Feasibility study to measure anisotropic physical properties of tissue by using MRI

• Project/Area Number: 21300162
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Kyoto University
• Principal Investigator: MATSUDA Tetsuya 京都大学, 情報学研究科, 教授 (00209561)
• Co-Investigator(Renkei-kenkyūsha): AMANO Akira 立命館大学, 生命科学部, 教授 (60252491) ; MIZUTA Shinobu 京都大学, 情報学研究科, 助教 (40314265) ; OIDA Takenori 京都大学, 工学研究科, 助教 (70447910)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000); Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000); Fiscal Year 2009: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
• Keywords: MRI / MR Elastography / 弾性テンソル / 組織異方性

Research Abstract

Noninvasive assessment of microscopic tissue structure has been realized by diffusion tensor image(DTI) of MRI that measures anisotropic behavior of water molecule diffusion in neural and muscular tissues with cell structures. In this study, we have intended to obtain anisotropic structure of tissue by other physical properties than water diffusion such as tissue elasticity or electrical impedance. Preliminary experimental results showed the feasibility to measure anisotropy of electrical impedance in chicken meat.

Research Products

• [Journal Article] Peri-1nfarct Zone on Early Contrast-Enhanced CMR lmaging in Patients With Acute Myocardia1Infarction (2011)
  • Author(s): Matsmoto H, Matsuda T, Miyamoto K, Shimada T, Mikuri M, Hiraoka Y
  • Journal Title: J. Am. Coll. Cardiol. Img Volume: 4 Pages: 610-618
• [Journal Article] 細胞モデルの微分代数方程式に対する可解な計算条件の効率的設定手法 (2011)
  • Author(s): 嶋吉隆夫, 天野晃, 松田哲也
  • Journal Title: 情報処理学会論文誌 Volume: 52 Pages: 2412-2421
  • NAID: 110008591656
• [Journal Article] Design of chemical Shift-Switching 19F MRlProbe for the Specific Detection of Human Monoamine Oxidase (2011)
  • Author(s): Yamaguchi K, Ueki R, Nonaka H, Sugihara F, Matsuda T. Sando S
  • Journal Title: A., J. Am. Chem. Soc Volume: 133 Issue: 36 Pages: 14208-14211
  • DOI: 10.1021/ja2057506
  • Peer Reviewed
• [Journal Article] Peri-Infarct Zone on Early Contrast-Enhanced CMR Imaging in Patients With Acute Myocardial Infarction (2011)
  • Author(s): Hidenari Matsunoto, et al
  • Journal Title: J.Am.Coll.Cardiol.Img. Volume: 4 Issue: 6 Pages: 610-618
  • DOI: 10.1016/j.jcmg.2011.03.015
  • Peer Reviewed
• [Journal Article] Construction of a 19F-lectin biosensor for glycoprotein imaging by using affinity-guided DMAP chemistry (2011)
  • Author(s): Y.Sun, Y.Takaoka, S.Tsukiji, M.Narazaki, T.Matsuda, I.Hamachi
  • Journal Title: Bioorg.Med.Chem.Lett. Volume: 21 Issue: 15 Pages: 4393-4396
  • DOI: 10.1016/j.bmcl.2011.06.038
  • Peer Reviewed
• [Journal Article] Early enhancement on contrast-enhanced cardiovascular magnetic resonance imaging in takotsubo cardiomyopathy : Two cases (2011)
  • Author(s): Hidenari Matsumoto, et al
  • Journal Title: International Journal of Cardiology Volume: 155 Issue: 3 Pages: e54-e56
  • DOI: 10.1016/j.ijcard.2011.07.061
  • Peer Reviewed
• [Journal Article] Constitutive SIRT1 Overexpression Impairs Mitochondria and Reduces Cardiac Function in Mice (2011)
  • Author(s): Tsuneaki Kawashima, et al
  • Journal Title: Journal of Molecular and Cellular Cardiology Volume: 51 Issue: 6 Pages: 1026-1036
  • DOI: 10.1016/j.yjmcc.2011.09.013
  • Peer Reviewed
• [Journal Article] p-Aminophenyl Alky1 Ether-based 19F MRI Probe for Specific Detection and Imaging of Hypochlorite Ion (2011)
  • Author(s): Tomohiro Doura
  • Journal Title: Chem.Lett. Volume: 40 Issue: 12 Pages: 1357-1359
  • DOI: 10.1246/cl.2011.1357
  • NAID: 10030221016
  • Peer Reviewed
• [Journal Article] Synthesis and Evaluation of Water-soluble Fluorinated DendriticBlock-Copolymer Nan particles as a19F-MRl Contrast Agent (2010)
  • Author(s): Ogawa M, Nitahara S, Aoki H, lto S, Narazaki M, Matsuda T
  • Journal Title: Macro mol., Chem. Phys Volume: 211 Issue: 14 Pages: 1602-1609
  • DOI: 10.1002/macp.201000100
• [Journal Article] Late Gadolinium-Enhanced Cardiovascular Marl at End-Systole (2010)
  • Author(s): Matsumoto H, Matsuda T, Miyamoto K, Shimada T, Hayashi A, Mikuri M, Hiraoka Y
  • Journal Title: Feasibility Study Volume: 195 Issue: 5 Pages: 1088-1094
  • DOI: 10.2214/ajr.09.3860
• [Journal Article] Analysis of Metabolic Remodeling in Compensated Left Ventricular Hyertrophy and Heart (2010)
  • Author(s): Kato T, Niizuma S, Inuzuka Y, Kawashima T, Okuda J, Tamaki Y, Iwanaga Y, Narazaki M, Matsuda T, SogaT, Kita T, Kimura T, Shioi T
  • Journal Title: Circ Heart Fail Volume: 3 Issue: 3 Pages: 420-430
  • DOI: 10.1161/circheartfailure.109.888479
• [Journal Article] 3D MRI tags for the estimation of true3D cardiac motion parameters (2010)
  • Author(s): Shimizu Y, Amano A, Matsuda T. Oblique
  • Journal Title: Int JCardiovasc lmagimg Volume: 26 Issue: 8 Pages: 905-921
  • DOI: 10.1007/s10554-010-9646-8
• [Journal Article] 低酸素状態再現のために解糖系を導入した心筋細胞モデルの構築 (2010)
  • Author(s): 天野晃, 冨田幸子, 松岡達, 嶋吉隆夫, 陸健銀, 松田哲也
  • Journal Title: 電子情報通信学会論文誌 Volume: J93-D Pages: 398-408
  • NAID: 110007588774
• [Journal Article] Oblique 3D MRI tags for the estimation of true 3D cardiac motion parameters. (2010)
  • Author(s): Yu Shimizu, et al
  • Journal Title: Int J Cardiovasc Imaging Volume: 26 Pages: 905-921
  • Peer Reviewed
• [Journal Article] Late Gadolinium-Enhanced Cardiovascular MRI at End-Systole : Feasibility Study (2010)
  • Author(s): Hidenari Matsumoto, et al
  • Journal Title: AJR Volume: 195 Pages: 1088-1094
  • Peer Reviewed
• [Journal Article] Analysis of Metabolic Remodeling in Compensated Left Ventricular Hypertrophy and Heart Failure (2010)
  • Author(s): Takao Kato, et al
  • Journal Title: Circ Heart Fail Volume: 3 Pages: 420-430
  • Peer Reviewed
• [Journal Article] Synthesis and Evaluation of Water-Soluble Fluorinated Dendritic Block-Copolymer Nanoparticles as a 19F-MRI Contrast Agent. (2010)
  • Author(s): Michihiro Ogawa, et al
  • Journal Title: Macromol.Chem.Phys Volume: 211 Pages: 1602-1609
  • Peer Reviewed
• [Journal Article] Fluorinated Polymer Nanoparticles as a Novel 19F MRI Contrast Agent Prepared by Dendrimer Initiated Living Radical Polymerizationa. (2010)
  • Author(s): Michihiro Ogawa, et al
  • Journal Title: Macromol.Chem.Phys. Volume: 211 Pages: 1369-1376
  • Peer Reviewed
• [Journal Article] Analysis of Metabolic Remodeling in Compensated Left Ventricular Hypertrophy and Heart Failure (2010)
  • Author(s): Takao Kato
  • Journal Title: Circ Heart Fail (published online Feb 22, 2010)
  • Peer Reviewed
• [Journal Article] 低酸素状態再現のために解糖系を導入した心筋細胞モデルの構築 (2010)
  • Author(s): 天野晃
  • Journal Title: 電子情報通信学会論文誌D J93-D Pages: 398-408
  • NAID: 110007588774
  • Peer Reviewed
• [Journal Article] Monitoring of Biological One-Electron Reduction by 19F NMRUsing Hypoxia Selective Activation of an 19F-Labeled lndolequinone Derivative (2009)
  • Author(s): Tanabe K, Harada H, Narazaki M, TanakaK, Inafuku K, Komatsu H, Ito T, YamadaH, Chujo Y, Matsuda T, Hiraoka M, Nishimoto S
  • Journal Title: Am Chem Soc Volume: 131 Issue: 44 Pages: 15982-15983
  • DOI: 10.1021/ja904953b
• [Journal Article] Self-assembling nano-probes displaying off/on 19F NMR signals for protein detection and imaging (2009)
  • Author(s): Y. Takaoka, T. Sakamoto, S. Tsukiji, M. Narazaki, T. Matsuda, H. Tochio, M. Shirakawa, I. Hamachi
  • Journal Title: Nature Chemistry Volume: 1 Issue: 7 Pages: 557-561
  • DOI: 10.1038/nchem.365
  • NAID: 120001629984
  • Peer Reviewed
• [Journal Article] Monitoring of Biological One-Electron Reduction by ^<19>F NMR Using Hypoxia Selective Activation of an ^<19>F-Labeled Indolequinone Derivative (2009)
  • Author(s): Kazuhito Tanabe
  • Journal Title: J Am Chem Soc 131 Pages: 15982-15983
  • Peer Reviewed
• [Journal Article] Self-assembling nanoprobes that display off/on 19F nuclear magnetic resonance signals for protein detection and imaging (2009)
  • Author(s): Yousuke Takaoka
  • Journal Title: Nature Chemistry 1 Pages: 557-561
  • Peer Reviewed
• [Presentation] ススペクトル拡散法を応用したtagging MRIによる高分解運動解析法 (2011)
  • Author(s): 松田哲也, 他
  • Organizer: 第39回日本磁気共鳴医学会大会
  • Place of Presentation: 北九州市
  • Year and Date: 2011-09-30
• [Presentation] スペクトル拡散法を応用したtagging MRIによる高分解運動解析法 (2011)
  • Author(s): 松田哲也
  • Organizer: 第39回日本磁気共鳴医学会大会
  • Place of Presentation: 北九州市
  • Year and Date: 2011-09-30
• [Presentation] A motion tracking method applying spread spectrum communication to tagging MRI (2011)
  • Author(s): Y. Komori, et al
  • Organizer: Intl. Soc. Mag. Reson. Med
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2011-05-09
• [Presentation] motion tracking method applying spread spectrum communication to tagging M (2011)
  • Author(s): Y.Komori
  • Organizer: Intl.Soc.Mag.Reson.Med.
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2011-05-09
• [Presentation] スペクトラム拡散通信法のタギングシネMRIへの応用 (2010)
  • Author(s): 小森芳秋, 他
  • Organizer: 第38回日本磁気共鳴医学会大会
  • Place of Presentation: つくば市
  • Year and Date: 2010-09-30
• [Presentation] スペクトラム拡散通信の応用によるtagging MRIの運動解析精度の向上 (2010)
  • Author(s): 松田哲也, 他
  • Organizer: 第38回日本磁気共鳴医学会大会
  • Place of Presentation: つくば市
  • Year and Date: 2010-09-30
• [Presentation] スペクトラム拡散通信を応用したtagging MRIによる運動追跡精度の実験的検討 (2010)
  • Author(s): 金櫟, 他
  • Organizer: 電子情報通信学会医用画像研究会(MI)
  • Place of Presentation: 和光市
  • Year and Date: 2010-09-03
• [Presentation] スペクドラム拡散通信を応用したtagging MRIによる運動追跡精度の実験的検討 (2010)
  • Author(s): 金櫟
  • Organizer: 電子情報通信学会 医用画像研究会(MI)
  • Place of Presentation: 和光市
  • Year and Date: 2010-09-03
• [Presentation] TIにおけるノイズ特性を考慮した線維方向推定法評価 (2009)
  • Author(s): 井上智仁, 他
  • Organizer: 第37回日本磁気共鳴医学会大会
  • Place of Presentation: 横浜市
  • Year and Date: 2009-10-02
• [Presentation] DTIにおけるノイズ特性を考慮した線維方向推定法評価 (2009)
  • Author(s): 井上智仁
  • Organizer: 第37回日本磁気共鳴医学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-02
• [Presentation] EVALUATION OF CELL AND TISSUE HYPOXIC REACTION-MODEL STUDY (2009)
  • Author(s): Akira Amano
  • Organizer: XXXVI International Congress of Physiological Sciences (IUPS2009)
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2009-07-28
• [Presentation] CYBOW MODELLER : USER-INTUITIVE TOOLS FOR CELL MODELLING (2009)
  • Author(s): Takao Shimayoshi
  • Organizer: XXXVI International Congress of Physiological Sciences (IUPS2009)
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2009-07-28
• [Remarks]
  • URL: http://www.bme.sys.i.kyoto-u.ac.jp/