
• [Journal Article] Association between cognitive function and plasma lipids of the elderly after controlling for apolipoprotein E genotype
  • Author(s): Yasuno F, Tanimukai S, Sasaki M, Hidaka S, Ikejima C, Yamashita F, Kodama C, Mizukami K, Michikawa M, Asada T.
  • Journal Title: Am. J. Geriat. Psychiat Volume: (in press)
• [Presentation] ApoE dependent and independent Abeta clearance pathways in the brain (2012)
  • Author(s): Michikawa M
  • Organizer: Mount Sinai University, School of Medicine
  • Place of Presentation: New York, NY, USA
  • Year and Date: 2012-01-06
• [Presentation] 高齢者認知機能の経時変化に及ぼす血中脂質濃度、血圧およびApoE遺伝子多型の影響 (2011)
  • Author(s): 安野史彦、谷向知、佐々木恵、日高真、池嶋千秋、山下典生、児玉千稲、水上勝義、道川誠、朝田隆
  • Organizer: 日本認知症学会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-11
• [Presentation] The renin-angiotensin system modulates APP and ApoE metabolism (2011)
  • Author(s): 山内玲奈、ゾウクン、鄭且均、道川誠
  • Organizer: 日本認知症学会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-11
• [Presentation] Isoform-dependent and-independent functions of apolipoprotein E and Alzheimer disease (2011)
  • Author(s): Michikawa M
  • Organizer: 日本生化学会大会シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2011-09-23
• [Presentation] Arachidonic acid diet prevents memory impairment and brain Abeta deposition in Tg2576 mice (2011)
  • Author(s): Michikawa M
  • Organizer: Symposium : PUFA and its derivatives-brain, neuroprotective agents for senescence, ISN-ESN
  • Place of Presentation: Athens, Greece
  • Year and Date: 2011-08-30
• [Presentation] Two active domains of ACE are essential for Abeta43-conver ting activity (2011)
  • Author(s): Zou K, Liu J, Watanabe A, Liu S, Tanabe C, Maeda T, Oba R, Michikawa M, Komano H
  • Organizer: The International Conference of Korean Society for Gerontology
  • Place of Presentation: Athens, Greece
  • Year and Date: 2011-08-30
• [Presentation] Isoform-dependent and-independent functions of apolipoprotein E and Alzheimer disease (2011)
  • Author(s): Michikawa M
  • Organizer: The International Conference of Korean Society for Gerontology
  • Place of Presentation: Busan, Korea
  • Year and Date: 2011-07-09
• [Presentation] アルツハイマー病分子病態ならびに認知機能障害に対する不飽和脂肪酸経口摂取の影響 (2011)
  • Author(s): 道川誠
  • Organizer: 日本基礎老化学会第34回大会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2011-06-17
• [Presentation] Isoform-dependent functions of apolipoprotein E and Alzheimer disease (2011)
  • Author(s): Michikawa M
  • Organizer: The department seminar at Mayo Clinic
  • Place of Presentation: Mayo Clinic, Jacksonville, USA
  • Year and Date: 2011-06-08
• [Presentation] アルツハイマー病の分子病態/認知機能に対するアラキドン酸摂取の影響 (2011)
  • Author(s): 道川誠
  • Organizer: 認知症サプリメント研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-03-19
• [Presentation] 脳内脂質代謝変動とアルツハイマー病分子病態 (2011)
  • Author(s): 道川誠
  • Organizer: 第5回関西・中部認知症学会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-02-19
• [Presentation] 脳内脂質代謝は、アルツハイマー病発症に関わりうるか (2011)
  • Author(s): 道川誠
  • Organizer: 第8回アルツハイマー病の早期診断・治療・予防法の開発研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-02-18
• [Presentation] アルツハイマー病モデルマウス大脳皮質に発現するヘパラン硫酸グリコサミノグリカンの構造解析 (2010)
  • Author(s): 細野友美、新美しおり、ホサインモタラブ、菅谷典子、赤津裕康、トニーワイスコレイ、木全弘治、道川誠、内村健治
  • Organizer: 第83回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-09
• [Presentation] Immunolocalization of the RB4CD12 Anti-Heparan Sulfate Epitopein Brain Microvessels and Its Degradation by Sulf-1 and Sulf-2 (2010)
  • Author(s): Fukao-Hosono T, Hossain M, Ohtake-Niimi S, van Kuppevelt T, Michikawa M, Rosen S, Uchimura K.
  • Organizer: Annual meeting of Glycobiology
  • Place of Presentation: St.Pete Beach, USA
  • Year and Date: 2010-11-08
• [Presentation] APP代謝及びAb産生におけるATBF1の機能解析 (2010)
  • Author(s): 厳景玉、赤津裕康、三浦裕、道川誠、鄭且均
  • Organizer: 第29回日本認知症学会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-11-05
• [Presentation] リポ蛋白質リパーゼは初代培養アストロサイトによるアミロイドbの取り込みを促進する (2010)
  • Author(s): 西辻和親、細野崇、内村健治、道川誠
  • Organizer: 第29回日本認知症学会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-11-05
• [Presentation] 多価不飽和脂肪酸餌はLPSで誘導される脳内炎症を抑制する (2010)
  • Author(s): 細野崇、山内玲奈、紺谷昌仙、西辻和親、鄭且均、河島洋、木曽良信、道川誠
  • Organizer: 第29回日本認知症学会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-11-05
• [Presentation] Enhanced Alzheimer's-like pathology by ACE inhibition in APP transgenic mouse brain (2010)
  • Author(s): ゾウクン、劉俊俊、劉しゅ余、田邊千晶、前田智司、道川誠、駒野宏人
  • Organizer: 第29回日本認知症学会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-11-05
• [Presentation] アルツハイマー病モデルマウス脳内に発現するヘパラン硫酸糖鎖の内部ドメイン構造の解析 (2010)
  • Author(s): 細野友美、新美しおり、ホサインモタラブ、マーカスブリチギ、赤津裕康、菅谷典子、木全弘治、道川誠、トニーワイスコレイ、内村健治
  • Organizer: 第29回日本認知症学会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-11-05
• [Presentation] アポリポ蛋白Eとアルツハイマー病 (2010)
  • Author(s): 道川誠
  • Organizer: 教育講演:第18回中部老年期認知症研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-10-30
• [Presentation] Apolipoprotein E and Alzheimer's Disease (2010)
  • Author(s): 道川誠
  • Organizer: 中国瀋陽医学院・何氏視覚科学学院
  • Place of Presentation: 瀋陽、中国
  • Year and Date: 2010-09-27
• [Presentation] Apolipoprotein E and Alzheimer's Disease (2010)
  • Author(s): 道川誠
  • Organizer: 客員教授授与講演 中国藩陽医学院・何氏視覚科学学院
  • Place of Presentation: 藩陽,中国
  • Year and Date: 2010-09-27
• [Presentation] 炎症とアルツハイマー病 (2010)
  • Author(s): 道川誠
  • Organizer: 日本歯周病学会シンポジウム
  • Place of Presentation: 高松
  • Year and Date: 2010-09-19
• [Presentation] 血液脳関門機能に対するアポリポタンパク質Eアイソフォームの影響 (2010)
  • Author(s): 西辻和親、細野崇、中村俊行、道川誠
  • Organizer: Neuro2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-04
• [Presentation] APP代謝及びAb産生機構におけるホメオチィック因子AIBF1の機能解析 (2010)
  • Author(s): 鄭且均、厳景玉、三浦裕、赤津裕康、道川誠
  • Organizer: Neuro2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-03
• [Presentation] ACE阻害によるアルツハイマー病モデルマウス脳内変化の解析 (2010)
  • Author(s): ゾウクン、劉俊俊、劉しゅ余、田邊千晶、前田智司、道川誠、駒野宏人
  • Organizer: Neuro2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-02
• [Presentation] Immunolocalization of the RB4CD12 anti-heparan sulfate epitope in the brain and its degradation by Sulfs, extracellular endosulfatases (2010)
  • Author(s): Hossain M, Hosono T, Niimi S, van Kuppevelt T, Michikawa M, Rosen S, Uchimura K
  • Organizer: 25th International Carbohydrate Symposium (ICS2010)
  • Place of Presentation: Makuhari
  • Year and Date: 2010-08-05
• [Presentation] The Sulf-degrading heparan sulfate epitope accumulates in cerebral amyloid ss plaques of mouse models and patients of Alzheimer's disease (2010)
  • Author(s): Hosono T, Hossain M, Britschgi M, Akatsu H, van Kuppevelt T, Michikawa M, Wyss-Coray T, Uchimura K
  • Organizer: 25th International Carbohydrate Symposium (ICS2010)
  • Place of Presentation: Makuhari
  • Year and Date: 2010-08-02
• [Presentation] Potent inhibition of ACE leads to Alzheimer-like pathology in APP transgenic mouse brain (2010)
  • Author(s): Zou K, Liu S, Liu J, Tanabe C, Maeda T, Michikawa M, Komano H.
  • Organizer: International Conference on Alzheimer's Disease(ICAD)
  • Place of Presentation: Honolulu, Hawaii
  • Year and Date: 2010-07-11
• [Presentation] TBF1 interacts with amyloid precursor protein and enhances amyloid b production (2010)
  • Author(s): Uhm KO, Horike H, Michikawa M, Jung CG
  • Organizer: International Conference on Alzheimer's Disease(ICAD)
  • Place of Presentation: Honolulu, Hawaii
  • Year and Date: 2010-07-11
• [Presentation] Potent inhibition of ACE leads to Alzheimer-like pathology in APP transgenic mouse brain. (2010)
  • Author(s): Zou K, Liu S, Liu J, Tanabe C, Maeda T, Michikawa M, Komano H.
  • Organizer: International Conference on Alzheimer's Disease (ICAD)
  • Place of Presentation: Honolulu, Hawaii
  • Year and Date: 2010-07-11
• [Presentation] ATBF1 interacts with amyloid precursor protein and enhancesamyloid b production. (2010)
  • Author(s): Uhm KO, Horike H, Michikawa M, Jung CG
  • Organizer: International Conference on Alzheimer's Disease (ICAD)
  • Place of Presentation: Honolulu, Hawaii
  • Year and Date: 2010-07-11
• [Presentation] ATBF1 interacts with amyloid precusor protein and enhances amyloidβ-protein production (2010)
  • Author(s): Uhm KO, Horike H, Miura Y, Akatsu H, Michikawa M, Jung CG.
  • Organizer: The First International Conference on Neural Cell Culture(ICNCC 2010)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-06-25
• [Presentation] ATBF1 interacts with amyloid precusor protein and enhances amyloid β-protein production (2010)
  • Author(s): Uhm KO, Horike H, Miura Y, Akatsu H, Michikawa M, Jung CG.
  • Organizer: The First International Conference on Neural Cell Culture (ICNCC 2010)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-06-25
• [Presentation] Apolipioprotein E and Alzheimer's disease Hallym University (2010)
  • Author(s): Michikawa M.
  • Organizer: The 12th Ilsong International Symposium, Hallym-Nagoya Academic Joint Meeting
  • Place of Presentation: Hallym University, Gyeonggi-do, Korea
  • Year and Date: 2010-06-24
• [Presentation] Apolipioprotein E and Alzheimer's disease (2010)
  • Author(s): Michikawa M.
  • Organizer: Hallym University, The 12th Ilsong International Symposium, Hallym-Nagoya Academic Joint Meeting
  • Place of Presentation: Korea
  • Year and Date: 2010-06-24
• [Presentation] アルツハイマー病とスタチン脳を護るー認知症を防ぐー興和創薬 (2010)
  • Author(s): 道川誠
  • Organizer: 名古屋医師会共催シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2010-06-17
• [Presentation] アルツハイマー病とスタチン (2010)
  • Author(s): 道川誠
  • Organizer: 脳を護る-認知症を防ぐ-興和創薬・名古屋医師会共催シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2010-06-17
• [Presentation] Effect of apolipoprotein E isofrom on formation and maintenance of blood-brain-barrier function (2010)
  • Author(s): Kazuchika N, Hosono T, Nakamura T, and Michikawa M.
  • Organizer: Washington University, St
  • Place of Presentation: Louis, USA
  • Year and Date: 2010-06-07
• [Presentation] Effect of apolipoprotein E isofrom on formation and maintenance of blood-brain-barrier function (2010)
  • Author(s): Kazuchika N, Hosono T, Nakamura T, Michikawa M
  • Organizer: Apo E symposium, Washington University
  • Place of Presentation: St.Louis
  • Year and Date: 2010-06-07
• [Presentation] レニンアギオテシ系とアルツハイマー病 (2010)
  • Author(s): 道川誠
  • Organizer: 慈恵医大神経疾患研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-02-18
• [Presentation] レニンアンギオテンシン系とアミロイドベータ蛋白代謝 (2009)
  • Author(s): 道川誠
  • Organizer: 第28回日本認知症学会シンポジウム
  • Place of Presentation: 東北大学百周年記念会館,仙台
  • Year and Date: 2009-11-21
• [Presentation] レニンアンギオテン系とアミロイドβ蛋白代謝 (2009)
  • Author(s): 道川誠
  • Organizer: 第28回日本認知症学会シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2009-11-21
• [Presentation] The role of ATBF1 in Alzheimer's disease (2009)
  • Author(s): Jung CG, Kawaguchi M, Miura Y, Akatsu H, Hosono T, Uhm KO, Michikawa M.
  • Organizer: International Society for Neurochemistry(ISN)/Asia-Pacific Society for Neurochemistry(APSN)
  • Place of Presentation: Busan, Korea
  • Year and Date: 2009-08-24
• [Presentation] Apolipoprotein E(1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells (2009)
  • Author(s): Michikawa M, Nakamura T, Watanabe A, Hosono T, Fujino T.
  • Organizer: International Society for Neurochemistry(ISN)/Asia-Pacific Society for Neurochemistry(APSN)
  • Place of Presentation: Busan, Korea
  • Year and Date: 2009-08-24
• [Presentation] The cholesterol paradox in the pathogenesis of Alzheimer's disease (2009)
  • Author(s): 道川誠
  • Organizer: 第51回日本脂質生化学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-07-30
• [Presentation] The cholesterol paradox in the pathogenesis of Alzheimer's disease. (2009)
  • Author(s): 道川誠
  • Organizer: 第51回 日本脂質生化学会シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2009-07-30
• [Presentation] アルツハイマー病の予防・治療法開発の最前線 (2009)
  • Author(s): 道川誠
  • Organizer: 平成21年度日本大学生物資源科学部市民講座講演
  • Place of Presentation: 藤沢
  • Year and Date: 2009-07-04
• [Presentation] 脳内脂質代謝の生理学的ならびに病理学的意義について (2009)
  • Author(s): 道川誠
  • Organizer: 日本膜学会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2009-05-22
• [Presentation] Mechanism underlying apolipoprotein E(ApoE) isoform-dependent HDL generation and impairment of ApoE3-mediated HDL generation by homocysteine (2009)
  • Author(s): Minagawa K, Gong J-S, Akatsu H. Jung C-G, Watanabe A, Nishitsuji K, Hosono T, Lund-Katz S, Phillips M C, Komano H, Saito H, and Michikawa M
  • Organizer: International conference on Alzheimer's disease(ICAD)
  • Place of Presentation: Vienna, Austria
• [Presentation] Ab42-toAb40-and angiotensin-converting activities in different domains of angiotensin-converting enzyme (2009)
  • Author(s): Zou K, Maeda T, Oba R, Michikawa M, Komano H.
  • Organizer: International conference on Alzheimer's disease(ICAD)
  • Place of Presentation: Vienna, Austria
• [Presentation] Low activity of angiotensin-converting enzyme(ACE) is a risk factor for onset of Alzheimer's disease (2009)
  • Author(s): Akatsu H, Matsuyama Z, Matsukawa N, Hori A, Yamamoto T, Michikawa M
  • Organizer: International conference on Alzheimer's disease(ICAD)
  • Place of Presentation: Vienna, Austria
• [Presentation] Aβenhances the ATBF1 expression responsible for the neuronal cell death (2009)
  • Author(s): Jung CG, Kawaguchi M, Miura Y, Akatsu H, Hosono T, Uhm KO, Michikawa M.
  • Organizer: International conference on Alzheimer's disease(ICAD)
  • Place of Presentation: Vienna, Austria
• [Book] コレステロール代謝とアルツハイマー病 (2009)
  • Author(s): 道川誠
  • Publisher: シーエムシー出版
• [Patent(Industrial Property Rights)] アルツハイマー病の予防及び治療薬並びにアルツハイマー病の予防及び治療薬のスクリーニング方法 (2009)
  • Inventor(s): 道川誠、西辻和親
  • Industrial Property Rights Holder: 財団法人ヒューマンサイエンス振興財団
  • Filing Date: 2009-12-21
• [Patent(Industrial Property Rights)] アルツハイマー病の予防及び治療薬並びにアルツハイマー病の予防及び治療薬のスクリーニング方法 (2009)
  • Inventor(s): 道川誠、西辻和親
  • Industrial Property Rights Holder: 財団法人ヒューマンサイエンス振興財団
  • Industrial Property Number: 2009-289487
  • Filing Date: 2009-12-21