Development of Therapeutic Drugs Targeting Cancer with Bio-Nanoparticle Encapsulating Anti-Cancer Reagents
| Project/Area Number |
21300179
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Okayama University |
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Principal Investigator |
SENO Masaharu 岡山大学, 大学院・自然科学研究科, 教授 (90243493)
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| Co-Investigator(Kenkyū-buntansha) |
KUDOH Takayuki 岡山大学, 大学院・自然科学研究科, 助教 (00346412)
MIZUTANI Akifumi 岡山大学, 大学院・自然科学研究科, 助教 (50598331)
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| Research Collaborator |
FU Li 中国天津医科大学, 教授
EL-SAYED Ibrahim エジプトメノフェイア大学, 教授
SALOMON David s. 米国国立がん研究所, 主幹研究員
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 制がん剤 / ErbB2 / CD44 / DDSキャリア / 分子標的 / 細胞表面マーカー / DNAマイクロアレイ / 球面自己組織化マップ |
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| Research Abstract |
We tried to establish drug delivery systems, targeting cancer cells specifically, using bio-nano-particle composed of liposome and/or proteins as a carrier of anti-cancer reagents. Multivalent design of the carrier to present antibodies or ligands with high affinity to cell surface molecules was found to stimulate endocytosis of the particles. The targeting with the antibodies and ligands made the targeting efficient showing the incubation time of particle with the target cells clearly shorter. Furthermore, the particle escaped from phagocytic macrophages when lipid component was optimized.
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Report
(4 results)
Research Products
(75 results)
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[Journal Article] Enhanced internalization of ErbB2 in SK-BR-3 cells with multivalent forms of artificial ligand2011
Author(s)
Vaidyanath A, Hashizume T, Nagaoka T, Takeyasu N, Satoh H, Chen L, Wang J, Kasai T, Kudoh T, Satoh A, Fu L, Seno M
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Journal Title
J Cell Mol Med.
Volume: Vol.15, No.11
Pages: 2525-2538
Related Report
Peer Reviewed
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[Journal Article] Enhanced intemalization of ErbB2 in SK-BR-3 cells with multivalent forms of an artificial ligand2011
Author(s)
Vaidyanath A, Hashizume T, Nagaoka T, Takeyasu N, Satoh H, Chen L, Wang J, Kasai T, Kudoh T, Satoh A, Fu L, Seno M
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Journal Title
J Cell Mol Med
Volume: 15
Issue: 11
Pages: 2525-2538
DOI
Related Report
Peer Reviewed
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[Journal Article] Novel and simple loading procedure of cisplatin into liposomes and targeting tumor endothelial cells.2010
Author(s)
Hirai M, Minematsu H, Hiramatsu Y, Kitagawa H, Otani T, Iwashita S, Kudoh T, Chen L, Li Y, Okada M, Salomon DS, Igarashi K, Chikuma M, Seno M.
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Journal Title
Related Report
Peer Reviewed
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[Presentation] Application of cell penetrating liposome for Bioimaging2010
Author(s)
Takayuki Otani, Yoko Akazawa, Kazunori Oie, Masahiko Hirai, Yoshie Hiramatsu, Jun Tanaka, Hiroyuki Kitagawa, Wadhawa Renu, Kaul Sunil, Masaharu Seno, Koichi Igarashi
Organizer
第3回高度医療都市を創出する未来技術国際シンポジウム
Place of Presentation
岡山大学津島キャンパス(岡山県)
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