| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Research Abstract |
Polyplex nanomicelle is an effective and biocompatible gene carrier. By hydrodynamic injection of nanomicelle into skeletal muscle of mice, a prolonged transgene expression was obtained for more than a month. The addition of chondroitin sulfate to the nanomicelle further reduced the tissue damage in the muscle. In model mice of peripheral nerve injury, the introduction of IGF-1 gene into the muscle using the nanomicelle accelerated the recovery of motor function and sensation of the paralyzed limb, through the processes of the muscular hypertrophy induced by IGF-1. This strategy is promising for avoiding disuse atrophy and the eventual early recovery of motor and sensory functions after severe trauma.
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