Neural mechanisms in early visual information processing

• Project/Area Number: 21300148
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: The University of Tokyo
• Principal Investigator: TACHIBANA Masao 東京大学, 大学院・人文社会系研究科, 教授 (60132734)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000); Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2009: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
• Keywords: 神経科学 / 生理学 / 脳・神経 / シグナル伝達 / 視覚 / 網膜 / 電気シナプス / 抑制性シナプス / 抑制作シナプス / GABA

Research Abstract

We examined the visual information processing in the retina. Bipolar cells, the second order neurons, were electrically coupled with each other through gap junctions at their dendrites. At the axon terminal these cells received reciprocal inhibitory inputs and wide-field lateral inhibitory inputs from amacrine cells. Both inputs were GABAergic but their synaptic properties were different. Excitation of electrically-coupled multiple bipolar cells was essential for the activation of lateral inhibition.

Research Products

• [Journal Article] Active roles of electrically coupled bipolar cell network in the adult retina (2010)
  • Author(s): Itaru Arai, Masashi Tanaka, Masao Tachibana
  • Journal Title: The Journal of Neuroscience Volume: 30(27) Issue: 27 Pages: 9260-9270
  • DOI: 10.1523/jneurosci.1590-10.2010
• [Journal Article] TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade. (2010)
  • Author(s): Koike C, et al.
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America 107 Pages: 332-337
  • Peer Reviewed
• [Presentation] Local and global inhibition at the axon terminal of goldfish retinal bipolar cells (2011)
  • Author(s): Tanaka Masashi, Masao Tachibana
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-16
• [Presentation] Lateral inhibition through electrically-coupled bipolar-cell network in the retina (2011)
  • Author(s): Masao Tachibana, Itaru Arai, Masashi Tanaka
  • Organizer: 第34回日本神経科学大会(日本・中国神経科学学会合同シンポジウム)
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-15
• [Presentation] Lateral inhibition through electrically-coupled bipolar-cell network in the retina (2011)
  • Author(s): Masao Tachibana, Itaru Arai, Masashi Tanaka
  • Organizer: 第34回日本神経科学大会(日本・中国神経科学学会合同シンポジウム)
  • Place of Presentation: パシフィコ横浜(神奈川県)(招待講演)
  • Year and Date: 2011-09-15
• [Presentation] Reciprocal and lateral inhibitory inputs at the axon terminal of goldfish retinal bipolar cells (2011)
  • Author(s): Masao Tachibana
  • Organizer: 5th Asia and Oceania Conference for Photobiology
  • Place of Presentation: 奈良県立新公会堂(奈良県)
  • Year and Date: 2011-08-01
• [Presentation] Reciprocal and lateral inhibitory inputs at the axon terminal of goldfish retinal bipolar cells (2011)
  • Author(s): Masao Tachibana
  • Organizer: 5^<th> Asia and Oceania Conference for Photobiology
  • Place of Presentation: 奈良県立新公会堂(奈良県)(招待講演)
  • Year and Date: 2011-08-01
• [Presentation] 網膜における情報処理と逃避行動 (2009)
  • Author(s): 立花政夫
  • Organizer: 日本基礎心理学会
  • Place of Presentation: 日本女子大学目白キャンパス(東京都)
  • Year and Date: 2009-12-06
• [Presentation] 網膜における情報処理と逃避行動 (2009)
  • Author(s): 立花政夫
  • Organizer: 日本基礎心理学会
  • Place of Presentation: 東京
  • Year and Date: 2009-12-06
• [Presentation] Synaptic transmission from bipolar cells to ganglion cells in the goldfish retina (2009)
  • Author(s): Masao Tachibana
  • Organizer: Workshop "Active Zones as Organizers of Neuronal Communication"
  • Place of Presentation: Baeza, Spain
  • Year and Date: 2009-09-23
• [Presentation] Synaptic transmission from bipolar cells to ganglion cells in the goldfish retina (2009)
  • Author(s): Masao Tachibana
  • Organizer: Workshop"Active Zones as Organizers of Neuronal Communication"
  • Place of Presentation: Baeza, Spain
  • Year and Date: 2009-09-23
• [Presentation] Functional significance of gap junctions among retinal bipolar cells (2009)
  • Author(s): Masao Tachibana
  • Organizer: IUPS2009
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2009-07-29
• [Presentation] Functional significance of gap junctions among retinal bipolar cells (2009)
  • Author(s): Masao Tachibana
  • Organizer: IUPS2009
  • Place of Presentation: 京都
  • Year and Date: 2009-07-29
• [Remarks]
  • URL: http://www.l.u-tokyo.ac.jp/psy/
• [Remarks]
  • URL: http://www.l.u-tokyo.ac.jp/psy/
• [Remarks]
  • URL: http://www.l.u-tokyo.ac.jp/psy/tachibana2008.htm
• [Remarks]
  • URL: http://www.l.u-tokyo.ac.jp/psy/tachibana2008.htm