| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Research Abstract |
The dystrophic dog, a model of Duchene muscular dystrophy , shows a high mortality rate with a marked increase in serum creatine kinase (CK) levels in the neonatal period. By measuring serum CK levels in cord and venous blood, we found initial respiration resulted in massive diaphragm damage and lead to the high serum CK levels. cDNA microarray revealed that osteopontin was prominently upregulated even prior to the initial respiration and c-fos, egr-1, IL-6, and IL-8 were distinctly overexpressed after the respiration. These molecules could be associated with muscle damage in dystrophic muscle.
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