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Construction of in vitro liver model using ES, iPS, or somatic stem cells, and its application for drug metabolism assay

Research Project

Project/Area Number 21300178
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionTokyo Institute of Technology

Principal Investigator

TAGAWA Yoh-ichi  東京工業大学, 大学院・生命理工学研究科, 准教授 (70262079)

Co-Investigator(Renkei-kenkyūsha) OZEKI Eiichi  株式会社島津製作所, 主幹研究員 (30192529)
MIYAGAWA Shinichi  信州大学, 医学部, 教授 (80229806)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2011: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2009: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Keywordsバイオチップ / 肝 / 薬物代謝 / 毒性試験 / ES細胞 / iPS細胞 / 組織 / 細胞極性 / 肝組織 / アセトアミノフェン / 動物実験代替 / マイクロ培養装置 / 内皮細胞 / チップ / 門脈結紮 / 肝前駆細胞 / CYP
Research Abstract

We have succeeded to establish to construct in vitro liver model culturing primary hepatocytes, portal vein-ligation-induced hepatic stem cells, or human ES/iPS cell-derived hepatocytes with the networks of endothelial cells on EHS gels. The culture of these in vitro liver models in our original microfluidic system had significantly larger advantages for liver specific potentials compared to the non-fluidic. Our results lead strong expectation of our in vitro liver chips for application of drug metabolism and disposition.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (88 results)

All 2012 2011 2010 2009

All Journal Article (25 results) (of which Peer Reviewed: 11 results) Presentation (52 results) Book (4 results) Patent(Industrial Property Rights) (7 results) (of which Overseas: 2 results)

  • [Journal Article] Acetoaminophen-induced hepatotoxicity in a liver tissue model consisting of primary hepatocytes assembling around an endothelial cell network2012

    • Author(s)
      Toyoda, Y., M.Tamai, K.Kashikura, S.Kobayashi, Y.Fujiyama, T.Soga, Y.Tagawa
    • Journal Title

      Drug Metab.Dispos

      Volume: 40 Pages: 169-177

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acetoaminophen-induced hepatotoxicity in a liver tissue model consisting of primary hepatocytes assembling around an endothelial cell network2011

    • Author(s)
      Toyoda, Y., M. Tamai, K. Kashikura, S. Kobayashi, Y. Fujiyama, T. Soga, and Y. Tagawa^*
    • Journal Title

      Drug Metab. Dispos

      Volume: 40 Pages: 169-177

    • Related Report
      2011 Final Research Report
  • [Journal Article] Potential role of LMP2 as tumor-suppressor defines new targets for uterine leiomyosarcoma therapy2011

    • Author(s)
      Hayashi, T, A. Horiuchi, K. Sano, N. Hiraoka, M. Kasai, T. Ichimura, T. Sudo, Y. Tagawa, R. Nishimura, Ol Ishiko, Y. Kanai, N. Yaegashi, H. Aburatani, T. Shiozawa, I. Konishi
    • Journal Title

      Sci. Rep.

      Volume: 1 Pages: 180-180

    • Related Report
      2011 Final Research Report
  • [Journal Article] Mitochondrial development of the in vitro he patic organogenesis model with simultaneous cardiac mesoderm differentiation from murine induced pluripotent stem cells2011

    • Author(s)
      Tamai, M., A, Yamashita, and Y. Tagawa
    • Journal Title

      J. Biosci. Bioeng

      Volume: 122 Pages: 495-500

    • Related Report
      2011 Final Research Report
  • [Journal Article] Nrk, an X-linked protein kinase in the germinal center kinase family, is required for placental development and fetoplacental induction of labor2011

    • Author(s)
      Denda, K., K. Nkano-Wakabayashi, N. Okamoto, N. Kitamura, J. Ryu, Y. Tagawa, T. Ichisaka, S. Yamanaka, and M. Komada
    • Journal Title

      J. Biol. Chem.

      Volume: 286 Pages: 28802-28810

    • Related Report
      2011 Final Research Report
  • [Journal Article] Expression of human factors CD81, claudin-1, scavenger receptor, and occluding in mouse hepatocytes does not confer susceptibility to HCV entry2011

    • Author(s)
      Hikosaka, K., H. Noritake, W. Kimura, N. Sultana, M. T. K. Sharkar, Y. Tagawa, T. Uezato, Y. Kobayashi, T. Wakita, and N. Miura
    • Journal Title

      Biomedical Research

      Volume: 32 Pages: 143-150

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Nrk, an X-linked protein kinase in the germinal center kinase family, is required for placental development and fetoplacental induction of labor2011

    • Author(s)
      Denda, K., K.Nkano-Wakabayashi, N.Okamoto, N.Kitamura, J.Ryu, Y.Tagawa, T.Ichisaka, S.Yamanaka, M.Komada
    • Journal Title

      J.Biol.Chem.

      Volume: 286 Pages: 28802-28810

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial development of the in vitro hepatic organogenesis model with simultaneous cardiac mesoderm differentiation from murine induced pluripotent stem cells2011

    • Author(s)
      Tamai, M., A.Yamashita, Y.Tagawa
    • Journal Title

      J.Biosci.Bioeng.

      Volume: 112 Pages: 495-500

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential role of LMP2 as tumor-suppressor defines new targets for uterine leiomyosarcoma therapy2011

    • Author(s)
      Hayashi, T, A.Horiuchi, K.Sano, N.Hiraoka, M.Kasai, T.Ichimura, T.Sudo, Y.Tagawa, R.Nishimura, Ol Ishiko, Y.Kanai, N.Yaegashi, H.Aburatani, T.Shiozawa, I.Konishi
    • Journal Title

      Sci Rep

      Volume: 1 Issue: 1 Pages: 180-180

    • DOI

      10.1038/srep00180

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肝機能デバイスの開発2010

    • Author(s)
      明地将一、藤山陽一、玉井美保、田川陽一
    • Journal Title

      島津評論

      Volume: 67 Pages: 53-59

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] Direct ex vivo expansion of hematopoietic stem cells from umbilical cord blood on membranes2010

    • Author(s)
      A. Higuchi, S.-T. Yang, P.-T. Li, M. Tamai, Y. Tagawa, Y. Chang, Y. Chang, Q.-D. Ling, S.-T. Hsu
    • Journal Title

      J. Membrane Science

      Volume: 351 Pages: 104-111

    • Related Report
      2011 Final Research Report
  • [Journal Article] Polymeric Membranes for Chiral Separation of Pharmaceuticals and Chemicals-Short title ; Membranes for Chiral Separation2010

    • Author(s)
      A. Higuchi, M. Tamai, Y.-A. Ko, Y. Tagawa Y-H Wu, B. D. Freeman, J.-T. Bing, Y. Chang, Q.-D. Ling
    • Journal Title

      Polymer Reviews

      Volume: 50 Pages: 113-143

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] Characterization of a variant virus from ascites of subacute granulomatous serositis in interferon-γ-deficient C57BL/6 mice persistently infected with murine coronavirus2010

    • Author(s)
      Kyuwa, S., S. Takagaki, S. Matsuyama, F. Taguchi, J. Saegusa, Y. Iwakura, Y. Tagawa, and Y. Yoshikawa
    • Journal Title

      strain JHM. Viral Immunology

      Volume: 23 Pages: 437-442

    • Related Report
      2011 Final Research Report
  • [Journal Article] Carbonate apatite-facilitated intracellulary delivered siRNA for efficient knockdown of functional genes2010

    • Author(s)
      Hossain, S., A. Stanislaus, MJ, Chua, S. Tada, Y. Tagawa, EH. Chowdhury, T. Akaike
    • Journal Title

      J. Control. Release

      Volume: 147 Pages: 101-108

    • Related Report
      2011 Final Research Report
  • [Journal Article] Isolation and characterization of portal branch ligation-stimulated Hmga2-positive bipontent hepatic progenitor cells2010

    • Author(s)
      Sakai, H., Y. Tagawa, M. Tamai, H. Motoyama, S. Ogawa, J. Soeda, T. Nakata, S. Miyagawa
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 403 Pages: 298-304

    • Related Report
      2011 Final Research Report
  • [Journal Article] Adrenomedullin in sinusoidal endothelial cells play protective roles against cold injury of liver2010

    • Author(s)
      Iinuma, N., T. Sakurai, A. Kamiyoshi, Y. Ichikwawa-Shindo, T. Arai, T. Yoshizawa, T. Koyama, R. Uetake, H. Kawate, S. Muto, Y. Tagawa, S. Miyagawa, T. Shindo
    • Journal Title

      Peptides

      Volume: 31 Pages: 865-871

    • Related Report
      2011 Final Research Report
  • [Journal Article] Isolation and characterization of portal branch ligation-stimulated Hmga2-positive bipontent hepatic progenitor cells.2010

    • Author(s)
      Sakai, H., Y.Tagawa^*, M.Tamai, H.Motoyama, S.Ogawa, J.Soeda, T.Nakata, S.Miyagawa
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 403 Pages: 298-304

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carbonate apatite-facilitated intracellulary delivered siRNA for efficient knockdown of functional genes.2010

    • Author(s)
      Hossain, S., A.Stanislaus, MJ, Chua, S.Tada, Y.Tagawa, EH.Chowdhury, T.Akaike
    • Journal Title

      J.Control.Release

      Volume: 147 Pages: 101-108

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of a variant virus from ascites of subacute granulomatous serositis in interferon-γ-deficient C57BL/6 mice persistently infected with murine coronavirus, strain JHM.2010

    • Author(s)
      Kyuwa, S., S.Takagaki, S.Matsuyama, F.Taguchi, J.Saegusa, Y.Iwakura, Y.Tagawa, Y.Yoshikawa
    • Journal Title

      Viral Immunology

      Volume: 23 Pages: 437-442

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct ex vivo expansion of hematopoietic stem cells from umbilical cord blood on membranes2010

    • Author(s)
      A.Higuchi, S.-T. Yang, P.-T.Li, M.Tamai, Y.Tagawa, Y.Chang, Y.Chang, Q.-D. Ling, S.-T. Hsu
    • Journal Title

      J.Membrane Science

      Volume: 351 Pages: 104-111

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adrenomedullin in sinusoidal endothelial cells play protective roles against cold injury of liver.2010

    • Author(s)
      Iinuma, N., T.Sakurai, A.Kamiyoshi, Y.Ichikwawa-Shindo, T.Arai, T.Yoshizawa, T.Koyama, R.Uetake, H.Kawate, S.Muto, Y.Tagawa, S.Miyagawa, T.Shindo
    • Journal Title

      Peptides 385(in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro reprogramming of adult hepatoc ytes into insulin-producing cells without viral vectors2009

    • Author(s)
      Motoyama, H., Ogawa, S., Kubo, A., Miwa, S., Nakayama, J., Tagawa, Y., and Miyagawa, S.
    • Journal Title

      Biochem. Biophys. Res. Commun. 3

      Volume: 85 Pages: 123-128

    • Related Report
      2011 Final Research Report
  • [Journal Article] IFN-γdeficiency worsen Pneumocystis pneumonia with Th17 development in nude mice2009

    • Author(s)
      Hu, T., Takamoto, M., Hida S., Tagawa, Y., and Sugane, K.
    • Journal Title

      Immunol Lett.

      Volume: 127 Pages: 55-59

    • Related Report
      2011 Final Research Report
  • [Journal Article] IFN-γ deficiency worsen Pneumocystis pneumonia with Th17 development in nudemice.2009

    • Author(s)
      Hu, T., Takamoto, M., Hida S., Tagawa, Y., Sugane, K.
    • Journal Title

      Immunol Lett. 127

      Pages: 55-59

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro reprogramming of adult hepatocytes into insulin-producing cells without viral vectors.2009

    • Author(s)
      Motoyama, H., Ogawa, S., Kubo, A., Miwa, S., Nakayama, J., Tagawa, Y., Miyagawa, S.
    • Journal Title

      Biochem Biophys Res Commun 385

      Pages: 123-128

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] マウス個体を用いたアセトアミノフェン誘導肝障害モデル構築の試み:概日リズムと肝毒性との相関性2011

    • Author(s)
      守矢恒司、豊田優、田川陽一
    • Organizer
      日本分子生物学会(第34回日本分子生物学会年会)
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Clonality of pancreatic acini and ducts in chimeric mice2011

    • Author(s)
      Je-young Ryu and Yoh-ichi Tagawa
    • Organizer
      日本分子生物学会(第34回日本分子生物学会年会)
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ヒトES/iPS細胞を用いたin vitroヒト肝組織モデルの構築2011

    • Author(s)
      安成晧,三田村圭祐,安達栄治郎,田川陽一
    • Organizer
      日本分子生物学会(第34回日本分子生物学会年会)
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] オッセオインテグレーションにおける線維芽細胞の影響2011

    • Author(s)
      張本乾一,長岡紀幸,鈴木一臣,吉田靖弘,田川陽一
    • Organizer
      第33回日本バイオマテリアル学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-11-21
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Development and validation of in vitro liver tissue model consisting of primary hepatocytes assembling around an endothelial network2011

    • Author(s)
      Yu Toyoda, Miho Tamai, Koji Moriya, Shunsuke Kobayashi and Yoh-ichi Tagawa
    • Organizer
      6th Toin international symposium on Biomedical engineering 2011
    • Place of Presentation
      横浜
    • Year and Date
      2011-11-05
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Mouse model for acetaminophen-induced liver injury for screening of hepatoprotective compounds2011

    • Author(s)
      Koji Moriya, Yu Toyoda, Yoh-ichi Tagawa
    • Organizer
      6th Toin international symposium on Biomedical engineering 2011
    • Place of Presentation
      横浜
    • Year and Date
      2011-11-05
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Advantage of Osteoblasts in Cell Competition on Biomaterials2011

    • Author(s)
      Kenichi Harimoto, Noriyuki Nagaoka, Kazuomi Suzuki, Yasuhiro Yoshida, & Yoh-ichi Tagawa
    • Organizer
      6th Toin international symposium on Biomedical engineering 2011
    • Place of Presentation
      横浜
    • Year and Date
      2011-11-05
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Development of pancreatic acinar cells in chimera of eGFP and DsRed22011

    • Author(s)
      Je-young Ryu and Yoh-ichi Tagawa
    • Organizer
      6th Toin international symposium on Biomedical engineering 2011
    • Place of Presentation
      横浜
    • Year and Date
      2011-11-05
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] In vitro model of liver organogenesis using embryonic stem cells2011

    • Author(s)
      Yoh-ichi Tagawa
    • Organizer
      Taiwanese Society of Molecular Medicine
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2011-11-02
    • Related Report
      2011 Final Research Report
  • [Presentation] In vitro model of liver organogenesis using embryonic stem cells2011

    • Author(s)
      Yoh-ichi Tagawa
    • Organizer
      Taiwanese Society of Molecular Medicine
    • Place of Presentation
      Taipei, Taiwan(招待講演)
    • Year and Date
      2011-10-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 合成生物学による肝組織モデルの構築を目指して2011

    • Author(s)
      田川陽一,安成晧,玉井美保
    • Organizer
      日本生物工学会(第63回大会)
    • Place of Presentation
      東京
    • Year and Date
      2011-09-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Acetaminophen-induced hepatotoxicity in liver tissue-like structure consisting of primary hepatocytes assembling around endothelial cell network2011

    • Author(s)
      Yu Toyoda, Koji Moriya, Shunsuke Kobayashi, Miho Tamai, Eijiro Adachi, and Yoh-ichi Tagawa
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Acetaminophen-induced hepatotoxicity in a liver tissue model consisting of primary hepatocytes assembling around an endothelial cell network2011

    • Author(s)
      Yu Toyoda, Koji Moriya and Yoh-ichi Tagawa
    • Organizer
      2011 International Graduate Forum on Biotechnology, Bioengineering and Biomedical Science(IGF3B-2011)
    • Place of Presentation
      Beijing, China
    • Year and Date
      2011-08-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Advantage of Osteoblasts in Cell Competition on Biomaterials2011

    • Author(s)
      Kenichi Harimoto, Noriyuki Nagaoka, Kazuomi Suzuki, Yasuhiro Yoshida, & Yoh-ichi Tagawa
    • Organizer
      2011 International Graduate Forum on Biotechnology, Bioengineering and Biomedical Science(IGF3B-2011)
    • Place of Presentation
      Beijing, China
    • Year and Date
      2011-08-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Dynamics of Metal Ions in Murine Embryonic Stem Cells2011

    • Author(s)
      Hiroaki Aikawa, Yoh-ichi Tagawa, Tadashi Saito, Yuko Fujiwara, Yuki Mizobuchi, and Masaya Kawase
    • Organizer
      2011 International Graduate Forum on Biotechnology, Bioengineering and Biomedical Science(IGF3B-2011)
    • Place of Presentation
      Beijing, China
    • Year and Date
      2011-08-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Dynamics of Metal Ions in Murine Embryonic Stem Cells2011

    • Author(s)
      Hiroaki Aikawa, Yoh-ichi Tagawa, Tadashi Saito, Yuko Fujiwara, Yuki Mizobuchi, Masaya Kawase
    • Organizer
      2011 International Graduate Forum on Biotechnology, Bioengineering and Biomedical Science (IGF3B-2011)
    • Place of Presentation
      Beijing, China
    • Year and Date
      2011-08-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Advantage of Osteoblasts in Cell Competition on Biomaterials2011

    • Author(s)
      Kenichi Harimoto, Noriyuki Nagaoka, Kazuomi Suzuki, Yasuhiro Yoshida, Yoh-ichi Tagawa
    • Organizer
      2011 International Graduate Forum on Biotechnology, Bioengineering and Biomedical Science (IGF3B-2011)
    • Place of Presentation
      Beijing, China
    • Year and Date
      2011-08-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Acetaminophen-induced hepatotoxicity in a liver tissue model consisting of primary hepatocytes assembling around an endothelial cell network2011

    • Author(s)
      Yu Toyoda, Koji Moriya, Yoh-ichi Tagawa
    • Organizer
      2011 International Graduate Forum on Biotechnology, Bioengineering and Biomedical Science (IGF3B-2011)
    • Place of Presentation
      Beijing, China
    • Year and Date
      2011-08-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] In vivo organization of vascularized hepatic tissues model with fibroblast-embedded collagen fibrils formation at intraperitoneal sites in partially hepatectomised mice2011

    • Author(s)
      Miho Tamai, Toshihiro Akaike, Eijiro Adachi, Yoh-ichi Tagawa
    • Organizer
      Gordon Research Conference on collagen
    • Place of Presentation
      New London, USA
    • Year and Date
      2011-07-22
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 細胞組織工学を応用した肝毒性評価系の開発2011

    • Author(s)
      豊田優,守矢恒司,山下晃平,小林俊介,田川陽一
    • Organizer
      第18回肝細胞研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-24
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ヒトiPS細胞を用いたヒト型肝組織のin vitro構築2011

    • Author(s)
      安成晧、田川陽一
    • Organizer
      第10回日本再生医療学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-01
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Acetaminophen-induced hepatotoxicity in liver tissue-like structure consisting of primary hepatocytes assembling around endothelial cell network2011

    • Author(s)
      Yu Toyoda, Koji Moriya, Shunsuke Kobayashi, Miho Tamai, Eijiro Adachi, Yoh-ichi Tagawa
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都、日本
    • Related Report
      2011 Annual Research Report
  • [Presentation] 合成生物学による肝組織モデルの構築を目指して2011

    • Author(s)
      田川陽一, 安成皓, 玉井美保
    • Organizer
      日本生物工学会(第63回大会)
    • Place of Presentation
      東京(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 細胞組織工学を応用したex vivo肝毒性評価系の開発2010

    • Author(s)
      豊田優、守矢恒司、玉井美保、山下晃平、赤池敏宏、安達栄次郎、田川陽一
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] バイオマテリアルに対する細胞の接着性がオッセオインテグレーションに及ぼす影響2010

    • Author(s)
      張本乾一,長岡紀幸,赤池敏宏,鈴木一臣,吉田靖弘,田川陽一
    • Organizer
      第32回日本バイオマテリアル学会大会
    • Place of Presentation
      広島
    • Year and Date
      2010-11-29
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 増殖性肝前駆様細胞を用いた高密度コラーゲンゲルによる3次元肝組織化2010

    • Author(s)
      玉井美保、酒井宏司、宮川眞一、赤池敏宏、安達栄次郎、田川陽一
    • Organizer
      第32回日本バイオマテリアル学会大
    • Place of Presentation
      広島
    • Year and Date
      2010-11-29
    • Related Report
      2011 Final Research Report
  • [Presentation] In vitro systems of liver organogenesis derived from murineorhuman iPS cell have high multiple hepatic potentials in long culture2010

    • Author(s)
      Yoh-ichi Tagawa
    • Organizer
      International Conference on Systems Biology of Stem Cell
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2010-10-17
    • Related Report
      2011 Final Research Report
  • [Presentation] In Vitro systems of liver organogenesis derived from murineorhuman iPS cellhave high multiple hepatic potentials in long culture2010

    • Author(s)
      Yoh-ichi Tagawa
    • Organizer
      International Conference on Systems Biology of Stem Cells
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cell-adhesive advantage of osteoblasts on titanium in the model of in vitro osseointegration2010

    • Author(s)
      K. Harimoto, N. Nagaoka, T. Akaike, K. Suzuki, Y. Yoshida, Y. Tagawa
    • Organizer
      2010 Tissue Engineering and Regenerative Medicine International Symposium-Asia & Pacific
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2010-09-15
    • Related Report
      2011 Final Research Report
  • [Presentation] High hepatic potentials in liver tissue micro-sized flow-culture system using murine or human ES/iPS cell2010

    • Author(s)
      Yoh-ichi Tagawa
    • Organizer
      2010 Tissue Engineering and Regenerative Medicine International Symposium-Asia & Pacific
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2010-09-15
    • Related Report
      2011 Final Research Report
  • [Presentation] In vitro systems of liver organogenesis derived from murine or human iPS cell have high multiple hepatic potentials in long culture2010

    • Author(s)
      S. Ahn, A. Yamashita, M. Tamai, T. Akaike, and Y. Tagawa
    • Organizer
      International Society for Stem Cell Research, 8th Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2010-06-16
    • Related Report
      2011 Final Research Report
  • [Presentation] バイオマテリアルに対する細胞の接着性が骨形成に及ぼす影響2010

    • Author(s)
      張本乾一,長岡紀幸,赤池敏宏,鈴木一臣,吉田靖弘,田川陽一
    • Organizer
      第9回日本再生医療学会総会
    • Place of Presentation
      広島
    • Year and Date
      2010-03-18
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 門脈結紮による肝前駆細胞の増殖誘導2010

    • Author(s)
      酒井宏司、玉井美保、奥山久嗣、本山博章、小川真一郎、田川陽一、宮川眞一
    • Organizer
      第9回日本再生医療学会総会
    • Place of Presentation
      広島
    • Year and Date
      2010-03-18
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 増殖性肝前駆様細胞を用いた高密度コラーゲンゲルによる3次元肝組織化2010

    • Author(s)
      玉井美保、酒井宏司、宮川眞一、赤池敏宏、安達栄次郎、田川陽二
    • Organizer
      第32回日本バイオマテリアル学会大会
    • Place of Presentation
      広島
    • Related Report
      2010 Annual Research Report
  • [Presentation] In Vitro systems of liver organogenesis derived from murine or human iPS cell have high multiple hepatic potentials in long culture2010

    • Author(s)
      S.Ahn, A.Yamashita, M.Tamai, T.Akaike, Y.Tagawa
    • Organizer
      International Society for Stem Cell Research, 8th Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] High hepatic potentials in liver tissue micro-sized flow-culture system using murine or human ES/iPS cell2010

    • Author(s)
      Yoh-ichi Tagawa
    • Organizer
      2010Tissue Engineering and Regenerative Medicine International Symposium-Asia & Pacific
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cell-adhesive advantage of osteoblasts on titanium in the model of in vitro osseointegration2010

    • Author(s)
      K.Harimoto, N.Nagaoka, T.Akaike, K.Suzuki, Y.Yoshida, Y.Tagawa
    • Organizer
      2010Tissue Engineering and Regenerative Medicine International Symposium-Asia & Pacific
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肝様組織チップを用いたex vivo肝毒性評価系の構築2009

    • Author(s)
      豊田優、玉井美保、奥山久嗣、小林俊介、新藤隆行、安達栄治郎、藤山陽一、小関英一、田川陽一
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Developmental Engineering and Development of Novel Artificial Liver System2009

    • Author(s)
      Y. Tagawa
    • Organizer
      Seminar at National Cheng Kung University
    • Place of Presentation
      Tainan, Taiwan
    • Year and Date
      2009-12-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Developmental Engineering and Development of Novel Artificial Liver System.2009

    • Author(s)
      Y.Tagawa.
    • Organizer
      Seminar at National Cheng Kung University
    • Place of Presentation
      Tainan, Taiwan
    • Year and Date
      2009-12-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] ES細胞等を用いた肝組織チップの開発2009

    • Author(s)
      安成晧、玉井美保、豊田優、奥山久嗣、赤池敏宏、新藤隆行、藤山陽一、小関英一、田川陽一
    • Organizer
      第22回日本動物実験代替法学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-11-14
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Hepatic Portal Branch Ligation-Stimulated Appearance of Bipotent Hepatic Progenitor Cells in Mice2009

    • Author(s)
      Hiroshi Sakai, Yoh-ichi Tagawa, Hiroaki Motoyama, Shinichiro Ogawa, Shinichi Miyagawa
    • Organizer
      2009 Meeting of the International Society for Stem Cell Research(ISSCR)
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2009-11-08
    • Related Report
      2011 Final Research Report
  • [Presentation] Developmental Engineering and Development of Novel Artificial Liver System2009

    • Author(s)
      Y. Tagawa
    • Organizer
      2009 Asia Conference for Biomaterials & Stem cell Techniques in Dong Hwa University
    • Place of Presentation
      Hualien, Taiwan
    • Year and Date
      2009-09-22
    • Related Report
      2011 Final Research Report
  • [Presentation] Developmental Engineering and Development of Novel Artificial Liver System.2009

    • Author(s)
      Y.Tagawa.
    • Organizer
      2009 Asia Conference for Biomaterials & Stem cell Techniques in Dong Hwa University
    • Place of Presentation
      Hualien, Taiwan
    • Year and Date
      2009-09-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Developmental Analysis using Multi-Color Fluorescent Embryonic Stem Cell Lines.2009

    • Author(s)
      Y.Tagawa.
    • Organizer
      2009 Asia Conference for Biomaterials & Stem cell Techniques
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2009-09-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Developmental Analysis using Multi-Color Fluorescent Embryonic Stem Cell Lines2009

    • Author(s)
      Y. Tagawa
    • Organizer
      2009 Asia Conference for Biomaterials & Stem Cell Techniques
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2009-09-10
    • Related Report
      2011 Final Research Report
  • [Presentation] New Role of Feeder Cells to Embryonic Stem Cells-Metal Analysis of Embryonic Stem Cells by ICP-MS2009

    • Author(s)
      Hiroaki Aikawa, Tadashi Saito, Yuko Fujiwara, Yuki Mizobuchi, Toshihiro Akaike, Yoh-ichi Tagawa, Masaya Kawase
    • Organizer
      2nd World Congress of the Tissue Engineering and Regenerative Medicine International Society(TERMIS) in conjunction with 2009 Seoul Stem Cell Symposium
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-08-31
    • Related Report
      2011 Final Research Report
  • [Presentation] Establishment of the High Density Culturing System Using Primary Culture of Hepatocyte2009

    • Author(s)
      Miho TAMAI, Satoshi HOSOYA, Toshihiro AKAIKE, Eijiro ADACHI, Yoh-ichi TAGAWA
    • Organizer
      2nd World Congress of the Tissue Engineering and Regenerative Medicine International Society(TERMIS) in conjunction with 2009 Seoul Stem Cell Symposium
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-08-31
    • Related Report
      2011 Final Research Report
  • [Presentation] 初代培養肝細胞を用いた再構成コラーゲンゲル内培養の検討2009

    • Author(s)
      玉井美保、細谷智、赤池敏宏、安達栄次郎、田川陽一
    • Organizer
      第16回肝細胞研究会
    • Place of Presentation
      山形
    • Year and Date
      2009-06-26
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Establishment of the High Density Culturing System Using Primary Culture of Hepatocyte2009

    • Author(s)
      Miho TAMAI, Satoshi HOSOYA, Toshihiro AKAIKE, Eijiro ADACHI, Yoh-ichi TAGAWA
    • Organizer
      2nd World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS) in conjunction with 2009 Seoul Stem Cell Symposium
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2009 Annual Research Report
  • [Presentation] New Role of Feeder Cells to Embryonic Stem Cells -Metal Analysis of Embryonic Stem Cells by ICP-MS2009

    • Author(s)
      Hiroaki Aikawa, Tadashi Saito, Yuko Fujiwara, Yuki Mizobuchi Toshihiro Akaike, Yoh-ichi Tagawa, Masaya Kawase
    • Organizer
      2nd World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS) in conjunction with 2009 Seoul Stem Cell Symposium
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2009 Annual Research Report
  • [Presentation] Hepatic Portal Branch Ligation-Stimulated Appearance of Bipotent Hepatic Progenitor Cells in Mice2009

    • Author(s)
      Hiroshi Sakai, Yoh-ichi Tagawa, Hiroaki Motoyama, Shinichiro Ogawa, Shinichi Miyagawa
    • Organizer
      2009 Meeting of the International Society for Stem Cell Research (ISSCR)
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2009 Annual Research Report
  • [Book] 実験医学別冊核酸実験の原理とプロトコール(平尾一郎、胡桃坂仁志編集)2011

    • Author(s)
      三田村圭祐、田川陽一
    • Publisher
      羊土社
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Book] IFN「seriesモデル動物利用マニュアル疾患モデルの作製と利用免疫疾患」(岩倉洋一郎監修)2011

    • Author(s)
      瀧伸介、田川陽一
    • Publisher
      エル・アイ・シー
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Book] バイオ研究のフロンティア医療・診断をめざす先端バイオロジー2009

    • Author(s)
      田川陽一, 他
    • Total Pages
      186
    • Publisher
      工学図書株式会社
    • Related Report
      2011 Final Research Report
  • [Book] バイオ研究のフロンティア 医療・診断をめざす先端バイオロジー2009

    • Author(s)
      田川陽一, 他28
    • Total Pages
      186
    • Publisher
      工学図書株式会社
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 細胞培養デバイス2012

    • Inventor(s)
      藤山陽一、田川陽一
    • Industrial Property Rights Holder
      島津製作所・東京工業大学
    • Industrial Property Number
      2012-030204
    • Filing Date
      2012-02-15
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 細胞培養デバイス2012

    • Inventor(s)
      藤山陽一・田川陽一
    • Industrial Property Rights Holder
      島津製作所・東京工業大学
    • Industrial Property Number
      2012-030204
    • Filing Date
      2012-02-15
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 肝保護剤、医薬組成物、食品、細胞等の保護方法、および細胞等保護用組成物2011

    • Inventor(s)
      内沢秀光、田川陽一、斉藤ゆかり、玉井美保、白川和浩
    • Industrial Property Rights Holder
      青森産業技術センター・東京工業大学・白川商店
    • Industrial Property Number
      2011-159586
    • Filing Date
      2011-07-21
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Patent(Industrial Property Rights)] CELL CULTURE DEVICE AND CELL CULTURE METHOD(細胞培養デバイス及び細胞培養方法)2010

    • Inventor(s)
      藤山陽一、田川陽一
    • Industrial Property Rights Holder
      島津製作所・東京工業大学
    • Filing Date
      2010-09-10
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 細胞培養デバイス、細胞培養システム、及び細胞培養方法2010

    • Inventor(s)
      藤山陽一、田川陽一
    • Industrial Property Rights Holder
      島津製作所・東京工業大学
    • Industrial Property Number
      2010-118960
    • Filing Date
      2010-05-25
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 特許2010

    • Inventor(s)
      藤山陽一、田川陽一
    • Industrial Property Rights Holder
      島津製作所東京工業大学
    • Industrial Property Number
      2010-118960
    • Filing Date
      2010-05-25
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] PCT国際特許2010

    • Inventor(s)
      藤山陽一、田川陽一
    • Industrial Property Rights Holder
      島津製作所東京工業大学
    • Filing Date
      2010-09-10
    • Related Report
      2010 Annual Research Report
    • Overseas

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Published: 2009-04-01   Modified: 2016-04-21  

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