| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2011: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2009: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Research Abstract |
We have succeeded to establish to construct in vitro liver model culturing primary hepatocytes, portal vein-ligation-induced hepatic stem cells, or human ES/iPS cell-derived hepatocytes with the networks of endothelial cells on EHS gels. The culture of these in vitro liver models in our original microfluidic system had significantly larger advantages for liver specific potentials compared to the non-fluidic. Our results lead strong expectation of our in vitro liver chips for application of drug metabolism and disposition.
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