Basic study on viral genome related to pathogenesis of SHIV infection in non-human primate AIDS model
| Project/Area Number |
21300152
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Kyoto University |
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Principal Investigator |
MIURA Tomoyuki 京都大学, ウイルス研究所, 准教授 (40202337)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2011: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2009: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | 感染症 / エイズ / 動物モデル / アカゲザル / HIV / SHIV / 病原性 |
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| Research Abstract |
Highly pathogenic SHIV-KS661 was switched from CXCR4-tropic virus to CCR5-tropic by adding five amino acid substitutions to the env-V3 domain, which isthe co-receptor determinant of the virus. The virus was adapted to rhesus monkey and neutralization-resistant CCR5-tropic SHIV-MK38 was obtained by in vivo passages. The envregion of the virus was successfully introduced into new monkey tropic HIV-1mt. These results will contribute to establish a better AIDS model.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Generation of a replication-competent chimericsimian-human immunodeficiency virus carrying env from subtype C clinical isolate through intracellular homologous recombination.2013
Author(s)
Fujita, Y., Otsuki, H., Watanabe, Y.,Yasui, M., Kobayashi, T., Miura, T., and Igarashi, T.
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Journal Title
Virology
Volume: 436
Issue: 1
Pages: 100-111
DOI
Related Report
Peer Reviewed
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[Journal Article] Quantification system for the viral dynamics of a highly pathogenic simian/human immunodeficiency virus based on an in vitro experiment and a mathematical model.2012
Author(s)
Iwami, S., Holder, B. P., Beauchemin,C. A. A., Morita, S., Tada, T., Sato, K.,Igarashi, T., and Miura, T.
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Journal Title
Retrovirology
Volume: 9
Issue: 1
Pages: 18-18
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Evaluation of the immune response and protective effects of rhesus macaques vaccinated with biodegradable nanoparticles carrying gp120 of human immunodeficiency virus.2010
Author(s)
Himeno, A., Akagi, T., Uto, T., Wang, X., Baba, M., Ibuki, K., Matsuyama, M., Horiike, M., Igarashi, T., Miura, T., and Akashi, M.
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Journal Title
Vaccine
Volume: 28
Issue: 32
Pages: 5377-5385
DOI
Related Report
Peer Reviewed
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[Journal Article] In vivo analysis of a new R5 tropic SHIV generated from the highly pathogenic SHIV-KS661, a derivative of SHIV-89.6.2010
Author(s)
Matsuda, K., Inaba, K., Fukazawa, Y., Matsuyama, M., Ibuki, K., Horiike, M., Saito, N., Hayami, M., Igarashi, T., and Miura, T.
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Journal Title
Virology
Volume: 399
Issue: 1
Pages: 134-143
DOI
Related Report
Peer Reviewed
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[Journal Article] Small intestine CD4+cell reduction and enteropathy in SHIV-KS661-infected rhesus macaques in presence of low viral load2010
Author(s)
Inaba, K., Fukazawa, Y, Matsuda, K., Himeno, A., Matsuyama, M., Ibuki, K., Miura, Y., Koyanagi, Y., Nakajima, A., Blumberg, R. S., Takahashi, H., Hayami, M., Igarashi, T., and Miura, T.
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Journal Title
J. Gen. Virol.
Volume: 91
Issue: 3
Pages: 773-781
DOI
Related Report
Peer Reviewed
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