A novel approach to treat severe trauma using gene introduction by nanomicelle into skeletal muscle
| Project/Area Number |
21300177
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ITAKA Keiji 東京大学, 大学院・医学系研究科, 特任准教授 (60292926)
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| Co-Investigator(Kenkyū-buntansha) |
OSADA Kensuke 東京大学, 大学院・工学系研究科, 特任准教授 (10396947)
OGATA Toru 国立障害者リハビリテーションセンター研究所, 運動機能系障害研究部, 部長 (00392192)
KAWAGUCHI Hiroshi 東京大学, 医学部附属病院, 准教授 (40282660)
KATAOKA Kazunori 東京大学, 大学院・工学系研究科, 教授 (00130245)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | ナノバイオ / 遺伝子 / バイオテクノロジー / ナノ材料 / 外傷 / 骨格筋 / 外傷治療 |
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| Research Abstract |
Polyplex nanomicelle is an effective and biocompatible gene carrier. By hydrodynamic injection of nanomicelle into skeletal muscle of mice, a prolonged transgene expression was obtained for more than a month. The addition of chondroitin sulfate to the nanomicelle further reduced the tissue damage in the muscle. In model mice of peripheral nerve injury, the introduction of IGF-1 gene into the muscle using the nanomicelle accelerated the recovery of motor function and sensation of the paralyzed limb, through the processes of the muscular hypertrophy induced by IGF-1. This strategy is promising for avoiding disuse atrophy and the eventual early recovery of motor and sensory functions after severe trauma.
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Report
(4 results)
Research Products
(42 results)
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[Presentation] マクロファージ活性化を回避する安全な肺への遺伝子導入2011
Author(s)
位高啓史,内田智士, Qixian Chen,長田健介,石井武彦,柴田映子,柴田雅明,斯波真理子,片岡一則
Organizer
第21回アンチセンスシンポジウム,第11回遺伝子・デリバリー研究会シンポジウム合同シンポジウム
Place of Presentation
大阪大学(大阪府吹田市)
Year and Date
2011-09-02
Related Report
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