| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2011: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2009: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Research Abstract |
The drawback of luminescent probes is low tissue penetration of its excitation/emission light. To overcome this limitation, we created a new BTO derivative BTPHSA, which gives 710 nm emission light in the near infrared region. This probe enables tumors visible, which are transplanted 1.5 cm deep intraperitoneally from the skin surface in mice. To further increase tissue-accumulating capability of BTP analogues, we created dimethyl moiety-added BTP, BTO-DM, which enables tumors visible by a tenth of regular dosage of BTP in mice. We believe these innovative BTP derivatives will open up their new application to endoscopic imaging.
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