Identification of genetic components in a rat model of essential tremor
| Project/Area Number |
21300153
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHNO Yukihiro 大阪薬科大学, 薬学部, 教授 (00432534)
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| Co-Investigator(Renkei-kenkyūsha) |
KUWAMURA Mitsuru 大阪府立大学, 大学院・情報学研究科, 准教授 (20244668)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Keywords | 疾患モデル / 亜系統 / 本態性振戦 / 順遺伝学 / ラット / アスパルトアシラーゼ / HCN1チャネル / 下オリーブ核 / ミュータント / ポジショナルクローニング / HCN1 / チャネル拮抗薬 / 行動薬理 |
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| Research Abstract |
We established TRM rat as a good model of essential tremor(ET). Using the rat and mouse model systems, we identified Hcn1 and Aspa as genetic components essential to express ET. Interestingly, either Hcn1 or Aspa alone could not induce any ET in rat or mouse model system. Simultaneous inactivation of both Hcn1 and Aspa gene functions could induce ET. These findings suggest that HCN1 and ASPA are also essential to express the human ET.
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Report
(4 results)
Research Products
(48 results)
