Construction of OMRI scanner for Large Animal Construction of OMRI scanner for Large Animal Construction of OMRI scanner for Large Animal Construction of OMRI scanner for Large Animal

• Project/Area Number: 21300169
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Kyushu University
• Principal Investigator: ICHIKAWA Kazuhiro 九州大学, 先端融合医療創成センター, 教授 (10271115)
• Co-Investigator(Renkei-kenkyūsha): HYODO Fuminori 九州大学, 先端融合医療レドックスナビ研究拠点, 准教授 (10380693) ; YASUKAWA Keiji 九州大学, 大学院・薬学研究院, 助教 (80372738)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000); Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2009: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
• Keywords: 大型磁石 / バイオテクノロジー / 生物・生体工学 / 可視化

Research Abstract

In vivo oxidation-reduction(redox) state changed in various diseases, such as a lifestyle-related disease. In this research, imaging apparatus of in vivo redox status for large-sized animal was developed. The developed Overhauser enhanced MRI system has more than 20 cm of effective volume and the OMRI performance was examined both in phantom objects and laboratory animals. MRI signal map of the developed system is homogeneous over 20 cm area, showing the system is useful for large-sized objects.

Research Products

• [Journal Article] Mouse lactate dehydrogenase X : A promising magnetic resonance reporter protein using hyperpolarized pyruvic acid derivative Y (2012)
  • Author(s): Nishihara T, Nonaka H, Naganuma T, Ichikawa K, Sando S
  • Journal Title: Chem.Sci. Volume: 3 Issue: 3 Pages: 800-806
  • DOI: 10.1039/c1sc00919b
  • Peer Reviewed
• [Journal Article] Nitroxides prevent exacerbation of indomethacininduced gastric damage in adjuvant arthritis rats (2011)
  • Author(s): Deguchi H, Yasukawa K, Yamasaki T, Mite F, Kinoshita Y, Naganuma T, Sate S, Yamato M, Ichikawa K, Sakai K, Utsumi H, Yamada Kl.
  • Journal Title: Free Radic Biol Med Volume: 51 Pages: 1799-805
• [Journal Article] Mouse lactate dehydrogenase X : A promising magnetic resonance reporter protein using hyperpolarized pyruvic acid derivative Y (2011)
  • Author(s): Nishihara T, Nonaka H, Naganuma T, Ichikawa K, Sando S.
  • Journal Title: Chem. Sci Volume: 3 Pages: 800-806
• [Journal Article] Overhauser enhanced magnetic resonance imaging characterization of mitochondria functional changes in the 6hydroxydopamine rat model (2011)
  • Author(s): Yamato M, Shiba T, Naganuma T, Ichikawa K, Utsumi H, Yamada KI
  • Journal Title: Neurochem Int Volume: 59 Pages: 804-811
• [Journal Article] Nitroxides prevent exacerbation of indomethacin-induced gastric damage in adjuvant arthritis rats (2011)
  • Author(s): Deguchi H, Yasukawa K, Yamasaki T, Mito F, Kinoshita Y, Naganuma T, Sato S, Yamato M, Ichikawa K, Sakai K, Utsumi H, Yamada KI
  • Journal Title: Free Radic Biol Med. Volume: 51 Issue: 9 Pages: 1799-805
  • DOI: 10.1016/j.freeradbiomed.2011.08.010
  • Peer Reviewed
• [Journal Article] Overhauser-enhanced magnetic resonance imaging characterization of mitochondria functional changes in the 6-hydroxydopamine rat model (2011)
  • Author(s): Yamato M, Shiba T, Naganuma T, Ichikawa K, Utsumi H, Yamada KI
  • Journal Title: Neurochem Int. Volume: 59 Issue: 6 Pages: 804-811
  • DOI: 10.1016/j.neuint.2011.08.010
  • Peer Reviewed
• [Journal Article] Dynamic nuclear polarization studies of redoxsensitive nitroxyl spin probes in liposomal solution. (2010)
  • Author(s): Benial AM, Utsumi H, Ichikawa K, Murugesan R, Yamada K, Kinoshita Y, Naganuma T, Kato. M.
  • Journal Title: J. Magn. Reson Volume: 204 Pages: 131-138
• [Journal Article] Dynamic nuclear polarization studies of redox-sensitive nitroxyl spin probes in liposomal solution (2010)
  • Author(s): Benial AM.Utsumi H.Ichikawa K.Murugesan R.Yamada K.Kinoshita Y.Naganuma T.Kato, M.
  • Journal Title: J Magn Reson Volume: 204 Pages: 131-138
  • Peer Reviewed
• [Journal Article] Dynamic nuclear polarization studies of redox-sensitive nitroxyl spin probes in liposomal solution. (2010)
  • Author(s): Benial AM, et al.
  • Journal Title: J. Magn. Reson. 204 Pages: 131-138
  • Peer Reviewed
• [Presentation] LPS肺炎モデルのレドックス動態解析 (2012)
  • Author(s): 市川和洋
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-30
• [Presentation] High field OMRI scanner for Imaging in vivo functional information (2011)
  • Author(s): K.Ichikawa
  • Organizer: 5th SFRR-Asia/8th ASMRM/11th J-mit
  • Place of Presentation: Kagoshima(招待講演)
  • Year and Date: 2011-09-01
• [Presentation] High field OMRI scanner for Imaging in vivo functional information. 5th SFRR-Asia/8th ASMRM/11th J-mit (2011)
  • Author(s): K. Ichikawa.
  • Organizer: 1st Sept
  • Place of Presentation: Kagoshima
• [Presentation] Utsumi High field OMRI scanner for Imaging in vivo redox status (2011)
  • Author(s): K. Ichikawa, T. Naganuma, H.
  • Organizer: Euromar 2011
  • Place of Presentation: Frankfurt, Germany
• [Presentation] High field OMRI scanner for Imaging in vivo redox status (2011)
  • Author(s): K.Ichikawa, T.Naganuma, H.Utsumi
  • Organizer: Euromar 2011
  • Place of Presentation: Frankfurt, Germany
• [Presentation] High field OMRI scanner for in vivo redox imaging (2010)
  • Author(s): Kazuhiro Ichikawa
  • Organizer: SFRBM 2010
  • Place of Presentation: Orlando, FL
  • Year and Date: 2010-11-18
• [Presentation] High field OMRI scanner for in vivo redox imaging (2010)
  • Author(s): Kazuhiro Ichikawa
  • Organizer: SFRBM 2010
  • Place of Presentation: Orlando, FI
  • Year and Date: 2010-11-18
• [Presentation] Imaging in vivo redox status with magnetic resonance technique. (2010)
  • Author(s): Kazuhiro Ichikawa Hideo Utsumi.
  • Organizer: 17th International SPACC Symposium.
  • Place of Presentation: Kagoshima
  • Year and Date: 2010-10-15
• [Presentation] Imaging in vivo redox status with magnetic resonance technique (2010)
  • Author(s): Kazuhiro Ichikawa Hideo Utsumi
  • Organizer: 17th International SPACC Symposium
  • Place of Presentation: Kagoshima
  • Year and Date: 2010-10-15
• [Presentation] 磁気共鳴法による生体レドックス機能イメージング (2010)
  • Author(s): 市川和洋
  • Organizer: 北海道大学GCOE「知の創出を支える次世代IT基盤拠点」若手研究者支援のための産学協同国内シンポジウム
  • Place of Presentation: 札幌
  • Year and Date: 2010-10-07
• [Presentation] 高解像度生体レドックスイメージング装置の開発 (2010)
  • Author(s): 市川和洋、長沼辰弥、内海英雄.高解像度生体レドックスイメージング装置の開発
  • Organizer: 第63回日本酸化ストレス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-06-24
• [Presentation] 生体レドックス分子イメージング開発と応用 (2009)
  • Author(s): 市川和洋,山田健一,安川圭司,兵藤文紀,内海英雄.
  • Organizer: 第62回日本酸化ストレス学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2009-06-11
• [Presentation] Construction of OMRI scanner based on ESR imaging system (2009)
  • Author(s): 市川和洋
  • Organizer: 42nd Annual International Meeting of the ESR Group of the Royal Society of Chemistry
  • Place of Presentation: United Kingdom
  • Year and Date: 2009-04-22
• [Book] 薬学領域の分析化学 (2009)
  • Author(s): 市川和洋
  • Total Pages: 237
  • Publisher: 広川書店
• [Book] 薬学領域の分析化学 (2009)
  • Author(s): 市川和洋(財津潔編)
  • Total Pages: 237
  • Publisher: 広川書店
• [Remarks]
  • URL: http://redoxnavi.kyushu-u.ac.jp/group1/
• [Patent(Industrial Property Rights)] 生体内因性分子の検出方法 (2010)
  • Inventor(s): 内海英雄、兵藤文紀、市川和洋
  • Industrial Property Rights Holder: 内海英雄、兵藤文紀、市川和洋
  • Filing Date: 2010-10-29
• [Patent(Industrial Property Rights)] 生体内因性分子の検出方法 (2010)
  • Inventor(s): 内海英雄、兵藤文紀、市川和洋
  • Industrial Property Rights Holder: 九州大学
  • Filing Date: 2010-10-29
  • Overseas
• [Patent(Industrial Property Rights)] 生体内因性物質の分子イメージング法 (2009)
  • Inventor(s): 内海英雄、兵藤文紀、市川和洋
  • Industrial Property Rights Holder: 九州大学
  • Filing Date: 2009-10-29
• [Patent(Industrial Property Rights)] 生体内因性物質の分子イメージング法 (2009)
  • Inventor(s): 内海英雄, 他
  • Industrial Property Rights Holder: 九州大学
  • Filing Date: 2009-10-29
  • Overseas
• [Patent(Industrial Property Rights)] 電磁波治療器 (2009)
  • Inventor(s): 内海英雄, 他
  • Industrial Property Rights Holder: 九州大学
  • Filing Date: 2009-10-29
  • Overseas