| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Research Abstract |
We established TRM rat as a good model of essential tremor(ET). Using the rat and mouse model systems, we identified Hcn1 and Aspa as genetic components essential to express ET. Interestingly, either Hcn1 or Aspa alone could not induce any ET in rat or mouse model system. Simultaneous inactivation of both Hcn1 and Aspa gene functions could induce ET. These findings suggest that HCN1 and ASPA are also essential to express the human ET.
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